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Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung qi-Man Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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残胃癌的外科治疗(附19例临床分析)

四川肿瘤防治 2000年第1期13卷 36-38页

作者：陈思潮石成器陈文博福建省南安市医院外科南安362300

目的:探讨残胃癌的病因,外科治疗方法及对并发症防治。方法:整理分析本院10年来收治残胃癌19例的临床资料,对比根治性残胃全切除及合并邻近脏器联合切除、姑息性切除、非切除各组患者的治疗效果。结果:本组19例中,12例曾作BⅡ式切除术;... 详细信息

目的:探讨残胃癌的病因,外科治疗方法及对并发症防治。方法:整理分析本院10年来收治残胃癌19例的临床资料,对比根治性残胃全切除及合并邻近脏器联合切除、姑息性切除、非切除各组患者的治疗效果。结果:本组19例中,12例曾作BⅡ式切除术;残胃癌全切除后1年、2年、5年生存率分别为58.3%、25.0%、16.7%。非切除病例均在5～6月内死亡。结论:行远侧胃切除,应争取作BⅠ式切除术;对残胃癌应强调早期诊断及早期治疗,力争手术切除,消化道重建方式推荐P袢空肠代胃、消化道Rouxy重建术。

关键词：胃肿瘤残胃癌胃全切术消化道重建术治疗

Practical approach for detecting k-nonseparability of multipartite quantum states

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 32-48页

作者： Jie Guo Jinchuan Hou Xiaofei qi Kan He College of Mathematics Taiyuan University of Technology School of Mathematics and Statistics Shanxi University Key Laboratory of Complex Systems and Data Science of Ministry of Education Shanxi University

The instantaneous detection of entanglement in quantum states poses a significant challenge in the fields of quantum computation and quantum information, and there are no practical methods or tools to complete this task satisfactorily so far. We propose a sufficient and necessary criterion of k-nonseparability for any n-partite finite or infinite dimensional systems, 2 ≤ k ≤ n. This criterion serves as the foundation for a practical scheme designed to detect entanglement and k-nonseparability across multipartite finite-dimensional systems. To exemplify the application of our scheme, we have developed a software tool that facilitates swift and precise identification of entanglement, k-nonseparability, and genuine entanglement within n-qubit systems, specifically tailored for systems with 2 ≤ n ≤ 4.

关键词： multipartite systems entanglement states entanglement witnesses ${\bm~k}$-nonseparability

Interaction in Binary Mixtures of Gemini Surfactant G12-6-12 and CTAB by NMR

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Chinese Journal of Chemical Physics 2014年第3期27卷 307-314页

作者： Jin-zhi Zhang Li Xie shi-gan Chai qi-chao Zou Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials College of Chemistryand Chemical Engineering Ministry-of-Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules Hubei University Wuhan 430052 China

The interaction between N, N′-bis（dimethyldodecyl）-1,6-hexanediammoniumdibromide （G12-6-12） and cetyltrimethylammonium bromide （CTAB） in D20 aqueous medium has been investigated by NMR at 298 K. The G12-6-12 and CTAB are about 0.773 and measured critical micelle concentration （cmc） of 0.668 mmol/L, respectively. The cmc^＊（cmc of mixture） values are less than CMC^＊（cmc of ideally mixed solution） in the mixed system, and the interaction parameter βM〈0 at different molar fractions α of G12-6-12 in the mixed systems, but just when α≤0.3, cmc^＊ values are much smaller than CMC^＊, and βM satisfies the relation of ｜βM｜〉｜ln（cmc1/cmc2）｜（cmcl： cmc of pure G12-6-12 and cmc2： cmc Of pure CTAB）. The results indicate that there exists synergism between G12-6-12 and CTAB, and they can form mixed micelles, which is further proven by 2D NOESY and self-diffusion coefficient D experiments. There are intermolecular cross peaks between G12-6-12 and CTAB in 2D NOESY, and the radius of micelles in mixed solution is bigger than that in G12-6-12 pure solution in D experiments, indicating there are mixed micelles. However, when α〉0.3, we find that cmc^＊≈CMC^＊, βM≈0, obviously, the two surfactants are almost ideal mixing fitting the pseudo-phase separation model and regular solution theory.

关键词： Interaction Gemini surfactant Cetyltrimethylammonium bromide NMR

A new process of extracting vanadium from stone coal

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International Journal of Minerals,Metallurgy and Materials 2010年第4期17卷 381-388页

作者： Yan-hua Liu chao Yang Pei-you Li shi-qi Li Metallurgical and Ecological Engineering School University of Science and Technology Beijing Beijing 100083 China Beijing Nengtai Environmental Protection Group Corp Beijing 100022 China

A new process of extracting vanadium from the stone coal vanadium ore in Fangshankou, Dtmhuang area of Gansu Province, China was introduced. Various leaching experiments were carried out, and the results show that the vanadium ore in Fangshankou is difficult to process due to its high consumption of acid and the high leaching rate of impurities. However, the leaching rate can be up to 80% and the content of V2O5 in the residue can be between 0.22%-0.25% in the process of ore fme grinding→oxidation roasting→mixing and ripening→aqueous leaching→P2O4 solvent extraction→sulfuric acid stripping→oxidation and precipitation→decomposition by heat. Also, the quality of flaky V205 produced by this process can meet the requirements of GB3283--87. The total leaching rate of vanadium is 70%. Also, three types of wastes are easy to treat. The vanadium extraction process is better in relation to the aspect of environmental protection than the sodium method.

关键词： stone coal vanadium extraction leaching solvent extraction V2O5

Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo qi Han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Quantum metrology with single spins in diamond under ambient conditions

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National Science Review 2018年第3期5卷 346-355页

作者： Ming Chen chao Meng qi Zhang Changkui Duan Fazhan shi Jiangfeng Du Key Laboratory of Microscale Magnetic Resonance and Department of Modern Physics University of Science and Technology of China

The detection of single quantum systems can reveal information that would be averaged out in traditional techniques based on ensemble measurements. The nitrogen-vacancy(NV) centers in diamond have shown brilliant prospects of performance as quantum bits and atomic sensors under ambient conditions, such as ultra-long coherence time, high fidelity control and readout of the spin state. In particular, the sensitivity of the NV center spin levels to external environmental changes makes it a versatile detector capable of measuring various physical quantities, such as temperature, strain, electric fields and magnetic fields. In this paper, we review recent progress in NV-based quantum metrology, and speculate on its future.

关键词： diamond nitrogen-vacancy centers quantum metrology quantum sensing quantum information process

Integrating lipidomics and gut microbiota to study the anti-hyperlipidemia effect of Sargentodoxae Caulis extract

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Traditional Medicine Research 2025年第1期10卷 1-11页

作者： Xiao-Xiao Zhang Li Jia Xiu-Jun Zhan Charity Ngina qing-Rui Zhang Xiao-Ge Li qi-Bao Jiang shi Bai Miao-Miao Jiang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjin 301617China Haihe Laboratory of Modern Chinese Medicine Tianjin 301617China School of Medicine Taizhou UniversityTaizhou 318000China.

Background:Sargentodoxae Caulis(SC)is the vine stem of Sargentodoxa Cuneata(Oliv.)Rehd.&*** in ***,and it in traditional Chinese medicine has been known for promoting blood circulation and removing blood stasis as recorded in the ancient book“Illustrated Classics of Materia Medica”.It has been used effectively to treat blood stasis too in modern clinical ***,the anti-hyperlipidemia effect of SC is not fully *** paper aims at exploring the use of SC stems to improve the balance of blood lipids in the body,and its new role in treating ***:The effects of SC extract on hyperlipidemia were explored by combining lipidomics and gut ***,we explored the potential mechanism of SC in treating hyperlipidemia by pathway ***:The results showed that the stem extract of SC could restore the physiological and biochemical indices of hyperlipidemia in mice,as well as repair the morphological and structural damage to *** to the Model group,the SC extract significantly reduced the liver index,epididymal fat index,and Lee’s *** also significantly decreased serum levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,peroxisome proliferator-activated receptor gamma(PPAR-γ),D-lactate,and free fatty acids,while significantly increasing the relative content of peroxisome proliferator-activated receptor alpha(PPAR-α).These changes were statistically ***-targeted lipidomics,based on LC-MS,were utilized to investigate the lipid metabolism characteristics in serum,liver,and epididymal fat of the *** was observed that,compared to the blank group,the Model group exhibited significant changes primarily in glycerol lipids and *** treatment group also displayed alterations in these lipids.A total of 38,81,and 27 differential lipids were identified in serum,liver,and epididymal fat samples,*** these,14 common differenti

关键词： hyperlipidemia Sargentodoxae Caulis lipidomics intestinal flora

Effect of Different Raft Shapes on Hydrodynamic Characteristics of the Attenuator-Type Wave Energy Converter

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China Ocean Engineering 2023年第4期37卷 645-659页

作者： WANG Jin WANG Shu-qi JIANG qing-dian XU Yun-xin shi Wei-chao School of Naval Architecture and Ocean Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China Department of Naval Architecture Ocean and Marine EngineeringUniversity of StrathclydeGlasgowG40LZUK

A numerical simulation method based on CFD has been established to simulate the fully coupled motion for an atten-uator-type wave energy converter(WEC).Based on this method,a detailed parametric analysis has been conducted to investigate the design of the *** effects of different parameters(wave parameters,structural parameters and PTO parameters)on the hydrodynamic characteristics of the attenuator-type WEC were studied in *** results show that in terms of wave parameters,there is an optimal wave period,which makes the relative pitching angle amplitude of the WEC reach the maximum,and the increase of wave height is conducive to the relative pitching angle amplitude of wave *** different wave conditions,the relative pitch angle of the parallelogram raft device is the *** terms of structural parameters,the parallelogram attenuator-type device has the optimal values in different relative directions,different distances and different apex angle,which makes the relative motion amplitude of the device reach the maximum,and the spacing and the apex angle have influence on the motion frequency of the device,while the relative direction has almost no influence on *** terms of PTO parameters,there is an optimal damping coefficient,which makes the power generation efficiency of the WEC reach the *** research results provide a valuable reference for future research and design of the attenuator-type WEC.

关键词： wave energy converter attenuator-type shape hydrodynamic analysis power generation efficiency