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Decoding Human Biology and Disease Using Single-cell Omics Technologies

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Genomics, Proteomics & Bioinformatics 2023年第5期21卷 926-949页

作者： qiang shi Xueyan Chen Zemin Zhang Biomedical Pioneering Innovation Center School of Life SciencesPeking UniversityBeijing 100871China Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing 100871China Changping Laboratory Beijing 102206China

Over the past decade,advances in single-cell omics(SCO)technologies have enabled the investigation of cellular heterogeneity at an unprecedented resolution and scale,opening a new avenue for understanding human biology and *** this review,we summarize the developments of sequencing-based SCO technologies and computational methods,and focus on considerable insights acquired from SCO sequencing studies to understand normal and diseased properties,with a particular emphasis on cancer *** also discuss the technological improvements of SCO and its possible contribution to fundamental research of the human,as well as its great potential in clinical diagnoses and personalized therapies of human disease.

关键词： Single-cell omics Computational method Cellular heterogeneity Disease Cancer research

Redefined generalized fuzzy ideals of near-rings

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Applied Mathematics(A Journal of Chinese Universities) 2010年第3期25卷 341-348页

作者： ZHAN Jian-ming YIN yun-qiang Department of Mathematics Hubei Institute for Nationalities Enshi 445000 China College of Mathematics and Information Sciences East China Institute of Technology Fuzhou Jiangxi 344000 China

With a new idea, we redefine generalized fuzzy subnear-rings （ideals） of a near- ring and investigate some of its related properties. Some new characterizations are given. In particular, we introduce the concepts of strong prime （or semiprime）（∈, ∈∨ q）-fuzzy ideals of near-rings, and discuss the relationship between strong prime （or semiprime）（∈, ∈∨ q）-fuzzy ideals and prime （or semiprime）（∈, ∈∨ q）-fuzzy ideals of near-rings.

关键词： Near-ring subnear-ring (ideal) (∈^- ∈^-∨ q^-)-fuzzy subnear-ring (ideal) prime (semiprime) (∈ ∈∨ q)-fuzzy subnear-ring (ideal).

Density peak clustering using tensor network

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Science China(Information Sciences) 2024年第3期67卷 321-322页

作者： Xiao shi yun SHANG Institute of Mathematics Academy of Mathematics and Systems ScienceChinese Academy of Sciences School of Mathematical Sciences University of Chinese Academy of Sciences National Center for Mathematics and Interdisciplinary Sciences Key Laboratory of ManagementDecision and Information SystemsAcademy of Mathematics and Systems ScienceChinese Academy of Sciences

Tensor networks have been a powerful tool in simulating many-body physics and have recently gained recognition in the machine learning community due to their remarkable representation capabilities. However, using tens... 详细信息

关键词： Tensors

Improved response surface method for anti-slide reliability analysis of gravity dam based on weighted regression

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第6期11卷 432-439页

作者： Jian-yun CHEN qiang XY Jing LI Shu-li FAN qiang xu State Key Laboratory of Coastal and Offshore Engineering Daliatz University of Technology Dalian 116023 China School of Civil and Hydraulic Engineering Dalian University of Technology Dalian 116023 China

The aim of this study was to design and construct an improved response surface method(RSM) based on weighted regression for the anti-slide reliability analysis of concrete gravity *** limitation and lacuna of the traditional RSM were briefly ***,based on small experimental points,research was devoted to an improved RSM with singular value decomposition ***,the method was used on the basis of weighted regression and deviation coefficient correction to reduce iteration times and experimental points and improve the calculation method of checking ***,a test example was given to verify this *** with other conventional algorithms,this method has some strong advantages:this algorithm not only saves the arithmetic operations but also greatly enhances the calculation efficiency and the storage efficiency.

关键词： Response surface method(RSM) Reliability Gravity dam Singular value decomposition Weighted regression Deviation coefficient

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三种药剂对马铃薯发芽出苗的影响

黑龙江农业科学 2022年第10期 50-55页

作者：李鹤鹏于洪涛丁俊杰杨新春符强高雪冬石运强沈海军黑龙江省农业科学院绥化分院黑龙江绥化152052 黑龙江省农业科学院佳木斯分院黑龙江佳木斯154007

为解决马铃薯种植过程中常用赤霉素催芽浓度争议较大易造成植株徒长、种薯腐烂等问题,以克新23为材料开展盆栽药效试验,评价硼酸钠、碧护、超敏蛋白对马铃薯发芽至苗期的影响,探索替代赤霉素的可行性。结果表明,硼酸钠会抑制马铃薯出苗... 详细信息

为解决马铃薯种植过程中常用赤霉素催芽浓度争议较大易造成植株徒长、种薯腐烂等问题,以克新23为材料开展盆栽药效试验,评价硼酸钠、碧护、超敏蛋白对马铃薯发芽至苗期的影响,探索替代赤霉素的可行性。结果表明,硼酸钠会抑制马铃薯出苗及苗期生长,但会增加主茎数及鲜重,适宜浓度为0.7 mg·L^(-1);超敏蛋白对马铃薯出苗及生长等方面的促进作用相对较小,能够增加植株鲜重,并对萌发期至苗期病害具有一定防治潜力,适宜浓度为670 mg·L^(-1);碧护具有相对较好的促进地上部生长、增加主茎数量及壮株效果,适宜浓度为145 mg·L^(-1)。实际生产中可使用145 mg·L^(-1)碧护制剂喷淋薯块至表面湿润后晾干播种,这种改良的催芽方法可提高马铃薯主茎数量,并增加苗期茎粗、植株生长速度、地上部鲜重和地下部鲜重,具有替代赤霉素的潜在价值。

关键词：马铃薯生长硼酸钠碧护超敏蛋白

Microstructures of Fe_(77-x)Ni_(x)Cu_(1)Nb_(2)P_(14)B_(6) Soft Magnetic AlloysStudied by X-Ray Absorption Fine Structure

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Chinese Physics Letters 2000年第9期17卷 683-685页

作者： YIN shi-Long BIAN Qing WEI shi-qiang Department of Mathematics and Physics Hohai UniversityNanjing 210024 Department of Basic Science Institute of Communication EngineeringNanjing 210016 National Synchrotron Radiation Laboratory and Center for Fundamental Physics University of Science and Technology of ChinaHefei 230029

Local structures of the mechanically alloyed Fe_(77-x)Ni_(x)Cu_(1)Nb_(2)P_(14)B_(6)soft magnetic materials have been in vestigated by x-ray absorption fine *** results show that mechanical alloying(MA)can drive theFe_(77-x)Ni_(x)Cu_(1)Nb_(2)P_(14)B_(6)powder mixture to produce amorphous alloy when the atomic concentration of Fe ele ment is about and over 40%.On the contrary,the MA Fe_(77-x)Ni_(x)Cu_(1)Nb_(2)P_(14)B_(6)is a solid solution with an fcc-like structure in the region of lower Fe atomic concentration(<22%),preserving a medium-range order around Ni and Fe ***,we have found that the local structure geometry of Fe atom is similar to that of Ni atom for all the MA Fer7-xNixCu1 Nb2P14B6 *** indicates that the local structures of Fe and Ni atoms in a Fe_(77-x)Ni_(x)Cu_(1)Nb_(2)P_(14)B_(6)sample only depend on the x value of element Ni after ball milling.

关键词： structure alloying alloy

MECHANICAL AND THERMAL PROPERTIES OF NANOSIZED TITANIUM DIOXIDE FILLED RIGID POLY(VINYL CHLORIDE)

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Chinese Journal of Polymer Science 2013年第2期31卷 325-332页

作者： yun-xiang Zhang 宋义虎 qiang Zheng Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Department of PolymerScience and Engineering Zhejiang University

Nano-sized rod-like titanium dioxide （TiO2） filled rigid poly（vinyl chloride）（PVC） nanocomposites were prepared by using injection-molding method. Vicat, Charpy impact and tensile tests as well as thermogravimetric and dynamic mechanical analyses were used to characterize the structure and properties of the nanocomposites. The results showed that nano-TiO2 could improve Vicat softening temperature and also improve thermal stability of PVC during the stages of dehydrochlorination and formation of carbonaceous conjugated polyene sequences, which can be ascribed to restriction of the nanoparticles on the segmental relaxation as being evidenced by raises in glass transition and β-relaxation temperatures of PVC upon filling TiO2. Addition of TiO2 nanoparticles less than 40 phr （parts per hundreds of resin） could significantly improve impact strength of the composites while the TiO2 agglomeration at high contents leads to a reduction in impact toughness.

关键词： Poly(vinyl chloride) (PVC) Titanium dioxide (TiO2) Thermal property Mechanical property Impact strength.

Machine learning of phases and mechanical properties in complex concentrated alloys

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Journal of Materials Science & Technology 2021年第28期87卷 133-142页

作者： Jie Xiong San-qiang shi Tong-Yi Zhang School of Materials Science and Engineering Harbin Institute of TechnologyShenzhenChina Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong KongChina Shenzhen Research Institute The Hong Kong Polytechnic UniversityShenzhenChina Material Genome Institute Shanghai UniversityShanghaiChina

The mechanical properties of complex concentrated alloys(CCAs)depend on their formed phases and corresponding *** data-driven prediction of the phase formation and associated mechanical properties is essential to discovering novel *** present work collects 557 samples of various chemical compositions,comprising 61 amorphous,167 single-phase crystalline,and 329 multiphases crystalline *** classification models are developed with high accuracies to category and understand the formed phases of ***,two regression models are constructed to predict the hardness and ultimate tensile strength of CCAs,and the correlation coefficient of the random forest regression model is greater than 0.9 for both of two targeted ***,the Shapley additive explanation(SHAP)values are calculated,and accordingly four most important features are identified.A significant finding in the SHAP values is that there exists a critical value in each of the top four features,which provides an easy and fast assessment in the design of improved mechanical properties of *** present work demonstrates the great potential of machine learning in the design of advanced CCAs.

关键词： Materials informatics SHAP Complex concentrated alloys High entropy alloys

Optimizing the Copy-on-Write Mechanism of Docker by Dynamic Prefetching

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Tsinghua Science and Technology 2021年第3期26卷 266-274页

作者： Yan Jiang Wei Liu Xuanhua shi Weizhong qiang National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabHuazhong University of Science and TechnologyWuhan 430074China

Docker,as a mainstream container solution,adopts the Copy-on-Write(CoW)mechanism in its storage *** mechanism satisfies the need of different containers to share the same ***,when a single container performs operations such as modification of an image file,a duplicate is created in the upper readwrite layer,which contributes to the runtime *** the accessed image file is fairly large,this additional overhead becomes *** we present the concept of Dynamic Prefetching Strategy Optimization(DPSO),which optimizes the Co W mechanism for a Docker container on the basis of the dynamic prefetching *** the beginning of the container life cycle,DPSO pre-copies up the image files that are most likely to be copied up later to eliminate the overhead caused by performing this operation during application *** experimental results show that DPSO has an average prefetch accuracy of greater than 78%in complex scenarios and could effectively eliminate the overhead caused by the CoW mechanism.

关键词： Docker container Copy-on-Write(CoW) storage driver prefetch strategy