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Chinese Physics Letters 2012年第9期29卷 219-221页

作者： YU Zhi-Guo CHEN Peng YANG Guo-Feng liU Bin XIE Zi-li XIU Xiang-Qian WU Zhen-Long XU Feng XU Zhou HUA Xue-Mei HAN Ping shi YiZHANG Rong ZHENG you-Dou Jiangsu Provincial Key Laboratory of Advanced Photonic and Electronic Materials and School of Electronic Science and Engineering Nanjing UniversityNanjing 210093 Nanjing University Institute of Optoelectronics at Yangzhou Yangzhou 225009

Roughened surfaces of light-emitting diodes(LEDs)provide substantial improvement in light extraction *** preparing the self-assemble nanoporous Ni template through rapid annealing of a thin Ni film,followed by a low damage dry etching process,a p-side-up LED with a roughened surface has been *** to a conventional LED with plane surface,the light output of LEDs with nanoporous p-GaN surface increases up to 71%and 36%at applied currents of 1 mA and 20 mA,***,the electrical characteristics are not degraded obviously after surface roughening.

关键词： Rough preparing template

Human ACE2-Functionalized Gold“Virus-Trap”Nanostructures for Accurate Capture of SARS-CoV-2 and Single-Virus SERS Detection

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Nano-Micro Letters 2021年第7期13卷 105-117页

作者： Yong Yang Yusi Peng Chenglong lin li Long Jingying Hu Jun He Hui Zeng Zhengren Huang Zhi-Yuan li Masaki Tanemura Jianlin shi John R.Lombardi Xiaoying Luo State Key Laboratory of High-Performance Ceramics and Superfine Microstructures Shanghai Institute of CeramicsChinese Academy of Sciences1295 Dingxi RoadShanghai 200050People’s Republic of China Graduate School of the Chinese Academy of Sciences Beijing 100049People’s Republic of China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049People’s Republic of China School of Physics and Optoelectronics South China University of TechnologyGuangzhou 510640People’s Republic of China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer InstituteRenji HospitalShanghai Jiaotong University School of MedicineShanghai 200032People’s Republic of China Anhui Provincial Center for Disease Control and Prevention Hefei 12560AnhuiPeople’s Republic of China Public Health Research Institute of Anhui Province Hefei 12560AnhuiPeople’s Republic of China Shanghai Yangpu Hospital of Traditional Chinese Medicine Shanghai 200090People’s Republic of China Department of Frontier Materials Nagoya Institute of TechnologyNagoya 466-8555Japan Department of Chemistry The City College of New York160 Convent AvenueNew YorkNY 10031USA

The current COVID-19 pandemic urges the extremely sensitive and prompt detection of SARS-CoV-2 ***,we present a Human Angiotensin-converting-enzyme 2(ACE2)-functionalized gold“virus traps”nanostructure as an extremely sensitive SERS biosensor,to selectively capture and rapidly detect S-protein expressed coronavirus,such as the current SARS-CoV-2 in the contaminated water,down to the single-virus *** a SERS sensor features extraordinary 106-fold virus enrichment originating from high-affinity of ACE2 with S protein as well as“virus-traps”composed of oblique gold nanoneedles,and 109-fold enhancement of Raman signals originating from multi-component SERS ***,the identification standard of virus signals is established by machine-learning and identification techniques,resulting in an especially low detection limit of 80 copies mL^(−1) for the simulated contaminated water by SARS-CoV-2 virus with complex circumstance as short as 5 min,which is of great significance for achieving real-time monitoring and early warning of ***,here-developed method can be used to establish the identification standard for future unknown coronavirus,and immediately enable extremely sensitive and rapid detection of novel virus.

关键词： SERS SARS-CoV-2 Human ACE2 “Virus-trap”nanostructure Single-virus detection

Sm-like 5 knockdown inhibits proliferation and promotes apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2716-2726页

作者： Cai-Jing Mo Xiao-Yuan Deng Ru-Lan Ma Kun Zhu Lei shi Kang li Department of Surgical Oncology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Infectious Diseases The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND The role of Sm-like 5(LSM5)in colon cancer has not been *** this study,we investigated the role of LSM5 in progression of colon cancer and the potential underlying mechanism *** To determine the role of LSM5 in the progression of colon cancer and the potential underlying mechanism *** The Gene Expression Profiling Interactive Analysis database and the Human Protein Atlas website were used for LSM5 expression analysis and prognosis ***-time quantitative polymerase chain reaction and Western blotting were utilized to detect the expression of mRNAs and proteins.A lentivirus targeting LSM5 was constructed and transfected into colon cancer cells to silence LSM5 *** and apoptosis assays were also conducted to evaluate the growth of the colon cancer *** GeneChip assay and bioinformatics analysis were performed to identify the potential underlying mechanism of LSM5 in colon *** LSM5 was highly expressed in tumor tissue and colon cancer cells.A high expression level of LSM5 was related to poor prognosis in patients with colon *** of LSM5 suppressed proliferation and promoted apoptosis in colon cancer *** of LSM5 also facilitates the expression of p53,cyclin-dependent kinase inhibitor 1A(CDKN1A)and tumor necrosis factor receptor superfamily 10B(TNFRSF10B).The inhibitory effect of LSM5 knockdown on the growth of colon cancer cells was associated with the upregulation of p53,CDKN1A and *** LSM5 knockdown inhibited the proliferation and facilitated the apoptosis of colon cancer cells by upregulating p53,CDKN1A and TNFRSF10B.

关键词： Sm-like 5 Colon cancer Proliferation Apoptosis Knockdown

HBV recurrence lowered by lamivudine/HBIG combination therapy in liver transplant patients:ten-year experience

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Hepatobiliary & Pancreatic Diseases International 2013年第2期12卷 149-153页

作者： Chun-Hui Yuan Dian-Rong Xiu Bin Jiang Zhi-Fei li Lei li shi-Bing Song Tong-lin Zhang Department of General Surgery Peking University Third Hospital

BACKGROUND: Lamivudine and hepatitis B immunoglobulin (HBIG) are widely used to treat patients with hepatitis B recurrence after liver transplantation. However, the outcomes are inconclusive. The present study was undertaken to evaluate the effect of combined therapy on patients with hepatitis B recurrence after liver transplantation. METHODS: Twenty-two patients with hepatitis B recurrence after liver transplantation from August 2000 to October 2011 were enrolled in this study. Of these patients, 16 received lamivudine plus HBIG (combination therapy group) and 6 were treated with lamivudine alone (lamivudine-treated group) The clinical features were matched in the two groups. HBV recurrence parameters, HBsAg clearance rate, patient survival rate, and survival time were compared. RESULTS: The average time of follow-up was 47.2 months (range 13-99). Significant difference was noted in the HBsAg clearance rate in the lamivudine-treated and combination therapy groups (50% vs 93.8%, P0.05). CONCLUSION: Compared with lamivudine monotherapy combination therapy significantly increased the HBsAg clearance rate in patients with HBV recurrence after liver transplantation.

关键词： hepatitis B virus recurrence lamivudine hepatitis B immunoglobulin liver transplantation

Electrode design for multimode suppression of aluminum nitride tuning fork resonators

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Nanotechnology and Precision Engineering 2023年第4期6卷 11-21页

作者： Yi Yuan Qingrui Yang Haolin li Shuai shi Pengfei Niu Chongling Sun Bohua liu Menglun Zhang Wei Pang State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China

This paper is focused on electrode design for piezoelectric tuning fork *** relationship between the performance and electrode pattern of aluminum nitride piezoelectric tuning fork resonators vibrating in the in-plane flexural mode is investigated based on a set of resonators with different electrode lengths,widths,and *** and simulation results show that the electrode design impacts greatly the multimode effect induced from torsional modes but has little influence on other loss *** the electrode design suppresses the torsional mode successfully,thereby increasing the ratio of impedance at parallel and series resonant frequencies(R_(p)/R_(s))by more than 80%and achieving a quality factor(Q)of 7753,an effective electromechanical coupling coefficient(kt_(eff)^(2))of 0.066%,and an impedance at series resonant frequency(R_(m))of 23.6 kΩ.The proposed approach shows great potential for high-performance piezoelectric resonators,which are likely to be fundamental building blocks for sensors with high sensitivity and low noise and power consumption.

关键词： Tuning fork Multimode AlN-based resonator Microelectromechanical systems

Reconstruction of meandering paleo-channels using dense well data,Daqing Oil Field,Songliao Basin,China

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Petroleum Science 2018年第4期15卷 722-743页

作者： Jing-Fu Shan Zhi-Peng lin Le Chen Bin Zhang shi-Xiang Fang Xue Yan Wei Fang li-li Xie Bo liu Le Zhang Key Laboratory of Exploration Technologies for Oil and Gas Resources Ministry of EducationYangtze University School of Geosciences Yangtze University State Key Laboratory of Biogeology and Environmental Geology School of Earth Sciences and ResourcesChina University of Geosciences International Publishing and Distribution Headquarter China Academic Journal (CD) Electronic Publishing House CO.Ltd.

Reconstructing meandering paleo-channels is attracting global research attention. We implemented a novel method by comprehensively integrating migration models and sedimentary structures. Firstly, the migration architectures of the corresponding characteristics in planform and cross-sectional models were summarised as expansion, translation, expansion and translation, expansion and downstream rotation, constriction and downstream rotation, and expansion and countercurrent rotation models. Secondly, full continuous core data from 270 dense drilling wells were collected from the Daqing Oil Field in the Songliao Basin, China, providing information on rock textures, sedimentary cycles, and boundary information for the two layers being studied. Through a comprehensive analysis of dense drill cores and logging data, the abandoned channels and the initial and final channel centrelines were identified. Consequently, four profiles, including one longitudinal and three transverse sections, were constructed to reveal the cross-sectional structures and planform migration architecture. Profile interpretation revealed the evolution from the initial channel centreline to the final centreline. Using a method of rational interpolation, we were able to reconstruct the migration architecture of the meandering channels. The results showed that the average ancient bankfull width(Wc) was approximately 100 m, a single meandering belt was800 m, the radius of the curvature was 250 m, the length of the channel bend was 700 m, the average meander wavelength was 1300 m, the sinuosity was 3.0, and the annual average discharge rate was 450 m3/s. Furthermore, we compared the results from empirical equations, which verified that our reconstruction is both feasible and potentially widely applicable.

关键词： Songliao Basin Reconstruction Meandering paleo-channels Meandering rivers Point bar Planform Migration architectures

Using iTRAQ-Based Quantitative Proteomics Analysis to Identify Differentially Expressed Proteins Related to Larval Development of Portunus trituberculatus

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Journal of Ocean University of China 2021年第4期20卷 897-910页

作者： CHEN Xiayue MU Changkao li Ronghua YE Yangfang SONG Weiwei shi Ce liU Lei WANG Huan WANG Chunlin Collaborative Innovation Center for Zhejiang Marine High-Efficiency and Healthy Aquaculture Ningbo UniversityNingbo 315211China Key Laboratory of Applied Marine Biotechnology Ministry of EducationNingbo UniversityNingbo 315211China

The swimming crab Portunus trituberculatus is an economically important marine crustacean *** isobaric tags for relative and absolute quantitation(iTRAQ)analysis were used to identify proteins that are differentially expressed during larval development of *** to elucidate the underlying *** comparison with the first zoea stage(Z1),3980 proteins were identified from 32789 peptides,which were matched with 115497 spectrums.A total of 241 proteins were screened with significantly differential expressions in all development *** 241 proteins are involved in various biological processes,such as cytoskeleton organization,protein synthesis,energy production and substance metabolism,physiological activities,and *** analyses of the 241 differentially expressed proteins led to the generation of four protein clusters based on the overall similarity in protein expression *** 54,70,36,and 45 proteins clustered in profiles 10(0,0,0,−1,0,0),15(0,1,0,1,0,1),18(0,1,2,2,1,0),and 19(0,1,2,3,4,5),*** development and exoskeleton renewal were important processes throughout the development *** addition,protein synthesis,degradation,and digestion actively occurred,especially at the Z4 *** results provide novel insights into the mechanisms underlying larval development of swimming crab and can assist in larval rearing.

关键词： Portunus trituberculatus iTRAQ proteomics larval development

基于特征基函数的柱面共形吸波超材料的优化设计

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电子学报 2019年第3期47卷 671-677页

作者：于家傲彭世蕤李有权刘立国空军预警学院信息对抗系湖北武汉430019 海军工程大学电子工程学院湖北武汉430019

针对吸波超材料与柱面载体共形时其吸波性能变差的问题,提出了一种非均匀单元方案及其优化设计方法.在柱面共形设计中,根据吸波超材料在无曲率变化方向上的周期性建立周期边界条件.基于特征基函数法的子块划分个数通过周期边界条件进行... 详细信息

针对吸波超材料与柱面载体共形时其吸波性能变差的问题,提出了一种非均匀单元方案及其优化设计方法.在柱面共形设计中,根据吸波超材料在无曲率变化方向上的周期性建立周期边界条件.基于特征基函数法的子块划分个数通过周期边界条件进行压缩,降低了矩阵方程求解维度,提高了优化设计速度.通过遗传算法优化,得到一组非均匀单元设计参数,并进行加工和实测.仿真和实测结果表明,所设计的非均匀单元方案改善了柱面共形对吸波超材吸波性能的影响,在2.8～8.0GHz频段内实现了良好的雷达散射截面积减缩特性.

关键词：特征基函数吸波超材料六边形环宽带周期边界条件

Spin current transmission in Co1-xTbx films

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Chinese Physics B 2022年第2期31卷 144-148页

作者： li Wang Yangtao Su Yang Meng Haibin shi Xinyu Cao Hongwu Zhao Beijing National Laboratory for Condensed Matter Physics Instiute of PhysicsChinese Academy of SciencesBeiing 100190China School of Physical Sciences.University of Chinese Academy of Sciences Beijing 100049China Songshan Lake Materials Laboratory Dongguan 523808China

We investigate the spin to charge conversion phenomena in Y_(3)Fe_(5)O_(12)/Pt/Co_(1-x)Tb_(x)/Pt multilayers by both the spin pumping and spin Seebeck *** find that the spin transport efficiency is irrelevant to magnetization states of the perpendicular magnetized Co;Tb;films,which can be attributed to the symmetry requirement of the inverse transverse spin Hall ***,the spin transmission efficiency is significantly affected by the film concentration,revealing the dominant role of extrinsic impurity scattering caused by Tb *** present results provide further guidance for enhancing the spin transport efficiency and developing spintronic devices.

关键词： spin to charge conversion perpendicular magnetized ferrimagnetic alloy inverse spin Hall effect

Irreversible electroporation for liver metastasis from pancreatic cancer: A case report

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World Journal of Clinical Cases 2020年第2期8卷 390-397页

作者： Yang-Yang Ma Juan-Juan shi Ji-Bing Chen Ke-Chen Xu li-Zhi Niu Central Laboratory Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina Department of Oncology Fuda Cancer HospitalJinan UniversityGuangzhou 510665Guangdong ProvinceChina

BACKGROUND Pancreatic cancer has a poor prognosis;40%–50% of patients have liver metastases at the time of initial diagnosis and only 15%–20% undergo surgical resection. Irreversible electroporation(IRE) is a new, non-thermal local ablation method for solid tumors, which can induce cell membrane permeabilization,resulting in unrecoverable nanoscale perforation and apoptotic cell death without damaging the structural components of *** SUMMARY We report the case of a 66-year-old female patient with liver metastasis from pancreatic cancer with a pathological diagnosis of poorly differentiated adenocarcinoma. Carbohydrate antigen 19-9 was elevated to 420.3 U/m *** tomography showed a pancreas mass of 2.7 cm × 2.5 cm and single liver metastasis of 1.4 cm × 1.1 cm in the S6 area. The patient underwent IRE and arterial infusion chemotherapy and received tegafur. The therapeutic effect of the combination treatment has been evaluated as complete response. To date, the patient has survived for > 12 mo and is receiving tegafur as maintenance therapy(at the time this case report was written).CONCLUSION IRE plus arterial infusion chemotherapy and tegafur may be synergistic,providing a reference for treating liver metastasis from pancreatic cancer.

关键词： Irreversible electroporation liver metastasis from pancreatic cancer Chemotherapy Complete response Case report