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qiu shi 2018年第2期10卷 22-27页

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Cooperative inhibitory effect of sinomenine combined with5-fluorouracil on esophageal carcinoma

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World Journal of Gastroenterology 2013年第45期19卷 8292-8300页

作者： Jing Wang Zi-Rong Yang Wei-Guo Dong Ji-Xiang Zhang Xu-Feng Guo Jia Song shi qiu Department of Gastroenterology Renmin Hospital of Wuhan University

AIM:To investigate the inhibitory effects of sinomenine(SIN)combined with 5-fluorouracil(5-FU)on esophageal carcinoma in vitro and in ***:Esophageal carcinoma(Eca-109)cells were cultured in *** single or combined growth inhibition effects of SIN and 5-FU on the Eca-109 cells were examined by measuring the absorbance of CCK-8dye in living *** 33258 staining and an Annexin V/PI apoptosis kit were used to detect the percentage of cells undergoing *** blotting was used to investigate the essential mechanism underlying SIN and 5-FU-induced *** at 25mg/kg and 5-FU at 12 mg/kg every 3 d,either combined or alone,was injected into nude mice and tumor growth inhibition and side effects of the drug treatment were ***:SIN and 5-FU,both in combination and individually,significantly inhibited the proliferation of Eca-109 cells and induced obvious ***,the combined effects were greater than those of the individual agents(P<0.05).Annexin V/PI staining and Hoechst 33258 staining both indicated that the percentage of apoptotic cells induced by SIN and 5-FU combined or alone were significantly different from the control(P<0.05).The up-regulation of Bax and downregulation of Bcl-2 showed that the essential mechanism of apoptosis induced by SIN and 5-FU occurs via the mitochondrial *** and 5-FU alone significantly inhibited the growth of tumor xenografts in vivo,and the combined inhibition rate was even higher(P<0.05).During the course of chemotherapy,no obvious side effects were observed in the liver or ***:The combined effects of SIN and 5-FU on esophageal carcinoma were superior to those of the individual compounds,and the drug combination did not increase the side effects of chemotherapy.

关键词： Esophageal carcinoma Chemotherapy Sinomenine 5-Fluorouracil

Combining clinical parameters and multiparametric magnetic resonance imaging to stratify biopsy-naïve men for an optimum diagnostic strategy with prostate-specific antigen 4 ng ml^(−1) to 10 ng ml^(−1)

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Asian Journal of Andrology 2023年第4期25卷 492-498页

作者： Chi-Chen Zhang Xiang Tu Tian-Hai Lin Di-Ming Cai Ling Yang shi qiu Zhen-Hua Liu Lu Yang Qiang Wei Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu 610041China Department of Ultrasound West China HospitalSichuan UniversityChengdu 610041China Department of Radiology West China HospitalSichuan UniversityChengdu 610041China

We attempted to perform risk categories based on the free/total prostate-specific antigen ratio (%fPSA), prostate-specific antigen(PSA) density (PSAD, in ng ml^(−2)), and multiparametric magnetic resonance imaging (mpMRI) step by step, with the goal ofdetermining the best clinical diagnostic strategy to avoid unnecessary tests and prostate biopsy (PBx) in biopsy-naïve men with PSAlevels ranging from 4 ng ml^(−1) to 10 ng ml^(−1). We included 439 patients who had mpMRI and PBx between August 2018 and July2021 (West China Hospital, Chengdu, China). To detect clinically significant prostate cancer (csPCa) on PBx, receiver-operatingcharacteristic (ROC) curves and their respective area under the curve were calculated. Based on %fPSA, PSAD, and ProstateImaging-Reporting and Data System (PI-RADS) scores, the negative predictive value (NPV) and positive predictive value (PPV) werecalculated sequentially. The optimal %fPSA threshold was determined to be 0.16, and the optimal PSAD threshold was 0.12 for%fPSA ≥0.16 and 0.23 for %fPSA <0.16, respectively. When PSAD <0.12 was combined with patients with %fPSA ≥0.16, the NPVof csPCa increased from 0.832 (95% confidence interval [CI]: 0.766–0.887) to 0.931 (95% CI: 0.833–0.981);the detection rateof csPCa was similar when further stratified by PI-RADS scores (P = 0.552). Combining %fPSA <0.16 with PSAD ≥0.23 ng ml^(−2)predicted significantly more csPCa patients than those with PSAD <0.23 ng ml^(−2) (58.4% vs 26.7%, P < 0.001). Using PI-RADSscores 4 and 5, the PPV was 0.739 (95% CI: 0.634–0.827) when further stratified by mpMRI results. In biopsy-naïve patientswith PSA level of 4–10 ng ml^(−1), stratification of %fPSA and PSAD combined with PI-RADS scores may be useful in the decisionmaking process prior to undergoing PBx.

关键词： multiparametric magnetic resonance imaging predictive value prostate biopsy prostate cancer prostate-specific antigen PSA-derived parameter

Cell viability and extracellular matrix synthesis in a co-culture system of corneal stromal cells and adipose-derived mesenchymal stem cells

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International Journal of Ophthalmology(English edition) 2017年第5期10卷 670-678页

作者： Ting Shen Jiang Shen Qing-Qing Zheng qiu-shi Li Hai-Lan Zhao Lei Cui Chao-Yang Hong Zhejiang Provincial People's Hospital Hangzhou 310014Zhejiang Province China Beijing shijitan Hospital Beijing 100050 China Wenzhou Medical University Wenzhou 325035 Zhejiang Province China

AIM：To investigate the impact of adipose-derived mesenchymal stem cells（ADSCs） on cell viability and extracellular matrix（ECM） synthesis of corneal stromal cells（CSCs）. METHODS：ADSCs and CSCs were obtained from the corneas of New Zealand white rabbits and indirectly cocultured in vitro. The proliferative capacity of CSCs in the different groups was assessed by CCK-8 assays. Annexin V-fluorescein isothiocyanate（FITC）/proliferation indices（PI） assays were used to detect the apoptosis of CSCs. The expression levels of matrix metalloproteinase（MMP）, such as MMP1, MMP2, MMP9, and collagens were also evaluated by Western blot. RESULTS：ADSCs significantly promoted proliferation and invasion of CSCs in the indirect co-culture assays. The co-cultural group displayed much higher ability of proliferation, especially under the co-culture conditions of ADSCs for 3d, compared with that CSCs cultured alone. The PI of CSCs in the co-culture system were increased approximately 3-8-fold compared with the control group. A significant change was observed in the proportions of cells at apoptosis（early and late） between the negative control group（6.34% and 2.06%） and the ADCSs-treated group（4.69% and 1.59%）. The expression levels of MMPs were down regulated in the co-culture models. Compared with the control group, the decrease intensities of MMP-1, MMP-2 and MMP-9 in CSCs/ADSCs group were observed, 3.90-fold, 1.09-fold and 3.03-fold, respectively. However, the increase intensities of collagen type（I, II, III, IV, and V） in CSCs were observed in CSCs/ADSCs group, 3.47-fold,4.30-fold, 2.35-fold, 2.55-fold and 2.43-fold, respectively, compared to that in the control group. The expressions of aldehyde dehydrogenase and fibronectin in CSCs were upregulated in the co-culture ***：ADSCs play a promotive role in CSCs＇ growth and invasion, which may be partially associated with MMPs decrease and collagens increase, resulting in a positive participation in the plasticity and ECM synt

关键词： adipose-derived mesenchymal stem cell corneal stromal cells extracellular matrix plasticity

Extracellular matrix-derived mechanical force governs breast cancer cell stemness and quiescence transition through integrin-DDR signaling

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3524-3535页

作者： Cong Li shi qiu Xiaohan Liu Fengzhu Guo Jingtong Zhai Zhijun Li Linghui Deng Liming Ge Haili Qian Lu Yang Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Urology Institute of Urology and National Clinical Research Center for GeriatricsWest China Hospital of Sichuan UniversityChengdu 610041China National Clinical Research Center of Geriatrics The Center of Gerontology and GeriatricsWest China HospitalSichuan UniversityChengdu 610065China Institute of Oncology Research(IOR) Oncology Institute of Southern Switzerland(IOSI)Bellinzona 6500Switzerland Department of Histology and Embryology Basic Medical CollegeChina Medical UniversityShenyangLiaoning 110122China Department of Pharmaceutical and Bioengineering School of Chemical EngineeringSichuan UniversityChengdu 610065China

The extracellular matrix(ECM)serves as signals that regulate specific cell states in tumor *** evidence suggests that extracellular biomechanical force signals are critical in tumor *** this study,we aimed to explore the influence of ECM-derived biomechanical force on breast cancer cell *** were conducted using 3D collagen,fibrinogen.

关键词： breast cancer matrix

The comparison of survival between active surveillance or watchful waiting and focal therapy for low-risk prostate cancer:a real-world study from the SEER database

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Asian Journal of Andrology 2022年第3期24卷 305-310页

作者： Qi-Ming Yuan Tian-Hai Lin Kun Jin shi qiu Xiang-Hong Zhou Di Jin Jia-Kun Li Lu Yang Qiang Wei Department of Urology Institute of UrologyWest China Hospital of Sichuan UniversityChengdu 610041China

To reduce treatment-related side effects in low-risk prostate cancer(PCa),both focal therapy and deferred treatments,including active surveillance(AS)and watchful waiting(WW),are worth considering over radical prostatectomy(RP).Therefore,this study aimed to compare long-term survival outcomes between focal therapy and AS/*** were obtained and analyzed from the Surveillance,Epidemiology,and End Results(SEER)*** with low-risk PCa who received focal therapy or AS/WW from 2010 to 2016 were *** therapy included cryotherapy and laser *** Cox proportional hazards models were used to compare overall mortality(OM)and cancer-specific mortality(CSM)between AS/WW and focal therapy,and propensity score matching(PSM)was performed to reduce the influence of bias and unmeasured confounders.A total of 19292 patients with low-risk PCa were included in this *** multivariate Cox proportional hazards model analysis,the risk of OM was higher in patients receiving focal therapy than those receiving AS/WW(hazard ratio[HR]=1.35,95%confidence interval[CI]:1.02–1.79,P=0.037),whereas no significant difference was found in CSM(HR=0.98,95%CI:0.23–4.11,P=0.977).After PSM,the OM and CSM of focal therapy and AS/WW showed no significant differences(HR=1.26,95%CI:0.92–1.74,P=0.149;and HR=1.26,95%CI:0.24–6.51,P=0.782,respectively).For patients with low-risk PCa,focal therapy was no match for AS/WW in decreasing OM,suggesting that AS/WW could bring more overall survival benefits.

关键词： active surveillance cancer-specific mortality focal therapy low-risk prostate cancer overall mortality watchful waiting

Impurity Effects at Surfaces of a Photon-Dressed Bi2Se3 Thin Film

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Chinese Physics Letters 2018年第10期35卷 72-76页

作者： qiu-shi Wang Bin Zhang Wei-Zhu Yi Meng-Nan Chen Baigeng Wang R.Shen National Laboratory of Solid State Microstructures and Department of Physics Nanjing University Nanjing 210093 School of Science Hangzhou Dianzi University Hangzhou 310018 Collaborative Innovation Center of Advanced Microstructures Nanjing 210093

We investigate the impurity effects on surfaces of a thin film topological insulator, applied by an off-resonant circular polarized light. It is found that the off-resonant driving induces a quantized total Hall conductivity, when the driving strength is larger than a critical value and the Fermi level lies in the band gap, indicating that our system is converted into the topological phase. We also find that with the increasing disorder strength, the Dirac masses of top and bottom surfaces are renormalized and then fixed to half of their initial values, respectively,which will shrink the widths of the half-integer plateau of anomalous Hall conductivities.

关键词： Impurity Effects at Surfaces of a Photon-Dressed Bi2Se3 Thin Film Bi

Detection of lymphocyte subsets and regulatory T cells in peripheral blood of patients with acute leukemia and its clinical significance

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中国现代医学杂志 2011年第3期21卷 348-353页

作者： Hai-xia Tong qiu-shi Wang Chun-wei Lu Mei-yan Lu Department of Blood Transfusion Shengjing Hospital China Medical University Shenyang Liaoning 110022 P.R.China Section of Health Testing College of Public Health China Medical University Shenyang Liaoning 110001 P.R.China Section of Oral Technology College of Oral Medicine Medical University of Dalian Dalian Liaoning 116027 P.R.China

Objective To study the changes of lymphocyte subsets and regulatory T cells in peripheral blood of patients with acute leukemia(AL) and its clinical *** The different levels of peripheral blood lymphocyte subsets and regulatory T cells of 60 AL patients and 40 normal controls were detected with flow *** Compared with the normal controls,the percentages of CD3+ T cells,CD4+ T cells,CD16+CD56+ NK cells and the ratio of CD4+ /CD8+ obviously decreased in newly diagnosed AL group(P <0.05),while their percentages of CD8+ T cells and CD19+ B cells significantly increased(P <0.01).The percentage of CD4+ T cells and the ratio of CD4+ /CD8+ in acute lymphoblastic leukemia(ALL) group were much lower than those in acute myelogenous leukemia(AML) group(P <0.01).Compared with these in control group,the proportions of CD4+ CD25high Treg cells and CD4+ CD25+ T cells in newly diagnosed AL group were significantly increased(P <0.01).Conclusion Cellular immune function is significantly abnormal in patients with *** with AML patients,ALL patients had poorer cellular immune *** increased CD4 + CD25high Treg cells might be one of the important reasons of immunosuppression in *** of lymphocyte subsets and regulatory T cells is of clinical value on the evaluation of therapeutic effect and prognosis in AL patients.

关键词： acute leukemia lymphocyte subset regulatory T cell

Postmodemity of HAN Dong＇s Poetry

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Sino-US English Teaching 2016年第2期13卷 132-136页

作者： qiu shi-cun qiu Jia-cun Sichuan University of Arts and Science Dazhou Sichuan China Southwest University Chongqing China Guangdong College of Business and Technology Zhaoqing China

With the influence ofpostmodernism, ＂Third Generation＂ poetry rushes out of elite literature and makes Chinese new poetry focus on everyday life of common persons. As one of the most important representatives of ＂Third Generation＂ poets, HAN Dong has created many distinct postmodernist poems. Rejecting metaphor and symbolization, he takes an oral language of original ecology as his poetical discourse mode to affirm the everyday life of here and now, and then both deconstruct metaphoric and symbolic writing of＂Misty Poetry＂ and construct a writing mode of ＂aestheticization of life＂. HAN Dong＇s poetry can be taken as a kind of construction in deconstruction.

关键词： HAN Dong poetry postmodemity "Third Generation" poetry "Misty Poetry"

Management and outcomes of penile fracture： a retrospective analysis of 62 cases with long-term assessment

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Asian Journal of Andrology 2018年第4期20卷 412-413页

作者： Zhuang Tang Lu Wang Qiang Wei Fan Wang Liang-Ren Liu Ping Tan shi qiu Yu Fan Department of Urology West China Hospital Chengdu 610000 China Institute of Urology West China Hospital Chengdu 610000 China

Dear Editor, Penile fracture （PF） is defined as a traumatic rupture of the tunica albuginea of the corpora cavernosa with an estimated incidence of 500-600 cases per year in the USA） Sexual intercourse, masturbation, forced penile manipulation, and rolling over in bed onto the erect penis are considered common causes of this fracture.

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