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Small molecule metabolites:discovery of biomarkers and therapeutic targets

Signal Transduction and Targeted Therapy 2023年第4期8卷 1684-1720页

作者： shi qiu Ying Cai Hong Yao Chunsheng Lin Yiqiang Xie Songqi Tang Aihua Zhang International Advanced Functional Omics Platform Scientific Experiment CenterHainan General Hospital(Hainan Affiliated Hospital of Hainan Medical University)College of Chinese MedicineHainan Medical UniversityXueyuan Road 3Haikou 571199China Graduate School Heilongjiang University of Chinese MedicineHarbin 150040China First Affiliated Hospital Harbin Medical UniversityHarbin 150081China Second Affiliated Hospital Heilongjiang University of Chinese MedicineHarbin 150001China

Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite accumulation or deficiency which is wellrecognizedhallmarks of diseases. Metabolite signatures that have close proximity to subject’s phenotypic informative dimension,are useful for predicting diagnosis and prognosis of diseases as well as monitoring treatments. The lack of early biomarkers couldlead to poor diagnosis and serious outcomes. Therefore, noninvasive diagnosis and monitoring methods with high specificity andselectivity are desperately needed. Small molecule metabolites-based metabolomics has become a specialized tool for metabolicbiomarker and pathway analysis, for revealing possible mechanisms of human various diseases and deciphering therapeuticpotentials. It could help identify functional biomarkers related to phenotypic variation and delineate biochemical pathwayschanges as early indicators of pathological dysfunction and damage prior to disease development. Recently, scientists haveestablished a large number of metabolic profiles to reveal the underlying mechanisms and metabolic networks for therapeutictarget exploration in biomedicine. This review summarized the metabolic analysis on the potential value of small-moleculecandidate metabolites as biomarkers with clinical events, which may lead to better diagnosis, prognosis, drug screening andtreatment. We also discuss challenges that need to be addressed to fuel the next wave of breakthroughs.

关键词： diagnosis therapeutic Small

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Aerobic exercise improves ejaculatory behaviors and complements dapoxetine treatment by upregulating the BDNF-5-HT duo:a pilot study in rats

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Asian Journal of Andrology 2023年第5期25卷 637-642页

作者： Yuan-Yuan Huang Dang-Wei Peng qiu-shi Liu Hui Jiang Xian-Sheng Zhang Department of Urology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022China Department of Urology Peking University First HospitalBeijing 100000China Andrology Center Peking University First HospitalBeijing 100000China Institute of Urology Peking UniversityBeijing 100000China

Accumulating evidence has revealed many clues that regular aerobic exercise benefits brain health and *** aims of this study were to explore the effect of aerobic exercise on ejaculatory behaviors,as well as to make a preliminary assessment of aerobic exercise as a complementary strategy to dapoxetine treatment in rapid *** tests of rats and a treadmill training protocol were performed in this *** total,12 rapid ejaculators were selected on the basis of ejaculation distribution theory and randomly assigned to 4 groups:control(Ctrol)group,aerobic exercise(Ex)group,dapoxetine(Dapo)group,and Ex+Dapo *** evaluated the changes in ejaculatory parameters in the 4 *** in biological markers,including serum corticosterone,serotonin(5-HT),and brain-derived neurotrophic factor(BDNF)of the raphe nucleus,were determined by enzyme-linked immunosorbent assay(ELISA).The primary finding of our study was that both aerobic exercise and acute dapoxetine could enhance ejaculation control and prolong ejaculation latency in rapid ejaculator *** ejaculation delay effect of aerobic exercise was nearly equivalent to that of acute *** addition,both aerobic exercise and dapoxetine treatment could lead to increased expression of BDNF and 5-HT in the raphe nucleus of rapid ***,the two interventions,when applied together,may further upregulate the expression of BDNF-5-HT duo in a complementary *** study highlights the positive effects of aerobic exercise on ejaculation *** aerobic exercise might be a promising complementary treatment to dapoxetine in rats.

关键词： aerobic exercise animal model brain-derived neurotrophic factor premature ejaculation raphe nucleus serotonin

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Development and validation of an RP-HPLC method for simultaneous determination of Ramipril and Amlodipine in tablets

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Journal of Pharmaceutical Analysis 2013年第6期3卷 440-446页

作者： shi-Ying Dai shi-Ting qiu Wei Wu Chun-Mei Fu Key Laboratory of Drug Targeting and Drug Delivery System Ministry of EducationWest China School of Pharmacy Sichuan University

AnRP-HPLC method for the simultaneous determination ofRamipril （RP） andAmlodipine （AL） in tablets was developed and validated by Chinese Pharmacopoeia 2010. The linearity of the proposed method was investigated in the range of 0.01-0.25 mg/mL （r^2=0.9998） for RP and 0.014-0.36 mg/mL （r^2=0.9997） for AL. The limits of detection （LOD） were 0.06 lag/mL and 0.02 μg/mL for RP and AL, and the limits of quantitation （LOQ） were 0.2 Dg/mL and 0.07 μg/mL, respectively. Some major impurities and degradation products did not disturb the detection of RP and AL and the assay can thus be considered stability-indicating.

关键词： Ramipril Amlodipine RP-HPLC Stability-indicating

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Studies on aluminum powder combustion in detonation environment

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Chinese Physics B 2022年第4期31卷 426-435页

作者： Jian-Xin Nie Run-Zhe Kan Qing-Jie Jiao qiu-shi Wang Xue-Yong Guo shi Yan State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

The combustion mechanism of aluminum particles in a detonation environment characterized by high temperature(in unit 10^(3)K),high pressure(in unit GPa),and high-speed motion(in units km/s)was studied,and a combustion model of the aluminum particles in detonation environment was *** on this model,a combustion control equation for aluminum particles in detonation environment was *** can be seen from the control equation that the burning time of aluminum particle is mainly affected by the particle size,system temperature,and diffusion *** calculation result shows that a higher system temperature,larger diffusion coefficient,and smaller particle size lead to a faster burn rate and shorter burning time for aluminum *** considering the particle size distribution characteristics of aluminum powder,the application of the combustion control equation was extended from single aluminum particles to nonuniform aluminum powder,and the calculated time corresponding to the peak burn rate of aluminum powder was in good agreement with the experimental electrical conductivity *** equation can quantitatively describe the combustion behavior of aluminum powder in different detonation environments and provides technical means for quantitative calculation of the aluminum powder combustion process in detonation environment.

关键词： aluminum particle combustion model aluminum powder burn rate equation burning time

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Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats

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Neural Regeneration Research 2021年第6期16卷 1052-1061页

作者： qiu-shi Gao Ya-Han Zhang Hang Xue Zi-Yi Wu Chang Li Ping Zhao Department of Anesthesiology Shengjing Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent *** classical Rice-Vannucci model was used to induce hypoxic-ischemic injury,and newborn(postnatal day 7)rats were treated with 2.4%sevoflurane for 30 minutes after hypoxic-ischemic *** results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats,decreased astrogliosis and glial scar formation,increased numbers of dendritic spines,and protected the histomorphology of the ***,sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of *** of 1.52μg of the hypoxia-inducible factor-1αinhibitor YC-1(Lificiguat)into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by *** finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic *** underlying mechanism may be related to upregulated DJ-1 expression,reduced ubiquitination of hypoxia-inducible factor-1α,and stabilized hypoxiainducible factor-1α*** study was approved by the Laboratory Animal Care Committee of China Medical University,China(approval No.2016PS337K)on November 9,2016.

关键词： brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair

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Arthroplasty vs proximal femoral nails for unstable intertrochanteric femoral fractures in elderly patients: a systematic review and metaanalysis

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World Journal of Clinical Cases 2021年第32期9卷 9878-9888页

作者： Wen-Huan Chen Wen-Xuan Guo shi-Hua Gao qiu-shi Wei Zi-Qi Li Wei He The Third Clinical Medical School Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina The First Clinical College Zhejiang Chinese Medical UniversityHangzhou 310000Zhejiang ProvinceChina The First Clinical Medical School Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina Department of Joint Surgery The Third Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510405Guangdong ProvinceChina

BACKGROUND Proximal femoral nails(PFNs)are the most common method for the treatment of unstable intertrochanteric femoral fractures(IFFs),but postoperative bed rest is *** is a large amount of blood loss during the *** in elderly patients may cause nonunion of fractures and other *** can give patients early weight bearing and reduce financial burden,but whether it can replace PFNs remains *** To compare the clinical outcomes of arthroplasty and PFNs in the treatment of unstable IFFs in elderly *** A search was conducted in the PubMed,Embase,and Cochrane Library databases and included relevant articles comparing arthroplasty and *** search time was limited from January 1,2005 to November 1,*** investigators independently screened studies,extracted data and evaluated the quality according to the inclusion and exclusion *** to the research results,the fixed effect model or random effect model were selected for *** following outcomes were analyzed:Harris Hip score,mortality,complications,operation time,blood loos,hospital stay,weight-bearing time,fracture classification and type of *** We analyzed four randomized controlled trials that met the requirements.A total of 298 patients were included in these *** to the AO/OTA classification,there are 20 A1 types,136 A2 types,42 A3 types and 100 unrecorded *** outcome:The Harris Hip Score at the final follow-up of the PFN group was higher[mean difference(MD):9.01,95%confidence interval(CI):16.57 to 1.45),P=0.02].There was no significant difference between the two groups in the rate of overall mortality[risk ratio(RR):1.44,P=0.44]or the number of complications(RR:0.77,P=0.05).Secondary outcomes:blood loss of the arthroplasty group was higher(MD:241.01,95%CI:43.06–438.96,P=0.02);the operation time of the PFN group was shorter(MD:23.12,95%CI:10.46–35.77,P=0.0003);and the length of

关键词： Arthroplasty Proximal femoral nail Intertrochanteric femoral fracture Elderly Meta-analysis Systematic review

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Natural consolidation characteristics of viscous debris flow deposition

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Journal of Mountain Science 2016年第10期13卷 1723-1734页

作者： HE Song-Tang WANG Dao-Jie CHEN Shun ZHANG Shu-Juan CHANG shi-qiu Key Laboratory of Mountain Hazards and Earth Surface Processes Chinese Academy of SciencesChengdu 610041China Institute of Mountain Hazards and Environment Chinese Academy of Science&Ministry of Water ConservancyChengdu 510041China University of Chinese Academy of Sciences Beijing 100049China

Pore water pressure and water content are important indicators to both deposition and consolidation of debris flows, enabling a direct assessment of consolidation degree. This article gained a more comprehensive understanding about the entire consolidation process and focused on exploring pore water pressure and volumetric water content variations of the deposit body during natural consolidation under different conditions taking the viscous debris flow mass as a study subject and by flume experiments. The results indicate that, as the color of the debris changed from initial dark green to grayish-white color, the initial deposit thickness declined by 3% and 2.8% over a permeable and impermeable sand bed, respectively. A positive correlation was observed between pore water pressure and depth in the deposit for both scenarios, with deeper depths being related to greater pore water pressure. For the permeable environment, the average dissipation rate of pore water pressure measured at depths of 0.10 m and 0.05 m were 0.0172 Pa/d and 0.0144 Pa/d, respectively, showing a positivechanging trend with increasing depth. Under impermeable conditions, the average dissipation rates at different depths were similar, while the volumetric water content in the deposit had a positive correlation with depth. The reduction of water content in the deposit accelerated with depth under impermeable sand bed boundary conditions, but was not considerably correlated with depth under permeable sand bed boundary conditions. However, the amount of discharged water from the deposit was greater and consolidation occurred faster in permeable conditions. This indicates that the permeability of the boundary sand bed has a significant impact on the progress of consolidation. This research demonstrates that pore water and pressure dissipations are present during the entire viscous debris consolidation process. Contrasting with dilute flows, pore pressure dissipation in viscous flows cannot be complete

关键词： Viscous debris flow Natural consolidation Dissipation of pore water pressure Volumetric Water content Flume experiment

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Roles of Na^+/Ca^(2+) exchanger 1 in digestive system physiology and pathophysiology

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World Journal of Gastroenterology 2019年第3期25卷 287-298页

作者： qiu-shi Liao Qian Du Jun Lou Jing-Yu Xu Rui Xie Department of Gastroenterology Affiliated Hospital to Zunyi Medical College

The Na^+/Ca^(2+) exchanger(NCX) protein family is a part of the cation/Ca^(2+) exchanger superfamily and participates in the regulation of cellular Ca^(2+) homeostasis. NCX1, the most important subtype in the NCX family, is expressed widely in various organs and tissues in mammals and plays an especially important role in the physiological and pathological processes of nerves and the cardiovascular system. In the past few years, the function of NCX1 in the digestive system has received increasing attention; NCX1 not only participates in the healing process of gastric ulcer and gastric mucosal injury but also mediates the development of digestive cancer, acute pancreatitis, and intestinal *** review aims to explore the roles of NCX1 in digestive system physiology and pathophysiology in order to guide clinical treatments.

关键词： Na^+/Ca^2+exchanger Digestive system diseases Ion channel Sodium Calcium

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Simple and Efficient Aromatic C−H Oxazolination

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Precision Chemistry 2023年第5期1卷 316-325页

作者： qiu shi Yu Huang Wenbo H.Liu School of Chemistry Sun Yat-sen UniversityGuangzhou 510006China

Aromatic oxazolines are versatile in organic synthesis as directing groups,ligands,and protected carboxylic *** efficient approaches to oxazoline from an aromatic C−H bond is more desirable compared to the established protocols from carboxylic acid and its ***,a simple and efficient aromatic C−H oxazolination with broad substrate scope is *** employing this transformation as an enabling step,diversity-oriented synthesis of functionalized arenes and target-oriented synthesis of four drugs were *** experiments suggest that this aromatic oxazolination is an electrophilic aromatic *** is anticipated that this transformation will find applications in aromatic C−H functionalization with oxazoline either as a removable directing group or as a masked carboxylic acid.

关键词： aromatic C−H functionalization oxazolines metal free aromatic electrophilic substitution late-stage functionalization

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Structural response of aluminum core–shell particles in detonation environment

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Chinese Physics B 2019年第8期28卷 387-392页

作者： Qing-Jie Jiao qiu-shi Wang Jian-Xin Nie Hong-Bo Pei State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China China Academy of Engineering Physics Institute of Fluid PhysicsMianyang 621900China

Natural aluminum particles have the core-shell *** structure response refers to the mechanical behavior of the aluminum particle structure caused by external *** dynamic behavior of the structural response of aluminum core-shell particles before combustion is of great importance for the aluminum powder burning mechanism and its *** this paper,an aluminum particle combustion experiment in a detonation environment is conducted and analyzed;the breakage factors of aluminum particles shell in detonation environment are *** experiment results show that the aluminum particle burns in a gaseous state and condenses into a sub-micron particle *** calculation and simulation demonstrate that the rupture of aluminum particle shell in the detonation environment is mainly caused by the impact of the detonation *** detonation wave impacts the aluminum particles,resulting in shell cracking,and due to the shrinkage-expansion of the aluminum core and stripping of the detonation product,the cracked shell is fractured and peeled with the aluminum reacting with the detonation product.

关键词： aluminum core-shell particles structural response aluminum combustion aluminized explosives

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