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Exploring transcription factors reveals crucial members and regulatory networks involved in different abiotic stresses in Brassica napus L.

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Exploring transcription factors reveals crucial members and ...

Photoredox Catalysis Unlocks the Nickel-Catalyzed Cyanation of Aryl Halides under Benign Conditions

中国作物学会油料作物专业委员会第八次会员代表大会暨学术年会

作者： WANG Pei YANG Cui-ling CHEN Hao LENG qiu-li Li shi-cong WANG Dao-jie State Key Laboratory of Cotton Biology

Brassica napus encompasses diverse transcription factor(TF),but a clear characterization of TF families and their transcriptional responsiveness to multifarious stresses are still *** identified 518 BnAP2/EREBPs,252 BnbZIPs,721 BnMYBs,398 BnNACs and 278 BnWRKYs in *** based on genome-wide data,including some novel *** of BnAP2/EREBPs and BnMYBs on A and C sub-genome indicated that the 2 families may have suffered from duplication anddivergence during *** analysis reveals strong co-linearity between *** and its 2 ancestors,although chromosomal rearrangements have occurred and85 TFs have *** 7.6%and 9.4%TFs of the 5 families in *** are novel genes and conserved genes respectively,and both show preferences on C *** TF families contain various cis-acting elements that are critical for abioticstress *** analysis revealed that more than 80%TFs were abiotic stress inducible.315 crucial differentially expressed genes(DEGs) were screened *** analysis revealed that the 315 DEGs were highly *** gene network in *** revealed that a considerable amount of TFs can trigger differential expression of a large amount of target *** TFs may be triggered by its up-stream genes,resulting in a complex clustered regulatory network with clusters of genes responsible for targeted stress *** investigations deepen our understanding of TFs for stress tolerance in ***.

关键词： Brassica napus transcription factor stress response transcriptional sequencing regulatory network

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Photoredox Catalysis Unlocks the Nickel-Catalyzed Cyanation ...

纳米SiO_2复合处理对7A52铝合金微弧氧化陶瓷层孔隙率及性能的影响

中国化学会第二届全国光功能材料青年学者研讨会

作者： Yue Jia Yi-Yin Liu shi-Han Liu Liang-qiu Lu Yu Lan Wen-Jing Xiao CCNU-uOttawa Joint Research Centre Key Laboratory of Pesticide & Chemical Biology Ministry of Education College of Chemistry Central China Normal University College of Chemistry and Institute of Green Catalysis Zhengzhou University

Synthesizing aryl nitriles is a fundamentally important task in modern chemistry because they are versatile precursors that provide access to a variety of organic molecules. Moreover, Transition metal-catalyzed cyanations of aryl halides are well established as being among the most used and convenient methods for the synthesis of aryl nitriles. Despite the tremendous advances in this field, from the perspective of green chemical synthesis, this technology is still problematic because it uses highly toxic reagents, is poorly productive, produces excess metal waste, and/or requires harsh reaction conditions. In this study, we use a dual nickel/photoredox catalysis strategy to provide general access to a variety of aryl and alkenyl nitriles through the use of a commercially available α-aminoacetonitrile, which as a user-safe cyanation reagent, at room temperature（30 examples, 53–95% yield）. This methodology will attract substantial interest from the synthesis community and pharmaceutical chemists because of its use of green and sustainable conditions, More importantly, computational studies were used to better understand this unprecedented cyanation reaction, including possible pathways involving transient Ni（III） species and the unexpected aminoacetonitrile reactivity.

关键词： Nickel Catalysis Photoredox Catalysis Visible Light Cyanation Reaction Aryl Nitrile

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航空材料学报 2009年第6期29卷 66-69页

作者：索相波马世宁邱骥吕庆星装甲兵工程学院装备再制造工程系北京100072

通过向电解液中添加纳米二氧化硅颗粒(n-SiO2),经微弧氧化,在7A52铝合金表面制备n-SiO2复合陶瓷层,研究n-SiO2复合处理对陶瓷层孔隙率及性能的影响。结果表明,经n-SiO2复合处理后,陶瓷层孔隙尺寸减小,孔隙率降低,致密性提高,因而陶瓷层... 详细信息

通过向电解液中添加纳米二氧化硅颗粒(n-SiO2),经微弧氧化,在7A52铝合金表面制备n-SiO2复合陶瓷层,研究n-SiO2复合处理对陶瓷层孔隙率及性能的影响。结果表明,经n-SiO2复合处理后,陶瓷层孔隙尺寸减小,孔隙率降低,致密性提高,因而陶瓷层显微硬度和抗盐雾腐蚀性能显著提高。n-SiO2在放电通道处沉积是陶瓷层致密性提高的主要原因。

关键词：微弧氧化陶瓷层纳米二氧化硅孔隙率

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微杠杆在硅微谐振式加速度计中的应用

光学精密工程 2011年第4期19卷 805-809页

作者：石然姜劭栋裘安萍苏岩南京理工大学MEMS惯性技术研究中心江苏南京210094

从基于DDSOG(Deep Dry Silicon on Glass)工艺的硅微谐振式加速度计样机入手,阐述了加速度计中微杠杆结构对惯性力的放大作用,证明了标度因数与系统放大倍数n为正比关系,并以加速度计样机中的单级微杠杆为例,建立了加速度计的理论模型... 详细信息

从基于DDSOG(Deep Dry Silicon on Glass)工艺的硅微谐振式加速度计样机入手,阐述了加速度计中微杠杆结构对惯性力的放大作用,证明了标度因数与系统放大倍数n为正比关系,并以加速度计样机中的单级微杠杆为例,建立了加速度计的理论模型。推导了微杠杆的放大倍数A和轴向刚度K的计算公式,以此为基础导出了加速度计系统放大倍数n的计算方法。依据公式计算得到加速度计样机的系统放大倍数n的理论值为21.820,并用有限元方法对理论值进行了仿真验算,得出n的仿真值为19。最后对加速度样机进行了实际测试,测得加速度计的标度因数为127.33Hz/g,系统放大倍数n为25.466。对所得结果的比较表明,系统放大倍数的理论值与仿真值及实验值的误差分别为14.8%和14.3%,误差在可接受范围内。

关键词：硅微谐振式加速度计微杠杆放大倍数

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硅微陀螺仪的机械耦合误差分析

光学精密工程 2008年第5期16卷 894-898页

作者：施芹裘安萍苏岩朱欣华南京理工大学机械工程学院江苏南京210094

研究了硅微陀螺仪机械耦合误差的产生机理。以z轴硅微陀螺仪为研究对象,以动力学方程和矩阵理论为基础,分析了由于加工非理想性产生的不等弹性、阻尼不对称和质量不平衡产生误差的信号,建立了机械耦合误差信号的数学模型,并定量分析了z... 详细信息

研究了硅微陀螺仪机械耦合误差的产生机理。以z轴硅微陀螺仪为研究对象,以动力学方程和矩阵理论为基础,分析了由于加工非理想性产生的不等弹性、阻尼不对称和质量不平衡产生误差的信号,建立了机械耦合误差信号的数学模型,并定量分析了z轴硅微陀螺仪样品的机械耦合误差信号。结果表明,机械耦合误差信号包含了正交耦合误差和与有用信号同相位的误差信号,其中正交耦合误差为主要误差信号,且主要由不等弹性产生。最后,测试了z轴硅微陀螺仪的正交耦合误差信号为342.59°/s,且与理论结果相吻合。因此,抑制和补偿正交耦合误差是减小机械耦合误差的关键技术之一。

关键词：硅微陀螺仪机械耦合误差正交耦合误差

The role of radiotherapy in patients with refractory Hodgkin’s lymphoma after treatment with brentuximab vedotin and/or immune checkpoint inhibitors

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Journal of the National Cancer Center 2024年第1期4卷 86-92页

作者： Ruizhi Zhao Han Shao Guiqing shi Yanyan qiu Tianlan Tang Yuping Lin Silin Chen Cheng Huang Siqin Liao Jinhua Chen Haiying Fu Jianzhi Liu Benhua Xu Tingbo Liu Yujing Zhang Yong Yang Department of Radiation Oncology Fujian Medical University Union HospitalFujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors(Fujian Medical University)Clinical Research Center for Radiology and Radiotherapy of Fujian Province(DigestiveHematological and Breast Malignancies)FuzhouChina Department of Radiation Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaGuangzhouChina Department of Hematology Fujian Medical University Union HospitalFujian Institute of HematologyFujian Provincial Key Laboratory on HematologyFuzhouChina Department of PET/CT Fujian Medical University Union HospitalFuzhouChina Follow-Up Center Fujian Medical University Union HospitalFuzhouChina Department of Hematology The Third Affiliated People’s Hospital of Fujian University of Traditional Chinese MedicineThe Third People’s Hospital of Fujian ProvinceFuzhouChina Department of Otorhinolaryngology Fujian Medical University Union HospitalFuzhouChina

Background:Approximately 10%–30%of patients with Hodgkin’s lymphoma(HL)experience relapse or refractory(R/R)disease after first-line standard *** vedotin(BV)and immune checkpoint inhibitors(ICIs)have important roles in the salvage treatment of R/R ***,subsequent treatment for HL refractory to BV and/or ICI treatment is ***:We retrospectively analyzed patients in two institutions who had R/R HL,experienced BV or ICI treatment failure,and received radiotherapy(RT)*** overall response rate(ORR),duration of response(DOR),progression-free survival(PFS),and overall survival(OS)were ***:Overall,19 patients were ***-line systemic therapy comprised doxorubicin,bleomycin,vinblastine,and dacarbazine(ABVD,84.2%);AVD plus ICIs(10.5%);and bleomycin,etoposide,doxorubicin,cyclophosphamide,vincristine,procarbazine,and prednisone(BEACOPP,5.3%).After first-line therapy,15(78.9%)and four patients(21.1%)had refractory disease and relapsed,*** R/R HL diagnosis,six(31.6%),two(10.5%),and 11(57.9%)patients received BV and ICIs concurrently,BV monotherapy,and ICI monotherapy,*** patients received intensity-modulated RT(n=12,63.2%)or volumetric modulated arc therapy(VMAT;n=7,36.8%).The ORR as well as the complete response(CR)rate was 100%;the median DOR to RT was 17.2 months(range,7.9–46.7 months).Two patients showed progression outside the radiation field;one patient had extensive in-field,out-of-field,nodal,and extranodal *** a median follow-up time of 16.2 months(range,9.2–23.2 months),the 1-year PFS and OS were 84.4%and 100%,*** was associated with extranodal involvement(P=0.019)and gross tumor volume(P=0.044).All patients tolerated RT well without adverse events of grade≥***:RT is effective and safe for treating HL refractory to BV or ICIs and has the potential to be part of a comprehensive strategy for HL.

关键词： Radiotherapy Hodgkin’s lymphoma Brentuximab vedotin Immune checkpoint inhibitors Refractory Relapsed

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电视侦察弹与舰炮武器系统的优化匹配分析

兵工学报 2008年第12期29卷 1462-1466页

作者：李卉邱志明王航宇孙世岩海军工程大学电子工程学院湖北武汉430033 海军装备研究院系统研究所北京100073

电视侦察弹作为一种新型侦察探测手段,能否满足舰炮武器系统对岸远程打击的要求,是论证舰炮武器系统远程精确打击能力需要解决的关键问题。采用幂指数法结合模糊权重评价法计算系统总体效能,并以此作为优化的目标函数。对关键指标的匹... 详细信息

电视侦察弹作为一种新型侦察探测手段,能否满足舰炮武器系统对岸远程打击的要求,是论证舰炮武器系统远程精确打击能力需要解决的关键问题。采用幂指数法结合模糊权重评价法计算系统总体效能,并以此作为优化的目标函数。对关键指标的匹配约束进行分析,建立了系统匹配的优化模型,并对其进行恰当的变形为模糊几何规划,从而可充分发挥模糊几何规划的求解优势,使复杂的匹配问题简单化。针对电视侦察弹与某型大口径舰炮武器系统优化匹配的具体实例,给予了计算验证。本文提出的方法可为复杂大系统的指标优化匹配提供一种新的思路。

关键词：系统评估与可行性分析优化匹配幂指数法模糊权重模糊几何规划

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射频爆磁压缩发生器等效电路分析

哈尔滨工业大学学报 2008年第7期40卷 1044-1047页

作者：李红梅邱景辉贾世楼哈尔滨工业大学信息工程系哈尔滨150001 哈尔滨工业大学通信技术研究所哈尔滨150001

建立射频爆磁压缩发生器的辐射模型是采用等效电路法对其分析的难点.将射频爆磁压缩发生器的电容器和电感线圈分别作为辐射单元电偶极子和磁偶极子来考虑,建立了考虑装置自身辐射特性的辐射模型.在此基础上,建立了定子线圈分段结构的射... 详细信息

建立射频爆磁压缩发生器的辐射模型是采用等效电路法对其分析的难点.将射频爆磁压缩发生器的电容器和电感线圈分别作为辐射单元电偶极子和磁偶极子来考虑,建立了考虑装置自身辐射特性的辐射模型.在此基础上,建立了定子线圈分段结构的射频爆磁压缩发生器的电路方程并对其进行了数值模拟.数值模拟结果与实验数据对比表明,所建立的辐射模型和电路方程,能够正确描述装置的特性,可用于预测射频爆磁压缩发生器的行为和指导其工程设计.

关键词：射频爆磁压缩发生器等效电路辐射模型

Assessment of right ventricular function by pressure-volume loops in off-pump coronary artery bypass surgery

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Chinese Medical Journal 2008年第10期121卷 932-938页

作者： ZHAO Hong-wei WU An-shi LIU Yu RUI Yan WU Di LIU Juan ZHAO qiu-hua GUO Shu-rong ZHANG Yong-qian YUE Yun Department of Anesthesiology Beijing Chaoyang Hospital Capital Medical University Beijing100020 China

Background Right ventricular function plays an important role in the hemodynamic derangement during off-pump coronary artery bypass （OPCAB） surgery. Pressure-volume loops have been shown to provide load-independent information of cardiac function. Therefore, the aim of this study was to investigate the feasibility of construction of right ventricular pressure-volume loops with pressure and volume data measured by a volumetric pulmonary artery catheter （PAC） and to evaluate right ventricular systolic and diastolic function by end-systolic elastance （EEs） and end-diastolic stiffness （EED） in OPCAB surgery. Methods Twenty-eight patients who underwent OPCAB surgery were included. After anesthesia induction, a volumetric PAC was placed via the right internal jugular vein. Data were recorded at： anesthesia steady-state before skin incision （T1）; 5 minutes after the stabilizer device was placed for anastomosis on the heart＇s anterior wall （T2）, lateral wall （T3）, posterior wall （T4）, respectively; after sternal closure （T5）. Three sets of data were collected at each time point： first, hemodynamic variables were measured; second, right ventricular EEs and EED were calculated; third, right ventricular pressure-volume loops were constructed with pressure and volume data measured from end-diastole point, end-isovolumic systole point, peak-ejection point, end-systole point and end-isovolumic diastole point. Results Right ventricular pressure-volume loops generally shifted to the left during OPCAB surgery. Especially, the end-diastolic point shifted upward and to the left at T2--T5 compared with that at T1. Decrease in right ventricular ejection fraction, stroke volume index and end-diastolic volume index occurred （P 〈0.05） at T4 compared with values at TI. Pulmonary vascular resistance index at T4 increased relatively compared with that at T2 and T3. The change of EEs was not statistically significant during operation. Right atrial pressure increased only during coronary an

关键词： right ventricle cardiac function off-pump coronary artery bypass surgery pressure-volume loop pulmonary artery catheter