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Lingbao Huxin Pill Alleviates Apoptosis and Inflammation at Infarct Border Zone through SIRT1-Mediated FOXO1 and NF-κB Pathways in Rat Model of Acute Myocardial Infarction

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Chinese Journal of Integrative Medicine 2022年第4期28卷 330-338页

作者： TAN Yu BIE Yu-long CHEN Li ZHAO Yi-han SONG Lei MIAO Li-na YU Yan-qiao CHAI Hua MA Xiao-juan shi da-zhuo National Clinical Research Center for Chinese Medicine Cardiology Xiyuan HospitalChina Academy of Chinese Medical SciencesBeijing100091China Peking University Traditional Chinese Medicine Clinical Medical School(Xiyuan Hospital) Beijing100191China Department of Graduate School Beijing University of Chinese MedicineBeijing100029China

Objective To investigate whether Lingbao Huxin Pill(LBHX)protects against acute myocardial infarction(AMI)at the infarct border zone(IBZ)of myocardial tissue by regulating apoptosis and inflammation through the sirtuin 1(SIRT1)-mediated forkhead box protein O1(FOXO1)and nuclear factor-κB(NF-κB)signaling *** Six-week-old Wistar rats with normal diet were randomized into the sham,the model,Betaloc(0.9 mg/kg daily),LBHX-L(0.45 mg/kg daily),LBHX-M(0.9 mg/kg daily),LBHX-H(1.8 mg/kg daily),and LBHX+EX527(0.9 mg/kg daily)groups according to the method of random number table,13 in each *** this study,left anterior descending coronary artery(LADCA)ligation was performed to induce an AMI model in *** myocardial infarction area was examined using a 2,3,5-triphenyltetrazolium chloride solution staining assay.A TdT-mediated dUTP nick-end labeling(TUNEL)assay was conducted to assess cardiomyocyte apoptosis in the *** histopathology of myocardial tissue at the IBZ was assessed with Heidenhain,Masson and hematoxylineosin(HE)staining *** expression levels of tumor necrosis factorα(TNF-α),interleukin(IL)-6,IL-1β,and intercellular adhesion molecule-1 were measured using enzyme-linked immunosorbent assays(ELISAs).The mRNA expressions of SIRT1 and FOXO1 were detected by real-time qPCR(RT-qPCR).The protein expressions of SIRT1,FOXO1,SOD2,BAX and NF-κB p65 were detected by Western blot *** The ligation of the LADCA successfully induced an AMI *** LBHX pretreatment reduced the infarct size in the AMI rats(P<0.01).The TUNEL assay revealed that LBHX inhibited cardiomyocyte apoptosis at the ***,the histological examination showed that the LBHX pretreatment decreased the ischemic area of myocardial tissue(P<0.05),myocardial interstitial collagen deposition(P<0.05)and inflammation at the *** ELISA results indicated that LBHX decreased the serum levels of inflammatory cytokines in the AMI rats(P<0.05 or P<0.01).Furthermore,Western

关键词： Lingbao Huxin Pill Chinese medicine infarct border zone acute myocardial infarction SIRT1

Associations between remnant cholesterol levels and mortality in patients with diabetes

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World Journal of Diabetes 2024年第4期15卷 712-723页

作者： Deng Pan Lin Xu Li-Xiao Zhang da-zhuo shi Ming Guo Department of Cardiovascular Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Graduate School Beijing University of Chinese MedicineBeijing 100020China National Clinical Research Center for Chinese Medicine Cardiology Xiyuan Hospital of China Academy of Chinese Medical SciencesBeijing 100091China Gynecological Department of Traditional Chinese Medicine China-Japan Friendship HospitalBeijing 100020China

BACKGROUND Dyslipidemia is frequently present in patients with *** associations of remnant cholesterol and mortality remains unclear in patients with *** To explore the associations of remnant cholesterol with all-cause and cardiovas-cular mortality in patients with *** This prospective cohort study included 4740 patients with diabetes who par-ticipated in the National Health and Nutrition Examination Survey from 1999 through *** cholesterol was used as the exposure variable,and all-cause and cardiovascular mortality were considered outcome *** data were obtained from the National Death Index,and all participants were followed from the interview date until death or December 31,*** proportional Cox regression models were used to explore the associations between exposure and outcomes,in which remnant cholesterol was modeled as both a categorical and a continuous *** cubic splines(RCSs)were calculated to assess the nonlinearity of ***(stratified by sex,age,body mass index,and duration of diabetes)and a series of sensitivity analyses were performed to evaluate the robustness of the *** During a median follow-up duration of 83 months,1370 all-cause deaths and 389 cardiovascular deaths were *** with remnant cholesterol levels in the third quartile had a reduced risk of all-cause mortality[hazard ratio(HR)95%confidence interval(CI):0.66(0.52-0.85)];however,when remnant cholesterol was modeled as a continuous variable,it was associated with increased risks of all-cause[HR(95%CI):1.12(1.02-1.21)per SD]and cardiovascular[HR(95%CI):1.16(1.01-1.32),per SD]*** RCS demonstrated nonlinear associations of remnant cholesterol with all-cause and cardiovascular *** and sensitivity analyses did not reveal significant differences from the above *** In patients with diabetes,higher remnant cholesterol was associated wi

关键词： Diabetes Remnant cholesterol Mortality Cardiovascular National Health and Nutrition Examination Survey

Tongxinluo Capsule(通心络胶囊)for Cardiac Syndrome X：A Systematic Review and Meta-Analysis

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Chinese Journal of Integrative Medicine 2018年第4期24卷 296-303页

作者： MAO Hui-min LIU Mi QU Hua WANG Li-qiong shi da-zhuo Graduate School Beijing University of Chinese Medicine Beijing 100029 China Cardiovascular Disease Center Xiyuan Hospital China Academy of Chinese Medical Sciences Beijing 100091 China

Objective： To evaluate the efficacy and safety of Tongxinluo Capsule（通心络胶囊, TXL） for patients with cardiac syndrome X（CSX）. Methods： Randomized controlled trials（RCTs） regarding TXL in the treatment of CSX were searched in Chinese Biomedicine Literature database, China National Knowledge Infrastructure, Chinese Scientific Journal database, Wanfang database, Pub Med, EMBASE, Cochrane Central Register of Controlled Trial, websites of the Chinese and International Clinical Trial Registry platform up to June 30, 2015. The intervention was either TXL alone or TXL combined with conventional treatment, while the control intervention was conventional treatment with or without placebo. data extraction, methodological quality assessment and data analyses were performed according to the Cochrane criteria. The primary outcome was a composite event of death, acute myocardial infarction（AMI）, angina requiring hospitalization, revascularization, and heart failure. The secondary outcome measures were angina symptom improvement, electrocardiograph（ECG） improvement, and serum endothelin-1（ET-1） level. The adverse events were also recorded. RevMan 5.3 software was applied for data analyses. Results： Twelve RCTs（696 patients） were included. Compared with conventional treatment, the addition of TXL to conventional treatment showed some benefits on relieving angina symptoms [risk ratio（RR）： 1.46, 95% confidence interval（CI）（1.25, 1.71）, P〈0.01], and improving ECG [RR： 1.45, 95% CI（1.21, 1.74）, P〈0.01]. The pooled result did not support a benefit of TXL on reducing the incidence of primary outcome [RR： 0.20, 95% CI（0.02, 1.61）, P=0.13]. In addition, TXL decreased serum ET-1 concentration of CSX patients [standardized mean number： –1.63, 95% CI（–2.29, –0.96）, P〈0.01]. No serious adverse events were reported. Conclusions： TXL documents potential benefits on attenuating angina symptoms, improving ECG and decreasing serum ET-1 level for CSX patients. However, more rigorous RCTs with high qual

关键词： Tongxinluo Capsule cardiac syndrome X randomized controlled trial systematic review Chinese medicine

Long-Term Follow-Up of Chinese Herbal Medicines Combined with Conventional Treatment in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention: A Multicenter Randomized Controlled Trial

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Chinese Journal of Integrative Medicine 2017年第10期23卷 740-746页

作者： WANG Pei-li ZHANG Lei WANG Shao-li YANG Qiao-ning GAO Zhu-ye DU Jian-peng ZHANG da-wu FU Chang-geng GU Feng XU Hao Li Li-zhi WANG Cheng-long shi da-zhuo Institute of Cardiovascular Diseases Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Gastroenterology Guang'anmen Hospital China Academy of Chinese Medical Sciences

Objective： To evaluate the prognosis effect of Chinese herbal medicines（CHMs） for benefiting qi and activating blood circulation adjunctive to conventional treatment in patients with acute coronary syndrome（ACS） after percutaneous coronary intervention（PCI）. Methods： A total of 702 patients with ACS who underwent PCI were enrolled and randomly assigned to receive conventional treatment plus CHMs for benefiting qi and activating blood circulation（treatment group, 351 cases） or conventional treatment alone（control group, 351 cases） for 6 months. Six months later, all patients received conventional treatment alone. Follow-ups were scheduled at 6th, 12 th, 18 th, 24 th month after enrollment in April 2008, and the final follow-up visit was during September 2011 and November 2011. The primary endpoint was the composite of cardiac death, nonfatal myocardial infarction or revascularization（PCI or coronary artery bypass grafting）; and the secondary endpoint was the composite of re-admission for ACS, congestive heart failure, nonfatal stroke or other thrombus events. Results： A total of 621（88.59%） patients completed 35.4±3.8 months follow-up, while 80（11.41%） patients withdrew from the trial（41 in the treatment group and 39 in the control group）. The incidence of primary endpoint was 5.7%（20 patients） in the treatment group versus 10.86%（38 patients） in the control group [relative risk（RR）： 0.53; 95% confidence interval（CI）： 0.30, 0.88; P=0.013; absolute risk reduction（ARR）： –0.052, 95% CI： –0.06, 0.01]. The incidence of secondary endpoint was 5.98%（21 patients） in the treatment group versus 10.28%（36 patients） in control group（RR： 0.58, 95% CI： 0.33, 0.97, P=0.037; ARR： –0.043, 95% CI： 0.06, 0.01）. Most of the primary and secondary endpoints were occurred in 18 months（84.50% in the treatment group versus 78.10% in the control group）. Conclusion： CHMs for benefiting qi and activating blood circulation adjunctive to conventional treatment improved clinical outcomes for patie

关键词： long-term follow-up Chinese medicine benefit qi and activate blood circulation acute coronary syndrome percutaneous coronary intervention

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西洋参茎叶总皂甙的心血管效应及其机制探讨

中国中西医结合杂志 2011年第6期31卷 825-831页

作者：王琛史大卓中国中医科学院西苑医院心血管病中心北京100091

西洋参,又名美国人参,是名贵滋补药品,因其主要活性成分人参皂甙具有广泛的生物学效应,因此对于西洋参总皂甙的研究具有重要的临床及科研价值。现对其基本组成、生物学活性,以及它的心血管效应与作用机制作一探讨。

关键词：西洋参茎叶总皂甙心血管效应机制

A highly sensitive multiple-mode optical thermometer designed in Eu^(2+/3+)and Li^(+)co-doped polymorphism compound LaSc_(3)(BO_(3))_(4)

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Journal of Advanced Ceramics 2024年第6期13卷 821-833页

作者： Nan Yang zhuo Li Tingxia Zhou Ziwang Zhang Wen shi Yexiang Tong Jianxin shi School of Chemistry IGCMESun Yat-sen UniversityGuangzhou 510006China MOE of the Key Laboratory of Bioinorganic and Synthetic Chemistry IGCMEThe Key Lab of Low-Carbon Chemistry&Energy Conservation of Guangdong ProvinceSun Yat-sen UniversityGuangzhou 510006China

Noncontact optical thermometers have attracted widespread attention,but existing problems such as single-mode and low-sensitivity thermometers still urgently need to be ***,a novel multiple-mode thermometer was designed for the polymorphism LaSc_(3)(BO_(3))_(4):Eu^(2+/3+),Li^(+).X-ray diffraction(XRD)patterns revealed a slight transition betweenα-andβ-phases with the concentrations of the dopants,which is further proved by structure refinements and first-principles *** coexistence of Eu^(2+)and Eu^(3+)in the phosphors and their relative percentages were confirmed by X-ray absorption near-edge structure(XANES)*** from appropriate emissions from Eu^(2+)and Eu^(3+)without obvious energy transfer and their opposite changing trends with temperatures under 307 nm excitation,a triple-mode optical thermometer is obtained for this material within the temperature range of 150–450 *** highest sensitivities of 27.65,14.05,and 7.68%·K^(−1)are achieved based on two fluorescence intensity ratio(FIR)modes of Eu^(2+)and Eu^(3+)(5d–4f/^(5)D_(0)–^(7)F_(2,4))and the fluorescence lifetime(FL)mode of Eu^(2+),*** the best of our knowledge,the former is almost the highest in Eu^(2+)and Eu^(3+)co-doped *** results indicate that this material may be used as an excellent multiple-mode optical thermometer.

关键词： phase transition europium(Eu)ions multiple-mode optical thermometer thermal quenching properties fluorescence intensity ratio(FIR) fluorescence lifetime(FL)

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中医临床方病对应关系的思考

中国中西医结合杂志 2015年第7期35卷 882-885页

作者：刘玥史大卓中国中医科学院西苑医院心血管病中心中国中医科学院心血管病研究所北京100091

"辨病论治、方病对应",是中医临床治疗疾病的一个重要模式,其虽源于《内经》,但少有系统论述。现代中医临床面对的多是西医学诊断相对明确、具有特定病理生理变化的疾病,中医如何认识这些特定的病理生理变化,发挥自身优势,提高临床疗效... 详细信息

"辨病论治、方病对应",是中医临床治疗疾病的一个重要模式,其虽源于《内经》,但少有系统论述。现代中医临床面对的多是西医学诊断相对明确、具有特定病理生理变化的疾病,中医如何认识这些特定的病理生理变化,发挥自身优势,提高临床疗效,为现代中医临床不可回避的问题。笔者通过对中医"方病对应"关系的历史发展、临床应用及其与"方证对应"的差异进行系统阐述,提出中医临床应"方病对应"和"方证对应"相结合,以病为主轴,总结疾病辨治规律,提高中医方药治疗的针对性。

关键词：方病对应方证对应辨证论治辨病论治病证结合