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Knockdown of RCN1 contributes to the apoptosis of colorectal cancer via regulating IP3R1

BIOCELL 2024年第5期48卷 835-845页

作者： xuan shi YUFEN WANG CHENYU LI WANGSHU FU XINYUE ZHANG AIXIA GONG Department of Gastroenterology The First Affiliated Hospital of Dalian Medical UniversityDalianChina Department of Gastroenterology The First Affiliated Hospital of Jinzhou Medical UniversityJinzhouChina The First Clinical College Dalian Medical UniversityDalianChina

Background:The incidence of colorectal cancer(CRC)has been increasing in recent years.Thus,the discovery of factors that can assist in alleviating CRC is urgently warranted.Methods:To identify a potential factor involved in the development of CRC,we screened the upregulated genes in tumor tissues through four datasets from an online database.The expression of reticulocalbin 1(RCN1),a Ca2+-binding protein,was upregulated in the four datasets.Based on loss-offunction experiments,the effect of RCN1 on cell viability was assessed by Cell Counting Kit-8(CCK-8)assay.The regulatory effect of RCN1 on apoptosis was evaluated through Annexin V-fluorescein 5-isothiocyanate(FITC)/propidium iodide(PI)staining assay and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling(TUNEL)assay in RKO and SW480 cells.Activation of endoplasmic reticulum(ER)stress signaling pathways was confirmed by estimating the phosphorylation and expression of PRKR-like ER kinase(PERK),inositol-requiring kinase-1(IRE1),transcription factor 6(ACT6),and CCAAT/enhancer-binding protein-homologous protein(CHOP).The intracellular Ca2+homeostasis regulated by RCN1 was determined through the detection of Ca2+concentration and mitochondrial membrane potential(MMP)measurement.Moreover,whether inositol 1,4,5-trisphosphate receptor type 1(IP3R1)was involved in the regulation of RCN1 in CRC was verified through the depletion of IP3R1 in RKO cells.Results:Knockdown of RCN1 reduced cell viability and facilitated apoptosis in RKO and SW480 cells.Phosphorylation of PERK and IRE1,activation of ATF6,and upregulation of CHOP were induced by the absence of RCN1,suggesting that the unfolded protein response(UPR)was activated in CRC cells.The concentration of Ca2+in mitochondria was increased after RCN1 depletion,followed by reduction in the MMP and release of cytochrome c from mitochondria to the cytoplasm in RKO and SW480 cells.Moreover,it was demonstrated that IP3R1 mediates the effect of RCN1 on apoptosis induced by ER stress in CRC cells.The downregulat

关键词： Reticulocalbin 1 Unfolded protein response IP3R1 Colorectal cancer

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Hydromassage of macular hole edges for large and persistent full-thickness macular holes

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 551-557页

作者： Yi Cai Wen-Bo Liu Duo Wei Xun Deng Xiao-Xin Li Ming-Wei Zhao xuan shi Jian-Hong Liang Department of Ophthalmology Peking University People’s HospitalBeijing 100044China Eye Diseases and Optometry Institute Beijing 100044China Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases Beijing 100044China College of Optometry Peking University Health Science CenterBeijing 100044China Xiamen Eye Center of Xiamen University Xiamen 361102Fujian ProvinceChina Department of Ophthalmology the Second Hospital of Lanzhou UniversityLanzhou 730030Gansu ProvinceChina

●AIM:To introduce the macular hole(MH)hydromassage technique as a potentially beneficial approach for the treatment of large or persistent MH.●METHODS:This retrospective observational case series comprised 16 consecutive patients(17 eyes)diagnosed with MH.Inclusion criteria involved a hole aperture diameter larger than 600μm or the presence of an unclosed MH larger than 600μm following the previous vitrectomy.Standard MH repair procedures were administered in all cases,involving the manipulation and aspiration of the hole margin through the application of water flow with a soft-tip flute needle.A comprehensive assessment was conducted for each case before and after surgery,and optical coherence tomography(OCT)images were captured at every follow-up point.●RESULTS:The mean preoperative aperture diameter was 747±156μm(range 611-1180μm),with a mean base diameter of 1390±435μm(range 578-2220μm).Following surgery,all cases achieved complete anatomical closure of MH,with 13 cases(76.5%)exhibiting type 1 closure and 4 cases(23.5%)demonstrating type 2 closure.No significant differences were observed in the preoperative OCT variables between the two closure types.Eyes with type 1 closure showed a significantly improved visual acuity(0.70±0.10,range 0.50-0.80)compared to those with type 2 closure(0.90±0.12,range 0.80-1.00,P=0.014).●CONCLUSION:The MH hydromassage technique demonstrates promising results,achieving acceptable closure rates in cases of large or persistent MH.This technique may serve as an effective adjunctive maneuver during challenging MH surgery.

关键词： macular hole large macular hole persistent macular hole optical coherence tomography surgical technique hydromassage

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Endophthalmitis in silicone oil-filled eye: A case report

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World Journal of Clinical Cases 2024年第1期12卷 163-168页

作者： Hui-Chao Yan Ze-Lu Wang Wen-Zhen Yu Ming-Wei Zhao Jian-Hong Liang Hong Yin xuan shi Heng Miao Department of Ophthalmology Peking University People’s HospitalBeijing 100044China

BACKGROUND Endophthalmitis occurring in silicone oil-filled eyes is a very rare occurrence,with reported incidence rates ranging between 0.07%and 0.039%.Traditional methods of management of infectious endophthalmitis include the removal of silicone oil,washout of the vitreous cavity,administration of intravitreal antibiotics,and reinjection of silicone oil.CASE SUMMARY Herein,we report the case of a 39-year-old man with unilateral endophthalmitis after pars plana vitrectomy and silicone oil tamponade.Intravitreal injections of full-dose antibiotics and anterior chamber washout were used to treat the patient.No signs of retinal toxicity were observed during the follow-up period.CONCLUSION Intravitreal full-dose antibiotic injections and anterior chamber washout are promising alternatives to traditional therapies for endophthalmitis in silicone oilfilled eyes.

关键词： Endophthalmitis Intravitreal injection Silicone oil-filled eye Pars plana vitrectomy Washout Case report

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Influence of Rubber Powder Movement on Properties of Asphalt Rubber from the Mesoscopic View

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Journal of Wuhan University of Technology(Materials Science) 2023年第2期38卷 312-324页

作者： LI Haibin HU Yihong shi xuan ZHANG Mingming ZHAO Guijuan ZOU Xiaolong SENG Yanping School of Architecture and Civil Engineering Xi’an University of Science and TechnologyXi’an710054China Road Engineering Research Center Xi’an University of Science and TechnologyXi’an710054China School of Material Science and Engineering Chang’an UniversityXi’an710064China

The research on asphalt performance mainly focused on the macro performance and micro mechanism.Mesoscopic analysis was introduced to study the effect of rubber powder movement on asphalt rubber properties.After the preparation parameters and the preparation process of asphalt rubber were determined,the modification mechanism and rheological properties were analyzed which revealed the compatible stability mechanism.Then,the analysis model of asphalt rubber was established to focus on simulating the effect of rubber powder and the spatial movement on its mechanical properties.The experimental results show that rubber powder can make the asphalt rubber bear more uniform stress distribution and enhance the ability to resist deformation.Meanwhile,the rotational motion and final distribution of rubber powder have an obvious impact on the mechanical properties of asphalt rubber.In the selected feature points,the average stress of rubber powder at 0°space angle is only 34.1%of that at90°space angle.When the rubber powders are all in parallel in the ideal state,it enhances the mechanical properties the most.This study supplements the“mesoscopic”scale between macro and micro research.The relationship between micro mechanism and macro properties of asphalt rubber will be established from the mesoscopic perspective.It is also an effort to realize the effective correlation from micro,mesoscopic to macro in asphalt.

关键词： asphalt rubber rubber powder movement space angle of rubber powder mesoscopic scale numerical simulation

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Biomimetic natural biomaterials for tissue engineering and regenerative medicine:new biosynthesis methods,recent advances,and emerging applications

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Military Medical Research 2024年第1期11卷 50-79页

作者： Shuai Liu Jiang-Ming Yu Yan-Chang Gan Xiao-Zhong Qiu Zhe-Chen Gao Huan Wang shi-xuan Chen Yuan Xiong Guo-Hui Liu Si-En Lin Alec McCarthy Johnson V.John Dai-Xu Wei Hong-Hao Hou Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering the Fifth Affiliated HospitalSchool of Basic Medical ScienceSouthern Medical UniversityGuangzhou 510900China Department of Orthopedics Tongren HospitalShanghai Jiao Tong UniversityShanghai 200336China The Eighth Affiliated Hospital Sun Yat-Sen UniversityShenzhen 518033GuangdongChina Engineering Research Center of Clinical Functional Materials and Diagnosis&Treatment Devices of Zhejiang Province Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhou 325011ZhejiangChina Department of Orthopedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Orthopaedics and Traumatology Faculty of Medicinethe Chinese University of Hong KongHong Kong SAR 999077China Department of Functional Materials Terasaki Institute for Biomedical InnovationLos AngelesCA 90064USA Mary&Dick Holland Regenerative Medicine Program College of MedicineUniversity of Nebraska Medical CenterOmahaNE 68130USA Zigong Affiliated Hospital of Southwest Medical University Zigong Psychiatric Research CenterZigong Institute of Brain ScienceZigong 643002SichuanChina Key Laboratory of Resource Biology and Biotechnology in Western China Ministry of EducationSchool of MedicineDepartment of Life Sciences and MedicineNorthwest UniversityXi’an 710127China

Biomimetic materials have emerged as attractive and competitive alternatives for tissue engineering(TE)and regenerative medicine.In contrast to conventional biomaterials or synthetic materials,biomimetic scaffolds based on natural biomaterial can offer cells a broad spectrum of biochemical and biophysical cues that mimic the in vivo extracellular matrix(ECM).Additionally,such materials have mechanical adaptability,micro-structure interconnectivity,and inherent bioactivity,making them ideal for the design of living implants for specific applications in TE and regenerative medicine.This paper provides an overview for recent progress of biomimetic natural biomaterials(BNBMs),including advances in their preparation,functionality,potential applications and future challenges.We highlight recent advances in the fabrication of BNBMs and outline general strategies for functionalizing and tailoring the BNBMs with various biological and physicochemical characteristics of native ECM.Moreover,we offer an overview of recent key advances in the functionalization and applications of versatile BNBMs for TE applications.Finally,we conclude by offering our perspective on open challenges and future developments in this rapidly-evolving field.

关键词： Biomimic Scaffold Biosynthesis Natural biomaterial Tissue engineering

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14世纪至16世纪中国与意大利陶瓷人物装饰比较研究——以青花瓷与马约里卡陶器为例

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中国陶瓷 2024年第5期60卷 82-88,101页

作者：史文轩同济大学设计创意学院上海200082

14世纪至16世纪,中国青花瓷与意大利马约里卡陶器,由于制瓷技艺、城市建筑兴起及上层阶级品味的影响,人物装饰主题的陶瓷器物大量出现。研究为了探究中国与意大利陶瓷艺术背后的文化的差异,通过比较研究的分析方法,对比了青花瓷与马约... 详细信息

14世纪至16世纪,中国青花瓷与意大利马约里卡陶器,由于制瓷技艺、城市建筑兴起及上层阶级品味的影响,人物装饰主题的陶瓷器物大量出现。研究为了探究中国与意大利陶瓷艺术背后的文化的差异,通过比较研究的分析方法,对比了青花瓷与马约里卡陶器三种主要人物装饰在形式、审美及社会价值维度的异同。二者的差异性在于,明代青花瓷以用笔用线的绘画方式表现人物个性,具有东方审美的意蕴,官窑青花瓷代表了精英阶层的品位,而马约里卡陶器色彩丰富,以绘画的透视法则再现人物形象,突出叙事的装饰特点,是社会道德与个人身份的象征。其相似性是二者都借鉴了文学文本与其他艺术门类题材,人物形象是艺术情感的寄托。

关键词：青花瓷马约里卡陶器人物装饰比较研究

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原发性骨髓纤维化脾肿大发生机制及靶向治疗进展

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中国实验血液学杂志 2024年第1期32卷 308-312页

作者：陈紫薇王诗轩李菲南昌大学第一附属医院血液科江西南昌330006 江西省临床医学科学研究院血液病研究所江西南昌330006 南昌大学淋巴肿瘤疾病研究所江西南昌330006

原发性骨髓纤维化是一种骨髓增殖性肿瘤,脾肿大是其突出的临床特征,通常被认为与脾脏的髓外造血有关。CXCL12/CXCR4轴的异常可以导致造血干细胞和造血祖细胞从骨髓迁移到脾脏从而引起脾内髓外造血。此外,低GATA1表达和细胞因子异常分泌... 详细信息

原发性骨髓纤维化是一种骨髓增殖性肿瘤,脾肿大是其突出的临床特征,通常被认为与脾脏的髓外造血有关。CXCL12/CXCR4轴的异常可以导致造血干细胞和造血祖细胞从骨髓迁移到脾脏从而引起脾内髓外造血。此外,低GATA1表达和细胞因子异常分泌被发现与脾肿大显著相关。随着JAK1/2抑制剂在临床中的使用,原发性骨髓纤维化患者的脾大症状得到了显著改善。本文将对原发性骨髓纤维化脾肿大的发生机制及靶向治疗研究进展作一综述。

关键词：原发性骨髓纤维化脾肿大髓外造血靶向治疗

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利益耦合、共同行动与情感共鸣:社会组织建构社区治理共同体的三阶路径

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公共管理与政策评论 2024年第1期13卷 68-84页

作者：许文文石煊中国矿业大学(北京)文法学院

社会组织如何实现社区治理共同体的建构?依托个案挖掘,可以归纳出社会组织“自下而上”建构社区治理共同体的三阶路径:第一阶——利益耦合,零散治理主体再组织,构建“人人有责”的利益共同体;第二阶——共同行动,突破集体行动困境,构建... 详细信息

社会组织如何实现社区治理共同体的建构?依托个案挖掘,可以归纳出社会组织“自下而上”建构社区治理共同体的三阶路径:第一阶——利益耦合,零散治理主体再组织,构建“人人有责”的利益共同体;第二阶——共同行动,突破集体行动困境,构建“人人尽责”的行动共同体;第三阶——情感共鸣,找回“公共性”,构建“人人享有”的情感共同体。通过比较,该路径与党政力量主导的“自上而下”的社区治理共同体建构路径由于关键行动者所具备的核心资源不同,在组织结构、联结策略、运行机制、治理效果等维度上的表现均存在差异。

关键词：社会组织社区治理共同体利益耦合共同行动情感共鸣

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《资本论》与中国式现代化:共性、批判与超越

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当代经济研究 2024年第4期344卷 5-16,F0003页

作者：孔祥利侍萱陕西师范大学国际商学院西安710119

《资本论》是马克思毕生精力的经典杰作,蕴含着丰富的现代化思想。在这部恢弘著作中,马克思揭示了世界现代化进程中的一系列共性特征,包括机器大生产与工业化、资本有机构成提高与科技进步、商品流通与市场化、人口转移与城市化、生产... 详细信息

《资本论》是马克思毕生精力的经典杰作,蕴含着丰富的现代化思想。在这部恢弘著作中,马克思揭示了世界现代化进程中的一系列共性特征,包括机器大生产与工业化、资本有机构成提高与科技进步、商品流通与市场化、人口转移与城市化、生产国际化以及世界市场的形成等。同时,马克思对西方资本主义现代化进行了批判,揭示了其以资本为中心的逻辑、对物质主义的崇拜、资本积累的趋势以及暴力掠夺的实质。《资本论》作为“工人阶级的圣经”与“以人民为中心”的思想同宗同源,其中关于“人的全面自由发展”与“人民对美好生活向往”的目标追求是一脉相承。中国式现代化成功实现了对西方现代化的超越,具体表现在:中国式现代化创造了人类文明新形态,凸显了人的现代化新内涵,坚持了高质量发展的鲜明主题,提供了全球治理的中国方案。

关键词：《资本论》中国式现代化共性批判超越

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Early Nursing Intervention in Children with Viral Meningitis

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Journal of Behavioral and Brain Science 2024年第1期14卷 1-11页

作者： Jingyan Wang Qiuyan Peng Haomei Yang Jing Sun Xian Cai Xiulan Wen Congqun Li Yan Lin xuan shi Pediatric Emergency Department Guangzhou Women and Children’s Medical Center Guangzhou Medical University Guangzhou China

Aim: To explore the effect of a WeChat peer education program in children with severe viral meningitis combined with respiratory failure. Design: Retrospective cohort study. Methods: Patients who had severe viral meningitis combined with respiratory failure, were admitted to the hospital from March 2017 to June 2018, and who received the WeChat-based nursing intervention were included. Patients who received routine nursing were used as controls. The family’s emotional state, self-care ability, and rehabilitation were analyzed. Results: There were 37 patients in the WeChat group (19 boys (51.3%) and 18 girls (48.7%);mean of 5.1 ± 2.4 years of age) and 37 controls (20 boys (54.1%) and 17 girls (45.9%);mean of 5.9 ± 2.4 years of age) (all P > 0.05). After nursing, improvements in the self-assessed anxiety score and self-assessed depression score were better in the WeChat group (anxiety: -29.2% vs. -20.3%, P = 0.015;depression: -25.2% vs. -15.4%, P = 0.009). After nursing, the improvements in the condition management ability scale and condition management difficulty scale scores were better in the WeChat group (ability: +80.5% vs. +44.4%. P = 0.001;difficulty: +58.4% vs. +37.8%, P = 0.003). After nursing, the improvement in the Fugl-Meyer score was better in the WeChat group (+138.0% vs. +53.0%, P Conclusion: Early nursing intervention combined with WeChat peer education can improve the emotional state of children with severe viral meningitis combined with respiratory failure and their caregivers. Impact: Viral meningitis is associated with a good prognosis, but central nervous system complications can be observed. Early intervention is the key to a good prognosis. Internet-based nursing and coaching can improve self-efficacy and care ability in patients with various conditions, as well as improve the emotional state of the children and their caregivers. The research might have an impact on any children’s hospital that deals with viral meningitis.

关键词： Societies Nursing Early Intervention Educational Meningitis Viral Child

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