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Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya Cheng Duan-Rui Qiao Yi-ying Liu Wen-Na shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

A mathematical model for column leaching of ion adsorption-type rare earth ores

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International Journal of Minerals,Metallurgy and Materials 2020年第4期27卷 463-471页

作者： Ping Long Guan-shi wang Shuo Zhang shi-li Hu ying Huang School of Resources and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou 341000China Cooperative Innovation Center of Efficient Development and Application for Ionic Rare Earth Resources Jiangxi University of Science and TechnologyGanzhou341000China School of Architectural and Surveying and Mapping Engineering Jiangxi University of Science and TechnologyGanzhou 341000China

Column leaching experiments with ion adsorption-type rare earth ores for different lixiviant concentrations and different column heights were carried out.A mathematical model of column leaching was constructed based on the experimental *** parameters(a and b)in the model were determined according to the following methodology:the ore column was divided into several units;each unit was treated with multiple leaching *** leaching process was simulated as a series of batch leaching *** a of the model was determined based on the selectivity coefficient of the balanced batch leaching ***,the influences of ammonium sulfate concentration,rare earth grade,column height,permeability coefficient,and hydrodynamic dispersion coefficient on the extraction were *** between parameter b,the ammonium sulfate concentration,and the physical and mechanical properties of the ore column,were examined using dimensional *** was determined that the optimal ammonium sulfate concentration for different column heights(2.5,5.0,7.5,and 10.0 cm)using the mathematical model were 5.9,6.2,7.3,and 7.7 g/L,*** mathematical model can be used to estimate the breakthrough curve,leaching rate,and leaching period of rare earth ores,to achieve optimal extraction.

关键词： ion adsorption-type rare earth ores extraction ore leaching period concentration optimization

A concise synthetic approach to dihydrochalcone:First total syntheses of bipinnatone A and B

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Chinese Chemical Letters 2011年第10期22卷 1135-1138页

作者： shi Jun Da ying Li State Key Laboratory of Applied Organic Chemistry Lanzhou University Lanzhou 730000 China

The first total syntheses of bipinnatone A and B have been achieved starting from commercially available phloroglucinol,p-hydroxybenzaldehyde in ten *** features of the syntheses include Aldol reaction,aryl-alkylation... 详细信息

关键词： Bipinnatone A Bipinnatone B Aldol reaction InCl_3-NaBH_4 reduction

Controlled Growth Morphology of Porous Nanocrystal Iron Oxide by Electrodeposition

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Chemical Research in Chinese Universities 2009年第5期25卷 595-599页

作者： LI Li shi Ke-ying Key Laboratory of Functional Inorganic Material Chemistry Ministry of Education Laboratory of Physical Chemistry School of Chemistry and Materials Science Heilongjiang University Harbin 150080 P. R. China

Fe（Ⅱ） was deposited into the bottom of the mesopores of highly ordered large caged cubic mesoporous silica by electrodeposition. And the deposited Fe mesoporous silica thin film was treated by 1%---4% HF to remove the SiO2 template and then calcined. It was found that nanowire bundles, dendritic plates of porous iron oxide, dense parallel backbones of porous iron oxide were obtained at -1.4-- -1.6 V and 0.08--0.1 mol/L electrolyte concentration after calcinations; the dendritic pattern of porous iron oxide film templated by the SBA-16 film was obtained in macrostructure at a higher absolute value of cathode potential（-1.7-- -1.8 V） and a lower electrolyte concentration（0.02-0.05 mol/L）, the dendritic pattern of porous iron oxide film could copy the microstructure of SBA-16 film; Fe（II） nanowires grew and formed in one dimension（1D） and two-dimension（2D） electrocrystallization at a potential of-l.6-- -1.7 V and an electrolyte concentration of 0.05 mol/L, and the shape of the ID or 2D crystalline iron oxide nanowires calcined was similar to the original shape of the SBA-16 channels. The desired morphology and size of porous nanocrystal iron oxide can be obtained by adjusting the applied potential value and electrolyte concentration, and all kinds of morphologies of porous nanostructure crystal iron oxide can be prepared.

关键词： Electrocrystallization Deposition Porous iron oxide Morohology

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体相二硫化铼中点缺陷的形成与稳定性

原子与分子物理学报 2025年第5期42卷 143-150页

作者：何诗颖赵宇清邹代峰许英廖雨洁禹卓良湖南科技大学物理与电子科学学院湘潭411201 智能传感器与新型传感器材料湖南省重点实验室湘潭411201 湖南理工学院物理与电子科学学院岳阳414006

二硫化铼是过渡金属二硫族化合物的成员,由于层间的范德华作用、合适的带隙、高的光吸收系数和长的载流子迁移距离在光电子研究领域引起广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而半导体的缺陷能级对电子结构具有重要... 详细信息

二硫化铼是过渡金属二硫族化合物的成员,由于层间的范德华作用、合适的带隙、高的光吸收系数和长的载流子迁移距离在光电子研究领域引起广泛的关注.其中光电材料及器件的优良特性由电子结构决定,而半导体的缺陷能级对电子结构具有重要的调控,且体相二硫化铼的缺陷研究尚且缺乏.本文基于密度泛函理论的第一性原理计算,对体相二硫化铼的铼空位、硫空位、钨掺杂(或替代)铼、钨掺杂硫、锝掺杂铼和锝掺杂硫的缺陷形成能和稳定性进行了研究.结果表明:钨掺杂硫和锝掺杂硫形成深施主能级缺陷,铼空位形成浅施主能级缺陷.在富铼和富硫条件下,钨掺杂铼的缺陷形成能低且能有效降低体系总能,提高体系稳定性.钨掺杂硫的缺陷虽然能降低体系的总能提高二硫化铼的稳定性,但较大的缺陷形成能表明钨掺杂硫缺陷难以形成.上述研究结果有助于理解缺陷能级对半导体深浅能级和稳定性的影响,同时也为未来实验上设计基于二硫化铼的高效的光电子器件提供理论依据.

关键词：体相二硫化铼形成能缺陷能级稳定性

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Piperlongumine Inhibits Zika Virus Replication In vitro and Promotes Up-Regulation of HO-1 Expression, Suggesting An Implication of Oxidative Stress

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Virologica Sinica 2021年第3期36卷 510-520页

作者： Weizhi Lu Linjuan shi Jing Gao Huimin Zhu ying Hua Jintai Cai Xianbo Wu Chengsong wan Wei Zhao Bao Zhang Biosafety Level-3 Lab School of Public HealthSouthern Medical UniversityGuangzhou 510515China Department of Epidemiology School of Public HealthSouthern Medical UniversityGuangzhou 510515China

Owing to the widespread distribution of mosquitoes capable of transmitting Zika virus, lack of clinical vaccines and treatments, and poor immunity of populations to new infectious diseases, Zika virus has become a global public health concern. Recent studies have found that Zika virus can continuously infect human brain microvascular endothelial *** cells are the primary components of the blood–brain barrier of the cerebral cortex, and further infection of brain tissue may cause severe damage such as encephalitis and fetal pituitary disease. The present study found that a biologically active base, piperlongumine(PL), inhibited Zika virus replication in human brain microvascular endothelial cells, Vero cells, and human umbilical vein endothelial cells. PL also significantly increased heme oxygenase-1(HO-1) gene expression, while silencing HO-1 expression and using the reactive oxygen species scavenger, N-acetylcysteine, attenuated the inhibitory effect of PL on Zika virus replication. These results suggest that PL induces oxidative stress in cells by increasing reactive oxygen species. This, in turn, induces an increase in HO-1 expression, thereby inhibiting Zika virus replication. These findings provide novel clues for drug research on the prevention and treatment of Zika virus.

关键词： Piperlongumine Heme oxygenase-1(HO-1) Reactive oxygen species Zika virus(ZIKV) Human brain microvascular endothelial cells

Cellular Automata Simulations of Random Pitting Process on Steel Reinforcement Surface

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Computer Modeling in Engineering & Sciences 2021年第9期128卷 967-983页

作者： ying wang Haoran shi shibo Ren Jiangsu Key Laboratory of Engineering Mechanics Southeast UniversityNanjing211189China

The corrosion of reinforcement in the concrete will cause the effective cross-sectional area of reinforcement to be weakened and the performance of reinforcement to change and lead to the degradation of the bond behavior between reinforcement and concrete,which can seriously affect the mechanical properties of the structural ***,it is of great practical significance to accurately simulate the corrosion morphology and the corrosion products of *** paper improves the previous cellular automata models and establishes a new cellular automata model framework for simulating the random pitting corrosion process of reinforcement in *** model defines the detailed local evolution laws of material transformation,penetration and diffusion processes during the ***,based on the spatial inhomogeneity of corrosion,three parameters are introduced into the model:The dissolution probability parameter p,the local corrosion space parameterλand the local corrosion probability parameterε,which establishes a parameterized model of corrosion *** research results show that the common steel reinforcement corrosion morphology can be obtained by adjusting the *** volume expansion rate of the corrosion products is about 2,which is consistent with the relevant experimental research *** cellular automata model in this paper can simulate the common steel reinforcement corrosion morphology and corrosion products in engineering.

关键词： Corrosion of reinforcement cellular automata simulation corrosion morphology

Generalized Cauchy Matrix Approach for Lattice Boussinesq-Type Equations

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Chinese Annals of Mathematics,Series B 2012年第2期33卷 259-270页

作者： Songlin ZHAO Dajun ZHANG ying shi Department of Mathematics shanghai UniversityShanghai 200444China

The authors generalize the Cauchy matrix approach to get exact solutions to the lattice Boussinesq-type equations:lattice Boussinesq equation,lattice modified Boussinesq equation and lattice Schwarzian Boussinesq *** ... 详细信息

关键词： Lattice Boussinesq-type equations Generalized Cauchy matrixapproach Exact solutions

New Model for Image Restoration with Different Boundary Conditions

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Acta Mathematicae Applicatae Sinica 2010年第3期26卷 369-380页

作者： Yu-ying shi Qian-shun Chang Department of Mathematics and Physics North China Electric Power University Beijing 102206 China Institute of Applied Mathematics Academy of Mathematics and Systems Science Beijing 100190 China

In this paper, we propose a new time-dependent model for solving total variation （TV） minimization problems in image restoration. The main idea is applying a priori smoothness on the solution image. Five different B... 详细信息

关键词： image restoration Dirichlet BCs periodic BCs reflecting BCs antireflective BCs mean BCs