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基于空间多点位温度IGBT器件参数逆推的健康状态在线监测方法

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电工技术学报 2025年第2期40卷 452-462页

作者：胡震崔曼吴晓华施涛南京邮电大学自动化学院南京210042 苏州帝奥电梯有限公司苏州215200 北京理工大学信息与电子学院北京100081

绝缘栅双极型晶体管(IGBT)作为高压大功率能量转换系统的核心器件,已广泛应用于新能源发电、高速铁路、航空航天等领域,由于工作环境和运行工况的复杂多变,IGBT模块极易因键合线剥离和焊料层脱落等疲劳老化而失效,造成系统停机,开展IGB... 详细信息

绝缘栅双极型晶体管(IGBT)作为高压大功率能量转换系统的核心器件,已广泛应用于新能源发电、高速铁路、航空航天等领域,由于工作环境和运行工况的复杂多变,IGBT模块极易因键合线剥离和焊料层脱落等疲劳老化而失效,造成系统停机,开展IGBT模块健康状态的在线监测是提升功率器件可靠性、实现能量转换系统安全高效运行的重要保障。该文提出一种基于空间多点位温度IGBT器件参数逆推的健康状态在线监测方法,实现IGBT键合线和焊料层热疲劳损伤的在线监测和诊断,避免IGBT模块因热损伤累积超过安全阈值而突发失效,提升能量转换系统的可靠性。首先,考虑焊料层老化对模块内部热流路径的影响而引起基板空间多点位温度分布的改变,建立基于基板多点位温度差异度(T_(P))的焊料层疲劳老化在线监测模型,通过离线加速老化测试方法建立▽T_(P)和芯片至基板热阻抗(Z_(JC))的数据库,在应用中通过▽T_(P)调用(Z_(JC))实现焊料层健康状态的在线诊断;其次,建立IGBT混合老化模式下器件通态功率损耗的计算模型,提出基于通态损耗的集-射通态电压(V_(ce-on))的逆向计算方法,基于更新的Z_(JC)值计算芯片结温(T_(J)),将集电极电流I_(C)和T_(J)输入健康IGBT模块的I_(C)-T_(J)-V_(ce-on)数据库中调用当前结温下的V_(ce-on,data),消除焊料层老化引起的结温上升对V_(ce-on)的影响,基于V_(ce-on)和V_(ce-on,data)的偏差对键合线老化状态做出诊断。仿真和实验结果表明所提方法的有效性,在实验环境下诊断误差约为3%。

关键词：绝缘栅双极型晶体管(IGBT) 在线监测可靠性能健康状态

Modulation of suprathermal electron fluxes by ultra-low-frequency magnetic field fluctuations in the Martian foreshock

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Earth and Planetary Physics 2025年第02期 357-365页

作者： TaiFeng Jin BinBin Ni song Fu XiaoTong Yun ShuYue Pang MinYi Long QiongYue Zhang Nan Wang XinJie Xiong YiBin Zhao FangFei shi School of Earth and Space Science and Technology Wuhan University

Ultra-low-frequency(ULF) waves are ubiquitous in terrestrial and planetary environments, playing a crucial role in energy transfer and dissipation through wave–particle interactions within space plasmas. By performing a detailed event study in terms of particle distribution maps and wave–particle variable correlation maps, we report that ULF waves observed by the Mars Atmosphere and Volatile EvolutioN(MAVEN) spacecraft in the Martian foreshock can effectively modulate the suprathermal electron fluxes by the magnetic field fluctuations. In particular, the variations in electron fluxes at energies of ～10–100 eV are significant in the perpendicular direction, showing good relationships with changes in the wave field strength characterized by a correlation coefficient ～0.8. These findings demonstrate the generality of interactions of ULF waves with electrons, even at these low energies, highlighting the importance of such processes throughout the heliosphere.

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村庄发展政策何以连续?全过程人民民主视阈下的一种解释

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西北大学学报(哲学社会科学版) 2025年第1期55卷 117-129页

作者：任弢宋王杰中国政法大学政治与公共管理学院北京102249 西北大学经济管理学院陕西西安710127

“一张蓝图绘到底,一任接着一任干”是浙江八八战略和千万工程的成功经验之一。为了揭示长周期内政策何以独立于人事变动而保持持续稳定,以浙江A村为案例,基于多轮深度访谈和档案资料,运用单案例研究设计,试图归纳政策持续稳定的可能条... 详细信息

“一张蓝图绘到底,一任接着一任干”是浙江八八战略和千万工程的成功经验之一。为了揭示长周期内政策何以独立于人事变动而保持持续稳定,以浙江A村为案例,基于多轮深度访谈和档案资料,运用单案例研究设计,试图归纳政策持续稳定的可能条件。研究发现:①政策持续性取决于政策质量以及继任干部变更政策的意愿和能力。②全过程人民民主中民主协商和民主决策环节有助于形成“好”政策,“好”政策通过政策反馈机制得以持续。③全过程人民民主的民主管理环节有效限制了继任干部自由裁量权和自主行动空间,降低了官员变更政策的能力,从而有助于政策持续。④全过程人民民主的民主选举和民主监督环节有效降低了继任官员随意变更政策的意愿,从而进一步有助于政策持续。

关键词：全过程人民民主政策连续性政策反馈千万工程

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Readout electronics for the gamma detector of the HIRFL-CSR external target facility

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Nuclear Science and Techniques 2025年第2期36卷 71-81页

作者： Xian-Qin Li Hai-Bo Yang Xiao-Meng Ma Chao-Jie Zou tao Liu Xian-Cai Zhou Duo Yan Yang-Zhou Su Shu-Wen Tang shi-tao Wang Yu-Hong Yu Zhi-Yu Sun Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physics and Electronic Engineering Northwest Normal UniversityLanzhou 730070China School of Big Data and Information Engineering Guizhou UniversityGuiyang 550025China

The Cooling Storage Ring of the Heavy Ion Research Facility in Lanzhou(HIRFL-CSR)was constructed to study nuclear physics,atomic physics,interdisciplinary science,and related *** External Target Facility(ETF)is located in the main ring of the *** gamma detector of the ETF is built to measure emitted gamma rays with energies below 5 MeV in the center-of-mass frame and is planned to measure light fragments with energies up to 300 *** readout electronics for the gamma detector were designed and *** readout electronics consist of thirty-two front-end cards,thirty-two readout control units(RCUs),one common readout unit,one synchronization&clock unit,and one sub-trigger *** using the real-time peak-detection algorithm implemented in the RCU,the data volume can be significantly *** addition,trigger logic selection algorithms are implemented to improve the selection of useful events and reduce the data *** test results show that the integral nonlinearity of the readout electronics is less than 1%,and the energy resolution for measuring the 60 Co source is better than 5.5%.This study discusses the design and performance of the readout electronics.

关键词： HIRFL-CSR Gamma detector External target facility Readout electronics Readout control unit Common readout unit Peak-detection algorithm

Programmed cell death 1 inhibitor sintilimab plus S-1 and gemcitabine for liver metastatic pancreatic ductal adenocarcinoma

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World Journal of Clinical Oncology 2025年第2期16卷 29-35页

作者： shi-Qiong Zhou Peng Wan Seng Zhang Yuan Ren Hong-tao Li Qing-Hua Ke Department of Chemoradiotherapy The First Affiliated Hospital of Yangtze UniversityJingzhou 434000Hubei ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly aggressive cancer with poor *** it metastasizes to the liver,treatment options become particularly limited and *** treatment options for liver metastatic PDAC are limited,and chemotherapy alone often proves ***,particularly programmed cell death 1(PD-1)inhibitors like sintilimab,shows potential efficacy for various cancers but has limited reports on *** study compares the efficacy and safety of sintilimab plus S-1 and gemcitabine vs S-1 and gemcitabine alone in liver metastatic *** To explore the feasibility and effectiveness of combined PD-1 inhibitor sintilimab and S-1 and gemcitabine(combination group)vs S-1 and gemcitabine used alone(chemotherapy group)for treating liver metastatic pancreatic *** Eligible patients were those with only liver metastatic PDAC,an Eastern Cooperative Oncology Group performance status of 0-1,adequate organ and marrow functions,and no prior anticancer *** in the combination group received intravenous sintilimab 200 mg every 3 weeks,oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle,and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight cycles or until disease progression,death,or unacceptable *** in the chemotherapy group received oral S-140 mg/m²twice daily on days 1-14 of a 21-day cycle and intravenous gemcitabine 1000 mg/m²on days 1 and 8 of the same cycle for up to eight *** June 2020 and December 2021,66 participants were enrolled,with 32 receiving the combination treatment and 34 receiving chemotherapy *** The group receiving the combined therapy exhibited a markedly prolonged median overall survival(18.8 months compared to 10.3 months,P<0.05)and progression-free survival(9.6 months vs 5.4 months,P<0.05).compared to the chemotherapy *** incidence of severe adverse events did not differ sign

关键词： Immunotherapy Programmed cell death 1 inhibitor Sintilimab Chemotherapy Metastatic Pancreatic ductal adenocarcinoma

Molecular mechanism of pancreatic ductal adenocarcinoma:The heterogeneity of cancer-associated fibroblasts and key signaling pathways

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World Journal of Clinical Oncology 2025年第2期16卷 18-28页

作者： Zhong-Yuan Hu Ding Ding Yu song Ya-Feng Deng Cheng-Ming Zhang tao Yu First School of Clinical Medicine Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina College of Acupuncture and Massage Shaanxi University of Chinese MedicineXianyang 712000Shaanxi ProvinceChina Graduate School Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina Digestive Department I Shaanxi Provincial Hospital of Traditional Chinese MedicineXi’an 710000Shaanxi ProvinceChina

Pancreatic ductal adenocarcinoma stands out as an exceptionally fatal cancer owing to the complexities associated with its treatment and diagnosis,leading to a notably low five-year survival *** study offers a detailed exploration of epidemiological trends in pancreatic cancer and key molecular drivers,such as mutations in CDKN2A,KRAS,SMAD4,and TP53,along with the influence of cancer-associated fibroblasts(CAFs)on disease *** particular,we focused on the pivotal roles of signaling pathways such as the transforming growth factor-βand Wnt/β-catenin pathways in the development of pancreatic cancer and investigated their application in emerging therapeutic *** study provides new scientific perspectives on pancreatic cancer treatment,especially in the development of precision medicine and targeted therapeutic strategies,and demonstrates the importance of signaling pathway research in the development of effective therapeutic *** studies should explore the subtypes of CAFs and their specific roles in the tumor microenvironment to devise more effective therapeutic methods.

关键词： Pancreatic cancer Fibroblasts Signaling pathways Tumor microenvironment

Reversible spiking neural P systems

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Frontiers of Computer Science 2013年第3期7卷 350-358页

作者： tao song Xiaolong shi Jinbang XU Key Laboratory of Image Processing and Intelligent Control Department of Control Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China

Spiking neural （SN） P systems are a class of distributed parallel computing devices inspired by the way neurons communicate by means of spikes. In this work, we investigate reversibility in SN P systems, as well as the computing power of reversible SN P systems. Reversible SN P systems are proved to have Turing creativity, that is, they can compute any recursively enumerable set of non-negative integers by simulating universal reversible register machine.

关键词： membrane computing spiking neural P system reversible computing model universality reversible register machine

CT血管造影影像组学评估基底动脉尖动脉瘤破裂风险

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中国医学影像技术 2025年第1期41卷 20-24页

作者：刘松田超任涛曹宸靳松夏爽天津医科大学一中心临床学院天津300191 天津市环湖医院医学影像科天津300350 天津市第一中心医院放射科天津市影像医学研究所天津300190

目的观察CT血管造影(CTA)影像组学评估基底动脉尖动脉瘤(BTA)破裂风险的价值。方法回顾性收集133例BTA患者,根据BTA破裂与否分为破裂组(n=39)与未破裂组(n=94),并按7∶3比例划分训练集(n=93)与测试集(n=40)。针对CTA提取BTA影像组学特... 详细信息

目的观察CT血管造影(CTA)影像组学评估基底动脉尖动脉瘤(BTA)破裂风险的价值。方法回顾性收集133例BTA患者,根据BTA破裂与否分为破裂组(n=39)与未破裂组(n=94),并按7∶3比例划分训练集(n=93)与测试集(n=40)。针对CTA提取BTA影像组学特征并筛选其中最优者,计算影像组学评分(Radscore);分别利用逻辑回归(LR)、随机森林(RF)、决策树(DT)及K近邻(KNN)算法基于最优影像组学特征建立影像组学机器学习(ML)模型,基于Radscore建立Radscore模型;再利用后者联合临床及常规影像学表现建立联合模型。对比分析上述各模型鉴别破裂与未破裂BTA的效能。结果最终选出4个BTA最优影像组学特征,以之建立的LR、RF、DT及KNN 4种影像组学模型鉴别训练集破裂与未破裂BTA的曲线下面积(AUC)分别为0.770、0.816、0.817及0.795,在测试集分别为0.795、0.793、0.786及0.824;4种模型AUC差异均无统计学意义(P均>0.05)。性别、饮酒史、BTA形态及Radscore均为BTA破裂的独立影响因素(P均<0.05),以之建立临床-常规影像学模型。针对全部133例,联合模型鉴别BTA破裂与未破裂的AUC为0.877,Radscore模型为0.775,而临床-常规影像学模型为0.677,前者明显高于后两者(P均<0.05)。结论CTA影像组学有助于评估BTA破裂风险;联合临床及常规影像学表现可进一步提高其效能。

关键词：动脉瘤破裂体层摄影术,X线计算机机器学习影像组学

发展银发经济的战略设计、焦点难点及路径优化

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新疆师范大学学报（哲学社会科学版） 2025年第2期46卷 59-69,F0002页

作者：黄石松胡清中国人民大学国家发展与战略研究院北京100872 中国人民大学老年学研究所北京100872

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉... 详细信息

我国正处于由中度老龄化社会步入重度老龄化社会的进程,银发经济将逐步从“以政府为主导的事业发展”阶段转向“事业和产业协同发展”的新阶段。准确把握这一转型发展特征,适时调整工作重心和节奏,注重运用市场机制推进产业发展迫在眉睫。对银发产业进行业态划分是制定产业组织政策、产业管理政策、产业发展政策的前提和基础,文本尝试将我国银发产业划分为基础性产业、延伸性产业和战略性产业,并据此分析三类产业在发展中存在的焦点难点问题,按照分类精准施策原则,提出优化我国银发经济发展路径的政策建议。

关键词：银发经济老龄产业老龄事业战略设计业态划分