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China & The World Cultural Exchange 2024年第4期 44-48页

作者： Li Jun Shuang Rui shi linjing 不详

The discovery of Yin Xu has turned the history of the Shang Dynasty into credible history,continuing the trend of integrating civilizations from all directions for over a thousand years,and initiating a pattern of continuous,diversified,and unified civilization for more than three thousand *** the Yin Xu Site as the fulcrum,it constructs the spatialtemporal system of Xia-Shang archaeology and culture.

关键词： Site integrating unified

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含连翘中成药组方用药规律的数据挖掘分析

临床医学研究与实践 2024年第22期9卷 124-128页

作者：张晓菁闫晓霞牛宇龙史琳婧齐娜娜马保连长治医学院山西长治046000

目的探讨含连翘中成药的组方用药规律,为连翘的临床用药及进一步开发提供依据。方法收集整理2020版《中国药典》《新编国家中成药》与《中华人民共和国卫生部药品标准·中药成方制剂》中含连翘的中成药处方并建立数据库,运用数据挖掘技... 详细信息

目的探讨含连翘中成药的组方用药规律,为连翘的临床用药及进一步开发提供依据。方法收集整理2020版《中国药典》《新编国家中成药》与《中华人民共和国卫生部药品标准·中药成方制剂》中含连翘的中成药处方并建立数据库,运用数据挖掘技术对其进行频次分析、关联分析和聚类分析,以探索含连翘中成药的组方用药规律。结果获得含连翘中成药处方183个,共涉及302味中药,出现频数较高的前5味中药依次为连翘、甘草、黄芩、薄荷和金银花。药性频数较高的为寒、温,药味频数较高的为苦、辛,归经以肺、胃常见。含连翘中成药处方中使用频数最多的为清热药,其次为解表药、补虚药、化痰止咳平喘药。含连翘中成药中剂型以丸剂、片剂居多。结论以连翘-金银花为代表的清热解毒类中药在含连翘的中成药中应用较多,主要用于治疗肺系病类,与现代药理学研究结果一致。

关键词：连翘中成药用药规律

Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants

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Signal Transduction and Targeted Therapy 2023年第5期8卷 2345-2353页

作者： Qian Wang Chenchen Yang Li Yin Jing Sun Wei Wang Hengchun Li Zhengyuan Zhang Si Chen Bo Liu Zijian Liu linjing shi Xiaolin Liu Suhua Guan Chunhua Wang Linbing Qu Ying Feng Xuefeng Niu Liqiang Feng Jincun Zhao Pingchao Li Ling Chen Nanshan Zhong State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouChina Guangzhou nBiomed Ltd. GuangzhouChina Guangzhou Laboratory&Bioland Laboratory GuangzhouChina Guangdong Laboratory of Computational Biomedicine Guangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhouChina University of Chinese Academy of Sciences BeijingChina

The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains administered via intramuscular *** this study,we generated a recombinant,replication-incompetent human adenovirus type 5,Ad5-S-Omicron,that expresses Omicron BA.1 ***,but not intramuscular vaccination,elicited spike-specific respiratory mucosal IgA and residential T cell immune responses,in addition to systemic neutralizing antibodies and T cell immune responses against most Omicron *** tested intranasal Ad5-S-Omicron as a heterologous booster in mice that previously received intramuscular injection of inactivated ancestral *** addition to inducing serum broadly neutralizing antibodies,there was a significant induction of respiratory mucosal IgA and neutralizing activities against Omicron subvariants BA.1,BA.2,BA.5,BA.2.75,BF.7 as well as pre-Omicron strains Wildtype,Beta,and *** and mucosal neutralizing activities against recently emerged XBB,BQ.1,and BQ.1.1 could also be detected but were much *** lavage fluids from intranasal vaccination contained multimeric IgA that can bind to at least 10 spike proteins,including Omicron subvariants and pre-Omicron strains,and possessed broadly neutralizing *** vaccination using Ad5-S-Omicron or instillation of intranasal vaccinee’s nasal lavage fluids in mouse nostrils protected mice against Omicron *** together,intranasal Ad5-S-Omicron booster on the basis of ancestral vaccines can establish effective mucosal and systemic immunity against Omicron subvariants and multiple SARS-CoV-2 *** candidate vaccine warrants further development as a safe,effective,and user-friendly infection and transmission-blocking vaccine.

关键词： nasal immunity mucosal

Intercellular mitochondrial transfer as a means of tissue revitalization

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Signal Transduction and Targeted Therapy 2021年第3期6卷 705-722页

作者： Delin Liu Youshui Gao Jiao Liu Yigang Huang Junhui Yin Yuyao Feng linjing shi Bruno PMeloni Changqing Zhang Minghao Zheng Junjie Gao Centre for Orthopaedic Research School of SurgeryThe University of Western AustraliaNedlandsWA 6009Australia Perron Institute for Neurological and Translational Science NedlandsWA 6009Australia Department of Orthopaedics Shanghai Jiao Tong University Affiliated Shanghai Sixth People's HospitalShanghai 200233China Department of Hepatobiliary Surgery Shanghai Public Health Clinical CenterFudan UniversityShanghai 200083China School of Medicine Zhejiang UniversityHangzhouZhejiang Province 310058China School of Life Sciences Zhejiang UniversityHangzhouZhejiang Province 310058China

As the crucial powerhouse for cell metabolism and tissue survival,the mitochondrion frequently undergoes morphological or positional changes when responding to various stresses and energy *** addition to intracellular changes,mitochondria can also be transferred *** restoring stressed cells and damaged tissues due to mitochondrial dysfunction,the intercellular mitochondrial transfer also occurs under physiological *** this review,the phenomenon of mitochondrial transfer is described according to its function under both physiological and pathological conditions,including tissue homeostasis,damaged tissue repair,tumor progression,and ***,the mechanisms that contribute to this process are summarized,such as the trigger factors and transfer ***,various perspectives are explored to better understand the mysteries of cell-cell mitochondrial *** addition,potential therapeutic strategies for mitochondria-targeted application to rescue tissue damage and degeneration,as well as the inhibition of tumor progression,are discussed.

关键词： metabolism homeostasis degeneration

传媒场域、学术场域、政策场域互动互构社会议题——兼评《诚信社会建构中的传媒场域研究》

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长江大学学报（社会科学版） 2020年第1期43卷 100-103页

作者：史林静新华社河南分社河南郑州450003

议题或问题事实的客观存在,总是经历着社会建构,是政策场域、学术场域、传媒场域等相互型塑、共构共生的互构过程。按社会建构主义相关理论的阐述,建构活动可分为公共关注、议题聚合、舆论动员和对策行动,这一过程也可能是循环往复,不... 详细信息

议题或问题事实的客观存在,总是经历着社会建构,是政策场域、学术场域、传媒场域等相互型塑、共构共生的互构过程。按社会建构主义相关理论的阐述,建构活动可分为公共关注、议题聚合、舆论动员和对策行动,这一过程也可能是循环往复,不断推进的。不同的场域在建构的不同过程和活动中有着不同的定位和功能。《诚信社会建构中的传媒场域研究》这一著作正是基于建构主义理论,对社会诚信议题建构中传媒场域、学术场域、政策场域的互动作用机制进行宏观把握,进而对传媒场域在社会诚信建构中的角色定位和功能定位进行研究,为传媒研究和社会诚信研究提供了新的视角。

关键词：大众传媒社会诚信社会建构场域互动

邻苯二甲酸二甲酯对小鼠生长性能、免疫性能及小肠组织形态的影响

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动物营养学报 2023年第3期35卷 2030-2040页

作者：李晗星房晓欢齐雅天田凯石霖静郑文静李琳陈家弟李俊杰河北农业大学动物科技学院保定071000 河北省牛羊胚胎技术创新中心保定071000

本试验旨在探究小鼠生长发育时期接触邻苯二甲酸二甲酯(DMP)对其生长性能、免疫性能及小肠组织形态的影响及孕鼠妊娠期接触DMP对仔鼠生长发育和免疫性能的影响。试验一:选取3周龄的雌性青年ICR小鼠30只,随机分为3组,每组10只。在饲喂相... 详细信息

本试验旨在探究小鼠生长发育时期接触邻苯二甲酸二甲酯(DMP)对其生长性能、免疫性能及小肠组织形态的影响及孕鼠妊娠期接触DMP对仔鼠生长发育和免疫性能的影响。试验一:选取3周龄的雌性青年ICR小鼠30只,随机分为3组,每组10只。在饲喂相同基础饲粮条件下,2个试验组分别灌胃1000和2000 mg/(kg·d)DMP(以玉米油按照1 mL/kg的给药量稀释),对照组灌胃等量玉米油,试验期21 d。试验二:选取2月龄雌性ICR小鼠20只,随机分为2组,每组10只。2组小鼠饲喂相同的基础饲粮,DMP组灌胃1000 mg/(kg·d)DMP(以玉米油按照1 mL/kg的给药量稀释),对照组灌胃等量玉米油,从配种成功后第1天开始,直至分娩。试验一结果表明:1)与对照组相比,灌胃2000 mg/(kg·d)DMP使青年小鼠末重和平均日增重(ADG)显著降低(P0.05)。2)各组之间肝脏、脾脏、胸腺指数没有显著差异(P>0.05);与对照组相比,灌胃1000和2000 mg/(kg·d)DMP均显著降低了血清免疫球蛋白G(IgG)水平(P0.05)。3)与对照组相比,灌胃1000和2000 mg/(kg·d)DMP对十二指肠、回肠绒毛高度、隐窝深度及十二指肠绒隐比均无显著影响(P>0.05),但显著降低了空肠绒毛高度(P0.05),断奶重和8周龄体重显著降低(P0.05),空肠和回肠绒隐比显著降低(P<0.05)。综上所述,DMP对小鼠的正常生长发育有一定的影响,会降低小鼠免疫能力,且对小肠组织形态有一定的损伤。

关键词：邻苯二甲酸二甲酯小鼠生长性能免疫性能小肠组织形态

Regulated cell death in cancer:from pathogenesis to treatment

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Chinese Medical Journal 2023年第6期136卷 653-665页

作者： linjing Gong Dong Huang Yujun shi Zong’an Liang Hong Bu Department of Respiratory and Critical Care Medicine West China HospitalSichuan UniversityChengduSichuan 610041China Institute of Clinical Pathology Key Laboratory of Transplant Engineering and ImmunologyNHCWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Pathology West China HospitalSichuan UniversityChengduSichuan 610041China

Regulated cell death(RCD),including apoptosis,pyroptosis,necroptosis,and ferroptosis,is regulated by a series of evolutionarily conserved pathways,and is required for development and tissue *** on previous genetic and biochemical explorations of cell death subroutines,the characteristics of each are generally considered ***,recent in-depth studies noted the presence of crosstalk between the different forms of RCD;hence,the concept of PANoptosis ***,a complex genetic disease,is characterized by stepwise deregulation of cell apoptosis and proliferation,with significant morbidity and mortality *** present,studies on the different RCD pathways,as well as the intricate relationships between different cell death subroutines,mainly focus on infectious diseases,and their roles in cancer remain *** cancers are characterized by dysregulated cell death and inflammatory responses,most current treatment strategies aim to selectively induce cell death via different RCD pathways in cancer *** this review,we describe five types of RCD pathways in detail with respect to tumorigenesis and cancer *** potential value of some of these key effector molecules in tumor diagnosis and therapeutic response has also been *** then review and highlight recent progress in cancer treatment based on PANoptosis and ferroptosis induced by small-molecule compounds,immune checkpoint inhibitors,and ***,these findings may provide meaningful evidence to fill in the gaps between cancer pathogenesis and RCD pathways to develop better cancer therapeutic strategies.

关键词： Anti-cancer therapy Apoptosis Cancer Programmed cell death Pyroptosis PANoptosis Necroptosis Ferroptosis Diagnosis death Pyroptosis PANoptosis Necroptosis Ferroptosis Diagnosis

病房门诊相结合模式在全科专业住培医师儿科轮转中的应用

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中国病案 2022年第7期23卷 87-90页

作者：李超男封丽洁李娜师琳婧陈源张会丰河北医科大学第二医院河北省石家庄市050000

目的探讨半天病房结合半天门诊培训模式在全科专业住院医师规范化培训医师儿科轮转中的应用。方法选取对象为2015年9月1日-2019年3月31日期间在某医院儿科住院医师规范化培训基地参加培训的全科住培医师115名,随机分组,实验组58人,对... 详细信息

目的探讨半天病房结合半天门诊培训模式在全科专业住院医师规范化培训医师儿科轮转中的应用。方法选取对象为2015年9月1日-2019年3月31日期间在某医院儿科住院医师规范化培训基地参加培训的全科住培医师115名,随机分组,实验组58人,对照组57名。实验组上午参加病房工作下午参加门诊工作,对照组全天参加病房工作。培训结束统一参加出科考试和问卷调查。结果实验组和对照组的A2、A3型题目考核成绩分别为(34.93±4.71)分和(32.43±3.52)分,差异有统计学意义(P0.05)。调查问卷中,实验组培训满意程度、临床思维能力提高程度和医患沟通能力提高程度分别为(3.86±0.79)分、(3.53±0.68)分和(3.72±0.65)分,与对照组相比差异有统计学意义(P0.05)。结论全科住培医师在儿科轮转中,上午参加病房工作下午参加门诊工作可以提高临床思维能力和医患沟通能力,全科住培医师的满意度更高。

关键词：全科儿科住院医师规范化培训门诊病房相结合

Correction To:Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARSCoV-2 variants

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3184-3184页

作者： Qian Wang Chenchen Yang Li Yin Jing Sun Wei Wang Hengchun Li Zhengyuan Zhang Si Chen Bo Liu Zijian Liu linjing shi Xiaolin Liu Suhua Guan Chunhua Wang Linbing Qu Ying Feng Xuefeng Niu Liqiang Feng Jincun Zhao Pingchao Li Ling Chen Nanshan Zhong State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China Guangzhou Laboratory & Bioland Laboratory Guangzhou China Guangdong Laboratory of Computational Biomedicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China Guangzhou nBiomed Ltd. Guangzhou China University of Chinese Academy of Sciences Beijing China

Correction to:Signal Transduction and Targeted Therapy https://***/10.1038/s41392-023-01423-6,published online 17 April 2023 After online publication of the article^(1),the authors noticed two inadvertent mistakes occ... 详细信息

关键词： immunity mistake noticed

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脑卒中患者社会参与的纵向研究进展

护理学杂志 2024年第11期39卷 126-128,F0003页

作者：郭鑫石红英朱杉杉王帅有李丁丁潘勤贾琳婧张会敏新乡医学院护理学院河南新乡453003 河南省肿瘤医院新乡医学院第三附属医院

从脑卒中患者社会参与相关概念、纵向研究现状(定量研究、定性研究、时间点选取)、变化趋势(前6个月社会参与改善最大,以后改善幅度趋于稳定)、面临的挑战(重复多次收集资料,耗时长、成本高、失访率高,无法确定最佳研究时间点)等方面进... 详细信息

从脑卒中患者社会参与相关概念、纵向研究现状(定量研究、定性研究、时间点选取)、变化趋势(前6个月社会参与改善最大,以后改善幅度趋于稳定)、面临的挑战(重复多次收集资料,耗时长、成本高、失访率高,无法确定最佳研究时间点)等方面进行综述,旨在为开展更高质量的脑卒中患者社会参与纵向研究和针对性干预提供参考。

关键词：脑卒中社会参与社会活动社会隔离纵向研究综述文献