检索结果-南通市图书馆

短链脂肪酸对支气管扩张症模型大鼠的免疫调节作用机制

在线全文

学校读者我要写书评

暂无评论

延边大学医学学报 2024年第2期47卷 90-93页

作者：魏萍施金晶翁耀麟福建中医药大学第二临床医学院福建福州350102 福建中医药大学中西医结合学院福建福州350122

[目的]探讨短链脂肪酸(SCFAs)对铜绿假单胞菌(PA)液诱导的支气管扩张症模型大鼠的免疫调节作用机制.[方法]采用随机法将20只SPF级大鼠分为对照组、模型组、SCFAs低剂量组和高剂量组.采用气管注射给予10~128 CFU/mL PA 0.5 mL的方法建立... 详细信息

[目的]探讨短链脂肪酸(SCFAs)对铜绿假单胞菌(PA)液诱导的支气管扩张症模型大鼠的免疫调节作用机制.[方法]采用随机法将20只SPF级大鼠分为对照组、模型组、SCFAs低剂量组和高剂量组.采用气管注射给予10~128 CFU/mL PA 0.5 mL的方法建立支气管扩张症大鼠模型,SCFAs低、高剂量组大鼠每日分别灌胃给予100、150 mg/kg SCFAs混合液(乙酸、丙酸、丁酸比例为3∶1∶1),对照组和模型组分别灌胃给予生理盐水10 mL/(kg·d),连续7 d.取各组肺组织行HE染色,采用ELISA法检测各组大鼠血清中NF-κB、GM-CSF、IL-17A及IL-22水平,采用Western blot法检测肺组织中STAT3、STAT5及TLR2蛋白表达情况.[结果]模型组大鼠支气管管腔扩张变形,管壁增厚,周围见大量炎性细胞浸润,纤维组织形成;SCFAs低、高剂量组大鼠支气管管腔变形有所恢复,炎性细胞浸润及纤维组织明显减少,且高剂量组改善更为明显.与模型组比较,SCFAs低、高剂量组NF-κB、GM-CSF、IL-17A及IL-22水平显著升高(P0.05).[结论]SCFAs可促进炎症因子分泌,在PA诱导的支气管扩张症模型大鼠急性感染期发挥免疫调节作用,其机制认为可能与TLR2/NF-κB/STAT信号通路有关系.

关键词：支气管扩张症铜绿假单胞菌短链脂肪酸免疫调节大鼠

Quantum classifier with parameterized quantum circuit based on the isolated quantum system

在线全文

学校读者我要写书评

暂无评论

The Journal of China Universities of Posts and Telecommunications 2022年第4期29卷 21-31页

作者： shi jinjing Wang Wenxuan Xiao Zimeng Mu Shuai Li Qin School of Computer Science and Engineering Central South UniversityChangsha 410083China School of Computer Science and School of Cyberspace Science Xiangtan UniversityXiangtan 411301China

It is a critical challenge for quantum machine learning to classify the datasets *** article develops a quantum classifier based on the isolated quantum system(QC-IQS)to classify nonlinear and multidimensional ***,a model of QC-IQS is presented by creating parameterized quantum circuits(PQCs)based on the decomposing of unitary operators with the Hamiltonian in the isolated quantum ***,a parameterized quantum classification algorithm(QCA)is designed to calculate the classification results by updating the loss function until it ***,the experiments on nonlinear random number datasets and Iris datasets are designed to demonstrate that the QC-IQS model can handle and generate accurate classification results on different kinds of *** experimental results reveal that the QC-IQS is adaptive and learnable to handle different types of ***,QC-IQS compensates the issue that the accuracy of previous quantum classifiers declines when dealing with diverse *** promotes the process of novel data processing with quantum machine learning and has the potential for more comprehensive applications in the future.

关键词： quantum classifier quantum classification isolated quantum system parameterized quantum circuit Hamiltonian

Batch proxy quantum blind signature scheme

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2013年第5期56卷 202-210页

作者： shi jinjing shi RongHua GUO Ying PENG XiaoQi TANG Ying School of Information Science and Engineering Central South University Department of Information Science & Engineering Hunan First Normal University School of Physics Science and Technology Central South University

Motivated by proxy signature and blind signature for the secure communications,the batch signature is proposed to create a novel quantum *** is based on three-dimensional two-particle-entangled quantum system which is used to distribute the quantum keys and create strings of quantum-trits(qutrits) for *** of the messages,which are expected to be signed,are encrypted by the private key of the message owner during *** from the classical blind signature,an authenticity verification of signatures and an arbitrator’s efficient batch proxy signature are simultaneously applied in the present *** of security and efficiency shows that it enables us to achieve a large number of quantum blind signatures for quantities of messages with a high efficiency with the arbitrator’s secure batch proxy blind signature.

关键词： quantum cryptography quantum signature blind signature proxy signature batch signature

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

半航空电磁法全流程低噪声关键技术研究

地球物理学报 2023年第9期66卷 3904-3913页

作者：武欣薛国强陈卫营石金晶中国科学院矿产资源研究重点实验室中国科学院地质与地球物理研究所北京100029 中国科学院大学地球与行星科学学院北京100029

半航空电磁法(SAEM)是一种有利于在复杂地形地表条件下高效、低成本开展探测的新兴方法,尤其适合我国国情.SAEM数据受多种系统内外部噪声影响,信号质量不佳;传统去噪方法针对不同噪声逐一处理,步骤多、主观因素强.针对上述问题,本文考... 详细信息

半航空电磁法(SAEM)是一种有利于在复杂地形地表条件下高效、低成本开展探测的新兴方法,尤其适合我国国情.SAEM数据受多种系统内外部噪声影响,信号质量不佳;传统去噪方法针对不同噪声逐一处理,步骤多、主观因素强.针对上述问题,本文考虑同时在压制噪声来源与增强去噪方法两方面做工作,提出一套全流程低噪声解决方案:采用降噪搭载结构抑制主要外部噪声,低噪声混合放大电路抑制主要内部噪声,基于深度学习的一站式去噪方法克服主观因素影响,从而在整个SAEM观测与处理流程上实现低噪声.测试表明,在地形复杂、气流条件复杂地区,所研发的SAEM系统可稳定工作,数据可靠性一致性高,未来有望为我国资源探查、深部工程等工作提供更为有力的支撑.

关键词：半航空电磁法运动噪声搭载结构低噪声放大电路噪声去除

基于Arnold变换的量子图像混沌加密方法

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

电子与信息学报 2022年第12期44卷 4284-4293页

作者：石金晶陈添陈淑慧李琴施荣华中南大学计算机学院长沙410083 湘潭大学计算机学院湘潭411105

在确保量子图像密码算法安全的基础上,为进一步优化解密图像质量及计算复杂度,该文提出一种基于Arnold变换的量子图像混沌加密方案。方案使用量子细胞神经网络产生的混沌信号来控制量子Arnold变换、量子交换(SWAP)和量子控制非操作(CNO... 详细信息

在确保量子图像密码算法安全的基础上,为进一步优化解密图像质量及计算复杂度,该文提出一种基于Arnold变换的量子图像混沌加密方案。方案使用量子细胞神经网络产生的混沌信号来控制量子Arnold变换、量子交换(SWAP)和量子控制非操作(CNOT),然后将这些操作作用于量子明文图像中以获得相应的密文图像。研究结果表明:所提量子灰度图像加密方法具有高安全性、高解密图像质量及低计算复杂度的特点。

关键词：量子图像密码量子细胞神经网络量子混沌系统量子Arnold变换

IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第2期36卷 103-113页

作者： Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu Jane shi jinjing Xia Guangdong Lung Cancer Institute Guangdong Provincial Key Laboratory of Translational Medicine in Lung CancerGuangdong Provincial People's Hospital&Guangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080China Shanghai Lung Cancer Center Shanghai Chest HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200025China Department of Respiration Harbin Cancer HospitalHarbin Medical UniversityHarbin 150081China Department of Thoracic Oncology and Surgery the First Affliated Hospital of Guangzhou Medical UniversityGuangzhou 510120China Department of Medical Oncology Jiangsu Cancer HospitalNanjing 210009China Department of Medical Oncology Zhejiang Cancer HospitalHangzhou 330022China Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200030China Department of Medical Oncology Sir Run Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016China Department of Medical Oncology Shenzhen HospitalCancer Hospital of Chinese Academy of Medical SciencesShenzhen 518116China Department of Thoracic Oncology Beijing Cancer HospitalBeijing 100142China Product Development Shanghai Roche Pharmaceutical LtdShanghai 201203China

Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab *** as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian ***: Key eligibility criteria for this phase Ⅲ, open-label, randomized study included age ≥18 years;histologically documented advanced NSCLC per the Union for International Cancer Control/American Joint Committee on Cancer staging system(7th edition);Eastern Cooperative Oncology Group performance status of 0 or 1;and disease progression following platinum-based chemotherapy for advanced or metastatic NSCLC. Patients were randomized 2:1 to receive either atezolizumab(1,200 mg) or docetaxel(75 mg/m^(2)). The primary study endpoint was overall survival(OS) in the intention-to-treat(ITT) population with wild-type epidermal growth factor receptor expression(ITT EGFR-WT) and in the overall ITT ***: Median OS in the ITT EGFR-WT population(n=467) was 12.3 [95% confidence interval(95% CI),10.3-13.8] months in the atezolizumab arm(n=312) and 9.9(95% CI, 7.8-13.9) months in the docetaxel arm[n=155;stratified hazard ratio(HR), 0.82;95% CI, 0.66-1.03]. Median OS in the overall ITT population was 12.5(95% CI, 10.8-13.8) months with atezolizumab treatment and 11.1(95% CI, 8.4-14.2) months(n=377) with docetaxel treatment(n=188;stratified HR, 0.87;95% CI, 0.71-1.08). Grade 3/4 treatment-related adverse events(TRAEs) occurred in 18.4% of patients in the atezolizumab arm and 50.0% of patients in the docetaxel ***: IMpower210 did not meet its primary efficacy endpoint of OS in the ITT EGFR-WT or overall ITT populations. Atezolizumab was comparatively more tolerable than docetaxel, with a lower incidence of grade3/4 TRAEs.

关键词： Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody

CGG repeat expansion in LOC642361/NUTM2B-AS1 typically presents as oculopharyngodistal myopathy

在线全文

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第2期51卷 184-196页

作者： Yan shi Chunyan Cao Yiheng Zeng Yuanliang Ding Long Chen Fuze Zheng Xuejiao Chen Fanggui Zhou Xiefeng Yang jinjing Li Liuqing Xu Guorong Xu Minting Lin Hiroyuki Ishiura Shoji Tsuji Ning Wang Zhiqiang Wang Wan-Jin Chen Kang Yang Department of Neurology and Institute of Neurology of First Affiliated Hospital Institute of NeuroscienceFujian Key Laboratory of Molecular NeurologyFujian Medical UniversityFuzhouFujian 350005China Department of Neurology National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian 350212China The First Affiliated Hospital College of Clinical Medicine of Henan University of Science and TechnologyLuoyangHenan 471000China Department of Neurology Zhangzhou Municipal Hospital of Fujian Province and Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhouFujian 363000China Department of Neurology Jian'ou Municipal Hospital of Fujian ProvinceJian'ouFujian 353100China Department of Radiology First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian 350005China Department of Neurology Graduate School of MedicineThe University of TokyoTokyo 113-8655Japan Department of Neurology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayama 700-8558Japan Institute of Medical Genomics International University of Health and WelfareChiba 286-0048Japan

CGG repeat expansions in LOC642361/NUTM2B-AS1 have recently been identified as a cause of oculopharyngeal myopathy with ***,since only three patients from a single family were reported,it remains unknown whether their clinicopathological features are typical for CGG repeat expansions in LOC642361/***,using repeat-primed-polymerase chain reaction and long-read sequencing,we identify 12 individuals from 3 unrelated families with CGG repeat expansions in LOC642361/NUTM2B-AS1,typically presenting with oculopharyngodistal *** CGG repeat expansions range from 161 to 669 repeat *** of the patients present with ptosis,restricted eye movements,dysphagia,dysarthria,and diffuse limb muscle *** one patient shows T2-weighted hyperintensity in the cerebellar white matter surrounding the deep cerebellar nuclei on brain magnetic resonance *** biopsies from three patients show a myopathic pattern and rimmed *** of muscle biopsies suggest that CGG repeat expansions in LOC642361/NUTM2B-AS1 may deleteriously affect aggrephagic capacity,suggesting that RNA toxicity and mitochondrial dysfunction may contribute to *** study thus expands the phenotypic spectrum for the CGG repeat expansion of LOC642361/NUTM2B-AS1 and indicates that this genetic variant typically manifests as oculopharyngodistal myopathy with chronic myopathic changes with rimmed vacuoles and filamentous intranuclear inclusions in muscle fibers.

关键词： Oculopharyngeal myopathy with leukoencephalopathy Oculopharyngodistal myopathy CGG repeat expansion Rimmed vacuoles

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于正则图上量子游走的仲裁量子签名方案

电子与信息学报 2020年第1期42卷 89-97页

作者：施荣华冯艳艳石金晶中南大学计算机学院

量子游走已经被提出可以用于瞬时地传输量子比特或多维量子态。根据量子游走的隐形传输模型,该文提出一种无需提前准备纠缠源的基于正则图上量子游走的仲裁量子签名算法。在初始化阶段,密钥是由量子密钥分发系统制备;在签名阶段,基于正... 详细信息

量子游走已经被提出可以用于瞬时地传输量子比特或多维量子态。根据量子游走的隐形传输模型,该文提出一种无需提前准备纠缠源的基于正则图上量子游走的仲裁量子签名算法。在初始化阶段,密钥是由量子密钥分发系统制备;在签名阶段,基于正则图上的量子游走隐形传输模型被用于转移信息副本密文从发送者到接收者。具体地,发送者编码要签名信息的密文在硬币态上,通过两步正则图上的量子游走,可以自动地产生用于量子隐形传输必须的纠缠态。发送者和接收者对制备的纠缠态的测量为签名生成和签名验证的凭据。在验证阶段,在仲裁的辅助下,验证者依照发送者的经典结果核实签名的有效性。此外,随机数和认证的公共板被引进阻止接收方在接收真正信息序列之前的存在性伪造攻击和否认攻击。安全性分析表明设计的算法满足签名者和接收者的不可抵赖以及任何人的不可伪造。讨论表明方案不能抗击发送者的抵赖攻击,相应的建议被给出。由于实验上已经证明量子游走可以在多个不同的物理系统上实现,因此该签名方案未来是可实现的。

关键词：量子密码仲裁量子签名量子游走量子隐形传输

上市公司股东不可撤销表决权委托研究——问题、挑战与监管

在线全文

学校读者我要写书评

暂无评论

证券市场导报 2020年第5期 28-37页

作者：施金晶张斌华东政法大学经济法学院上海200042 上海证券交易所上市公司监管二部上海200120

表决权是上市公司股东参与管理决策的重要方式。证券监管实践表明,不可撤销表决权委托既有规避股份限售和减持规则的动机,也有出于增强控制权转让交易中博弈弹性的考虑。表决权委托并非一项简单的债权债务法律关系,其合规性及对证券市... 详细信息

表决权是上市公司股东参与管理决策的重要方式。证券监管实践表明,不可撤销表决权委托既有规避股份限售和减持规则的动机,也有出于增强控制权转让交易中博弈弹性的考虑。表决权委托并非一项简单的债权债务法律关系,其合规性及对证券市场的影响需引起足够的重视。为规范上市公司股东不可撤销的表决权委托,本文建议:在信息披露监管方面,重点关注表决权委托对权益变动、控制权稳定性、投资者保护的影响;在制度规范方面,发布表决权委托示范协议指引等规则,明确表决权委托的关键要素和监管要求。

关键词：表决权委托不可撤销委托信息披露公司控制权