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LEARN algorithm:a novel option for predicting non-alcoholic steatohepatitis

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 507-522,I0017-I0022页

作者： Gang Li Tian-Lei Zheng Xiao-Ling Chi Yong-Fen Zhu Jin-Jun Chen Liang Xu Jun-Ping shi Xiao-Dong Wang Wei-Guo Zhao Christopher D.Byrne Giovanni Targher Rafael S.Rios Ou-Yang Huang Liang-Jie Tang shi-Jin Zhang shi geng Huan-Ming Xiao Sui-Dan Chen Rui Zhang Ming-Hua Zheng MAFLD Research Center Department of Hepatologythe First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Artificial Intelligence Unit Department of Medical EquipmentThe Affiliated Hospital of Xuzhou Medical UniversityXuzhouChina Department of Hepatology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhouChina Department of Hepatology and Infection Sir Run Run Shaw HospitalAffiliated with School of MedicineZhejiang UniversityHangzhouChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Hepatology Unit Zengcheng BranchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Hepatology Tianjin Second People’s HospitalTianjinChina Department of Liver Diseases Hangzhou Normal University Affiliated HospitalHangzhouChina Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province WenzhouChina Southampton National Institute for Health and Care Research Biomedical Research Centre University Hospital Southampton&University of SouthamptonSouthampton General HospitalSouthamptonUK Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity of VeronaVeronaItaly Department of Pathology the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Department of Nutrition the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouChina Institute of Hepatology Wenzhou Medical UniversityWenzhouChina

Background:There is an unmet need for accurate non-invasive methods to diagnose non-alcoholic steatohepatitis(NASH).Since impedance-based measurements of body composition are simple,repeatable and have a strong association with non-alcoholic fatty liver disease(NAFLD)severity,we aimed to develop a novel and fully automatic machine learning algorithm,consisting of a deep neural network based on impedance-based measurements of body composition to identify NASH[the bioeLectrical impEdance Analysis foR Nash(LEARN)algorithm].Methods:A total of 1,259 consecutive subjects with suspected NAFLD were screened from six medical centers across China,of which 766 patients with biopsy-proven NAFLD were included in final *** patients were randomly subdivided into the training and validation groups,in a ratio of 4:*** LEARN algorithm was developed in the training group to identify NASH,and subsequently,tested in the validation ***:The LEARN algorithm utilizing impedance-based measurements of body composition along with age,sex,pre-existing hypertension and diabetes,was able to predict the likelihood of having *** algorithm showed good discriminatory ability for identifying NASH in both the training and validation groups[area under the receiver operating characteristics(AUROC):0.81,95%CI:0.77-0.84 and AUROC:0.80,95%CI:0.73-0.87,respectively].This algorithm also performed better than serum cytokeratin-18 neoepitope M30(CK-18 M30)level or other non-invasive NASH scores(including HAIR,ION,NICE)for identifying NASH(P value<0.001).Additionally,the LEARN algorithm performed well in identifying NASH in different patient subgroups,as well as in subjects with partial missing body composition ***:The LEARN algorithm,utilizing simple easily obtained measures,provides a fully automated,simple,non-invasive method for identifying NASH.

关键词： Non-alcoholic fatty liver disease(NAFLD) non-alcoholic steatohepatitis(NASH) bioeLectrical impEdance Analysis foR Nash(LEARN)algorithm body composition

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p53活性四聚体全原子分子动力学分析

物理学报 2024年第4期73卷 300-313页

作者：周晗耿轶钊晏世伟北京师范大学物理学系北京100875 河北工业大学理学院天津300131 北京师范大学文理学院珠海519085

p53是一种肿瘤抑制蛋白,对阻碍癌症发展、维持遗传完整性起着至关重要的作用.在细胞核内,4个p53分子通过高度协同的方式、通过DNA结合域与DNA结合,形成稳定的四聚体活性结构,并转录激活或抑制其靶向基因.然而,大多数肿瘤细胞中存在大量... 详细信息

p53是一种肿瘤抑制蛋白,对阻碍癌症发展、维持遗传完整性起着至关重要的作用.在细胞核内,4个p53分子通过高度协同的方式、通过DNA结合域与DNA结合,形成稳定的四聚体活性结构,并转录激活或抑制其靶向基因.然而,大多数肿瘤细胞中存在大量p53的突变,其中绝大部分突变发生在p53的DNA结合域,而p53的DNA结合域又是p53形成四聚体活性结构、调控下游靶基因转录的重要区域.本文通过全原子分子动力学模拟,研究了野生型p53四聚体内分子间的相互作用机制.结果表明,位于DNA两侧的对称二聚体是一个稳定的二聚体,在与DNA结合前后都能维持稳定的结构.位于DNA同侧的两个单体依靠两个接触面提供的蛋白-蛋白相互作用和DNA的骨架作用使四聚体活性结构保持稳定,这些相互作用为四聚体的形成机制提供了重要支撑.该工作厘清了p53四聚体在动力学过程中的内部相互作用机制和关键残基,揭示了四聚化过程中各个相互作用界面的关键位点,对于理解p53的抑癌机制、探索有效治癌策略、发展治癌药物具有重要意义.

关键词： p53核心四聚体 p53核心结构域蛋白-蛋白相互作用分子动力学模拟

Autophagy Activation Contributes to the Protection of MinocyclineAgainst Oxygen-glucose Deprivation and Reperfusion in PC12 Cells

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Autophagy Activation Contributes to the Protection of Minocy...

MEMS加工误差对微弹簧力学特性的影响分析

华东六省一市生物化学与分子生物学学会2014年学术交流大会暨浙江省第十一届学会会员代表大会

作者： DONG Weng-bin XIAO shi-geng CHENG Min YE Xiao-di ZHENG Gao-li Institute of Materia Medica Zhejiang Academy of Medical sciences College of Pharmaceutical Science Zhejiang Chinese Medical University

Objective:Autophagy serves as a stress response and it is a process involved in neurodegeneration *** data suggest that activation of autophagy may contribute to neuroprotection against cerebral ischemia,Minocycline,a semisynthetic tetracycline antibiotic,can inhibit cell apoptosis and protect neurons in neurodegenerative *** this study,we further explored this effect that whether autophagy contributes to the protection of minocycline against cerebral ischemia,using an in vitro model of cerebral ischemia reperfusion injury to neuronal PC 12 ***:Cultured PC12 cells were subjected to 2h of oxygen-glucose deprivation(OGD)followed by 6h of simulated reperfusion,either minocycline(1,10,100μM)or together with autophagy inhibitor 3-methyladenine(3-MA,5mM)administration immediately after *** stained cells with monodansylcadaverin to observe autophagic vacuole and cell viability was determined by MTT *** expression ofautophagy-related proteins LC3Ⅱ,Beclinl and P62,three were determined by western ***:We found that low dose(1,10μM)minocycline significantly promotes cell survival(84.5%±5.6%,82.4%±4.5%)after oxygen-glucose deprivation and 6h of reperfusion compared with the model group(65.6%±4.1%),while the higher doses(100μM)exacerbates the cell injury(56.8%±5.5%)[Fig.1A].We demonstrated that minocycline significantly increased the levels of LC3II and Beclinl in a dose-dependent manner[Fig.1B].And the autophagy inhibitor 3-MA reverses the protection of minocycline[Fig.2A],impelling cell to death by reducing the expression of LC3Ⅱ,Beclin1 and concomitant with an increase of p62[Fig.2B].Conclusion:Our data indicate that only low dose minocycline inhibits neuronal cell death,whereas the high dose exacerbates the ischemia *** minocycline can markedly strengthen autophagic processes via increasing the expression of autophagy-related proteins(LC3Ⅱ,Beclinl),promoting PC 12 cells survival after oxygen-glucose deprivation an

关键词： autophagy minocycline PC12 cells oxygen-glucose deprivation

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压电与声光 2009年第5期31卷 735-737,741页

作者：李华石庚辰何光清华大学精密仪器与机械学系北京100084 北京理工大学机电学院北京100081

S型微弹簧是一种在微机电系统中应用广泛的微弹性元件,利用力学分析法,首次推导出S型微弹簧在空间3个方向上的弹性系数计算公式,ANSYS仿真验证了公式推导的正确性。采用LIGA工艺,设计加工了一种金属镍S型微弹簧。用精密微小型计算机显... 详细信息

S型微弹簧是一种在微机电系统中应用广泛的微弹性元件,利用力学分析法,首次推导出S型微弹簧在空间3个方向上的弹性系数计算公式,ANSYS仿真验证了公式推导的正确性。采用LIGA工艺,设计加工了一种金属镍S型微弹簧。用精密微小型计算机显微测量仪测量得到微弹簧的线宽,长度和厚度与设计值的误差分别为4μm、50μm和24μm。分析了微弹簧各个结构参数的加工误差对微机电系统(MEMS)微弹簧力学特性的影响,指出微弹簧线宽的加工误差对其力学特性影响最大,Tytron250微小力拉伸实验机实验验证了结论的正确性。

关键词：微机电系统 S型微弹簧弹性系数加工误差

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虚拟现实在发电机检修培训系统设计中的应用

计算机仿真 2017年第7期34卷 170-173,293页

作者：史耕金华北电力大学自动化系河北保定071003

针对目前火电厂对于大型发电设备——发电机检修培训的需求,结合虚拟检修培训技术的发展现状、系统结构特征以及涉及到的关键技术,设计了基于虚拟现实技术的发电机检修工艺培训专家系统。上述培训系统融合了三维建模、虚拟现实交互、数... 详细信息

针对目前火电厂对于大型发电设备——发电机检修培训的需求,结合虚拟检修培训技术的发展现状、系统结构特征以及涉及到的关键技术,设计了基于虚拟现实技术的发电机检修工艺培训专家系统。上述培训系统融合了三维建模、虚拟现实交互、数据库、JavaEE的技术实现B/S形式的学习考核交互平台,系统中虚拟现实交互部分与发电机检修过程完美结合,真实再现检修过程,最大限度的提高学员的学习和培训效果。

关键词：虚拟现实发电机检修培训

凝胶-燃烧-熔盐法制备Ca_(2-x)Al_2SiO_7∶Dy_x^(3+)白光荧光粉

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人工晶体学报 2014年第10期43卷 2710-2716页

作者：陈林刘悦李石庚曾蓉刘芳施卫国萍乡学院材料与化学工程系萍乡337000

采用凝胶-燃烧-熔盐法合成了Ca2-xAl2SiO7∶Dy3+x(x=0.01、0.02、0.03、0.04、0.05)白光荧光粉,探讨了Dy3+的掺杂量对荧光粉发光性能的影响,通过X射线衍射仪、扫描电子显微镜和荧光光谱仪对样品进行了测试表征。结果表明:所得Ca1.97Al2S... 详细信息

采用凝胶-燃烧-熔盐法合成了Ca2-xAl2SiO7∶Dy3+x(x=0.01、0.02、0.03、0.04、0.05)白光荧光粉,探讨了Dy3+的掺杂量对荧光粉发光性能的影响,通过X射线衍射仪、扫描电子显微镜和荧光光谱仪对样品进行了测试表征。结果表明:所得Ca1.97Al2SiO7∶Dy3+0.03样品为四方钙铝黄长石结构,平均粒径在0.9~1μm之间;该样品的激发光谱由一组尖锐的激发峰组成,对应于Dy3+的6H15/2→6P3/2(321 nm)、6H15/2→6P7/2(345 nm)、6H15/2→6P5/2(363nm)、6H15/2→4F7/2(384 nm)、6H15/2→4G11/2(425 nm)、6H15/2→4I15/2(452 nm)和6H15/2→4F9/2(470 nm)跃迁,发射光谱由位于477 nm的蓝光发射和580 nm的黄光发射组成,对应于Dy3+的4F9/2→6H15/2(477 nm)和4F9/2→6H13/2(580nm)跃迁,其CIE1931色坐标为(x=0.3017,y=0.3011),接近于理想的白光(x=0.333,y=0.333);当Dy3+掺杂量大于0.03时出现浓度猝灭,这主要是电偶极-电偶极的相互作用引起的。

关键词：白色荧光粉凝胶-燃烧-熔盐法 Ca2-xAl2SiO7∶Dyx^3+

专家系统在GP设计非线性系统控制器中的应用

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计算机仿真 2017年第6期34卷 357-360页

作者：史耕金华北电力大学自动化系河北保定071003

针对于一类非线性对象,在原有遗传规划算法实现控制器参数寻优的基础上,引入专家系统,指导和优化控制器参数寻优过程。其目的一方面是设计的控制器能够满足更高质量的控制要求,另一方面加快寻优过程,缩短寻优时间。仿真结果表明,引入专... 详细信息

针对于一类非线性对象,在原有遗传规划算法实现控制器参数寻优的基础上,引入专家系统,指导和优化控制器参数寻优过程。其目的一方面是设计的控制器能够满足更高质量的控制要求,另一方面加快寻优过程,缩短寻优时间。仿真结果表明,引入专家系统,利用先验知识确定适应度函数的参数,能够使被控对象具有更加优秀的控制品质。

关键词：遗传规划专家系统非线性系统控制器

WiMAX Mesh网络中基于团划分的中继部署算法

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计算机学报 2013年第5期36卷 937-946页

作者：廖卓凡王建新张士庚中南大学信息科学与工程学院长沙410083 长沙理工大学计算机与通信工程学院长沙410004

集成多跳中继技术的WiMAX Mesh网络中,当发送功率和信道数目一定时,用户接入链路的传输速率直接取决于用户到中继的距离.在满足用户到中继距离要求的条件下,研究最少中继部署问题具有保证网络性能、降低组网成本的意义.文中将该问题转... 详细信息

集成多跳中继技术的WiMAX Mesh网络中,当发送功率和信道数目一定时,用户接入链路的传输速率直接取决于用户到中继的距离.在满足用户到中继距离要求的条件下,研究最少中继部署问题具有保证网络性能、降低组网成本的意义.文中将该问题转化为最少团划分问题,基于用户邻居信息提出启发式算法MAXDCP,基于用户位置信息提出启发式算法GEOCP.模拟结果表明:与该问题的最新算法MIS相比,在相同时间复杂度下,MAXDCP部署中继的个数平均减少23.8%,GEOCP平均减少35%;与已有PTAS算法HS相比,GEOCP部署中继个数平均减少18.5%,且时间复杂度更低.MAXDCP和GEOCP很好地保证了网络性能、降低了组网成本.

关键词： WiMAX Mesh网络中继多跳部署团划分

Application of Nutritional Support in the Comprehensive Treatment of Gastric Cancer: A Case Report

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Journal of Nutritional Oncology 2020年第4期5卷 196-200页

作者： Yue Li Zun Yue Zhang Hua Wei Wang Jing Jiao Zhao shi Tao geng Kun Hua Wang National Health Commission(NHC)Key Laboratory of Drug Addiction Medicine First Affiliated Hospital of Kunming Medical UniversityKunming Medical UniversityKunming 650032China Department of Gastrointestinal and Hernia Surgery First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Scientific Research Laboratory Center First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Yunnan Institute of Digestive Disease First Affiliated Hospital of Kunming Medical UniversityKunming 650032China Department of Reproduction and Genetics First Affiliated Hospital of Kunming Medical UniversityKunming 650032China

Objective To relieve long-term malnutrition caused by a malignant tumor affecting the pylorus and to prolong the patient *** A patient presented with complete pyloric obstruction due to pyloric tumors,and achieved good therapeutic effects through nutritional support and effective *** After about 40 days of treatment,all physiological indicators were *** chemotherapy,the pyloric tumor shrank and the complete obstruction was *** patient was able to eat and drink *** Nutritional support,combined with chemotherapy,may effectively treat complete pyloric obstruction caused by advanced tumors.

关键词： Nutritional support Gastric cancer Pyloric obstruction Advanced gastric cancer