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EB病毒衣壳抗原IgA抗体检测试剂参考品的建立

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中国病毒病杂志 2015年第4期5卷 277-280页

作者：周海卫石大伟沈舒曹丽梅张春涛中国食品药品检定研究院体外诊断试剂二室卫生部生物技术产品检定方法及其标准化重点实验室北京100050 中国食品药品检定研究院标准物质与标准化研究所北京100050

目的建立EB病毒衣壳抗原IgA抗体检测试剂国家参考品,为相关试剂盒的质量控制和评价提供依据。方法通过收集鼻咽癌患者及正常人血浆,对其进行酶联免疫法抗体筛查,膜条法和免疫荧光法抗体确证,获得VCA-IgA抗体阳性样本;使用市场常用的7种E... 详细信息

目的建立EB病毒衣壳抗原IgA抗体检测试剂国家参考品,为相关试剂盒的质量控制和评价提供依据。方法通过收集鼻咽癌患者及正常人血浆,对其进行酶联免疫法抗体筛查,膜条法和免疫荧光法抗体确证,获得VCA-IgA抗体阳性样本;使用市场常用的7种EB病毒衣壳抗原IgA抗体检测试剂盒对候选样本进行协作标定,确定EB病毒衣壳抗原IgA抗体检测试剂参考品的组成及质量标准;并对其进行稳定性考核。结果协作标定结果为阴性参考品符合率9/10~10/10,阳性参考品符合率7/10~10/10,精密性1.0%~10.7%,最低检出限最低为1∶4,最高为1∶16;4℃放置1周及2周、室温(25℃)放置3d及反复冻融5次均不影响参考品的稳定性。结论成功建立了EB病毒衣壳抗原IgA抗体检测试剂参考品,可用于该类试剂的质量控制。

关键词： EB病毒衣壳抗原IgA抗体参考品

Analysis of radiation diffusion of COVID-19 driven by social attributes

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Chinese Physics B 2024年第1期33卷 773-779页

作者：年福忠杨晓晨师亚勇 Lanzhou University of Technology School of Computer&CommunicationLanzhou 730050China University of Science and Technology Beijing School of Computer&Communication EngineeringBeijing 100083China

This paper first estimated the infectious capacity of COVID-19 based on the time series evolution data of confirmed cases in multiple countries. Then, a method to infer the cross-regional spread speed of COVID-19 was introduced in this paper, which took the gross domestic product(GDP) of each region as one of the factors that affect the spread speed of COVID-19 and studied the relationship between the GDP and the infection density of each region(China's Mainland, the United States, and EU countries). In addition, the geographic distance between regions was also considered in this method and the effect of geographic distance on the spread speed of COVID-19 was studied. Studies have shown that the probability of mutual infection of these two regions decreases with increasing geographic distance. Therefore, this paper proposed an epidemic disease spread index based on GDP and geographic distance to quantify the spread speed of COVID-19 in a region. The analysis results showed a strong correlation between the epidemic disease spread index in a region and the number of confirmed cases. This finding provides reasonable suggestions for the control of epidemics. Strengthening the control measures in regions with higher epidemic disease spread index can effectively control the spread of epidemics.

关键词： COVID-19 basic reproduction number gross domestic product(GDP) geographic distance cross-regional spread

Support design method for deep soft-rock tunnels in non-hydrostatic high in-situ stress field

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Journal of Central South University 2024年第7期31卷 2431-2445页

作者： ZHENG Ke-yue shi Cheng-hua ZHAO Qian-jin LEI Ming-feng JIA Chao-jun PENG Zhu National Engineering Research Center of High-speed Railway Construction Technology Changsha 410075China School of Civil Engineering Central South UniversityChangsha 410075China China Railway Group Co. Ltd.Beijing 100039China

Due to the long-term plate tectonic movements in southwestern China,the in-situ stress field in deep formations is *** passing through deep soft-rock mass under non-hydrostatic high in-situ stress field,tunnels will suffer serious asymmetric *** is no available support design method for tunnels under such a situation in existing studies to clarify the support time and support *** study first analyzed the mechanical behavior of tunnels in non-hydrostatic in-situ stress field and derived the theoretical equations of the ground squeezing curve(GSC)and ground loosening curve(GLC).Then,based on the convergence confinement theory,the support design method of deep soft-rock tunnels under non-hydrostatic high in-situ stress field was established considering both squeezing and loosening *** addition,this method can provide the clear support time and support stiffness of the second layer of initial *** proposed design method was applied to the Wanhe tunnel of the China-Laos railway in *** data indicated that the optimal support scheme had a good effect on controlling the tunnel deformation in non-hydrostatic high in-situ stress *** applications showed that the secondary lining could be constructed properly.

关键词： non-hydrostatic stress field high in-situ stress deep soft-rock tunnel squeezing pressure loosening pressure support design method

城市游径网络的非连续路段识别及空间活力推演

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华南理工大学学报（自然科学版） 2024年第7期52卷 88-96页

作者：赵渺希梁锡燕张小星师浩辰华南理工大学建筑学院广东广州510640 华南理工大学亚热带建筑与城市科学全国重点实验室广东广州510640 广州市城市规划勘测设计研究院有限公司广东广州510060

自组织游径网络的活力提升是城市更新规划的重要目标。由于老城区游径网络存在不连续性和断头路现象,居民游憩活动的舒适性受到了挑战,而游径网络的自组织性意味着自上而下的规划设计模式难以匹配市民需求。如何自下而上地推演游憩规划... 详细信息

自组织游径网络的活力提升是城市更新规划的重要目标。由于老城区游径网络存在不连续性和断头路现象,居民游憩活动的舒适性受到了挑战,而游径网络的自组织性意味着自上而下的规划设计模式难以匹配市民需求。如何自下而上地推演游憩规划的空间活力,进而识别潜力地块,是提升城市游径网络品质的重要命题。文中以广州市老城区为案例,基于复杂网络理论,构建游径网络的非连续性和空间活力测度指标;以GPS轨迹数据识别既有游径网络的非连续区段,定量探讨了基于市民游憩行为的非连续路段空间的识别和城市更新改造项目的活化作用,推演更新项目实施带来的潜在影响。游径网络的非连续性分析表明,当前广州市老城区游径路段的非连续度总体较低,连接程度较好,但由于区位和历史遗留问题,仍有部分路段存在明显的非连续现象。城市游径网络的空间活力推演结果表明,城市更新项目对自组织游径网络会产生一定的正面影响,可依据推演分析来判定城市游憩品质提升项目的实施计划和日程。本研究从规划和交通维度出发,对城市的自组织特性进行了有益探索,弥补了“自上而下”式规划对城市自组织游径网络考虑不足的缺陷。

关键词：游径网络城市规划城市更新非连续性空间活力规划推演

中药组方对黄曲霉毒素B1中毒雏鸭肝功能的影响

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动物医学进展 2012年第2期33卷 31-34页

作者：石达友廖申权林远超李鹏飞刘念郭铭生唐兆新华南农业大学兽医学院广东广州510642 广东省农科院兽医研究所广东广州510640

为观察黄曲霉毒素B1(AFB1)对试验雏鸭肝功能血清指标的影响及复方中药对AFB1的颉颃效应,本试验选用7日龄健康雏鸭90只,分为3组,每组30只。Ⅰ组为空白对照组,灌胃与试验组等体积二甲基亚砜;Ⅱ组、Ⅲ组为试验组。每天分别按0.1mg/kg剂量... 详细信息

为观察黄曲霉毒素B1(AFB1)对试验雏鸭肝功能血清指标的影响及复方中药对AFB1的颉颃效应,本试验选用7日龄健康雏鸭90只,分为3组,每组30只。Ⅰ组为空白对照组,灌胃与试验组等体积二甲基亚砜;Ⅱ组、Ⅲ组为试验组。每天分别按0.1mg/kg剂量给Ⅱ组、Ⅲ组雏鸭灌胃AFB1一次,连续投药21d,试验期间给Ⅲ组雏鸭日粮中添加2%复方中药。分别在给雏鸭投药后7、14、21d,检测雏鸭肝功能部分血清指标。结果显示,Ⅱ组、Ⅲ组雏鸭丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)与Y-谷氨酰转肽酶(GGT)活性显著高于Ⅰ组(P<0.05),而血清总蛋白(TP)与白蛋白(ALB)含量显著下降(P<0.05);与Ⅱ组比较,在日粮中添加复方中药的Ⅲ组雏鸭各项血清指标均有显著改善(P<0.05)。说明黄曲霉毒素B1导致雏鸭肝功能发生显著的变化,而复方中药能明显改善其变化。

关键词：黄曲霉毒素B1 肝功能雏鸭复方中药

Memristive switching in the surface of a charge-density-wave topological semimetal

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Science Bulletin 2024年第13期69卷 2042-2049页

作者： Jianwen Ma Xianghao Meng Binhua Zhang Yuxiang Wang Yicheng Mou Wenting Lin Yannan dai Luqiu Chen Haonan Wang Haoqi Wu Jiaming Gu Jiayu Wang Yuhan Du Chunsen Liu Wu shi Zhenzhong Yang Bobo Tian Lin Miao Peng Zhou Chun-Gang Duan Changsong Xu Xiang Yuan Cheng Zhang State Key Laboratory of Surface Physics and Institute for Nanoelectronic Devices and Quantum Computing Fudan UniversityShanghai 200433China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China Key Laboratory of Computational Physical Sciences(Ministry of Education) Institute of Computational Physical SciencesState Key Laboratory of Surface PhysicsDepartment of PhysicsFudan UniversityShanghai 200433China Shanghai Qi Zhi Institute Shanghai 200030China School of Physics Southeast UniversityNanjing 211189China Key Laboratory of Polar Materials and Devices(Ministry of Education) Department of ElectronicsEast China Normal UniversityShanghai 200241China Shanghai Center of Brain–inspired Intelligent Materials and Devices East China Normal UniversityShanghai 200241China State Key Laboratory of ASIC and System School of MicroelectronicsFudan UniversityShanghai 200433China Frontier Institute of Chip and System Fudan UniversityShanghai 200433China Zhangjiang Fudan International Innovation Center Fudan UniversityShanghai 201210China School of Physics and Electronic Science East China Normal UniversityShanghai 200241China

Owing to the outstanding properties provided by nontrivial band topology,topological phases of matter are considered as a promising platform towards low-dissipation electronics,efficient spin-charge conversion,and topological quantum *** ferroelectricity in topological materials enables the non-volatile control of the quantum states,which could greatly facilitate topological electronic ***,ferroelectricity is generally incompatible with systems featuring metallicity due to the screening effect of free *** this study,we report the observation of memristive switching based on the ferroelectric surface state of a topological semimetal(TaSe_(4))*** find that the surface state of(TaSe_(4))2I presents out-of-plane ferroelectric polarization due to surface *** the combination of ferroelectric surface and charge-density-wave-gapped bulk states,an electric-switchable barrier height can be achieved in(TaSe_(4))2I-metal *** employing a multi-terminal-grounding design,we manage to construct a prototype ferroelectric memristor based on(TaSe_(4))2I with on/off ratio up to 103,endurance over 103 cycles,and good retention *** origin of the ferroelectric surface state is further investigated by first-principles calculations,which reveal an interplay between ferroelectricity and band *** emergence of ferroelectricity in(TaSe_(4))2I not only demonstrates it as a rare but essential case of ferroelectric topological materials,but also opens new routes towards the implementation of topological materials in functional electronic devices.

关键词： Topological semimetal Schottky barrier Surface ferroelectricity Memristor

Ablation of drivers in patients with persistent atrial fibrillation refractory to pulmonary vein antral isolation: Target characteristics and 3-year outcomes

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中华医学杂志(英文版) 2024年第14期137卷 1747-1749页

作者： shi Liang Qi Jie Wang Yanjiang Liao Wenkai Li Xuexun He Shunan Huang Lihong Tian Ying Liu Xingpeng Department of Cardiology Beijing Chaoyang Hospital Capital Medical University Beijing China

To the Editor: Pulmonary vein antral isolation (PVAI) is the cornerstone of catheter ablation techniques used in the treatment of patients with atrial fibrillation (AF). However, the outcomes of a PVAI-only strategy for persistent AF have proven suboptimal. The majority of patients with persistent AF may require further atrial ablation beyond PVAI. Ablation of AF drivers, a patient-tailored ablation strategy for persistent AF with a procedural endpoint of AF termination, has garnered increasing attention in recent years. We aimed to determine the electrogram (EGM) characteristics of AF drivers that can predict AF termination.

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多组学分析在非创伤性股骨头坏死中的应用现状和研究进展

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新乡医学院学报 2024年第6期41卷 596-600页

作者：史明月卢发强大连大学附属中山医院医学检验中心辽宁大连116001 大连大学中山临床学院辽宁大连116001

非创伤性股骨头坏死(NONFH)是一种髋关节致残性疾病,严重影响患者生活质量。NONFH发病机制复杂,目前尚未完全研究清楚,临床诊疗也存在一定局限性。近年来,多组学通过高通量检测和分析技术,在揭示NONFH疾病特征和辅助疾病诊断方面发挥着... 详细信息

非创伤性股骨头坏死(NONFH)是一种髋关节致残性疾病,严重影响患者生活质量。NONFH发病机制复杂,目前尚未完全研究清楚,临床诊疗也存在一定局限性。近年来,多组学通过高通量检测和分析技术,在揭示NONFH疾病特征和辅助疾病诊断方面发挥着重要作用。本文对基因组学、转录组学、蛋白质组学和代谢组学的多组学研究在NONFH中的最新应用和研究进展进行综述,以期为进一步探索NONFH的发病机制提供新思路。

关键词：非创伤性股骨头坏死基因组学转录组学蛋白质组学代谢组学多组学

综合实践活动与跨学科主题学习统整实施的价值与路径

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教学与管理 2024年第20期 22-24页

作者：施美珠福建省晋江市第六实验小学

综合实践活动是国家课程体系中的一门跨学科必修课程,《义务教育课程方案(2022年版)》优化课程内容结构,又提出设立跨学科主题学习活动。从价值取向分析综合实践活动课程与跨学科主题学习统筹实施的意义,并从二者实施的“痛点”入手,提... 详细信息

综合实践活动是国家课程体系中的一门跨学科必修课程,《义务教育课程方案(2022年版)》优化课程内容结构,又提出设立跨学科主题学习活动。从价值取向分析综合实践活动课程与跨学科主题学习统筹实施的意义,并从二者实施的“痛点”入手,提出构建课时保障机制、构建内容整合机制、构建跨学科共研机制、构建跨学科学习模式等统整实施的路径,以期为推进综合学习提供有益的参考。

关键词：综合实践活动跨学科学习综合素养