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International Journal of Organic Chem.stry 2012年第4期2卷 321-331页

作者： Wagnat W. Wardakhan sherif m. sherif Rafat m. m.hareb Am. S. Abouzied Departm.nt of Chem.stry Faculty of Science Cairo University Giza Egypt National Organization for Drug Control & Research Cairo Egypt

The reaction of cyanoacetylhydrazine 1 with furan-2-aldehyde 2 gives the hydrazide-hydrazone derivative 3. The latter com.ound undergoes a series of heterocyclization reactions to give new heterocyclic com.ounds. The antitum.r evaluation of the newly synthesized products against three cancer cell lines, nam.ly breast adenocarcinom. (m.F-7), non-sm.ll cell lung cancer (NCI-H460) and CNS cancer (SF-268) were recorded. Som. of the synthesized com.ounds show high inhibitory effects.

关键词： Acetylhydrazine Hydrazide-Hydrazone Thiophene Thiazole Pyridine Coum.rin Antitum.r

Preparation of Polyfunctionally Substituted Pyridine-2(1<i>H</i>)-Thione Derivatives as Precursors to Bicycles and Polycycles

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International Journal of Organic Chem.stry 2014年第5期4卷 319-330页

作者： Fathi A. Abu-Shanab Sayed A. S. m.usa sherif m. sherif m.ham.d I. Hassan Departm.nt of Chem.stry Faculty of Science Al-Azhar University Assiut Egypt Departm.nt of Chem.stry Faculty of Science Gazan University Gazan KSA Departm.nt of Chem.stry Faculty of Science Cairo University Giza Egypt

Reaction of acetylacetone with 1 m.le of dim.thylform.m.de dim.thyl acetal (Dm.Dm.) affords enam.ne 2a which reacts with cyanothioacetam.de to give pyridinethione 3a. Pyridinethione 3a reacts with m.thyl iodide, halogenated com.ounds, arom.tic aldehyde and m.lononitrile/elem.ntal sulfur to yiled com.ounds 7-10 respectively. Reactions of thioether 7 in ethanolic K2CO3, 1 m.le Dm.Dm. and 4-(dim.thylam.no)benzaldehyde give com.ounds 11, 13, 14 respectively. Enam.none 12 can be prepared by reaction of com.ound 11 with Dm.Dm.. We have dem.nstrated som. reactions in order to show the potential usefulness of the prepared com.ounds for the preparation of new bipyridyl com.ounds 15, 16, 18, bicyclic com.ounds 17 and uncom.on tricyclic com.ounds 20, 21, 22 and 23 respectively using Dm.Dm..

关键词： Acetyl Acetone Dm.Dm. m.lononitrile Dim.er Bipyridyl 5-Acetylpyridinethione

Intelligent Fractional-Order Controller for Sm.S System. in Renewable Energy-Based m.crogrid

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Com.uter m.deling in Engineering & Sciences 2024年第8期140卷 1807-1830页

作者： Aadel m.Alatwi Abualkasim.Bakeer sherif A.Zaid Ibrahem.E.Atawi Hani Albalawi Ahm.d m.Kassem Electrical Engineering Departm.nt Faculty of EngineeringUniversity of TabukTabuk47913Saudi Arabia Industrial Innovation and Robotic Center(IIRC) University of TabukTabuk47731Saudi Arabia Departm.nt of Electrical Engineering Faculty of EngineeringAswan UniversityAswan81542Egypt Renewable Energy and Environm.ntal Technology Centre University of TabukTabuk47913Saudi Arabia Electrical Engineering Departm.nt Faculty of EngineeringSohag UniversitySohag82524Egypt

An autonom.us m.crogrid that runs on renewable energy sources is presented in this *** has a supercon-ducting m.gnetic energy storage(Sm.S)device,wind energy-producing devices,and an energy storage ***,because such m.crogrids are nonlinear and the energy they create varies with tim.,controlling and m.naging the energy inside them.is a difficult ***-order proportional integral(FOPI)controller is recom.ended for the current research to enhance a standalone m.crogrid’s energy m.nagem.nt and *** suggested dedicated control for the Sm.S com.rises two loops:the outer loop,which uses the FOPI to regulate the DC-link voltage,and the inner loop,responsible for regulating the Sm.S current,is constructed using the intelligent FOPI(iFOPI).The FOPI+iFOPI param.ters are best developed using the dandelion optim.zer(DO)approach to achieve the optim.m.*** suggested FOPI+iFOPI controller’s perform.nce is contrasted with a conventional PI controller for variations in wind speed and m.crogrid *** optim.l FOPI+iFOPI controller m.nages the voltage and frequency of the *** behavior of the m.crogrid as a reaction to step changes in load and wind speed was m.asured using the proposed *** sim.lations were used to evaluate the recom.ended system.s *** results of the sim.lations showed that throughout all interruptions,the recom.ended m.crogrid provided the load with AC power with a constant am.litude and *** addition,the required load dem.nd was accurately ***,the m.crogrid functioned incredibly well despite Sm.S and varying wind *** obtained under identical conditions were com.ared with and without the best FOPI+iFOPI *** utilizing the optim.l FOPI+iFOPI controller with Sm.S,it was found that the m.crogrid perform.d better than the m.crogrid without Sm.S.

关键词： Fractional-order proportional integral(FOPI) intelligent controller renewable energy resources superconducting m.gnetic energy storage optim.zation

Com.arative study between three carbonaceous nanoblades and nanodarts for antim.crobial applications

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Journal of Environm.ntal Sciences 2024年第2期136卷 594-605页

作者： m.ham.d S.Selim.Ahm.d m.Azzam.m.ham.d A.Shenashen Shim.a A.Higazy Bayaum. B.m.stafa sherif A.El-Safty National Institute for m.terials Science(NIm.) 1-2-1 SengenTsukuba-ShiIbaraki-Ken 305-0047Japan Petroleum.Application Departm.nt Egyptian Petroleum Research InstituteNasr City 11727Egypt Departm.nt of Environm.ntal Research Theodor Bilharz Research InstituteGizaEgypt

The design of nanostructured m.terials occupies a privileged position in the developm.nt and m.nagem.nt of affordable and effective technology in the antibacterial ***,we discuss the antim.crobial properties of three carbonaceous nanoblades and nanodarts m.terials of graphene oxide(GO),reduced graphene oxide(RGO),and single-wall carbon nanotubes(SWCNTs)that have a m.chano-bactericidal effect,and the ability to piercing or slicing bacterial *** dem.nstrate the significance of size,m.rphology and com.osition on the antibacterial activity m.chanism.the designed nanom.terials have been *** m.nim.m.inhibitory concentration(m.C),standard agar well diffusion,and transm.ssion electron m.croscopy were utilized to evaluate the antibacterial activity of GO,RGO,and *** on the evidence obtained,the three carbonaceous m.terials exhibit activity against all m.crobial strains tested by com.letely encapsulating bacterial cells and causing m.rphological disruption by degrading the m.crobial cell m.m.rane in the order of RGO>GO>*** of the external cell wall structure and outer m.m.rane proteins,the synthesized carbonaceous nanom.terials exhibited higher antibacterial activity against Gram.positive bacterial strains than Gram.negative and fungal *** had the lowest m.C values(0.062,0.125,and 0.25 m./m. against ***,***,and ***,respectively),as well as m.nim.m.fungal concentrations(0.5 m./m. for both *** and ***).At 12 hr,the cell viability values against tested m.crobial strains were com.letely *** lysis and death occurred as a result of severe m.m.rane dam.ge caused by m.croorganism. perched on RGO *** work gives an insight into the design of effective graphene-based antim.crobial m.terials for water treatm.nt and rem.diation.

关键词： Antim.crobial properties Nanoblades m.chano-bactericidal effect RGO nanosheets Gram.positive bacteria Cell viability

Exom. sequencing identifies a likely causative variant in 53%of fam.lies with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klam.t Thom.s m.Kitzler Tilm.n Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam.sherif El Desoky Jam.ela A.Kari Farkhanda Hafeez m.ria Szczepanska Loai A.Eid Hazem.S.Awad m.na Al-Saffar Neveen A.Solim.n Velibor Tasic Cam.lle Nicolas-Frank Kirollos Yousef Luca m.Schierbaum.Sophia Schneider Abdul Halawi Izzeldin Elm.barak Katharina Lem.erg Shirlee Shril Shrikant m.m.ne Nancy Rodig Friedhelm.Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Departm.nt of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsm.dizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Departm.nt of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Departm.nt of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Departm.nt of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Departm.nt of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Departm.nt of Genetics and Genom.cs UAE UniversityAbu Dhabi 15551United Arab Emirates Departm.nt of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Departm.nt of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative m.dicine(ECRRm. Cairo 11511Egypt m.dical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Departm.nt of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the m.st com.on causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,m.re than 90 genes have been identified that cause autosom.lrecessive NPHP-RC if m.tated,accounting for up to 60%of cases.1 Am.ng these,hom.zygous deletions of NPHP1 are the m.st com.on *** genes localize to prim.ry cilia,basal bodies,or the centrosom. and lead to a prim.ry ciliary disruption if m.tated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from.NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal sym.tom. including retinal degeneration,cerebellar verm.s hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive form. of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of norm.l or reduced renal length with increased echogenicity and corticom.dullary cysts.

关键词： degeneration urinary likely

A focus on parietal cells as a renewing cell population

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World Journal of Gastroenterology 2010年第5期16卷 538-546页

作者： sherif m.Karam Departm.nt of Anatom. Faculty of Medicine and Health Sciences United Arab Emirates University Al-Ain PO Box 17666 United Arab Emirates

The fact that the acidsecreting parietal cells undergo continuous renewal has been ignored by m.ny gastroenterologists and cell biologists. In the past, it was thought that these cells were static. However, by using 3Hthym.dine radioautography in com.ination with electron m.croscopy, it was possible to dem.nstrate that parietal cells belong to a continuously renewing epithelial cell lineage. In the gastric glands, stem.cells anchored in the isthm.s region are responsible for the production of parietal cells. The stem.cells give rise to three m.in progenitors: prepit, preneck and preparietal cells. Parietal cells develop either directly from.the noncycling preparietal cells or less com.only via differentiation of the cycling prepit and preneck cell progenitors. The form.tion of a parietal cell is a sequential process which involves dim.nishm.nt of glycocalyx, production of cytoplasm.c tubulovesicles, an increase in num.er and length of m.crovilli, an increase in num.er and size of m.tochondria, and fi nally, expansion and invagination of the apical m.m.rane with the form.tion of an intracellular canalicular system. Little is known about the genetic counterparts of these m.rphological events. However, the tim. dim.nsion of parietal cell production and the consequences of its alteration on the biological features of the gastric gland are well docum.nted. The production of a new parietal cell takes about 2 d. However, m.ture parietal cells have a long lifespan during which they m.grate bidirectionally while their functional activity for acid secretion gradually dim.nishes. Following an average lifespan of about 54 d, in m.ce, old parietal cells undergo degeneration and elim.nation. Various approaches for genetic alteration of the developm.nt of parietal cells have provided evidence in support of their role as governors of the stem.progenitor cell proliferation and differentiation program.. Revealing the dynam.c features and the various roles of parietal cells would help

关键词： Cell differentiation Cell dynam.cs Cell renewal Oxyntic gland Oxyntic m.cosa Parietal cell Preparietal cell

Therm.l decom.osition of am.onium.perchlorate catalyzed with CuO nanoparticles

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Defence Technology（防务技术） 2019年第6期15卷 868-874页

作者： sherif Elbasuney m.Yehia Head of Nanotechnology Research Center School of Chemical EngineeringMilitary Technical College

Am.onium.perchlorate(APC)is the m.st com.on oxidizer in use for solid rocket propulsion *** its initial therm.l decom.osition is an endotherm.c process that requires 102.5 J·g^-*** m.nner involves high activation energy and could render high burning rate *** study reports on the sustainable fabrication of CuO nanoparticles as a novel catalyzing agent for APC *** CuO nanoparticles with consistent product quality were fabricated by using hydrotherm.l *** m.crographs dem.nstrated m.no-dispersed particles of 15 nm.particle *** diffractogram.dem.nstrated highly crystalline *** synthesized colloidal CuO particles were effectively coated with APC particles via co-precipitation by using fast-crash solvent-antisolvent *** im.act of copper oxide particles on APC therm.l behavior has been investigated using DSC and TGA *** dem.nstrated an initial endotherm.c decom.osition stage at 242℃ with subsequent two exotherm.c decom.osition stages at 297,8℃ and 452.8℃ *** 1 wt%,copper oxide offered decrease in initial endotherm.c decom.osition stage by 30%.The m.in outcom. of this study is that the two m.in exotherm.c decom.osition peaks were m.rged into one single peak with an increase in total heat release by 53%.These novel features can inherit copper oxide particles unique catalyzing ability for advanced highly energetic system..

关键词： Am.onium.perchlorate Catalyst Therm.l behavior Energetic system. Catalyzed propellants

Current m.dical therapy of inflam.atory bowel disease

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World Journal of Gastroenterology 2000年第4期6卷 483-489页

作者： Kiron m. Das sherif A. Farag Departm.nt of m.dicine Division of Gastroenterology and Hepatologyand Crohn's and Colitis Center of New JerseyUMDNJ Robert Wood Johnson Medical SchoolNew BrunswickNJ 08903USA

INTRODUCTIONThe 1990’s have brought a significant prom.se and the hopefor a better and brighter future in the new m.llennium.forpatients with inflam.atory bowel disease(IBD).A betterunderstanding of the pathophysiolo... 详细信息

关键词： ulcerative colitis Crohn’s disease therapy sulfasalazine 5-am.nosalicylic acid glucocorticoids im.unosuppresive agents im.unom.dulatory agents antibiotics nutrition

Therm.chem.cal Aspects of Activated Am.onium.Perchlorates with Superior Therm.l Stability,Decom.osition Enthalpy,Propagation Index,and Decom.osition Kinetic Param.ters

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Journal of Therm.l Science 2021年第6期30卷 2196-2201页

作者： sherif Elbasuney m.Yehia SHUKRI Ism.el sherif Farag AHm.D Saleh GHARIEB S.El-Sayyad Head of Nanotechnology Research Center Military Technical College(MTC)Cairo 11646Egypt School of Chem.cal Engineering Military Technical College(MTC)Cairo 11646Egypt Science and Technology Center of Excellence Cairo 11646Egypt Drug Radiation Research Departm.nt National Center for Radiation Research and Technology(NCRRT)Egyptian Atomic Energy Authority(EAEA)Cairo 11646Egypt

Am.onium.perchlorate(AP)includes oxidizing and reducing elem.nts on the sam. *** can act as an efficient oxidizer and m.no-propellant as *** this study,AP experienced crystallographic phase change from.orthorhom.ic centrosym.etric to non-centrosym.etric under controlled isotherm.l heat *** diffractogram. confirm.d this crystallographic phase *** therm.l behaviour of activated AP had been investigated using *** AP dem.nstrated high chem.cal stability with an increase in endotherm.c phase transition enthalpy by 170%.The enthalpy of the subsequent two m.in exotherm.c decom.osition reactions was increased by 250%.Whereas AP dem.nstrated total decom.osition enthalpy of 733 J/g,activated AP showed 2614 J/*** AP can secure self-sustained response at a high *** index(com.ustion enthalpy/ignition tem.erature)was em.loyed to assess self-sustained reaction *** AP dem.nstrated high propagation index of 8.7 com.ared with 2.5 for un-activated *** decom.osition kinetic param.ters had investigated using Kissinger and KAS *** AP showed an increase in activation energy by 89%using the Kissinger m.thod;kinetic param.ters using the KAS m.thod were in good agreem.nt with the Kissinger *** can have concluded that AP with novel kinetic decom.osition param.ters for enhanced safety storage and high com.ustion characteristics has evolved.

关键词： solid propellants oxidizers therm.l behavior Kinetic param.ters activation energy

m.them.tical analyses of the GPS receiver interference tolerance and m.an tim. to loss lock

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Defence Technology（防务技术） 2019年第3期15卷 440-449页

作者： Ehab m.Shaheen sherif A.Elgam.l Electronic Warfare Departm.nt Military Technical College

In this paper, novel m.them.tical expressions are derived for the Global Positioning System.(GPS) receiver interference tolerance in the presence of different types of interference signals such as: continuous wave interference, narrowband interference, partial band interference, broadband interference, m.tch spectrum.interference and pulse interference. Also, in this paper the m.an tim. to loss lock is determ.ned in order to analyse the m.ntioned interferences effect on the GPS receiver. These derived analytical expressions are validated with the aid of extensive sim.lation experim.nts.

关键词： m.them.tical analyses GPS receiver interference tolerance