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Dosage and utilization of dexamethasone in the management of COVID-19: A critical review

World Journal of Virology 2024年第3期13卷 107-114页

作者： Imran Sethi Asim Shaikh Musa Sethi Hira Khalid Chohan sheraz younus Syed A Khan Salim Surani Department of Critical Care Medicine Marion General HospitalMarionIN 46952United States Department of Medicine Aga Khan UniversityKarachi 74200SindhPakistan Department of Medicine Eman SchoolFishersIN 46038United States Department of Internal Medicine Dow University of Health ScienceKarachi 74200SindhPakistan Department of Hospital Medicine Franciscan HealthIndianapolisIN 46237United States Department of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Department of Medicine and Pharmacology Texas A and M UniversityCollege StationTX 77843United States

BACKGROUND The severe respiratory manifestations observed in severe coronavirus disease 2019(COVID-19)cases are often associated with an excessive inflammatory ***,a synthetic glucocorticoid,exerts its anti-inflammatory effects by inhibiting the transcription of pro-inflammatory genes and suppressing the activity of various immune *** mechanism has implications for mitigating the cytokine storm observed in severe COVID-19 *** on in the pandemic,the Recovery Collaborative working group showed a mortality benefit of using dexamethasone in decreasing mortality in patients with COVID-19 requiring respiratory ***,the optimal dosage of corticosteroids remains *** studies that compare different doses of dexamethasone in COVID-19 exist,but the results are *** To review the latest evidence regarding dosage,safety,and efficacy of dexamethasone in severe *** We followed preferred reporting items for systematic reviews and meta-analysis guidelines.A detailed literature search was conducted across PubMed,Google Scholar,and Medline to include publications up to March *** keywords included“COVID-19”“SARS-CoV-2”“dexamethasone”“corticosteroid”“steroid”and“glucocorticoid”-along with their *** employed the Cochrane Risk of Bias Tool and the Newcastle-Ottawa scale to evaluate the integrity and potential of bias in the included studies.A meta-analysis was conducted using a random-effects model,assessing pooled odds ratios and mean differences,with heterogeneity gauged by the I2 statistic and theχ^(2) *** No statistical differences were found in 28-day all-cause mortality[pooled odds ratio(OR)=1.109,95%CI:0.918-1.340],60-day all-cause mortality(OR=0.873,95%CI:0.744-1.024;I2=47.29%),mean length of hospital stay(mean difference=-0.08 days,95%CI:-0.001 to 0.161)and adverse events(OR=0.877,95%CI:0.707-1.087).CONCLUSION Differing doses of corticosteroids have no clinical implication

关键词： COVID-19 Steroids Corticosteroids Steroid dosage Critical care Corona virus

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Detection of onset of agglomeration in a bubbling fluidized bed biomass combustor using reactive Eulerian computational fluid dynamics

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Particuology 2024年第7期90卷 504-515页

作者： Abdullah Tasleem Atta Ullah Fei Li Qun Yi William Nimmo Syed sheraz Daood Department of Chemical Engineering Pakistan Institute of Engineering and Applied Sciences(PIEAS)Lehtrar RoadP.O.Nilore45650IslamabadPakistan Institute of Process Engineering Chinese Academy of SciencesBeijing100190China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan430205China Energy Engineering Group Energy 2050Department of Mechanical EngineeringUniversity of SheffieldSheffieldS37RDUnited Kingdom Institute of Energy and Environmental Engineering Faculty of ElectricalEnergy&Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahorePakistan Energy Engineering Research and Development Centre Faculty of ElectricalEnergy&Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahorePakistan

The choice of a type of combustion technology to be used for heat or power generation depends on economic,technical,operational and fuel availability *** benefits associated with the evolving market driven by the fluidised bed combustion(FBC)technology cannot be overlooked especially when gauged at 65 GWth of worldwide installed capacity alongside added benefits of handling fuel variation,low pollutant emissions and high combustion *** or biomass waste will continue to have a vital role to play in the future FBC technology-based power *** often contains high levels of inorganic species that can form sticky agglomerates posing a significant risk to boiler operation resulting in unscheduled *** added complexity of the behaviour of the fuel and bed material mix highlights the requirement for simulation models to identify agglomeration to help improve the overall performance and reliability of FBC *** resolve this problem,this research devised a simulation strategy for the detection of agglomeration using the Eulerian–Eulerian *** developed modelling strategy is validated with the experimental data available in literature for two-dimensional simplified geometry of a pilot-scale fluidised bed *** model results were found promising and robust to predict bed defluidisation times and other parameters consistent with the experimental data.

关键词： Fluidized bed combustion Eulerian Models Biomass Agglomeration Defluidisation

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Smart Energy Management System Using Machine Learning

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Computers, Materials & Continua 2024年第1期78卷 959-973页

作者： Ali sheraz Akram Sagheer Abbas Muhammad Adnan Khan Atifa Athar Taher M.Ghazal Hussam Al Hamadi School of Computer Science National College of Business Administration&EconomicsLahore54000Pakistan Riphah School of Computing&Innovation Faculty of ComputingRiphah International UniversityLahore CampusLahore54000Pakistan Pattern Recognition and Machine Learning Lab Department of SoftwareGachon UniversitySeongnamGyeonggido13120Korea Department of Computer Science COMSATS University IslamabadLahore CampusLahore54000Pakistan School of Information Technology Skyline University CollegeSharjah1797United Arab Emirates Network and Communication Technology Lab Center for Cyber SecurityFaculty of Information Science and TechnologyUniversiti Kebangsaan MalaysiaBangiSelangor43600Malaysia College of Engineering and IT University of DubaiDubaiUnited Arab Emirates

Energy management is an inspiring domain in developing of renewable energy ***,the growth of decentralized energy production is revealing an increased complexity for power grid managers,inferring more quality and reliability to regulate electricity flows and less imbalance between electricity production and *** major objective of an energy management system is to achieve optimum energy procurement and utilization throughout the organization,minimize energy costs without affecting production,and minimize environmental *** energy management is an essential and complex subject because of the excessive consumption in residential buildings,which necessitates energy optimization and increased user *** address the issue of energy management,many researchers have developed various frameworks;while the objective of each framework was to sustain a balance between user comfort and energy consumption,this problem hasn’t been fully solved because of how difficult it is to solve *** inclusive and Intelligent Energy Management System(IEMS)aims to provide overall energy efficiency regarding increased power generation,increase flexibility,increase renewable generation systems,improve energy consumption,reduce carbon dioxide emissions,improve stability,and reduce energy *** Learning(ML)is an emerging approach that may be beneficial to predict energy efficiency in a better way with the assistance of the Internet of Energy(IoE)*** IoE network is playing a vital role in the energy sector for collecting effective data and usage,resulting in smart resource *** this research work,an IEMS is proposed for Smart Cities(SC)using the ML technique to better resolve the energy management *** proposed system minimized the energy consumption with its intelligent nature and provided better outcomes than the previous approaches in terms of 92.11% accuracy,and 7.89% miss-rate.

关键词： Intelligent energy management system smart cities machine learning

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Effect of low power laser irradiation on bio-physical properties of wheat seeds

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Information Processing in Agriculture 2020年第3期7卷 456-465页

作者： Samiya Sikandar Afta Ayesha younus Institute of Soil and Environmental Sciences University of AgricultureFaisalabadPakistan Department of Civil and Environmental Engineering 209 Neungdong-roGwangjin-guSejong University SeoulSouth Korea Department of Physics and Astronomy and Graphene Research Institute Sejong UniversitySeoul 05006Korea Department of Physics University of AgricultureFaisalabadPakistan

The production of quality food is indispensable and essential to overcome its global *** order to exercise the facile route to acquire massive production,a laser irradiation treatment method was *** have investigated the effects of diode laser irradiation on wheat seeds germination,its early growth and biochemical *** variation in germination parameters,caused by laser treatment were monitored carefully.A comparison study was accomplished to examine the laser irradiation effects on treated and control *** red laser indicated an enhancement of 25%in germination percentage,4.68 cm in shoot length,and 0.64 cm in root length while green laser showed 6.25%less germination percentage than the untreated *** green laser showed 9.67 cm increase in shoot length,5.39 cm in root length as compared to untreated *** was found that the seeds which were irradiated with green laser showed an amount of superoxide dismutase(SOD),catalase(CAT)and peroxidase(POD),of 11.9,10,and 1.53 per mg of protein,respectively as compared to control ***,these investigations are promising and suitable for upcoming research on a large scale.

关键词： Wheat Diode laser Germination parameter Biochemical parameters Protein

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Detection and management of oligometastatic disease in oesophageal cancer and identification of prognostic factors: A systematic review

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World Journal of Gastrointestinal Oncology 2019年第9期11卷 741-749页

作者： Sara Jamel Karina Tukanova sheraz Markar Department Surgery and Cancer Imperial College London

BACKGROUND Oesophageal cancer is the eighth most common cancer *** prognosis of oesophageal cancer patients still remains *** 5-year survival rate rarely exceeds 5%in case of metastatic *** patients may however present with oligometastasis which can be treated with loco-regional *** To assess the current practice regarding the management of patients with oligometastatic oesophageal cancer and identify prognostic factors affecting survival following treatment for *** A systematic search of the literature was performed in Cochrance Library,MEDLINE and EMBASE databases from September 1950 to January *** electronic databases were searched for studies assessing the clinical outcome of *** A total of 14 publications were included,of which 12 studies assessing metachronous oligometastasis and 2 on synchronous *** included articles evaluated the specific outcomes of metastasis,management modality and survival *** majority of the patients presented with oesophageal squamous cell *** median disease free interval(time to recurrence)in patients was 19.6 mo and the overall survival reached 30.8 *** prognostic factors were assessed in eight studies and included time to recurrence20 mm),disease free interval(DFI)<12 mo,extra-pulmonary metastasis,primary tumour pathological stage III/*** Oligometastatic oesophageal cancer in selected patients is amenable to locoregional treatment,and the overall survival of this patient cohort may be improved with patient and tumour-specific treatments.

关键词： Oligometastasis Oesophageal cancer Neoplasm Liver Pulmonary

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Exciton-polariton based WS_(2)polarization modulator controlled by optical Stark beam

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Opto-Electronic Advances 2022年第11期5卷 54-60页

作者： Mahnoor Shahzadi Chuyuan Zheng sheraz Ahmad Shanshan Wang Weili Zhang School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu 611731China College of Petroleum Engineering China University of PetroleumBeijing 102249China

The recent era of fast optical manipulation and optical devices owe a lot to exciton-polaritons being lighter in mass,faster in speed and stronger in nonlinearity due to hybrid light-matter *** room temperature existence of polaritons in two dimensional materials opens up new avenues to the design and analysis of all optical devices and has gained the researchers ***,spin-selective optical Stark effect is introduced to form a waveguide effect in uniform community of polaritons,and is used to realize polarization modulation of *** proposed device basically takes advantage of the spin-sensitive properties of optical Stark effect of polaritons inside the WS_(2)microcavity so as to guide different modes and modulate polarization of *** is shown that polaritonic wavepacket of different mode profiles can be generated by changing intensity of the optical Stark beam and the polarization of polaritons can be controlled and changed periodically along the formed waveguide by introduction birefringence that is sensitive to polarization degree of the optical Stark beam.

关键词： Stark beam polaritons modulator TMDs polarization degree

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On Fuzzy Conformable Double Laplace Transform with Applications to Partial Differential Equations

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 2163-2191页

作者： Thabet Abdeljawad Awais younus Manar A.Alqudah Usama Atta Department of Mathematics and Sciences Prince Sultan UniversityRiyadh11586Saudi Arabia Department of Medical Research China Medical UniversityTaichung40402Taiwan Centre for Advanced Studies in Pure and Applied Mathematics Bahauddin Zakaryia UniversityMultan60000Pakistan Department of Mathematical Sciences Faculty of SciencesPrincess Nourah Bint Abdulrahman UniversityRiyadh11671Saudi Arabia

The Laplace transformation is a very important integral transform,and it is extensively used in solving ordinary differential equations,partial differential equations,and several types of integro-differential *** purpose in this study is to introduce the notion of fuzzy double Laplace transform,fuzzy conformable double Laplace transform(FCDLT).We discuss some basic properties of *** obtain the solutions of fuzzy partial differential equations(both one-dimensional and two-dimensional cases)through the double Laplace *** demonstrate through numerical examples that our proposed method is very successful and convenient for resolving partial differential equations.

关键词： Fuzzy conformable laplace transform fuzzy double laplace transform fuzzy conformable double laplace transform fuzzy conformable partial differential equation

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Oblique propagation of nonlinear ion-acoustic cnoidal waves in magnetized electron–positron–ion plasmas with nonextensive electrons

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Plasma Science and Technology 2021年第3期23卷 76-81页

作者： Muhammad KHALID Ghufran ULLAH Mohsin KHAN sheraz AHMAD Sardar NABI Daud KHAN Depatment of Physics Govermment Post Gaduate College MardanMardan 23200Pakistan Department of Physics Islamia College Peshawar(Public Sector University)Peshawar 25120Pakistan Department of Physics Government Post Graduate College NowsheraNowshera 24100Pakistan

Theoretical investigation of nonlinear electrostatic ion-acoustic cnoidal waves(IACWs) is presented in magnetized electron–positron–ion plasma with nonextensive electrons and Maxwellian positrons. Using reductive perturbation technique, Korteweg–de Vries equation is derived and its cnoidal wave solution is analyzed. For given plasma parameters, our model supports only positive potential(compressive) IACW structures. The effect of relevant plasma parameters(viz., nonextensive parameter q, positron concentration p, temperature ratio σ,obliqueness l3) on the characteristics of IACWs is discussed in detail.

关键词： ion-acoustic cnoidal waves KdV equation q-distribution

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Spatial cluster analysis of human cases of Crimean Congo hemorrhagic fever reported in Pakistan

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Infectious Diseases of Poverty 2015年第1期4卷 62-66页

作者： Tariq Abbas Muhammad younus Sayyad Aun Muhammad Section of Veterinary Preventive Medicine and Public Health University College of Veterinary and Animal SciencesThe Islamia University of BahawalpurBahawalpurPakistan Department of Pathobiology College of Veterinary and Animal SciencesJhangPakistan Department of Clinical Sciences College of Veterinary and Animal SciencesJhangPakistan

Background:Crimean Congo hemorrhagic fever(CCHF)is a tick-borne viral zoonotic disease that has been reported in almost all geographic regions in *** aim of this study was to identify spatial clusters of human cases of CCHF reported in ***:Kulldorff’s spatial scan statisitc,Anselin’s Local Moran’s I and Getis Ord Gi*tests were applied on data(*** of laboratory confirmed cases reported from each district during year 2013).Findings:The analyses revealed a large multi-district cluster of high CCHF incidence in the uplands of Balochistan province near it border with *** cluster comprised the following districts:Qilla Abdullah;Qilla Saifullah;Loralai,Quetta,Sibi,Chagai,and *** cluster was detected in Punjab and included Rawalpindi district and a part of ***:We provide empirical evidence of spatial clustering of human CCHF cases in the *** districts in the clusters should be given priority in surveillance,control programs,and further research.

关键词： Crimean Congo hemorrhagic fever Pakistan Spatial autocorrelation Clusters Adjusted cumulative incidence

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Photocatalytic and Antibacterial Activities of Ag/ZnO Nanocomposities Fabricated by Co-Precipitation Method

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Acta Metallurgica Sinica(English Letters) 2014年第2期27卷 223-232页

作者： Md.Abdus Subhan M.R.Awal Tanzir Ahmed M.younus Department of Chemistry Shah Jalal University of Science and Technology

A Ag/ZnO nanocomposite has been synthesized and characterized for investigating its photocatalytic activity. The morphology and particle size of the Ag/ZnO was studied by scanning electron microscope （SEM） and the microstructure of the as-synthesized nanocomposite was confirmed by X-ray diffraction （XRD） analysis. The elemental com- position of the metal oxide was determined by energy dispersion spectrometry （EDS）. Diffuse reflectance spectra （DRS）, Photoluminescence （PL） spectra, and Fourier transform infrared spectroscopy （FTIR） were also studied for characterizing the nanocomposite. The average particle size was found to be around 20-30 nm. Photocatalytic activity of Ag/ZnO has been investigated over methyl violet （6B） dye under UV and visible light irradiation. The degradation of methyl violet （6B） dye using ZnO and Ag/ZnO was compared and found that Ag/ZnO composite is more efficient than ZnO. The rate of disappearance of dye was monitored spectrophotometrically in the maximum visible absorption wavelength and the extent of degradation was discussed in terms of Langmuir-Hinshelwood model. The Ag/ZnO composite was found capable of degrading the industrial dye effluent. Effect of H202 addition on dye degradation by the Ag/ZnO was investigated and Ag/ ZnO was found to be an effective antimicrobial agent. Reusability of Ag/ZnO catalyst was also tested.

关键词： Nanocomposite Photocatalyst Metal oxide Dye degradation Photoluminescence

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