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基于Monte Carlo模拟的某污染场地土壤重金属健康风险评估研究

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合肥工业大学学报（自然科学版） 2022年第2期45卷 267-273页

作者：熊鸿斌张含笑陈神剑合肥工业大学资源与环境工程学院安徽合肥230009

文章针对土壤重金属健康风险评价中存在的不确定性问题,参照相关规范中的计算模型,采用Monte Carlo模拟技术模拟某搬迁铅蓄电池场地中Pb、Cr、As、Cd 4种重金属元素质量比的分布特征,进而评价其人体健康风险水平。研究结果表明:研究区... 详细信息

文章针对土壤重金属健康风险评价中存在的不确定性问题,参照相关规范中的计算模型,采用Monte Carlo模拟技术模拟某搬迁铅蓄电池场地中Pb、Cr、As、Cd 4种重金属元素质量比的分布特征,进而评价其人体健康风险水平。研究结果表明:研究区重金属元素存在致癌风险和非致癌风险,其中致癌风险和非致癌风险均以重金属Cr^(6+)为主要影响因素,其对非致癌风险和致癌风险的贡献率分别为50.9%、44.9%。该研究定量分析土壤重金属元素健康风险评估中存在的不确定性,可为解决类似场地的土壤重金属元素健康风险评估的不确定性问题提供参考。

关键词：重金属健康风险评估 Monte Carlo模拟污染场地不确定性

浙江新昌盆地北缘地热资源成矿模式与三维可视化预测

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物探化探计算技术 2017年第4期39卷 484-489页

作者：郑伟军彭鹏吴鹏阳翔陈沈健韦毅浙江省水文地质工程地质大队宁波315012

为在浙江新昌盆地北缘开发更具投资价值的地热井,开展了重力与可控源音频大地电磁测深(CSAMT)相结合的综合物探工作,推断盆地北缘深部为断裂接触关系,浅部为不整合接触关系,并初步分析该区地热资源的成矿模式为构造裂隙型带状热储,三维... 详细信息

为在浙江新昌盆地北缘开发更具投资价值的地热井,开展了重力与可控源音频大地电磁测深(CSAMT)相结合的综合物探工作,推断盆地北缘深部为断裂接触关系,浅部为不整合接触关系,并初步分析该区地热资源的成矿模式为构造裂隙型带状热储,三维视电阻率模型预测该区勘查开发地热资源的有利区位为盆地北缘深部断裂。

关键词：新昌盆地北缘地热成矿模式可视化预测

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无线传输的板形仪压力测量系统设计

单片机与嵌入式系统应用 2016年第11期16卷 63-65,70页

作者：周校晨陈圣俭魏子杰装甲兵工程学院控制工程系北京100072

板形仪测量辊有多个测量区,每个测量区等角度嵌有多个传感器用于测量带材的受压状况。采用接触式连接的板形仪无法避免摩擦和磨损造成的波动和干扰,出产的带材质量低、品质差。基于无线传输的板形仪采用无线模块,可以有效地解决摩擦磨... 详细信息

板形仪测量辊有多个测量区,每个测量区等角度嵌有多个传感器用于测量带材的受压状况。采用接触式连接的板形仪无法避免摩擦和磨损造成的波动和干扰,出产的带材质量低、品质差。基于无线传输的板形仪采用无线模块,可以有效地解决摩擦磨损问题。这套适用于板形仪的信号处理系统前端由调理电路实现整流、滤波、解调和放大,再通过多个单片机主从式并行工作实现信号的传输和处理。上位机负责信号的最终处理,实现板形仪工作时的可视化监视。经实验验证,本系统能够实现信号的无线传输和处理,出产的带材品质也有一定程度的提高。

关键词：无线传输压力测量系统 MCU

基于信号相似性度量的胸外按压训练质量评价技术的研究

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生物医学工程研究 2016年第4期35卷 279-283页

作者：丁杰雄陈沈俭魏思琪徐吉瑞吴丽红电子科技大学机械电子工程学院四川成都611731

心肺复苏是抢救心脏骤停患者的唯一有效途径,其中胸外按压是关键环节。为了对学习胸外按压学员的操作质量进行总体评估,提出了一种基于信号相似性度量的评价方法。基于训练者胸外按压操作全过程的按压深度波形信号,通过特征提取将胸外... 详细信息

心肺复苏是抢救心脏骤停患者的唯一有效途径,其中胸外按压是关键环节。为了对学习胸外按压学员的操作质量进行总体评估,提出了一种基于信号相似性度量的评价方法。基于训练者胸外按压操作全过程的按压深度波形信号,通过特征提取将胸外按压操作转化为一组由时域特征构成的多元时间序列,并利用相似性度量算法进行不同按压信号之间的相似性比较。最后,设计了实验,计算了按压技能不同水平群体的胸外按压信号之间的相似度,实验结果验证了该方法的有效性。

关键词：胸外按压评价按压信号相似性度量多元时间序列

宁波市地下空间开发利用地质环境制约因素研究

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城市地质 2016年第4期11卷 39-43,65页

作者：吴炳华蔡国成潘小青陈沈健浙江省水文地质工程地质大队宁波315012

地质环境条件是制约地下空间开发利用的最基本因素,只有正确认识地下空间开发对地质环境的影响,才能避免地下空间利用中产生的各种不利后果。基于对宁波市地质环境背景条件的认识,分别从水文地质条件、工程地质条件和环境地质问题等三... 详细信息

地质环境条件是制约地下空间开发利用的最基本因素,只有正确认识地下空间开发对地质环境的影响,才能避免地下空间利用中产生的各种不利后果。基于对宁波市地质环境背景条件的认识,分别从水文地质条件、工程地质条件和环境地质问题等三个方面,研究了地下空间开发利用的影响因素。研究结果表明,水文地质条件的制约因素有孔隙潜水位埋深、含水层厚度、岩土层透水性能和基坑突涌可能性等;工程地质条件的制约因素有软土厚度、人工填土厚度、土质均匀性和地层组合等;主要环境地质问题为地面沉降和浅层天然气影响等。通过本次研究,为宁波市地下空间开发利用地质环境适宜性评价奠定了基础,为宁波市地下空间的合理开发利用提供了技术支撑。

关键词：地下空间开发利用地质环境制约因素宁波市

Seismic prompt gravity strain signals in a layered spherical Earth

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Earthquake Science 2023年第5期36卷 341-355页

作者： shenjian Zhang Rongjiang Wang Xiaofei chen Department of Earth and Space Sciences Southern University of Science and TechnologyShenzhen 518055China Helmholtz Center Potsdam GFZ German Research Center for GeosciencesD-14473 PotsdamGermany Guangdong Provincial Key Laboratory of Geophysical High-resolution Imaging Technology Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Deep Offshore Oil and Gas Exploration Technology Southern University of Science and TechnologyShenzhen 518055China

Seismic waves generated by an earthquake can produce dynamic perturbations in the Earth’s gravity field before the direct arrival of *** of these so-called prompt elasto-gravity signals by ground-based gravimeters and broadband seismometers have been reported for some large events,such as the 2011 M_(W)9.1 Tohoku *** studies have introduced prompt gravity strain signals(PGSSs)as a new type of observable seismic gravity perturbation that can be used to measure the spatial gradient of the perturbed gravity ***,these types of signals can be recorded by indevelopment instruments termed gravity strainmeters,although no successful detection has been reported as ***,we propose an efficient approach for PGSSs based on a multilayered spherical Earth *** compared the simulated waveforms with analytical solutions obtained from a homogeneous half-space model,which has been used in earlier *** comparison indicates that the effect of the Earth’s structural stratification is *** the help of the new simulation approach,we also demonstrated how the PGSSs depend on the magnitude of the seismic *** further conducted synthetic tests estimating earthquake magnitude using gravity strain signals to demonstrate the potential application of this type of signal in earthquake early warning *** results provide essential information for future studies on the synthesis and application of earthquake-induced gravity strain signals.

关键词： gravity strain synthetic seismogram earthquake early warning system

Low-frequency Rayleigh waves excited by the Jan. 15, 2022 eruption of Hunga Tonga-Hunga Ha'apai volcano

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Low-frequency Rayleigh waves excited by the Jan. 15, 2022 er...

Cytokine receptor-like factor 1(CRLF1)promotes cardiac fibrosis via ERK1/2 signaling pathway

2022年中国地球科学联合学术年会

作者： shenjian ZHANG Rongjiang WANG Xiaofei chen Southern University of Science and Technology GFZ German Research Centre for Geosciences Potsdam

After the powerful eruption of Hunga Tonga-Hunga Ha’apai volcano on Jan. 15, 2022, low-frequency signals are detected on long period and very long period seismometers worldwide. The amplitude spectrum of this kind of signals consists of three clear peaks locating at 3.72, 4.61 and 6.07 m Hz. The spectrogram analysis shows that this low-frequency energy lasts for several hour and is independent of air wave arrival, while normal-mode analysis relates this signal to the resonances between the atmosphere and the solid earth.

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2023年第8期24卷 682-697页

作者： shenjian LUO Zhi YANG Ruxin chen Danming YOU Fei TENG Youwen YUAN Wenhui LIU Jin LI Huijie ZHANG Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Southern Medical UniversityGuangzhou 510515China State Key Laboratory of Organ Failure Research Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Department of Endocrinology Shanxi Medical University Affiliated Second HospitalTaiyuan 030001China

Cardiac fibrosis is a cause of morbidity and mortality in people with heart ***-fibrosis treatment is a significant therapy for heart disease,but there is still no thorough understanding of fibrotic *** study was carried out to ascertain the functions of cytokine receptor-like factor 1(CRLF1)in cardiac fibrosis and clarify its regulatory *** found that CRLF1 was expressed predominantly in cardiac *** expression was up-regulated not only in a mouse heart fibrotic model induced by myocardial infarction,but also in mouse and human cardiac fibroblasts provoked by transforming growth factor-β1(TGF-β1).Gain-and loss-of-function experiments of CRLF1 were carried out in neonatal mice cardiac fibroblasts(NMCFs)with or without TGF-β1 ***1 overexpression increased cell viability,collagen production,cell proliferation capacity,and myofibroblast transformation of NMCFs with or without TGF-β1 stimulation,while silencing of CRLF1 had the opposite *** inhibitor of the extracellular signal-regulated kinase 1/2(ERK1/2)signaling pathway and different inhibitors of TGF-β1 signaling cascades,comprising mothers against decapentaplegic homolog(SMAD)-dependent and SMAD-independent pathways,were applied to investigate the mechanisms ***1 exerted its functions by activating the ERK1/2 signaling ***,the SMAD-dependent pathway,not the SMAD-independent pathway,was responsible for CRLF1 up-regulation in NMCFs treated with TGF-β*** summary,activation of the TGF-β1/SMAD signaling pathway in cardiac fibrosis increased CRLF1 ***1 then aggravated cardiac fibrosis by activating the ERK1/2 signaling ***1 could become a novel potential target for intervention and remedy of cardiac fibrosis.

关键词： Cytokine receptor-like factor 1(CRLF1) TGF-β1/SMAD signaling pathway ERK1/2 signaling pathway Cardiac fibrosis Myofibroblast transformation Extracellular matrix(ECM)

Alternate day fasting aggravates atherosclerosis through the suppression of hepatic ATF3 in Apoe^(-/-)mice

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Life Metabolism 2024年第3期3卷 46-59页

作者： Yajuan Deng Xiaoyu Yang Xueru Ye Youwen Yuan Yanan Zhang Fei Teng Danming You Xuan Zhou Wenhui Liu Kangli Li shenjian Luo Zhi Yang Ruxin chen Guojun Shi Jin Li Huijie Zhang Department of Endocrinology and Metabolism Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Guangdong Provincial Key Laboratory of Shock and Microcirculation Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China State Key Laboratory of Organ Failure Research National Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityShanxi Medical UniversityTaiyuanShanxi 030001China Department of Endocrinology and Metabolism Guangdong Provincial Key Laboratory of DiabetologyThe Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510630China

Atherosclerosis is the major contributor to cardiovascular mortality *** day fasting(ADF)has gained growing attention due to its metabolic ***,the effects of ADF on atherosclerotic plaque formation remain inconsistent and controversial in atherosclerotic animal *** present study was designed to investigate the effects of ADF on atherosclerosis in apolipoprotein E-deficient(Apoe^(-/-))***-week-old male Apoe^(-/-)mice fed with Western diet(WD)were randomly grouped into ad libitum(AL)group and ADF group,and ADF aggravated both the early and advanced atherosclerotic lesion formation,which might be due to the disturbed cholesterol profiles caused by ADF *** significantly altered cholesterol metabolism pathways and down-regulated integrated stress response(ISR)in the *** hepatic expression of activating transcription factor 3(ATF3)was suppressed in mice treated with ADF and hepatocyte-specific overexpression of Aft3 attenuated the effects of ADF on atherosclerotic plaque formation in Apoe^(-/-)***,the expression of ATF3 could be regulated by Krüppel-like factor 6(KLF6)and both the expressions of ATF3 and KLF6 were regulated by hepatic cellular ISR *** conclusion,ADF aggravates atherosclerosis progression in Apoe^(-/-)mice fed on *** inhibits the hepatic ISR signaling pathway and decreases the expression of KLF6,subsequently inhibiting ATF3 *** suppressed ATF3 expression in the liver mediates the deteriorated effects of ADF on atherosclerosis in Apoe^(-/-)*** findings suggest the potentially harmful effects when ADF intervention is applied to the population at high risk of atherosclerosis.

关键词： alternate day fasting atherosclerosis cholesterol integrated stress response activating transcription factor 3