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Microglial glutaminase 1 mediates chronic restraint stress-induced depression-like behaviors and synaptic damages

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Signal Transduction and Targeted Therapy 2024年第1期9卷 40-43页

作者： Huili Chen shengyang fu Xiangyu Li Meng Shi Jiazhen Qian Shu Zhao Ping Yuan Lu Ding Xiaohuan Xia Jialin C.Zheng Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of Medicine200065 ShanghaiChina Department of Cardio-Pulmonary Circulation Shanghai Pulmonary HospitalSchool of MedicineTongji UniversityShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s Hospital affiliated to Tongji University School of Medicine200434 ShanghaiChina

Dear Editor,Major depressive disorder(MDD)is one of the most common psychiatric illnesses that significantly increase the risk of suicide.1 Stress-triggered dysfunctions of microglia have been identified as a commonly occurred pathological feature of MDD.1–3 Microglial dysfunction contributes to the pathogenesis of MDD via immunoresponses/neuroinflammation-mediated neural damage and pathological synapse loss-mediated neural circuit disruption.1 Although the involvement of microglia in MDD has been widely investigated,the molecular mechanisms underlying microglial dysfunction remain largely ***,we identified glutaminase 1(Gls1)as one key protein that participates in microglial dysfunction.4–6 Gls1 catalyzes the hydrolysis of glutamine to produce glutamate in the brain.4 Besides its well-known role in excitatory neurotoxicity,we found Gls1 up-regulation in microglia in animal models of Alzheimer’s disease and ischemic stroke.4,7 Gls1 activates microglia to overproduce cytokines and release inflammatory extracellular vesicles,therefore leading to neuroinflammation in animal models of Alzheimer’s disease and ischemic stroke.4–6 More importantly,Gls1 has been found to be up-regulated in the brains of MDD patients,and microglial Gls1 deficiency mitigated LPS-induced depression-like behaviors.8 However,LPS exposure is not an appropriate model to mimic MDD phenotypes,leaving the involvement of Gls1 in MDD an undetermined question.

关键词： involvement inflammation media

Neural stem cell-derived extracellular vesicles mitigate Alzheimer’s disease-like phenotypes in a preclinical mouse model

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Signal Transduction and Targeted Therapy 2023年第7期8卷 3232-3235页

作者： Ge Gao Congcong Li Yizhao Ma Zhanping Liang Yun Li Xiangyu Li shengyang fu Yi Wang Xiaohuan Xia Jialin C.Zheng Center for Translational Neurodegeneration and Regenerative Therapy Tongji Hospital affiliated to Tongji University School of MedicineShanghai 200065China Translational Research Center Shanghai Yangzhi Rehabilitation Hospital affiliated to Tongji University School of MedicineShanghai 201613China Shanghai Frontiers Science Center of Nanocatalytic Medicine Tongji UniversityShanghai 200331China

Dear Editor,Alzheimer’s disease(AD)is the most common neurodegenerative disorder and the No.1 cause of dementia in elderly with no effective treatments.1 The application of stem cell-derived extracellular vesicles(EVs)has emerged as a promising therapeutic strategy for AD.2 EVs are small bilipid layer-enclosed vesicles that display blood-brain barrier(BBB)penetrating ability and similar potency to their parental cells.

关键词： Alzheimer clinical extracellular

保险监管沙盒模式下的消费者权益保护机制研究

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福建金融 2019年第6期 51-57页

作者：傅盛阳王焕平郑坤中国银行保险监督管理委员会福建监管局福建福州350003

在保险科技发展的浪潮下,保险科技沙盒应运而生,其不仅顺应了保险创新的时代潮流,还具有缓解保险科技创新与监管法律冲突、降低保险创新成本等多重优势,但与此同时保险监管沙盒对消费者也存在诸多潜在风险,对此境外国家和地区在建立保... 详细信息

在保险科技发展的浪潮下,保险科技沙盒应运而生,其不仅顺应了保险创新的时代潮流,还具有缓解保险科技创新与监管法律冲突、降低保险创新成本等多重优势,但与此同时保险监管沙盒对消费者也存在诸多潜在风险,对此境外国家和地区在建立保险监管沙盒制度时,均特别突出了对消费者权益的保护。而相较于英国、新加坡、中国香港等发达国家和地区而言,我国保险行业的整体水平以及保险公司的自我规制能力都仍有较大的发展空间,侵害保险消费者权益的事件亦时有发生,因此未来我国在构建保险监管沙盒制度时,更应建立完善的消费者权益保护机制,以避免保险科技创新对消费者权益造成额外侵害。

关键词：保险科技创新监管沙盒消费者权益保护

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基于相干分解的低复杂度同步检测算法

湖北师范大学学报（自然科学版） 2024年第3期44卷 13-19页

作者：朱文杰姚雨晨伏胜洋湖北师范大学计算机与信息工程学院湖北黄石435000

针对5G下行同步系统高复杂度的联合检测问题,提出了一种低复杂度的相干两步检测算法。首先,在整数频率偏移(IFO)的检测阶段,采用相干累积技术处理信号的相位信息,通过分析累积相位差分估计IFO值。接着,为了避免在确定扇区身份时所带来... 详细信息

针对5G下行同步系统高复杂度的联合检测问题,提出了一种低复杂度的相干两步检测算法。首先,在整数频率偏移(IFO)的检测阶段,采用相干累积技术处理信号的相位信息,通过分析累积相位差分估计IFO值。接着,为了避免在确定扇区身份时所带来的高复杂度,采用了基于符号误差的启发式算法,通过比较接收信号与每个扇区信号复数值之间的差异,选择符号误差最小的扇区作为最终结果。仿真结果表明,与传统联合检测算法相比,该算法能够有效降低计算复杂度,满足5G系统对定时同步的要求。

关键词： 5G系统整数频率偏移相干累积符号误差扇区身份

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基于稀疏角域的6G信道估计智能反射面算法

湖北师范大学学报（自然科学版） 2024年第2期44卷 72-78页

作者：朱文杰伏胜洋姚雨晨湖北师范大学计算机与信息工程学院湖北黄石435000

智能反射面(Reconfigurable Intelligent Surface,RIS)有着操纵性强、能耗低、方便部署等优势,已成为6G(第六代移动通信)的关键技术。研究了关于智能反射面的信道估计算法,对于传统算法在传播时路径会因角度原因发生偏移的情况,采用了Tu... 详细信息

智能反射面(Reconfigurable Intelligent Surface,RIS)有着操纵性强、能耗低、方便部署等优势,已成为6G(第六代移动通信)的关键技术。研究了关于智能反射面的信道估计算法,对于传统算法在传播时路径会因角度原因发生偏移的情况,采用了Tucker分解的稀疏角度域高阶奇异值分解(High Order Singular Value Decomposition,HOSVD)信道估计算法来解决路径偏移的问题。为了验证所提出算法的鲁棒性,对比了传统的交替最小二乘法信道估计算法,可以得到不管是在用户数量、传播的路径偏移上都能取得比传统的信道估计算法更好的归一化最小均方误差(Normalized Mean Squared Error,NMSE)效果。

关键词：智能反射面稀疏角域 Tucker分解归一化最小均方误差信道估计

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含铈硅酸钙修饰的PET人工韧带对移植物-骨愈合影响的实验研究

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中国运动医学杂志 2019年第5期38卷 396-405页

作者：康展荣傅声扬俞斌丁惠锋胡健禹宝庆黄建明复旦大学附属浦东医院骨科上海201399 上海理工大学材料与工程学院上海200093 复旦大学上海医学院上海市公共卫生临床中心骨科上海200032

目的:观察含铈硅酸钙(Ce-CS)修饰的PET人工韧带对大鼠骨髓间充质干细胞(rat bone marrow mesenchymal stem cells,rBMSCs)增殖和成骨分化的影响,及其在动物体内对移植物-骨愈合的影响。方法:根据PET韧带表面处理情况分为2组:PET组(PET... 详细信息

目的:观察含铈硅酸钙(Ce-CS)修饰的PET人工韧带对大鼠骨髓间充质干细胞(rat bone marrow mesenchymal stem cells,rBMSCs)增殖和成骨分化的影响,及其在动物体内对移植物-骨愈合的影响。方法:根据PET韧带表面处理情况分为2组:PET组(PET材料未经任何表面处理)和Ce-CS组(PET韧带经含铈硅酸钙进行表面修饰)。将rBMSCs接种到上述两组不同的材料上,培养一段时间后进行各项检测。扫描电镜(SEM)和X线能谱分析(EDS)观察材料涂层情况。rBMSCs在材料上接种培养1、3、7天后,使用Cell Counting Kit-8(CCK-8)试剂盒,检测rBMSCs细胞增殖情况。rBMSCs经成骨诱导培养7天和14天后,检测碱性磷酸酶(ALP)的活性,Real Time PCR(RT-PCR)检测骨钙蛋白(OCN)、Ⅰ型胶原(COL-1)的表达;诱导培养21天后,进行茜素红染色。选取12只新西兰大白兔,建立关节外腱-骨愈合模型。左侧植入未经处理的PET韧带,右侧植入Ce-CS修饰的PET韧带。在韧带植入8周后处死兔子,取出股骨样本,分别进行Micro-CT和Masson、HE染色。结果:SEM和EDS结果显示,Ce-CS材料涂层的PET韧带制备成功。CCK-8结果显示,Ce-CS组细胞在接种培养后第3天和第7天的增殖情况要优于对照组(P<0.05)。诱导培养7天和14天后,Ce-CS组ALP活性均高于对照组(P<0.05);诱导培养7天后OCN表达高于对照组(P<0.05);诱导培养14天后,OCN、COL-1表达均高于对照组(P<0.05)。Ce-CS组形成的矿化结节要多于对照组(P<0.05)。Micro-CT结果显示,CE-CS组骨缺损处的骨矿密度(BMD)、相对骨体积(BV/TV)均高于对照组。Masson、HE染色显示Ce-CS组韧带与宿主骨之间连接较为紧密,有较多新生骨组织生成,对照组与宿主骨之间连接疏松,未见有新生骨组织生成。结论:含铈硅酸钙修饰的PET韧带在体外能够明显促进大鼠骨髓间充质干细胞的增殖和成骨分化,体内能够促进新骨再生,促进人工韧带与宿主骨之间的愈合。

关键词：聚对苯二甲酸乙二醇酯铈硅酸钙骨髓间充质干细胞人工韧带移植物-骨愈合

Damage evolution and dynamic response of cement asphalt mortar layer of slab track under vehicle dynamic load

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Science China(Technological Sciences) 2014年第10期57卷 1883-1894页

作者： ZHU shengyang fu Qiang CAI ChengBiao SPANOS Pol D State Key Laboratory of Traction Power Southwest Jiaotong University School of Civil Engineering Central South University Ryon Chair in Engineering Rice University

The damage evolution and dynamic performance of a cement asphalt(CA)mortar layer of slab track subjected to vehicle dynamic load is investigated in this ***,a statistical damage constitutive model for the CA mortar layer is developed using continuous damage mechanics and probability *** this model,the strength of the CA mortar elements is treated as a random variable,which follows the Weibull *** inclusion of strain rate dependence affords considering its influence on the damage development and the transition between viscosity and *** with experimental data support the reliability of the model.A three-dimensional finite element(FE)model of a slab track is then created with the commercial software ABAQUS,where the devised model for the CA mortar is implemented as a user-defined material ***,a vertical vehicle model is coupled with the FE model of the slab track,through the wheel-rail contact forces,based on the nonlinear Hertzian contact *** evolution of the damage and of the dynamic performance of the CA mortar layer with various initial damage is investigated under the train and track *** analysis indicates that the proposed model is capable of predicting the damage evolution of the CA mortar layer exposed to vehicle dynamic *** dynamic compressive strain,the strain rate,and the induced damage increase significantly with an increase in the initial damage,whereas the dynamic compressive stress exhibits a sharp decrease with the increasing initial ***,it is found that the strain rate dependence significantly influences the damage evolution and the dynamic behavior of the CA mortar layer.

关键词： cement asphalt mortar slab track statistical damage constitutive model vehicle-track coupled dynamics damage evolution

Selective and stable Au-Cu bimetallic catalyst for CO-PROX

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Nano Research 2023年第7期16卷 9031-9038页

作者： Feng Hong Guanjian Cheng Weihao Hu shengyang Wang Qike Jiang Junhong fu Botao Qiao Jiahui Huang Dalian National Laboratory for Clean Energy Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Energy Soochow Institute for Energy and Materials Innovations(SIEMIS)Soochow UniversitySuzhou 215006China CAS Key Laboratory of Science and Technology on Applied Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China School of Chemistry and Chemical Engineering Yulin UniversityYulin 719000China University of Chinese Academy of Sciences Beijing 100049China

Gold-based catalysts are promising in CO preferential oxidation(CO-PROX)reaction in H_(2)-rich stream on account of their high intrinsic activity for CO elimination even at ambient ***,the decrease of CO conversion at elevated temperature due to the competition of H_(2)oxidation,together with the low stability of gold nanoparticles,has posed a dear ***,we report that Au-Cu bimetallic catalyst prepared by galvanic replacement method shows a wide temperature window for CO total conversion(30-100℃)and very good catalyst stability without deactivation in a 200-h *** characterizations combined with density functional theory(DFT)calculation reveal that the synergistic effect of Au-Cu,the electron transfer from Au to Cu,leads to not only strengthened chemisorption of CO but also weakened dissociation of H_(2),both of which are helpful in inhibiting the competition of H_(2)oxidation thus widening the temperature window for CO total conversion.

关键词： gold catalysis CO preferential oxidation(CO-PROX) electronic interaction galvanic replacement

Engineering Multi‑field‑coupled Synergistic Ion Transport System Based on the Heterogeneous Nanofluidic Membrane for High‑Efficient Lithium Extraction

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Nano-Micro Letters 2023年第8期15卷 436-449页

作者： Lin fu Yuhao Hu Xiangbin Lin Qingchen Wang Linsen Yang Weiwen Xin shengyang Zhou Yongchao Qian Xiang‑Yu Kong Lei Jiang Liping Wen CAS Key Laboratory of Bio‑Inspired Materials and Interfacial Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190People’s Republic of China School of future Technology University of Chinese Academy of SciencesBeijing 100049People’s Republic of China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101People’s Republic of China

The global carbon neutrality strategy brings a wave of rechargeable lithium‐ion batteries technique development and induces an ever-growing consumption and demand for lithium(Li).Among all the Li exploitation,extracting Li from spent LIBs would be a strategic and perspective approach,especially with the low energy consumption and eco-friendly membrane separation ***,current membrane separation systems mainly focus on monotonous membrane design and structure optimization,and rarely further consider the coordination of inherent structure and applied external field,resulting in limited ion ***,we propose a heterogeneous nanofluidic membrane as a platform for coupling multi-external fields(i.e.,lightinduced heat,electrical,and concentration gradient fields)to construct the multi-field-coupled synergistic ion transport system(MSITS)for Li-ion extraction from spent *** Li flux of the MSITS reaches 367.4 mmol m^(−2)h^(−1),even higher than the sum flux of those applied individual fields,reflecting synergistic enhancement for ion transport of the multi-field-coupled *** from the adaptation of membrane structure and multi-external fields,the proposed system exhibits ultrahigh selectivity with a Li^(+)/Co^(2+)factor of 216,412,outperforming previous *** based on nanofluidic membrane proves to be a promising ion transport strategy,as it could accelerate ion transmembrane transport and alleviate the ion concentration polarization *** work demonstrated a collaborative system equipped with an optimized membrane for high-efficient Li extraction,providing an expanded strategy to investigate the other membrane-based applications of their common similarities in core concepts.

关键词： Nanofluids Ion separation Lithium extraction Synergistic effect Spent lithium-ion battery