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Global status and trends in hepatitis B virus DNA mutation research from 2003 to 2022:A comprehensive bibliometric view

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Portal Hypertension & Cirrhosis 2024年第1期3卷 14-21页

作者： Ming Li Xiaoming Xu Yong Liu Minxin Mao Yu Geng shengxia yin Xin Tong Chao Wu Jie Li Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Department of Laboratory Medicine Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsuChina Institute of Viruses and Infectious Diseases Nanjing UniversityNanjingJiangsuChina

Aims:Hepatitis B virus(HBV)is an enveloped DNA virus belonging to the Hepadnaviridae *** is a significant contributor to the prevalence of chronic liver disease on a global *** in HBV DNA can affect the diagnosis,treatment,and prognosis of patients with chronic hepatitis *** numerous studies on HBV DNA mutations have been conducted,few bibliometric studies have been performed to *** study aimed to analyze changes in scientific output to gain a better understanding of the current research status and identify potential new research directions in the field of HBV DNA ***:Relevant studies published between 2003 and 2022 were retrieved from the Web of Science Core Collection *** version 6.1.R6 was used to construct network maps to evaluate collaborations among countries,institutions,authors,journals,and ***:In total,1508 publications over the past 20 years were obtained,mainly from China,the United States,and *** major research institutions in China included the University of Hong Kong,Fudan University,and Peking *** Ching Lung was the most productive author,whereas Anna Suk-Fong Lok was the most frequently co-cited *** keyword“HBsAg”was the strongest burst keyword in recent years,indicating possible future study ***:This bibliometric analysis intuitively revealed the overall research status of HBV DNA mutations,providing valuable information for researchers,funding agencies,and policymakers to explore the current research status,research hotspots,and new directions for future research.

关键词： bibliometrics DNA hepatitis B virus mutation

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Clinical impact and mechanisms of hepatitis B virus infection concurrent with non-alcoholic fatty liver disease

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Chinese Medical Journal 2022年第14期135卷 1653-1663页

作者： Xin Tong Yu Song shengxia yin Jian Wang Rui Huang Chao Wu Junping Shi Jie Li Department of Infectious Diseases Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsu 210008China Institute of Viruses and Infectious Diseases Nanjing UniversityNanjingJiangsu 210008China Department of Hepatology Zhejiang Chinese Medical UniversityHangzhouZhejiang 310053China Department of Hepatology The Affiliated Hospital of Hangzhou Normal UniversityHangzhouZhejiang 310015China

Chronic hepatitis B(CHB)virus infection is an important threat to global health despite the administration of vaccines and the use of antiviral *** recent years,as the prevalence of obesity and metabolic syndrome has increased,non-alcoholic fatty liver disease(NAFLD)in patients with CHB has become more *** diseases can lead to liver fibrosis and even hepatocellular carcinoma,but the risk of dual etiology,outcome,and CHB combined with NAFLD is not fully *** this review,we assess the overlapping prevalence of NAFLD and CHB,summarize recent studies of clinical and basic research related to potential interactions,and evaluate the progressive changes of treatments for CHB patients with *** review increases the understanding of the relationship and mechanisms of interaction between steatosis and hepatitis B virus infection,and it provides new strategies for the future clinical management and treatment of CHB combined with NAFLD.

关键词： Chronic hepatitis B Non-alcoholic fatty liver disease Steatosis Mechanism

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Cellular & Molecular Immunology 2014年第3期11卷 232-244页

作者： Xia Liu shengxia yin Wenqiang Cao Wei Fan Lei Yu Li yin Lie Wang Jianli Wang Institute of Immunology Zhejiang University School of Medicine Hangzhou China

The interplay between the CD4-1ineage transcription factor ThPok and the CD8-iineage transcription factor, runt-related transcription factor 3 （Runx3）, in T-cell development has been extensively documented. However, little is known about the roles of these transcription factors in invariant natural killer T （iNKT） cell development. CDld-restricted iNKT cells are committed to the CD4＋CD8- and CD4-CD8- sublineages, which respond to antigen stimulation with rapid and potent release of T helper （Th） 1 and Th2 cytokines. However, previous reports have demonstrated a new population of CD8~ NKT cells in ThPok-deficient mice. In the current study, we sought to determine whether Runx3 was involved in the re-expression of CD8 and function of iNKT cells in the absence of ThPok. We used mice lacking Runx3, ThPok or both and verified that Runx3 was partially responsible for the appearance of CD8^＋ iNKT cells in ThPok knockout mice. Additionally, Runx3 participated in the immune response mediated by iNKT cells in a model of α-galactosylceramide-induced acute hepatitis. These results indicate that Runx3 is crucial for the phenotypic and functional changes observed in ThPok-deficient iNKT cells.

关键词： α-galactosylceramide iNKT cells liver Runx3 ThPok

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Gamma-glutamyl Transpeptidase to Platelet Ratio Predicts Liver Injury in Hepatitis B e Antigen-negative Chronic Hepatitis B Patients With Normal Alanine Aminotransferase

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Journal of Clinical and Translational Hepatology 2022年第2期10卷 247-253页

作者： Xiang-An Zhao Jian Wang Jie Wei Jiacheng Liu Guangmei Chen Li Wang Guiyang Wang Juan Xia Weihua Wu shengxia yin Xin Tong Xiaomin Yan Weimao Ding Xiaoxing Xiang Rui Huang Chao Wu Department of Gastroenterology Northern Jiangsu People’s HospitalClinical Medical College of Yangzhou UniversityYang-zhouJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower Hospital Clini-cal College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsuChina Department of Infectious Diseases Affiliated Hospital of Nanjing University of Chinese MedicineNanjingJiangsuChina Department of Hepatology Huai’an No.4 People’s HospitalHuai’anJiangsuChina

Background and Aims:Chronic hepatitis B virus(HBV)infection is a serious health problem *** liver injury in patients with hepatitis B e antigen(HBeAg)-negative chronic hepatitis B(CHB)with detectable HBV DNA and normal alanine aminotransferase(ALT)is crucial to guide their clinical *** aimed to investigate the stages of liver inflammation and fibrosis as well as the predictive accuracy of gamma-glutamyl transpepti-dase-to-platelet ratio(GPR)in these ***:A total of 184 treatment-naïve HBeAg-negative CHB pa-tients with detectable HBV DNA and normal ALT were *** Scheuer scoring system was used to classify liver inflammation and ***:The distribution of patients with different liver inflammation grades were as follows:G0,0(0%);G1,97(52.7%);G2,68(37.0%);G3,12(6.5%);and G4,7(3.8%).The distribution of patients with different liver fibrosis stages were as follows:S0,22(12.0%);S1,72(39.1%);S2,42(22.8%);S3,19(10.3%);and S4,29(15.8%).The areas under the re-ceiver operating characteristic(AUROC)curves of GPR in predicting significant inflammation,severe inflammation,and advanced inflammation were 0.723,0.895,and 0.952,*** accuracy of GPR was significantly superior to that of ALT in predicting liver *** AUROCs of GPR in predicting significant fibrosis,severe fibrosis,and cirrhosis were 0.691,0.780,and 0.803,*** predictive accuracy of GPR was significantly higher than that of aminotransferase-to-platelet ratio index(APRI)and fibrosis index based on four factors(FIB-4)in identifying advanced fibrosis and cirrhosis,and it was superior to FIB-4 but comparable to APRI in identifying significant ***:Nearly half of the HBeAg-negative CHB patients with detectable HBV DNA and normal ALT levels had significant liver inflammation or *** can serve as an accurate predictor of liver inflammation and fibrosis in these patients.

关键词： Chronic hepatitis B Liver injury Gamma-glutamyl transpeptidase Platelet

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Long-lived lunar volcanism sustained by precession-driven core-mantle friction

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National Science Review 2024年第2期11卷 114-123页

作者： Shuoran Yu Xiao Xiao shengxia Gong Nicola Tosi Jun Huang Doris Breuer Long Xiao Dongdong Ni State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology Planetary Science Institute State Key Laboratory of Geological Processes and Mineral Resources School of Earth Sciences China University of Geosciences CAS Key Laboratory of Planetary Sciences Shanghai Astronomical Observatory Institute of Planetary Research German Aerospace Centre(DLR)

Core-mantle friction induced by the precession of the Moon's spin axis is a strong heat source in the deep lunar mantle during the early phase of a satellite's evolution, but its influence on the long-term thermal evolution still remains poorly explored. Using a one-dimensional thermal evolution model, we show that core-mantle friction can sustain global-scale partial melting in the upper lunar mantle until ～3.1 Ga, thus accounting for the intense volcanic activity on the Moon before ～3.0 Ga. Besides, core-mantle friction tends to suppress the secular cooling of the lunar core and is unlikely to be an energy source for the long-lived lunar core dynamo. Our model also favours the transition of the Cassini state before the end of the lunar magma ocean phase(～4.2 Ga), which implies a decreasing lunar obliquity over time after the solidification of the lunar magma ocean. Such a trend of lunar obliquity evolution may allow volcanically released water to be buried in the lunar regolith of the polar regions. As a consequence, local water ice could be more abundant than previously thought when considering only its accumulation caused by solar wind and comet spreading.

关键词： Moon precession orbit volcanism

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B Cell-mediated Humoral Immunity in Chronic Hepatitis B Infection

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Journal of Clinical and Translational Hepatology 2021年第4期9卷 592-597页

作者： Yang Li shengxia yin Rahma Issa Xin Tong Guiyang Wang Juan Xia Rui Huang Guangmei Chen Dan Weng Chen Chen Chao Wu Yuxin Chen School of Environmental and Biological Engineering Nanjing University of Science&TechnologyNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina Department of Infectious Diseases Nanjing Drum Tower HospitalClinical College of Nanjing Medical UniversityNanjingJiangsuChina Department of Infectious Diseases Jiangsu Province Hospital of Chinese MedicineNanjingJiangsuChina Department of Clinical Pharmacology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsuChina Department of Laboratory Medicine Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjingJiangsuChina

B cell-mediated humoral immunity plays a vital role in viral infections,including chronic hepatitis B virus(HBV)infection,which remains a critical global public health *** hepatitis B surface antigen-specific antibodies are essential to eliminate viral infections,the reduced immune functional capacity of B cells was identified,which was also correlated with chronic hepatitis B(CHB)*** addition to B cells,T follicular helper(Tfh)cells,which assist B cells to produce antibodies,might also be involved in the process of anti-HBVspecific antibody ***,we provide a comprehensive review of the role of various subsets of B cells and Tfh cells during CHB progression and discuss current novel treatment strategies aimed at restoring humoral *** the mechanism of dysregulated B cells and Tfh cells will facilitate the ultimate functional cure of CHB patients.

关键词： Chronic hepatitis B(CHB) B cell T follicular helper(Tfh)cells Antibody Therapeutics

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The mechanism of transcription factor IRF4 in bacterial infected bowel disease mediated by Innate lymphoid cell 3

The mechanism of transcription factor IRF4 in bacterial infe...

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中国生物化学与分子生物学会2016年全国学术会议

作者： shengxia yin Jingjing Yu Chengyu Lu Lie Wang Institute of Immunology Zhejiang University School of Medicine

Innate Lymphoid Cells(ILC)were newly discovered cells that existed between innate and adaptive immunity,which can be divided into ILC1,ILC2 and *** had been reported that ILC3s can influence the inflammatory bowel dis... 详细信息

关键词： Innate Lymphoid Cells Bacterial Infected Bowel Disease IRF4 Cytokines

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乡村振兴赋能共同富裕的影响机制与实现路径

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农村经济 2024年第5期 15-29页

作者：刘强李冬徐生霞首都经济贸易大学统计学院北京市100070

乡村振兴是实现共同富裕的必经之路,其如何有效赋能共同富裕是实现中国式现代化的关键所在。基于经济高质量发展理念,构建乡村振兴发展水平综合指标体系,考虑到政策重视程度差异,对PP-IPM模型测算的乡村振兴发展水平进行调整。同时,从... 详细信息

乡村振兴是实现共同富裕的必经之路,其如何有效赋能共同富裕是实现中国式现代化的关键所在。基于经济高质量发展理念,构建乡村振兴发展水平综合指标体系,考虑到政策重视程度差异,对PP-IPM模型测算的乡村振兴发展水平进行调整。同时,从经济发展和收入差异两个方面对共同富裕进行测度,分析二者的演进特征。进一步,探究乡村振兴赋能共同富裕的机制与路径,并从不同发展程度和区域差异两个层面进行异质性分析。研究发现:首先,样本期内,中国乡村振兴发展水平和共同富裕程度均呈现上升态势,且二者均体现出东、中、西地区依次递减的空间分布特征;其次,乡村振兴对共同富裕有赋能效应,通过缩小城乡收入差距促进共同富裕程度的提升,而在乡村振兴发展水平较高的地区直接影响效应更强,在乡村振兴发展水平较低的地区间接影响效应更强;最后,异质性分析结果表明,乡村振兴对低程度共同富裕的促进作用更明显,可有效赋能中、西部地区的共同富裕。基于研究结论,在乡村振兴战略的实施过程中要努力激发治理有效和生态宜居对共同富裕的赋能效应;要注重农业现代化建设、农村医疗教育保障,逐步实现富民增收;要针对东、中、西三大区域,因地制宜地实施乡村振兴战略。

关键词：乡村振兴共同富裕影响机制异质性分析 PP-IPM模型门槛模型

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大型压裂技术在苏里格气田开发中的优化应用

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油气井测试 2024年第4期33卷 31-36页

作者：张圣霞河北省煤田地质局第二地质队(河北省干热岩研究中心) 河北邢台054001

为实现苏里格区块难采储量的有效动用,对以往大型压裂技术进行优化升级,压裂液体系由胍胶交联冻胶压裂液升级为“滑溜水+线性胶+胍胶压裂液冻胶”变黏度复合压裂液,支撑剂选用中密度高强度40/70目+20/40目陶粒组合,通过裂缝支撑剖面模... 详细信息

为实现苏里格区块难采储量的有效动用,对以往大型压裂技术进行优化升级,压裂液体系由胍胶交联冻胶压裂液升级为“滑溜水+线性胶+胍胶压裂液冻胶”变黏度复合压裂液,支撑剂选用中密度高强度40/70目+20/40目陶粒组合,通过裂缝支撑剖面模拟和优化压裂施工参数,在保障施工安全的前提下,设计施工排量可满足8.0~9.0 m 3/min,形成了适合苏里格气田大型压裂技术。现场应用表明,大型压裂技术采用大排量、大液量、大砂量造复杂裂缝,加大了储层的渗透率,增加了气体可动区域,用液强度平均增大99%,加砂强度平均增大97%,日产气平均增加101.3%,取得了较好的增产效果,为后续该类区块的开发起到较好的借鉴和指导作用。

关键词：苏里格气田大型压裂技术复合压裂液组合支撑剂裂缝剖面复杂裂缝增产效果

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流动身份·再造传统·土腔风格——潮汕青年电影观察

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粤海风 2024年第3期 29-38,F0003页

作者：霍胜侠广州美术学院跨媒体艺术学院

近年,南方电影不断涌现,通过地方性知识生产为今天全球化语境下逐渐凸显的现代性困局提供另类方案。而潮汕青年电影是其中一支值得关注的新生力量。它们通过对于“都市—城镇”“陆地—海洋”之间流动主题的持续关注和书写,试图翻转既... 详细信息

近年,南方电影不断涌现,通过地方性知识生产为今天全球化语境下逐渐凸显的现代性困局提供另类方案。而潮汕青年电影是其中一支值得关注的新生力量。它们通过对于“都市—城镇”“陆地—海洋”之间流动主题的持续关注和书写,试图翻转既定的“中心—边缘”关系,重塑潮汕自身的主体性。在这个过程中,如何再造潮汕的家族主义传统,使其在新的语境下焕发生命力,成为其中一个重要议题。同时,与内容主旨相一致,潮汕青年电影正在形成一种区别于主流商业电影的土腔风格和土腔制作模式。

关键词：潮汕青年电影流动家族主义土腔

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