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Pathological and physiological functional cross-talks ofα-synuclein and tau in the central nervous system

Neural Regeneration Research 2024年第4期19卷 855-862页

作者： Mingyue Jin shengming wang Xiaodie Gao Zhenyou Zou Shinji Hirotsune Liyuan Sun Guangxi Key Laboratory of Brain and Cognitive Neuroscience Guilin Medical University Department of Genetic Disease Research Osaka Metropolitan University Graduate School of Medicine Department of Scientific Research Brain Hospital of Guangxi Zhuang Autonomous Region

α-Synuclein and tau are abundant multifunctional brain proteins that are mainly expressed in the presynaptic and axonal compartments of neurons,*** works have revealed that intracellular deposition ofα-synuclein and/or tau causes many neurodegenerative disorders,including Alzheimer’s disease and Parkinson’s *** intense investigation,the normal physiological functions and roles ofα-synuclein and tau are still unclear,owing to the fact that mice with knockout of either of these proteins do not present apparent ***,the co-occurrence ofα-synuclein and tau aggregates was found in post-mortem brains with synucleinopathies and tauopathies,some of which share similarities in clinical ***,the direct interaction ofα-synuclein with tau is considered to promote the fibrillization of each of the proteins in vitro and in *** the other hand,our recent findings have revealed thatα-synuclein and tau are cooperatively involved in brain development in a stage-dependent *** findings indicate strong cross-talk between the two proteins in physiology and *** this review,we provide a summary of the recent findings on the functional roles ofα-synuclein and tau in the physiological conditions and pathogenesis of neurodegenerative diseases.A deep understanding of the interplay betweenα-synuclein and tau in physiological and pathological conditions might provide novel targets for clinical diagnosis and therapeutic strategies to treat neurodegenerative diseases.

关键词： alpha-synuclein microtubule-associated protein neurodegenerative disease tau

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三塔四跨悬索桥施工阶段颤振性能研究

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世界桥梁 2024年第4期52卷 92-98页

作者：王盛铭莫威杨海忠唐浩俊李永乐温州瓯江口大桥有限公司浙江温州325002 西南交通大学桥梁工程系四川成都610031

为了解双主跨悬索桥加劲梁吊装期间颤振稳定性,以跨度为(230+800+800+348)m三塔四跨悬索桥为背景,分析该桥加劲梁吊装期间的颤振性能。建立该桥不同吊装阶段三维有限元模型,分析竖弯、扭转模态特性,采用理想平板颤振临界风速理论公式计... 详细信息

为了解双主跨悬索桥加劲梁吊装期间颤振稳定性,以跨度为(230+800+800+348)m三塔四跨悬索桥为背景,分析该桥加劲梁吊装期间的颤振性能。建立该桥不同吊装阶段三维有限元模型,分析竖弯、扭转模态特性,采用理想平板颤振临界风速理论公式计算桥梁不同吊装阶段及各模态组合下的颤振临界风速,以确定最不利吊装阶段及模态组合;基于此,设计节段模型风洞试验测试原断面及上桥面中央增设竖向稳定板断面桥梁颤振临界风速。结果表明:三塔四跨悬索桥施工阶段的模态特性复杂,颤振分析时模态组合需考虑两主跨间的振动关系;该桥吊装率为8.5%和19.8%时,颤振临界状态由以北侧主跨振动为主的扭弯模态组合确定,吊装率≥29.3%时,颤振临界状态由以南侧主跨振动为主的扭弯模态组合确定,最不利吊装率为40.8%;该桥加劲梁原断面的颤振性能较差,在上桥面中央增设竖向稳定板可以有效提升桥梁的颤振临界风速。

关键词：三塔四跨悬索桥施工阶段颤振性能模态组合吊装率竖向稳定板风洞试验

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双缆三塔悬索桥力学性能参数分析

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上海公路 2024年第2期 55-62,I0011页

作者：潘济王盛铭贾丽君温州苍泰高速公路有限公司浙江温州325000 同济大学土木工程学院上海200092

为研究双缆三塔悬索桥关键设计参数对结构受力性能的影响,对双缆三塔悬索桥关键力学指标进行了近似计算公式的推导,研究了主缆在活载、恒载下的线性和内力,并以主跨跨径为1 500 m、2 000 m和2 500 m的三塔钢箱梁悬索桥为研究对象,分析... 详细信息

为研究双缆三塔悬索桥关键设计参数对结构受力性能的影响,对双缆三塔悬索桥关键力学指标进行了近似计算公式的推导,研究了主缆在活载、恒载下的线性和内力,并以主跨跨径为1 500 m、2 000 m和2 500 m的三塔钢箱梁悬索桥为研究对象,分析了不同跨径下的悬索桥静力特性随顶缆恒载分担系数、索塔纵向刚度、主缆矢跨比、边中跨比等结构设计参数改变的变化规律,为双缆三塔悬索桥初步设计时的参数选取提供参考。

关键词：双缆三塔悬索桥简化计算受力性能参数分析

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Simulated and experimental studies on the array dielectric barrier discharge of water electrodes

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Plasma Science and Technology 2017年第3期19卷 75-82页

作者： Lele wang Xiutao HUANG Junfeng CHEN shengming wang Zhaoyang HU Minghai LIU School of Electrical and Electronic Engineering Huazhong University of Science and Technology Wuhan 430074 People＇s Republic of China

A kind of dielectric barrier discharge（DBD） device composed of water electrodes with 3×3forms can produce large-area low-temperature plasmas at atmospheric *** reflect the discharge characteristics of DBD better,a dynamic simulation model,which is based on the voltage controlled current source（CCS）,is established,then the established model in Matlab/Simulink is used to simulate the DBD in *** voltage-current waves and Lissajous at a voltage of 10 kV,11 kV and 12 kV peak value with a frequency of 15 kHz are *** change of the discharge power of DBD with a different amplitude and frequency of applied voltage is also *** result shows the voltage-current waves,Lissajous and discharge power of DBD under different conditions from the simulation agree well with those of the *** addition,we propose a method to calculate the dielectric barrier capacitance Cd and the gap capacitance Cg,which is valid through analyzing the variation of capacitance at different voltage amplitudes.

关键词： dielectric barrier discharge Matlab/Simulink lissajous dielectric barrier capaci-tance gap capacitance

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Take Every Step Firmly with Sharp Eyes

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Chinese Journal of Chemistry 2024年第10期42卷 1065-1066页

作者： shengming Ma Chinese Journal of Chemistry

Chinese Journal of Chemistry(CJC)is committed to becoming a prominent international journal for chemistry and the related *** are working very hard towards this *** offers a diverse range of manuscript types,including... 详细信息

关键词： journal becoming diverse

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Study on metal recovery process and kinetics of oxidative leaching from spent LiFePO_(4)Li-batteries

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Chinese Journal of Chemical Engineering 2024年第4期68卷 94-102页

作者： Xiaoming Zhang Wen Xie Xiaolei Zhou Wenjie Zhang Jiawei Wen Xin wang Guoyong Huang shengming Xu College of New Energy and Materials China University of PetroleumBeijing 102249China State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumBeijing 102249China Beijing Spacecrafts Beijing 100094China Ganfeng Lithium Group Co. Ltd.Xinyu 338000China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Beijing Key Laboratory of Fine Ceramics Tsinghua UniversityBeijing 100084China

A green environmental protection and enhanced leaching process was proposed to recover all elements from spent lithium iron phosphate(LiFePO_(4)) lithium *** order to reduce the influence of Al impurity in the recovery process,NaOH was used to remove *** impurity removal,the spent LiFePO_(4) cathode material was used as raw material under the H_(2)SO_(4) system,and the pressure oxidation leaching process was adopted to achieve the preferential leaching of *** E-pH diagram of the Fe-P-Al-H_(2)O system can determine the stable region of each element in the recovery process of spent LiFePO_(4)*** the optimal conditions(500 r·min^(-1),15 h,363.15 K,0.4 MPa,the liquid-solid ratio was 4:1 ml·g^(-1)and the acid-material ratio was 0.29),the leaching rate of Li was 99.24%,Fe,Al,and Ti were 0.10%,2.07%,and 0.03%,*** Fe and P were precipitated and recovered as FePO_(4)·2H_(2)*** kinetic analysis shows that the process of high-pressure acid leaching of spent LiFePO_(4) materials depends on the surface chemical *** the life cycle assessment(LCA)of the spent LiFePO_(4) whole recovery process,eight midpoint impact categories were selected to assess the impact of recovery *** results can provide basic environmental information on production process for recycling industry.

关键词： Spent LiFePO_(4)Li-batteries Oxidative leaching Kinetic study Life cycle assessment

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Relationships between Terrain Features and Forecasting Errors of Surface Wind Speeds in a Mesoscale Numerical Weather Prediction Model

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Advances in Atmospheric Sciences 2024年第6期41卷 1161-1170页

作者： Wenbo XUE Hui YU shengming TANG Wei HUANG Chinese Academy of Meteorological Sciences Beijing 100081China University of Chinese Academy of Sciences Beijing 101408China Shanghai Typhoon Institute/CMA Shanghai 200030China Key Laboratory of Numerical Modeling for Tropical Cyclone/CMA Shanghai 200030China

Numerical weather prediction(NWP)models have always presented large forecasting errors of surface wind speeds over regions with complex *** this study,surface wind forecasts from an operational NWP model,the SMS-WARR(Shanghai Meteorological Service-WRF ADAS Rapid Refresh System),are analyzed to quantitatively reveal the relationships between the forecasted surface wind speed errors and terrain features,with the intent of providing clues to better apply the NWP model to complex terrain *** terrain features are described by three parameters:the standard deviation of the model grid-scale orography,terrain height error of the model,and slope *** results show that the forecast bias has a unimodal distribution with a change in the standard deviation of *** minimum ME(the mean value of bias)is 1.2 m s^(-1) when the standard deviation is between 60 and 70 m.A positive correlation exists between bias and terrain height error,with the ME increasing by 10%−30%for every 200 m increase in terrain height *** ME decreases by 65.6%when slope angle increases from(0.5°−1.5°)to larger than 3.5°for uphill winds but increases by 35.4%when the absolute value of slope angle increases from(0.5°−1.5°)to(2.5°−3.5°)for downhill *** sensitivity experiments are carried out with a model output statistical(MOS)calibration model for surface wind speeds and ME(RMSE)has been reduced by 90%(30%)by introducing terrain parameters,demonstrating the value of this study.

关键词： surface wind speed terrain features error analysis MOS calibration model

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Technical Improvements on the LM-3

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Aerospace China 1995年第1期 28-31页

作者： Fan Shihe Hu shengming wang Yuexiang

APstar-1 satellite has been successfully placed into the predetermined orbit by the LM-3 launch *** the fulfillment of this launch service,technical modifications have been made on the launch vehicle in the following aspects:increase of the launch capability,improvement of reliability and adaption of the thunder and raining weather.

关键词：心目人心

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Cation-doped LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2) cathode with high rate performance

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Chinese Journal of Chemical Engineering 2024年第6期70卷 139-148页

作者： Long Zhang Dongsheng Yang Lilei Miao Chunmeng Zhang Jiexiang Li Jiawei Wen Chunxia wang Tiantian Cao Guoyong Huang shengming Xu College of New Energy and Materials China University of PetroleumBeijing 102249China State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumBeijing 102249China Beijing Spacecrafts Beijing 100094China SINOPEC Sales Co. Ltd.Beijing 100728China SINOPEC Research Institute of Petroleum Processing Co. LtdBeijing 100083China Institute of Nuclear and New Energy Technology Tsinghua UniversityBeijing 100084China Beijing Key Laboratary of Fine Ceramics Tsinghua UniversityBeijing 100084China

The nickel-rich layered cathode material LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)(NCM811)has high energy density,lower cost and is a promising cathode material currently under ***,its electrochemical and structural stability is poor during *** the many modification methods,cation doping has been consistently proven to be an effective strategy for enhancing electrochemical ***,the NCM811 cathode material was modified by solid-phase reactions with Mg and Al *** addition,the corresponding mechanism of NCM811 cathode material-doped modification is explored by density functional theory(DFT)calculations,and we have extended this approach to other ternary cathode materials with different ratios and obtained universal *** with DFT calculations,the results show that Mg2+occupies the Li+site and reduces the degree of Li^(+)/Ni^(2+) mixture;Al^(3+) acts as a structural support during charging and discharging to prevent structural *** electrochemical properties were tested by an electrochemical workstation and the LAND system,and the results showed that the capacity retention rate increased to varying degrees from 63.66%to 69.87%and 89.05%for NCM811-Mg and NCM811-Al at room temperature after 300 cycles,*** study provides a theoretical basis and design strategy for commercializing cationic-doped modification of nickel-rich cathode materials.

关键词： Li-ion batteries Cathode materials Doped Electrochemical properties DFT calculation

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适应多级调度安全稳定分析资源共享的分布式计算管理平台

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电力系统自动化 2016年第23期40卷 1-8页

作者：方勇杰王胜明华北电力大学电气与电子工程学院北京市102206 南瑞集团公司(国网电力科学研究院) 江苏省南京市211106 智能电网保护和运行控制国家重点实验室江苏省南京市211106 国电南瑞科技股份有限公司江苏省南京市211106

针对大电网多级调度安全稳定协同分析与控制计算对分布式计算管理平台的资源共享和统一管理的新需求,结合各级调度计算资源独立部署的现状,基于"资源调度分级管理、计算服务全局共享"设计思想提出了一种动态树形架构的分布式计算管理平... 详细信息

针对大电网多级调度安全稳定协同分析与控制计算对分布式计算管理平台的资源共享和统一管理的新需求,结合各级调度计算资源独立部署的现状,基于"资源调度分级管理、计算服务全局共享"设计思想提出了一种动态树形架构的分布式计算管理平台及其设计原则,分别从用户管理层、计算管理层、资源管理层和信息代理层阐述了平台的主要功能,并讨论了平台实现需要解决的多级调度协调管理机制、任务调度管理策略和计算资源优化分配方法等关键技术问题。

关键词：多级调度分布式计算动态树形架构任务调度资源共享

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