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Screening for viruses in lung adenocarcinoma in China

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第3期2卷 197-199页

作者： Zhuxing Chen Peng Liang Haoxiang Xu shengli yang Jilong Liu Shifu Chen Ran Zhong Akira Sugimoto Wenhua Liang Jianxing He Tomoya Kawaguchi Department of Thoracic Surgery and Oncology the First Affiliated Hospital of Guangzhou Medical UniversityChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory DiseaseGuangzhouGuangdong 510120China Pulmonary Nodule Surgical Department the First People’s Hospital of FoshanFoshanGuangdong 528000China Center for Medical Research the First People’s Hospital of YulinThe Sixth Affiliated Hospital of Guangxi Medical UniversityYulinGuangxi 537000China Department of General Medicine the Second Affiliated Hospital(Guangdong Provincial Hospital of Chinese Medicine)Guangzhou University of Chinese MedicineGuangzhouGuangdong 510120China Day Surgery Center the First People’s Hospital of FoshanFoshanGuangdong 528000China BGI Genomics BGI-ShenzhenShenzhenGuangdong 510120China HaploX Biotechnology Co.LtdShenzhenGuangdong 518000China Department of Respiratory Medicine Graduate School of MedicineOsaka Metropolitan UniversityChemotherapy CenterOsaka City University HospitalOsaka 558-8585Japan The First Clinical College Southern Medical UniversityGuangzhouGuangdong 510120China

To the Editor,Considerable numbers of cases of lung adenocarcinoma(LUAD)in non-smokers with unclear etiology have been *** and bacterial infections are the common causes of lung and respiratory diseases.1 However,whether LUAD development coexists with virus infection is still *** staining and polymerase chain reaction(PCR)are often used to detect virus in blood,sputum,and alveolar lavage fluid ***-genome sequencing(WGS)is an unbiased method with a high throughput nature that can be applied for a broader assessment of *** studies described the viral landscape in pan-cancer in The Cancer Genome Atlas(TCGA)or cohort studies;however,these studies did not include Asian ***,we sought to screen the common viral pathogens in a nationwide cohort of LUAD patients in China and further explored other potential viral pathogens by analyzing the WGS data from our single-center cohort.2 To systematically investigate the viral associations with LUAD in China,we conducted a comprehensive study that included two distinct cohorts.

关键词： adenocarcinoma lung respiratory

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煤与天然气协同开采理论与技术构想

煤炭科学技术 2024年第4期52卷 50-68页

作者：杨胜利张燊王旭东张凯辛德林翟瑞昊中国矿业大学(北京)能源与矿业学院北京100083 厚煤层绿色智能开采教育部工程研究中心北京100083 中国矿业大学(北京)内蒙古研究院内蒙古鄂尔多斯017004 神华新街能源有限责任公司内蒙古鄂尔多斯017200 煤炭开采水资源保护与利用全国重点实验室北京102209 中煤科工集团武汉设计研究院有限公司湖北武汉430061

我国存在大量的煤炭与天然气重叠赋存资源,出于对资源开采效率的要求,大量的煤与天然气重叠资源需要在同一时空内同步开采,传统的煤与天然气开采理论与技术难以满足协同开采出现的技术难题,煤与天然气协同开采的进程受到了严重制约。基... 详细信息

我国存在大量的煤炭与天然气重叠赋存资源,出于对资源开采效率的要求,大量的煤与天然气重叠资源需要在同一时空内同步开采,传统的煤与天然气开采理论与技术难以满足协同开采出现的技术难题,煤与天然气协同开采的进程受到了严重制约。基于此,结合国内煤与天然气重叠赋存情况对煤与天然气协同开采进行了科学定义,总结了已有可借鉴的煤与天然气开采技术和相关理论。建立了天然气井近场岩体力学理论、天然气近场围岩耦合损伤理论、“围岩–水泥环–套管”耦合损伤理论、煤与天然气协同开采垂直场围岩耦合损伤理论,揭示了煤与天然气协同开采围岩的耦合损伤机理,为煤与天然气技术体系的构建提供了理论基础。提出了“煤与天然气协同开采技术”“煤炭开采通过废弃井技术”和“天然气近场小煤柱留设技术”3项技术以及“协同开采分区规划系统”“透明地质与生产信息动态监测系统”和“煤与天然气协同区安全监测与评价系统”三大系统,为煤与天然气协同开采提供技术支持,提高煤炭与天然气资源的开采效率。在此基础上,构建了煤与天然气协同开采的理论与技术体系,明确了煤与天然气协同开采未来的研究重点,提出了我国煤与天然气资源安全、绿色、高效协同开采的技术路径与研究方向。

关键词：煤与天然气重叠资源协同开采无人智能化耦合损伤

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基于中厚板理论的顶板断裂失稳规律研究

岩石力学与工程学报 2024年第9期43卷 2092-2107页

作者：杨胜利岳豪唐岳松陈勇升惠鼎恒中国矿业大学(北京)能源与矿业学院北京100083 厚煤层绿色智能开采教育部工程研究中心北京100083 放顶煤开采煤炭行业工程研究中心北京100083 英属哥伦比亚大学NBK矿业工程学院加拿大不列颠哥伦比亚省温哥华V6T 1Z4

厚顶板工作面动载现象强烈,动载冲击作用下煤壁片帮、支架压架等现象常有发生。为了提升厚顶板条件下的采场围岩控制效果,以赵固二矿14030工作面为工程背景,采用理论分析、数值模拟和现场实测等方法,研究顶板变形与应力特征、破坏模式,... 详细信息

厚顶板工作面动载现象强烈,动载冲击作用下煤壁片帮、支架压架等现象常有发生。为了提升厚顶板条件下的采场围岩控制效果,以赵固二矿14030工作面为工程背景,采用理论分析、数值模拟和现场实测等方法,研究顶板变形与应力特征、破坏模式,探究动载效应及控制方法。结果表明:工作面初次来压时,最大拉应力和最大剪应力位于煤壁侧和开切眼侧中点,顶板发生拉伸破坏;周期来压时顶板在煤壁侧两端头形成了剪应力集中区,且剪切裂隙明显发育,顶板发生拉剪混合破坏。得到工作面推进距离与顶板厚度对拉(剪)应力的影响特征,分析顶板厚度效应对顶板破坏模式的影响。基于PFC3D建立顶板初次破断和周期破断数值模型,确定了顶板破坏形态、裂隙分布特征与破坏模式。基于砂体介入和厚度效应解释了顶板易发生剪切破坏的原因,揭示了顶板动载产生机制。利用动量守恒定理确定了顶板不同破断位置对采场造成的动载冲击力,得到液压支架受动载冲击影响的工作阻力,提出动载控制方法。研究结果可为中厚顶板或不满足薄板条件的顶板提供理论依据,指导中厚顶板工作面的安全生产。

关键词：采矿工程中厚板初次来压周期来压动载冲击

Probability and reliability analysis of pillar stability in South Africa

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International Journal of Mining Science and Technology 2018年第4期28卷 704-708页

作者： Gaofeng Song shengli yang School of Civil Engineering North China University of Technology College of Resources and Safety Engineering China University of Mining & Technology

A deterministic approach is frequently used in engineering design. In this quantitative design methodology, a safety factor, which is typically a strength-to-stress ratio, is derived as an index for the stability assessment of the engineering design. In underground coal mining applications such as pillar design,however, the inputs of pillar design are variables. This is widely overlooked in the deterministic approach. A probabilistic approach assessing the probability of failure or reliability of a system might be an alternative to the conventional quantitative methodology. This approach can incorporate the degree of uncertainty and deviations of variables and provide more versatile and reliable results. In this research, the reliability of case histories from stable and failed pillars of South Africa presented by Merwe and Mathey is examed. The updated Salamon and Munro strength formula(S-M formula) and Merwe and Mathey strength formula(M-M formula) are evaluated through a probabilistic approach. It is concluded that stable pillar cases have a reliability value greater than 0.83 while the reliability value of failed pillar cases are slightly larger than 0.50. There seems to be a positive relation between safety factor and reliability. The reliability of a pillar increases with pillar width but decreases with depth of cover, pillar height and entry width. The reliability analysis also confirms that M-M strength formula has a better distinction between the stable and failed pillar cases.

关键词： Pillar design Probabilistic approach Reliability Monte Carlo simulation

Editorial for the Special Issue on New Technology of Tumor Diagnosis and Treatment

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Engineering 2021年第10期7卷 1343-1344页

作者： Hongyang Wang shengli yang Fudan University Shanghai Cancer Center Shanghai 200032China International Cooperation Laboratory on Signal Transduction&Key Laboratory of Signaling Regulation and Targeting Therapy of Liver Cancer Ministry of Education&Shanghai Key Laboratory of Hepatobiliary Tumor BiologyEastern Hepatobiliary Surgery HospitalSecond Military Medical UniversityShanghai 200438China Shanghai Institute Nutrition and Health Chinese Academy of SciencesShanghai 200031China

Cancer is a global public health threat and a leading cause of death in *** 2020,the number of new cancer cases around the world reached approximately 19.3 million,and about 10.0 million cancer-related deaths *** diagnosis and treatment remain a huge challenge due to the diversity of cancer etiology,the complicated mechanism and long process of tumorigenesis,and the significant heterogeneity between *** cancer is a systemic disease,tumor diagnosis is *** treatment has evolved from the initial conventional surgery,radiotherapy,and chemotherapy to the current multimethod and multidisciplinary comprehensive *** the continuous deepening and advancement of research in disease biology,we have gained a better understanding of cancer.

关键词： diagnosis chemotherapy treatment

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工程教育通识课程智慧课堂设计与实践

大学教育 2024年第2期 11-16页

作者：吴仁伦侯运炳杨胜利中国矿业大学(北京) 北京100083

中国矿业大学(北京)工程教育通识课程——能源开发概论课程组在智慧课堂教学设计总体框架下,设计了以“课内讲授”为基础空间、承载“习得”“交流”“资源”三个互动空间的基本联结模式,并将其内嵌到教学实践中加以扩充,形成了该类课... 详细信息

中国矿业大学(北京)工程教育通识课程——能源开发概论课程组在智慧课堂教学设计总体框架下,设计了以“课内讲授”为基础空间、承载“习得”“交流”“资源”三个互动空间的基本联结模式,并将其内嵌到教学实践中加以扩充,形成了该类课程智慧课堂教学设计的整体框架与实操指导。该模式借鉴时空系统视角、学科交叉思维、教育教学原理、信息时代发展的基本理论与最新信息,优先结合学科特色、师生特点、可应用场景,实现了教学方法、学习内容、组织形式等教学要素的灵活组合及调整,有利于面向不同专业背景的学生开展工程类通识教育课程的教学活动,助力以理工科为特色的高校探索创新工程教育方式与手段。

关键词：工程教育通识课程智慧课堂教学设计互动联结

共同富裕背景下公共服务均等化对城乡居民收入差距的作用机制与实践检验

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石家庄铁道大学学报（社会科学版） 2024年第2期18卷 19-27页

作者：杨胜利王媛冯丹宁河北大学经济学院/共同富裕研究中心河北保定071000

基于2011—2020年省级面板数据,运用固定效应模型、中介效应模型检验了公共服务均等化对城乡收入差距的影响、作用机制及空间差异。结果表明:第一,公共服务均等化水平的提升能够有效降低城乡居民收入差距;第二,公共服务均等化对城乡收... 详细信息

基于2011—2020年省级面板数据,运用固定效应模型、中介效应模型检验了公共服务均等化对城乡收入差距的影响、作用机制及空间差异。结果表明:第一,公共服务均等化水平的提升能够有效降低城乡居民收入差距;第二,公共服务均等化对城乡收入差距的影响存在空间异质性,在西部地区、人口净流出较多的地区,公共服务均等化对城乡收入差距的影响更为显著;第三,公共服务均等化可以通过促进劳动力流动与人力资本积累两个渠道影响城乡收入差距。研究结论为国家和政府在新时期推动经济持续稳定发展、保障和改善民生、全面推动社会建设、促进共同富裕提供了参考。

关键词：公共服务均等化收入差距人口流动人力资本提升

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阿坝盆地黄土记录的青藏高原东部末次冰期环境变化

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海洋地质与第四纪地质 2024年第4期44卷 168-179页

作者：徐雪超刘丽杨胜利问琛李睿张景钊王海燕兰州大学资源环境学院西部环境教育部重点实验室兰州730000

青藏高原东部广泛分布的风成黄土沉积是记录过去气候变化和大气粉尘活动历史的重要陆地档案,恢复和重建其环境记录可以为深入理解高原环境演化过程和机制提供重要证据。本研究基于石英光释光测年建立了阿坝盆地各莫黄土剖面的年代框架,... 详细信息

青藏高原东部广泛分布的风成黄土沉积是记录过去气候变化和大气粉尘活动历史的重要陆地档案,恢复和重建其环境记录可以为深入理解高原环境演化过程和机制提供重要证据。本研究基于石英光释光测年建立了阿坝盆地各莫黄土剖面的年代框架,并利用多种环境代用指标重建了阿坝黄土记录的青藏高原东部约47 ka以来的环境变化历史。黄土磁化率、色度和碳酸盐记录表明深海氧同位素3阶段(MIS3)中晚期印度夏季风加强,青藏高原环境相对湿润。粒度重建结果记录了4次海因里希(Heinrich)事件和新仙女木(YD)事件,表明青藏高原末次冰期粉尘活动强烈,气候变化具有快速波动的特征。区域记录对比显示,北半球高纬地区气候系统对青藏高原地区快速气候变化有重要影响,大西洋经向翻转环流可能是高原地区粉尘活动和气候变化的主要控制因素。该研究为更好地认识青藏高原末次冰期环境演化过程提供了重要证据。

关键词：黄土光释光测年粒度磁化率末次冰期

The Quest for the Modernization and Internationalization of Traditional Chinese Medicine

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Engineering 2019年第1期5卷 1-2页

作者： Boli Zhang shengli yang De-an Guo Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Traditional Chinese medicine (TCM) is deeply rooted in ancient Chinese culture and has been practiced by Chinese people for thousands of years in order to maintain their health and fight against disease. This ancient Chinese wisdom has accumulated from the long struggle to cope with various diseases through hundreds or even thousands of trial-and-error practices. However, due to its empirical character, TCM has long been criticized as being deficient in scientific evidence, and is still not widely accepted by the mainstream conventional medical system. The complexity of the chemical components of TCM and the clarification of its mechanisms remain an enormous challenge in the conversion of TCM into an evidence-based medicine. Thanks to incredible progress in biomedical research, TCM has evolved at an astonishing pace in various aspects, as indicated by the 2015 Nobel Prize awarded to Professor Youyou Tu for her discovery of artemisinin.

关键词： Traditional Chinese medicine ancient Chinese has accumulated