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Punicalagin prevents obesity-related cardiac dysfunction through promoting DNA demethylation in mice

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Food Science and Human Wellness 2024年第3期13卷 1465-1474页

作者： shengjie Pei Run Liu Qingqing Ma Peng Jiang Xin He Zhongshi Qi Jiacheng Fang xu Yang Zirui Yao Xiaoqian Liu Xianfeng Jing Lei Chen Duo Li Institute of Nutrition&Health Qingdao UniversityQingdao 266071China School of Public Health Qingdao UniversityQingdao 266071China Central Laboratory Guizhou Aerospace HospitalZunyi 563000China Health Centers of Licha Town Qingdao 266071China College of Computer Science and Technology Qingdao UniversityQingdao 266071China

The aim of this study was to investigate whether punicalagin(PU)could prevent obesity-related cardiac dysfunction by promoting DNA demethy lation,and to explore its possible mechanism.C57BL/6J mice were fed with standard diet,high-fat diet(HFD),HFD supplemented with resveratrol,low-dose PU(LPU)and high-dose PU(HPU)for 8 *** with HFD group,body weight was significantly lower in PU treatment groups,number of cardionwocytes and the protein level of myosin heavy chain 7B were significantly higher in PU treatment *** of 5-hydroxymethylcytosine and 5-formylcytosine were significantly lower in HFD group than in other *** with the HFD group,the protein level of ten-eleven translocation enzyme(TET)2 was significantly higher in PU treatment groups,p-AMP-activated protein kinase(AMPK)was significantly higher in LPU *** of total antioxidant capacity and the protein levels of complexesⅡ/Ⅲ/Ⅴ,oxoglutarate dehydrogenase,succinate dehydrogenase B and fumarate hdrolase were significantly lower in HFD group than PU treatment *** ratio of(succinic acid+fumaric acid)/a-ketoglutarate was significantly higher in HFD group than other *** conclusion,PU up-regulated TETs enzyme activities and TET2 protein stability through alleviating mitochondrial dysfunction and activating AMPK,so as to promote DNA demethylation,thus preventing obesity-related cardiac dysfunction.

关键词： DNA demethylation Mitochondrial function Obesity-related cardiac dysfunction Punicalagin Ten-eleven translocation family enzymes

Design of All-Fused-Ring Electron Acceptors with High Thermal,Chemical,and Photochemical Stability for Organic Photovoltaics

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CCS Chemistry 2021年第6期3卷 1070-1080页

作者： Xiaozhang Zhu Songjun Liu Qihui Yue Wuyue Liu Shaoming Sun shengjie xu Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of ChemistryChinese Academy of SciencesBeijing 100190 School of Chemical Sciences University of the Chinese Academy of SciencesBeijing 100190

High-performance donor-acceptor electron acceptors containing 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile(INCN)-type terminals are labile toward photooxidation and basic conditions,and new molecular designs toward electron acceptors that can achieve both high power conversion efficiencies and high stability are urgently *** replacing the central benzene ring in the classical ladder-type n-type semiconductor,2,2′-(indeno[1,2-b]fluorene-6,12-diylidene)dimalononitrile,with the electron-rich 4,4,9,9-tetrahexyl-4,9-dihydro-s-indaceno[1,2-b:5,6-b′]dithiophene,we report herein the design of 2,2′-(7,7,15,15-tetrahexyl-7,15-dihydro-sindaceno[1,2-b:5,6-b′]diindeno[1,2-d]thiophene-2,10(2H)-diylidene)dimalononitrile(ITYM),a new type of all-fused-ring electron acceptor(AFRA).A threestep reaction including a key Pd-catalyzed double C-H activation/intramolecular cyclization is established for the efficient synthesis of such type of electron *** is confirmed by singlecrystal X-ray analysis,which shows a planar nonacyclic structure with strongπ-π*** with the classical carbon-bridged INCN-type acceptors,ITYM exhibits extraordinary stability with very promising *** AFRA concept opens a new avenue toward high-efficiency and-stability organic photovoltaics(OPVs).

关键词： organic photovoltaics nonfullerene acceptor all-fused-ring design C-H activation stability

Adhere to Win-Win Cooperation and Strengthen Confidence in Road of China:On My Visit with Delegation of CAFIU

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International Understanding 2016年第4期 46-47页

作者： xu shengjie Ma Jiatai the Chinese Association for International Understanding Henan Puyuan Construction Group Co. Ltd

People often say travelling is more eye-opening than reading/’Reading'sometimes cannot replace what you see or feel,and only what people see or feel during the process of'travelling'can inspire more profound thinking... 详细信息

关键词： Adhere to Win-Win Cooperation and Strengthen Confidence in Road of China

Ultrafast photoexcitation dynamics behavior of hydrogen-bonded polyfluorenol

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Chinese Chemical Letters 2024年第1期35卷 486-491页

作者： Man xu Chuanxin Wei Yunlong Zhang Hao Li Jingyao Ma Jinyi Lin shengjie Wang Wei xue Qi Wei Linghai Xie Wei Huang State Key Laboratory of Organic Electronics and Information Displays&School of Chemistry and Life Sciences&Institute of Advanced Materials(IAM) Nanjing University of Posts&TelecommunicationsNanjing 210023China Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM) Nanjing Tech University(NanjingTech)Nanjing 211816China Frontiers Science Center for Flexible Electronics(FSCFE) Shaanxi Institute of Flexible Electronics(SIFE)&Shaanxi Institute of Biomedical Materials and Engineering(SIBME)Northwestern Polytechnical UniversityXi’an 710072China

Exciton behavior is crucial to the exploitation of light-emitting conjugated polymer(LCPs)for optoelectronic *** excitons are easily trapped by the intrinsically defect ***,we set a polyfluorenol(PPFOH)as an example to systematically investigate its photophysical behavior to check the role of defect structures in *** to time-resolved photoluminescence analysis,the feature emission peaks from individual chain of PPFOH in diluted DMF solution is effectively avoided the influence of fluorenone formation,but the residual green-band emission at 550nm is easily observed in the PL spectra of PPFOH dilute toluene solution obtained delay 1.5 ns,confirmed the formation of“guest”physical aggregation-induced defect ***,efficient and ultrafast energy transfer from individual chain to defect structure is observed in PPFOH ***,the efficient energy transfer happened for the film obtained from DMF solution(200 ps)than those of toluene ones(600 ps).Meanwhile,compared to relatively stable green-band emission in PPFOH film from toluene solution,red-shifted emission peak(11 nm)of PPFOH film from DMF solutions exposed to saturated DNT vapor also confirmed their different aggregation-induced green-band ***,this aggregation defect structures are influenced on the photophysical property of LCPs in solid states.

关键词： Photoexcitation dynamics Polyfluorenol Aggregation behavior Energy transfer Exciton migration

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气垫船围裙成型数值计算与试验研究

中国造船 2022年第1期63卷 51-64页

作者：徐圣杰熊逸凡陈科杰汤宇嘉马涛唐文勇上海交通大学海洋工程国家重点实验室上海200240 中国船舶及海洋工程设计研究院上海200011

气垫船围裙为三维复杂柔性结构,承受的外载荷复杂,其成型计算具有强非线性特点,一直是气垫船研究的重点和难点。论文以某极地运输气垫船围裙为研究对象,采用有限元方法,基于动态显式求解法计算了围裙典型分段和全船围裙的成型,并通过围... 详细信息

气垫船围裙为三维复杂柔性结构,承受的外载荷复杂,其成型计算具有强非线性特点,一直是气垫船研究的重点和难点。论文以某极地运输气垫船围裙为研究对象,采用有限元方法,基于动态显式求解法计算了围裙典型分段和全船围裙的成型,并通过围裙典型分段模型成型试验和气垫船缩尺船模陆上静垫升试验分别对围裙成型计算方法及其对陆上静垫升特性的影响进行了分析。结果表明,基于有限元法的围裙成型计算方法较传统解析方法精度更高,与成型试验结果相比误差更小;全船围裙成型有限元计算结果与典型分段计算结果基本一致,基于全船围裙有限元法计算得到的静垫升特性参数预报精度较高,对提高气垫船总体性能预报精度具有指导意义。

关键词：气垫船围裙成型计算成型试验静垫升性能

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外泌体在癫痫炎症反应中的作用

中国神经免疫学和神经病学杂志 2022年第5期29卷 414-418页

作者：徐圣洁吴涛郭子正王中琳山东中医药大学第一临床医学院 250014 山东中医药大学附属医院 250014

癫痫是一种突发性大脑神经元高度同步化反复异常过度放电引起短暂性脑功能失调的慢性大脑疾病,中枢神经系统内特定区域的炎症反应是癫痫的共同特征之一。研究发现,外泌体可通过抑制胶质细胞激活、调节免疫应答等方式减轻炎症反应,并依... 详细信息

癫痫是一种突发性大脑神经元高度同步化反复异常过度放电引起短暂性脑功能失调的慢性大脑疾病,中枢神经系统内特定区域的炎症反应是癫痫的共同特征之一。研究发现,外泌体可通过抑制胶质细胞激活、调节免疫应答等方式减轻炎症反应,并依赖其脂质双层结构和能够穿越血-脑屏障的优势,可作为给药载体应用于癫痫的治疗。现就外泌体在癫痫炎症反应过程中作用的研究进展进行综述,以期寻求诊断与治疗癫痫的潜在方案。

关键词：外泌体癫痫炎症胶质细胞免疫应答

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针织纬编工艺设计基本方法

丝绸 2000年第10期37卷 30-32页

作者：许生杰杭州针织厂浙江杭州310009

针织纬编工艺设计包括使用的原料、组织结构、设备的选用、工艺流程及上机工艺参数等 ,文中对以上内容及纬编工艺设计中的三种常用方法一一作了介绍。

关键词：针织物纬编工艺设计原料组织结构设备

黄芪建中汤靶向BMAL1调控cAMP/PKA/CREB信号通路对3T3-L1细胞脂解及棕色化模型影响的研究

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北京中医药大学学报 2023年第10期46卷 1400-1410页

作者：吴涛曲一玮徐圣洁李晓王咏马度芳山东中医药大学中医学院济南250013 山东中医药大学第一临床医学院山东中医药大学附属医院

目的探索黄芪建中汤含药血清对异丙肾上腺素(ISO)诱导的3T3-L1脂肪细胞脂解及棕色化模型的抑制作用及与脑和肌肉芳烃受体核转录因子样蛋白-1(BMAL1)调控环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/环磷酸腺苷反应成分结合蛋白(CREB)信号通路的关... 详细信息

目的探索黄芪建中汤含药血清对异丙肾上腺素(ISO)诱导的3T3-L1脂肪细胞脂解及棕色化模型的抑制作用及与脑和肌肉芳烃受体核转录因子样蛋白-1(BMAL1)调控环磷酸腺苷(cAMP)/蛋白激酶A(PKA)/环磷酸腺苷反应成分结合蛋白(CREB)信号通路的关系。方法制备空白及黄芪建中汤含药血清。体外培养3T3-L1脂肪细胞,诱导其分化成熟后分为对照组、空白组、2.5%含药血清组、5%含药血清组、10%含药血清组。除对照组外,其余各组加入10 mmol/L ISO以构建脂肪细胞过度脂解及棕色化模型。采用油红O染色法和酶联免疫吸附剂测定(ELISA)法检测各组脂肪细胞内脂滴阳性面积比及其水解后产物的含量,采用实时荧光PCR法和蛋白质印迹法检测各组脂肪细胞脂解及棕色化相关基因及蛋白的表达,以筛选出最优体积分数的含药血清进行下一步慢病毒转染实验。取分化成熟的3T3-L1脂肪细胞,分别加入BMAL1小干扰RNA、空载体小干扰RNA,构建沉默BMAL1的3T3-L1脂肪细胞。将细胞分为空载体组、含药血清空载体组、BMAL1沉默组和含药血清BMAL1沉默组。各组加入ISO孵育后,油红O染色法检测各组脂肪细胞内脂滴阳性面积比;ELISA法检测各组脂肪细胞内甘油三酯(TG)、cAMP及培养基中游离脂肪酸(FFA)的含量;蛋白质印迹法检测PKA、CREB的蛋白表达;实时荧光PCR法检测激素敏感性脂肪酶(HSL)、甘油三酯脂肪酶(ATGL)、线粒体解偶联蛋白1(UCP1)和T-box转录因子1(TBX1)的mRNA表达。结果与2.5%及5%含药血清组比较,10%含药血清组细胞内cAMP含量及培养基中FFA含量降低(均P<0.05)、TG含量升高(P<0.05)、PKA蛋白表达降低(P<0.05)、HSL及ATGL mRNA表达降低(均P<0.05)。慢病毒转染3T3-L1脂肪细胞后,与空载体组比较,BMAL1沉默组中BMAL1蛋白表达降低(P<0.05),表明BMAL1沉默的脂肪细胞成功构建。与空载体组比较,BMAL1沉默组细胞内脂滴阳性面积比及TG含量降低(均P<0.05),培养基中FFA含量、细胞内cAMP含量和PKA、CREB蛋白表达升高(均P<0.05),HSL、ATGL、UCP1和TBX1 mRNA表达量升高(均P<0.05)。与BMAL1沉默组比较,含药血清BMAL1沉默组细胞内脂滴阳性面积比及TG含量升高(均P<0.05),培养基中FFA含量、细胞内cAMP含量、PKA和CREB蛋白表达降低(均P<0.05),HSL、ATGL、UCP1及TBX1的mRNA表达降低(均P<0.05)。结论黄芪建中汤含药血清可以抑制ISO诱导的3T3-L1脂肪细胞脂解及棕色化,其机制可能通过介导BMAL1调控cAMP/PKA/CREB信号通路有关。

关键词：黄芪建中汤恶病质脂肪消耗脑和肌肉芳烃受体核转录因子样蛋白-1 环磷酸腺苷/蛋白激酶A/环磷酸腺苷反应成分结合蛋白信号通路大鼠

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中文专利数据可视化分析系统研究与设计

计算机应用与软件 2023年第1期40卷 24-29页

作者：陈挺徐胜捷陈龙陆间张丽丽河海大学商学院江苏南京211100 河海大学计算机与信息学院江苏南京211100

现有的专利分析系统在可视化方面存在诸多不足,针对中文专利的可视化分析工具更是少之又少。结合文本挖掘技术,设计并实现“中文专利数据可视化分析系统”,具有专利态势分析、专利聚类分析、专利引证分析三种分析功能,多角度分析了中文... 详细信息

现有的专利分析系统在可视化方面存在诸多不足,针对中文专利的可视化分析工具更是少之又少。结合文本挖掘技术,设计并实现“中文专利数据可视化分析系统”,具有专利态势分析、专利聚类分析、专利引证分析三种分析功能,多角度分析了中文专利数据,并将数据分析结果通过可视化模块直观地呈现出来,为专利信息使用者提供更好服务。

关键词：专利分析可视化文本聚类系统设计