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Radiomics for predicting perineural invasion status in rectal cancer

World Journal of Gastroenterology 2021年第33期27卷 5610-5621页

作者： Mou Li Yu-mei Jin Yong-Chang Zhang Ya-Li Zhao Chen-Cui Huang sheng-mei liu Bin Song Department of Radiology West China Hospital of Sichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Radiology Chengdu Seventh People’s HospitalChengdu 610213Sichuan ProvinceChina Department of Research Collaboration R&D CenterBeijing Deepwise&League of PHD Technology Co.LtdBeijing 100080China

BACKGROUND Perineural invasion(PNI),as a key pathological feature of tumor spread,has emerged as an independent prognostic factor in patients with rectal cancer(RC).The preoperative stratification of RC patients according to PNI status is beneficial for individualized treatment and improved ***,the preoperative evaluation of PNI status is still *** To establish a radiomics model for evaluating PNI status preoperatively in RC *** This retrospective study enrolled 303 RC patients in a single institution from March 2018 to October *** patients were classified as the training cohort(n=242)and validation cohort(n=61)at a ratio of 8:2.A large number of intraand peritumoral radiomics features were extracted from portal venous phase images of computed tomography(CT).After deleting redundant features,we tested different feature selection(n=6)and machine-learning(n=14)methods to form 84 *** best performing classifier was then selected to establish ***,the clinicoradiological model(combined model)was developed by combining Rad-score with clinical *** models for predicting PNI were compared using receiver operating characteristic curve(ROC)analysis and area under the ROC curve(AUC).RESULTS One hundred and forty-four of the 303 patients were eventually found to be *** factors including CT-reported T stage(cT),N stage(cN),and carcinoembryonic antigen(CEA)level were independent risk factors for predicting PNI *** established Rad-score by logistic regression analysis after selecting features with the L1-based *** combined model was developed by combining Rad-score with cT,cN,and *** combined model showed good performance to predict PNI status,with an AUC of 0.828[95%confidence interval(CI):0.774-0.873]in the training cohort and 0.801(95%CI:0.679-0.892)in the validation *** comparison of the models,the combined model achieved a higher AUC than the clinic

关键词： Radiomics Perineural invasion Rectal cancer Computed tomography Preoperative prediction Model building

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Recent progress in the applications of presynaptic dopaminergic positron emission tomography imaging in parkinsonism

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Neural Regeneration Research 2025年第1期20卷 93-106页

作者： Yujie Yang Xinyi Li Jiaying Lu Jingjie Ge Mingjia Chen Ruixin Yao mei Tian Jian Wang Fengtao liu Chuantao Zuo Key Laboratory of Arrhythmias Ministry of EducationDepartment of Medical GeneticsShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina Department of Neurology National Research Center for Aging and MedicineNational Center for Neurological Disordersand State Key Laboratory of Medical NeurobiologyHuashan HospitalFudan UniversityShanghaiChina Department of Nuclear Medicine&PET Center National Center for Neurological Disordersand National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghaiChina International Human Phenome Institutes(Shanghai) ShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Nowadays,presynaptic dopaminergic positron emission tomography,which assesses deficiencies in dopamine synthesis,storage,and transport,is widely utilized for early diagnosis and differential diagnosis of *** review provides a comprehensive summary of the latest developments in the application of presynaptic dopaminergic positron emission tomography imaging in disorders that manifest *** conducted a thorough literature search using reputable databases such as PubMed and Web of *** criteria involved identifying peer-reviewed articles published within the last 5 years,with emphasis on their relevance to clinical *** findings from these studies highlight that presynaptic dopaminergic positron emission tomography has demonstrated potential not only in diagnosing and differentiating various Parkinsonian conditions but also in assessing disease severity and predicting ***,when employed in conjunction with other imaging modalities and advanced analytical methods,presynaptic dopaminergic positron emission tomography has been validated as a reliable in vivo *** validation extends to screening and exploring potential neuropathological mechanisms associated with dopaminergic *** summary,the insights gained from interpreting these studies are crucial for enhancing the effectiveness of preclinical investigations and clinical trials,ultimately advancing toward the goals of neuroregeneration in parkinsonian disorders.

关键词： aromatic amino acid decarboxylase brain imaging dopamine transporter Parkinson’s disease parkinsonism positron emission tomography presynaptic dopaminergic function vesicle monoamine transporter type 2

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Kruppel样因子4对内毒素所致IL-6基因表达的调控及机制研究

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生物化学与生物物理进展 2009年第10期36卷 1313-1318页

作者：冯衍生刘梅冬刘瑛刘俊文陈广文张华莉肖献忠中南大学湘雅医学院病理生理学系长沙410078

探讨Kruppel样因子4(KLF4)对内毒素所致白介素(IL-6)的基因表达以及释放的影响,并对其调控机制做了初步研究.使用RT-PCR和Westernblot检测KLF4mRNA和蛋白质的表达.采用KLF4过表达的RAW264.7巨噬细胞株或反义寡核苷酸技术抑制内源性KLF4... 详细信息

探讨Kruppel样因子4(KLF4)对内毒素所致白介素(IL-6)的基因表达以及释放的影响,并对其调控机制做了初步研究.使用RT-PCR和Westernblot检测KLF4mRNA和蛋白质的表达.采用KLF4过表达的RAW264.7巨噬细胞株或反义寡核苷酸技术抑制内源性KLF4的表达,用RT-PCR和ELISA检测内毒素(LPS)刺激后IL-6mRNA和蛋白质的表达.采用荧光素酶报告基因检测RAW264.7细胞中KLF4过表达对IL-6基因启动子报告基因转录活性的影响.使用EMSA法检测细胞中KLF4与IL-6基因启动子区KLF4元件的结合.结果表明:LPS可以诱导RAW264.7巨噬细胞KLF4的表达以及IL-6蛋白表达.KLF4过表达明显抑制IL-6的mRNA和蛋白质的表达,而KLF4缺失使这种作用消失.荧光素酶报告基因的结果显示,KLF4可以抑制LPS所致的IL-6基因启动子的转录活性.EMSA显示KLF4不能与IL-6启动子区的KLF4结合元件直接结合.结果表明,LPS可以促进RAW264.7小鼠巨噬细胞KLF4的表达和IL-6的释放.KLF4能抑制LPS诱导的IL-6表达和释放,其机制是抑制IL-6启动子的转录活性,但KLF4的抑制作用不是通过直接与IL-6基因的启动子区相结合而实现的.

关键词： Kruppel样因子4(KLF4) 内毒素(LPS) 白介素6(IL-6) 炎症

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-Qiang Jiao Ming Li Xi Chen mei-Ze Xu Tian Ding Xiao-Ping Gong Zhuo-mei Li Xue-Yuan liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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多壁碳纳米管固定化生物酶修饰电极检测杂色曲霉素的初步研究

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生物工程学报 2004年第4期20卷 601-606页

作者：姚冬生文圣梅刘大岭谢春芳白燕冉艳红暨南大学生命科学技术学院生物技术室暨南大学生命科学技术学院化学系分析化学教研室广州510632

杂色曲霉素 (ST)是一种致癌致畸的真菌毒素 ,已报道的检测ST的技术有TLC、HPLC、ELISA以及毒素基因的PCR检测技术。初步探索了酶生物传感器三电极系统对ST的电化学分析。在实验中 ,应用多壁碳纳米管作为分子识别元件ADTZ的固定化基质和... 详细信息

杂色曲霉素 (ST)是一种致癌致畸的真菌毒素 ,已报道的检测ST的技术有TLC、HPLC、ELISA以及毒素基因的PCR检测技术。初步探索了酶生物传感器三电极系统对ST的电化学分析。在实验中 ,应用多壁碳纳米管作为分子识别元件ADTZ的固定化基质和传感器的电子传递体构建了Au工作电极 ,对ST进行CV和DPV分析 ,结果表明 :ST在 - 6 0 0mV位置有一明显的特征还原峰电位 ,线性检测范围是 8 32× 1 0 - 5～ 6 6 5 6× 1 0 - 5mg mL ,检测下限为8 32× 1 0 - 5mg mL ,响应时间 1 0s。

关键词：杂色曲霉素多壁碳纳米管酶传感器

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当归补血合剂对放射性肺炎小鼠血清转化生长因子和超氧化物歧化酶的影响

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中国卫生检验杂志 2016年第20期26卷 2920-2921,2924页

作者：刘利胜刘美芹龚继勇陈海生刘敏山东大学附属山东省肿瘤医院检验科山东济南250117 山东大学附属山东省肿瘤医院药学部山东济南250117

目的研究当归补血合剂对放射性肺炎模型小鼠血清转化生长因子(TGF-β1)、超氧化物歧化酶(SOD)的影响,以了解当归补血合剂对放射性肺炎的防治作用。方法将60只昆明小鼠随机分为4组:对照组、单纯给药组、单纯照射组、照射给药组;每组15只... 详细信息

目的研究当归补血合剂对放射性肺炎模型小鼠血清转化生长因子(TGF-β1)、超氧化物歧化酶(SOD)的影响,以了解当归补血合剂对放射性肺炎的防治作用。方法将60只昆明小鼠随机分为4组:对照组、单纯给药组、单纯照射组、照射给药组;每组15只,建立急性放射性肺炎小鼠模型,以当归补血合剂灌胃给药,照射后21 d,检测TGF-β1以及SOD的含量变化;并制作小鼠肺组织切片行HE染色,观察小鼠肺组织病理改变。结果照射给药组血清TGF-β1浓度低于单纯照射组,照射给药组和单纯照射组TGF-β1的浓度均高于对照组和单纯给药组,差异有统计学意义(P<0.01);而照射给药组以及单纯照射组血清SOD的浓度低于对照组和单纯给药组,但照射给药组SOD浓度高于单纯照射组,差异均有统计学意义(P<0.01)。结论当归补血合剂可降低急性放射性肺炎小鼠的血清TGF-β1浓度,提高血清SOD的含量,在一定程度上减轻急性肺损伤,对放射性肺炎有一定的防护作用。

关键词：放射性肺炎转化生长因子β1 超氧化物歧化酶当归

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缺血性结肠炎的临床特点

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山西医科大学学报 2004年第3期35卷 262-264页

作者：冯秀生庞梅梅刘旭光山西省阳泉市第一人民医院消化内科阳泉045000

目的　探讨缺血性结肠炎 (IC)患者的临床、内镜及选择性血管造影特点及诊断治疗。方法　分析 2 4例缺血性结肠炎(IC)患者的一般资料、临床表现、结肠镜检查、病理组织学、选择性血管造影、治疗反应等改变。结果　本病多发生于 5 0岁以... 详细信息

目的　探讨缺血性结肠炎 (IC)患者的临床、内镜及选择性血管造影特点及诊断治疗。方法　分析 2 4例缺血性结肠炎(IC)患者的一般资料、临床表现、结肠镜检查、病理组织学、选择性血管造影、治疗反应等改变。结果　本病多发生于 5 0岁以上的中老年人 (87.5 0 % ) ,女性多见 (女∶男为 2∶1) ,且多数 (79.2 % )伴有基础疾病 ,包括心血管疾病、糖尿病、心律失常、腹部手术史。临床表现为腹痛、血便及腹泻等 ,病变多数局限在左半结肠。病变大多为一过性 ,早期内镜和选择性血管造影有助于诊断。早期诊断和尽早使用扩血管及防治感染药物治疗 ,多数预后良好。结论　结肠镜检查、选择性血管造影是诊断缺血性结肠炎 (IC)的主要方法。本病应尽早选用扩血管及防治感染药物进行治疗。

关键词：结肠炎缺血性结肠镜检查血管造影术

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Oxidation of Mercaptans from Light Oil Sweetening by Fe_2O_3/MgO/Al_2O_3 Supported CoPcS Catalyst

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China Petroleum Processing & Petrochemical Technology 2010年第3期12卷 12-17页

作者： mei Hua liu Hui sheng Kuang College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing 210009 Research Center of Surface and Interface Chemical and Engineering Technology Nanjing University

MgO/Al2O3 and Fe2O3/MgO/Al2O3 solid bases were prepared through mixing method. After sulfonated cobalt phthalocyanine （CoPcS） being supported on these solid bases, the catalytic performance of these catalysts was evaluated by means of mercaptan oxidation reaction. The samples were characterized by X-ray diffraction （XRD）, CO2 temperature-programmed desorption （CO2-TPD）, FTIR spectroscopy, and X-ray photoelectron spectroscopy （XPS）. Investigation was focused on the effect of Fe2O3 on activity, crystal structure, basicity, and stability of the catalyst and also on the role of Fe2O3 in the mercaptan oxidation processes. Test results have shown that the Fe2O3/MgO/Al2O3- CoPcS catalyst has a higher initial activity and a much longer service life than the MgO/Al2O3-CoPcS catalyst. The increased types of basic sites coupled with an enhanced oxidation ability resulted from the addition of Fe2O3 have contributed to the improvement of the catalytic activity of the MgO/Al2O3-CoPcS catalyst.

关键词： mercaptan oxidation solid base Fe2O3/MgO/Al2O3

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Dynamics and screening characteristics of a vibrating screen with variable elliptical trace

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Mining Science and Technology 2009年第4期19卷 508-513页

作者： HE Xiao-mei liu Chu-sheng School of Mechanical and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

The ideal motion characteristics for the vibrating screen was presented according to the principle of screening process with constant bed thickness.A new vibrating screen with variable elliptical trace was *** accurate mechanical model was constructed according to the required structural motion *** multi-degree-of-freedom vibration theory,characteristics of the vibrating screen was *** parameters of the vibrating screen which motion traces were linear,circular or elliptical were *** stable solutions of the dynamic equations gave the motions of the vibrating screen by means of computer *** parameters,including amplitude,movement velocity and throwing index,of five specific points along the screen surface were gained by theoretical *** results show that the traces of the new designed vibrating screen follow the ideal screening *** screening efficiency and processing capacity may thus be effectively improved.

关键词： variable elliptical trace screening process with constant bed thickness dynamic model motion characteristic screening characteristics

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加热炉炉温的模糊广义预测控制仿真研究

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化工自动化及仪表 2017年第7期44卷 624-627,642页

作者：薛美盛刘波孟俊杨猛秦宇海中国科学技术大学信息科学技术学院江苏庞景节能科技有限公司

针对加热炉炉温的大惯性、大滞后及非线性等特点,提出一种基于T-S模糊模型的模糊广义预测控制策略。T-S模糊模型的前件和后件参数分别采用粒子群优化的模糊C-均值算法和递推最小二乘法辨识,根据输入变量更新模型隶属度并将T-S模糊模型... 详细信息

针对加热炉炉温的大惯性、大滞后及非线性等特点,提出一种基于T-S模糊模型的模糊广义预测控制策略。T-S模糊模型的前件和后件参数分别采用粒子群优化的模糊C-均值算法和递推最小二乘法辨识,根据输入变量更新模型隶属度并将T-S模糊模型等价转换为线性模型,以此作为预测模型应用于广义预测控制。仿真结果表明:该方法在不同工况下均具有较短的调节时间,在扰动作用下有很强的鲁棒性。

关键词：模糊广义预测控制加热炉炉温 T-S模糊模型

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