检索结果-南通市图书馆

Therapeutic effects of the extract of Sancao Formula, a Chinese herbal compound, on imiquimod-induced psoriasis via cysteine-rich protein 61

引用

Journal of Integrative Medicine 2022年第4期20卷 376-384页

作者： Wan-jun Guo Yi Wang Yu Deng Lin-yan Cheng Xin Liu Ruo-fan Xi sheng-jie zhu Xin-yi Feng Liang Hua Kan Ze Jian-yong zhu Dong-jie Guo Fu-lun Li Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China School of Medicine Chengdu UniversityChengdu 610106Sichuan ProvinceChina Institute of Cancer Biology and Drug Discovery Chengdu UniversityChengdu 610106Sichuan ProvinceChina Clinical Laboratory Medicine Center Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

Objective: Psoriasis is a common chronic inflammatory skin disease that is prone to recurrence, and the proinflammatory factor, cysteine-rich protein 61(Cyr61), is important in its pathophysiology. Long-term clinical practice has shown that Sancao Formula(SC), a Chinese herbal compound, is effective in the treatment of psoriasis, but the precise mechanism remains unknown. In this study, we investigate the mechanism by which SC extract alleviates imiquimod(IMQ)-induced ***: The expression of Cyr61 in psoriatic lesions and normal healthy skin was detected using immunohistochemical analysis to investigate the biological role of Cyr61 in models of psoriatic inflammation. A psoriatic mouse model was established by topical application of IMQ, and the effect of topical application of SC extract was evaluated using the psoriasis area and severity index(PASI) score,hematoxylin-eosin staining, and histopathological features of the skin. Next, a HaCaT cell inflammation model was established using interferon-γ(IFN-γ), and the effect of SC extract on the mRNA and protein levels of Cyr61 and intercellular cell adhesion molecule-1(ICAM-1) was confirmed using Western blot and quantitative real-time polymerase chain reaction ***: Immunohistochemical staining showed that the expression of Cyr61 in psoriatic lesions was higher than that in normal skin samples(78.26% vs 41.18%, P < 0.05), and the number of Cyr61-positive cells in psoriatic lesions was also significantly higher than in normal skin(18.66 ± 2.51 vs4.33 ± 1.52, P < 0.05). Treatment in mice with IMQ-induced psoriasis showed that SC extract could significantly improve the inflammatory phenotype, PASI score(10.875 ± 0.744 vs 3.875 ± 0.582, P < 0.05),and pathological features compared with those in IMQ model group;SC treatment was also associated with decreased levels of Cyr61 and ICAM-1. In the IFN-γ-induced inflammatory cell model, the mRNA and protein levels of Cyr61 and ICAM-1 were upregulated, w

关键词： Traditional Chinese medicine Sancao Formula Psoriasis Plant extracts Cysteine-rich protein 61 Intercellular cell adhesion molecule-1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Cyano migration-mediated radical-polar crossover cyclopropanation

引用

Science China Chemistry 2025年第01期 241-248页

作者： Ziqiang Wang Yasu Chen jie Li Chen zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

人工集鱼装置对黄鳍金枪鱼生物学及其生态学影响的研究进展

引用

大连海洋大学学报 2017年第3期32卷 373-380页

作者：叶圣杰朱国平上海海洋大学海洋科学学院上海201306 国家远洋渔业工程技术研究中心上海201306 大洋渔业资源可持续开发省部共建教育部重点实验室上海201306

随着人工集鱼装置(FAD)在热带大洋海域的广泛使用,金枪鱼围网渔业产量大幅增加,但同时也造成了诸多生态影响。为了更好地了解人工集鱼装置对黄鳍金枪鱼Thunnus albacares生物学与生态学产生的影响,从人工集鱼装置下黄鳍金枪鱼的行为方式... 详细信息

随着人工集鱼装置(FAD)在热带大洋海域的广泛使用,金枪鱼围网渔业产量大幅增加,但同时也造成了诸多生态影响。为了更好地了解人工集鱼装置对黄鳍金枪鱼Thunnus albacares生物学与生态学产生的影响,从人工集鱼装置下黄鳍金枪鱼的行为方式,生物学与生态学影响,以及全球针对人工集鱼装置的管理等方面,总结了近30年来国内外关于人工集鱼装置与黄鳍金枪鱼相互关系的研究成果。结果表明:人工集鱼装置的大规模使用可能会潜在地影响黄鳍金枪鱼原有的行为规律,但因标志、个体数量和试验时间等因素的限制,影响的程度和方式尚需进一步研究;人工集鱼装置会影响到黄鳍金枪鱼种群的健康与生长以及摄食习惯;一些新技术和手段(水下声学装置、标志放流、卫星定位等)的发展也促进了该领域的研究,但无法掌握鱼群较长时间内的行为规律,标志放流技术,尤其是档案式标志放流将成为将来研究的主要方式,同时应将研究重点从对单个人工集鱼装置的研究提升到对网络式分布的人工集鱼装置上,从而阐明人工集鱼装置是否会对黄鳍金枪鱼的行为产生交互影响,漂流人工集鱼装置的相关研究也应进一步加强;全球针对人工集鱼装置渔法的管理日趋严格,各区域性渔业管理组织和沿海国出台的相关措施也使得人工集鱼装置渔法的前景呈现较大的不确定性。

关键词：人工集鱼装置黄鳍金枪鱼行为方式

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hengqin:Gateway for Going Global

引用

China Today 2025年第1期74卷 50-53页

作者： zhu jie zhuhai Dahengqin Company Limited

The synergy and complementary strengths between Macao and Hengqin can create an important channel for Chinese companies to *** enterprises have placed much emphasis on going global in recent years,from traditional manufacturing giants to emerging tech unicorns,and from traditional sectors to emerging industries like electric vehicles,lithium batteries,and photovoltaic *** enthusiasm to internationalize reached unprecedented levels in 2024.

关键词： companies Gateway lithium

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Study on Surface Topography of Lithium Tantalate Implanted with Helium Ions

引用

近代物理研究所和兰州重离子加速器实验室年报：英文版 2009年第1期 83-84页

作者： Pang Lilong Wang Zhiguang Zang Hang Yao Cunfeng Sun Jianrong Wei Kongfang Shen Tielong Ma Yizhun sheng Yanbin Gou jie zhu Yabin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

轻量级可移交CA的MANET网络认证体系

引用

计算机科学 2017年第3期44卷 145-149,157页

作者：郭萍傅德胜朱节中成亚萍南京信息工程大学计算机与软件学院江苏省网络监控中心南京210044 南京信息工程大学滨江学院南京210044

为解决移动自组网(Mobile Ad Hoc Network,MANET)网络信道开放、节点灵活多变且资源受限以及难以部署复杂认证机制的问题,结合轻量级CA思想,构造出一种适用于生存周期短、拓扑结构高度动态变化的MANET的认证体系结构即轻量级可移交认证... 详细信息

为解决移动自组网(Mobile Ad Hoc Network,MANET)网络信道开放、节点灵活多变且资源受限以及难以部署复杂认证机制的问题,结合轻量级CA思想,构造出一种适用于生存周期短、拓扑结构高度动态变化的MANET的认证体系结构即轻量级可移交认证中心(Lightweight and Shifted Certification Authority,LSCA)。LSCA结构简化了传统基于证书CA机制的公钥产生及验证的复杂性,无需证书管理;同时以移交CA角色的方式工作,不需预先配置节点及预知网络拓扑结构,使系统在不采用门限机制的情况下具备一定的容侵能力。性能分析及仿真实验表明:LSCA对DoS攻击表现出较强的健壮性,在通信、计算及存储代价方面均优于分布式CA及门限机制CA,适用于动态多变、生存周期较短的MANET网络应用。

关键词：无线网络安全移动自组网(MANET) 轻量级移交CA(LSCA) 认证体系

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

引用

Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

水基浆料涂覆结合原位反应制备C_f/SiC复合材料表面光学涂层（英文）

引用

无机材料学报 2017年第2期32卷 210-214页

作者：宋盛星殷杰朱云洲黄毅华刘学建黄政仁中国科学院上海硅酸盐研究所高性能陶瓷和超微结构国家重点实验室上海200050 中国科学院大学北京100049

本研究提出一种C_f/SiC复合材料表面改性新方法为水基浆料涂覆结合原位反应烧结工艺。系统研究了SiC和炭黑在水基浆料中的共分散、粘结剂的量和浆料固含量对浆料流变性能的影响、涂层的微观结构和性能等。研究结果表明:采用水基浆料涂... 详细信息

本研究提出一种C_f/SiC复合材料表面改性新方法为水基浆料涂覆结合原位反应烧结工艺。系统研究了SiC和炭黑在水基浆料中的共分散、粘结剂的量和浆料固含量对浆料流变性能的影响、涂层的微观结构和性能等。研究结果表明:采用水基浆料涂覆工艺可在基材表面制备一层气孔率达49%的多孔C/SiC预涂层;通过液相渗硅原位反应工艺,多孔预涂层转变为高致密、与基材强结合的光学涂层,并且在涂层与基材间形成了~15μm的化学反应过渡层;Si/SiC涂层的维氏硬度为(14.19±0.46)GPa,断裂韧性为(3.02±0.30)MPa·m1/2;经过精细研磨抛光,涂层的表面粗糙度可达2.97 nm RMS。

关键词： Si/SiC涂层 Cf/SiC 水基浆料涂覆反应烧结

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Trinuclear gold-catalyzed site-selective alkylation of peptides

引用

Science China Chemistry 2025年第1期 249-256页

作者： Qing-Yun Fang Chengyihan Gu Yinghan Chen Wencheng Yan Yong Liang Weipeng Li Chengjian zhu jie Han Jin Xie State Key Laboratory of Coordination Chemistry Jiangsu Key Laboratory of Advanced Organic Materials Chemistry and Biomedicine Innovation Center (Chem BIC) School of Chemistry and Chemical Engineering Nanjing University Green Catalysis Center College of Chemistry Zhengzhou University State Key Laboratory of Natural Medicines China Pharmaceutical University

Selective modification of peptides has always been a challenging issue. The selective alkylation of peptides can alter the biological activity and physical properties of molecules, and it has gained significant research interest. We herein disclose an intriguing gold-catalyzed alkylation of peptides using bench-stable unactivated alkyl bromides under photoredox catalysis. A wide range of structurally diverse primary, secondary and tertiary alkyl bromides serve as effective coupling partners to precisely connect with the α-C(sp3)–H in glycine residue of peptides. This protocol demonstrates an exceptionally broad scope for alkyl halides and excellent tolerance for a wide range of useful functional groups. A series of relay transformations to construct cyclic peptides, to proceed click reaction and to realize peptide fluorescence labeling further enhance its synthetic practicality. In addition, mechanistic studies and density functional theory(DFT) calculations reveal an inner-sphere and subsequent outersphere single electron transfer(SET) mechanism.

关键词：

来源：

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

引用

Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-jie zhu Xiao-Jia Yang Qian-Ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：