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Optimized simulated annealing algorithm for thinning and weighting large planar arrays

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Journal of Zhejiang University-Science C(Computers and Electronics) 2010年第4期11卷 261-269页

作者： Peng CHEN Bin-jian SHEN li-sheng zhou Yao-wu CHEN Institute of Advanced Digital Technologies and lnstrumentation Zhejiang University Hangzhou 310027 China Hangzhou Applied Acoustics Research Institute Hangzhou 310012 China

This paper proposes an optimized simulated annealing(SA) algorithm for thinning and weighting large planar arrays in 3D underwater sonar imaging *** optimized algorithm has been developed for use in designing a 2D planar array(a rectangular grid with a circular boundary) with a fixed side-lobe peak and a fixed current taper ratio under a narrow-band *** extensions of the SA algorithm and the procedure for the optimized SA algorithm are *** examples of planar arrays are used to assess the efficiency of the optimized *** proposed method achieves a similar beam pattern performance with fewer active transducers and faster convergence ability than previous SA algorithms.

关键词： Simulated annealing(SA) Sparse planar arrays 3D underwater sonar imaging Beam pattern Optimization

Static Anti-windup Synthesis for a Class of linear Systems Subject to Actuator Amplitude and Rate Saturation

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自动化学报 2009年第7期35卷 1003-1006页

作者： liU sheng zhou li-Ming College of Automation Harbin Engineering University Harbin150001 P.R. China

For a wide class of linear saturated systems, we address the anti-windup synthesis problem. By absorbing the actuator dynamics into the augmented system, we show that the original system can be simplified to a larger system with only amplitude saturation. The static anti-windup gain is therefore obtained through the proposed linear matrix inequality (LMI) based optimization procedures with regional closed-loop stability and minimized nonlinear L2 gain. A simulation example illustrates the effectiveness of the approaches.

关键词：自动化系统动力系统机械设计设计方案

Basic Study Long non-coding RNA TP73-AS1 promotes pancreatic cancer growth and metastasis through miRNA-128-3p/GOLM1 axis

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World Journal of Gastroenterology 2021年第17期27卷 1993-2014页

作者： Bin Wang Xing Sun Ke-Jian Huang li-sheng zhou Zheng-Jun Qiu Department of General Surgery Shanghai General HospitalShanghai Jiao Tong University School of MedicineShanghai 200080China

BACKGROUND Previous studies have suggested that long non-coding RNAs(lncRNA)TP73-AS1 is significantly upregulated in several ***,the biological role and clinical significance of TP73-AS1 in pancreatic cancer(PC)remain *** To investigate the role of TP73-AS1 in the growth and metastasis of *** The expression of lncRNA TP73-AS1,miR-128-3p,and GOLM1 in PC tissues and cells was detected by quantitative real-time polymerase chain *** bioinformatics prediction software ENCORI was used to predict the putative binding sites of *** regulatory roles of TP73-AS1 and miR-128-3p in cell proliferation,migration,and invasion abilities were verified by Cell Counting Kit-8,wound-healing,and transwell assays,as well as flow cytometry and Western blot *** interactions among TP73-AS1,miR-128-3p,and GOLM1 were explored by bioinformatics prediction,luciferase assay,and Western *** The expression of TP73-AS1 and miRNA-128-3p was dysregulated in PC tissues and *** TP73-AS1 expression was correlated with a poor ***73-AS1 silencing inhibited PC cell proliferation,migration,and invasion in vitro as well as suppressed tumor growth in ***,TP73-AS1 was validated to promote PC progression through GOLM1 upregulation by competitively binding to *** Our results demonstrated that TP73-AS1 promotes PC progression by regulating the miR-128-3p/GOLM1 axis,which might provide a potential treatment strategy for patients with PC.

关键词： Pancreatic cancer Long non-coding RNA TP73-AS1 miR-128-3p GOLM1

Multiple sub-array beamspace CAATI algorithm for multi-beam bathymetry system

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Journal of Marine Science and Application 2007年第1期6卷 47-52页

作者： li Zi-sheng li Hai-sen zhou Tian YUAN Yan-yi College of Underwater Acoustic Engineering Harbin Engineering University Harbin 150001 China

This paper extends CAATI （Computed Angle-of-Arrival Transient Imaging） technique of Multi-angle Swath Bathymetry Sidesean Sonar （MSBSS） into Multi-Beam Bathymetry Sonar （MBBS） and presents a new Multiple Sub-array Beamspaee - CAATI （MSB-CAATI） algorithm. The method not only can achieve high resolution seafloor mapping in the whole wide swath, but also can work well in complex acoustic environments or geometries. Simulation results and processing results of sea-experiment data prove the validity and superiority of the algorithm.

关键词： MSB-CAATI swath bathymetry high resolution multi-beam

Composition and immuno-stimulatory properties of extracellular DNA from mouse gut flora

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World Journal of Gastroenterology 2017年第44期23卷 7830-7839页

作者： Ce Qi Ya li Ren-Qiang Yu sheng-li zhou Xing-Guo Wang Guo-Wei Le Qing-Zhe Jin Hang Xiao Jin Sun The Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of EducationSchool of BiotechnologyJiangnan University School of Food Science and Technology Jiangnan University Wuxi Maternal and Child Health Hospital Quality of Research and Development Department COFCO Fortune Food Sales&Distribution Co.Ltd. Department of Food Science University of Massachusetts 不详

AIM To demonstrate that specific bacteria might release bacterial extracellular DNA(e DNA) to exert immunomodulatory functions in the mouse small *** Extracellular DNA was extracted using phosphate buffered saline with 0.5 mmol/L dithiothreitol combined with two phenol extractions. TOTO-1 iodide, a cell-impermeant and high-affinity nucleic acid stain, was used to confirm the existence of e DNA in the mucus layers of the small intestineand colon in healthy Male C57 BL/6 mice. Composition difference of e DNA and intracellular DNA(i DNA) of the small intestinal mucus was studied by Illumina sequencing and terminal restriction fragment length polymorphism(T-RFLP). Stimulation of cytokine production by e DNA was studied in RAW264.7 cells in *** TOTO-1 iodide staining confirmed existence of e DNA in loose mucus layer of the mouse colon and thin surface mucus layer of the small intestine. Illumina sequencing analysis and T-RFLP revealed that the composition of the e DNA in the small intestinal mucus was significantly different from that of the i DNA of the small intestinal mucus bacteria. Illumina Miseq sequencing showed that the e DNA sequences came mainly from Gram-negative bacteria of Bacteroidales S24-7. By contrast, predominant bacteria of the small intestinal flora comprised Grampositive bacteria. Both e DNA and i DNA were added to native or lipopolysaccharide-stimulated Raw267.4 macrophages, respectively. The e DNA induced significantly lower tumor necrosis factor-α/interleukin-10(IL-10) and IL-6/IL-10 ratios than i DNA, suggesting the predominance for maintaining immune homeostasis of the *** Our results indicated that degraded bacterial genomic DNA was mainly released by Gram-negative bacteria, especially Bacteroidales-S24-7 and Stenotrophomonas genus in gut mucus of mice. They decreased pro-inflammatory activity compared to total gut flora genomic DNA.

关键词： Bacterial extracellular DNA Flora Immunestimulatory property Gut microbiota Mouse Small intestine

Clinicopathological characterization of ten patients with primary malignant melanoma of the esophagus and literature review

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1739-1757页

作者： sheng-li zhou lian-Qun Zhang Xue-Ke Zhao Yue Wu Qiu-Yu liu Bo li Jian-Jun Wang Rui-Jiao Zhao Xi-Juan Wang Yi Chen li-Dong Wang ling-Fei Kong Department of Pathology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina Department of Gastroenterology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina State Key Laboratory of Esophageal Cancer Prevention and Treatment Henan Key Laboratory for Esophageal Cancer ResearchThe First Affiliated HospitalZhengzhou UniversityZhengzhou 450052Henan ProvinceChina Department of Radiology Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina Department of Thoracic Surgery Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina Department of Pediatrics Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina Clinical Research Service Center Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityPeople’s Hospital of Henan UniversityZhengzhou 450003Henan ProvinceChina

BACKGROUND Primary malignant melanoma of the esophagus(PMME) is a rare malignant disease and has not been well characterized in terms of clinicopathology and *** To investigate the clinical features and survival factors in Chinese patients with *** The clinicopathological findings of ten cases with PMME treated at Henan Provincial People’s Hospital were summarized. Moreover, the English-and Chinese-language literature that focused on Chinese patients with PMME from 1980 to September 2021 was reviewed and analyzed. Univariate and multivariate analyses were employed to investigate the clinicopathologic factors that might be associated with *** A total of 290 Chinese patients with PMME, including ten from our hospital and 280 from the literature were enrolled in the present study. Only about half of the patients(55.8%) were accurately diagnosed before surgery. Additionally, 91.1% of the patients received esophagectomy, and 88 patients(36.5%) received adjuvant therapy after surgery. The frequency of lymph node metastasis(LNM) was 51.2%(107/209), and LNM had a positive rate of 45.3% even when the tumor was confined to the submucosal layer. The risk of LNM increased significantly with the p T stage [P < 0.001, odds ratio(OR): 2.47, 95% confidence interval(CI): 1.72-3.56] and larger tumor size(P = 0.006, OR: 1.21, 95%CI: 1.05-1.38). The median overall survival(OS) was 11.0 mo(range: 1-204 mo). The multivariate Cox analysis showed both the p T stage [P = 0.005, hazard ratio(HR): 1.70, 95%CI: 1.17-2.47] and LNM(P = 0.009, HR: 1.78, 95%CI: 1.15-2.74) were independent prognostic factors for OS. The median disease-free survival(DFS) was 5.3 mo(range: 0.8-114.1 mo). The multivariate analysis indicated that only the advanced p T stage(P = 0.02, HR: 1.93, 95%CI: 1.09-3.42) was a significant independent indicator of poor RFS in patients with *** The correct diagnosis of PMME before surgery is low, and physicians should pay more attention t

关键词： Primary malignant melanoma of the esophagus Clinicopathological characteristics Treatment Recurrence Survival

Inhibition of CXCR4 activity with AMD3100 decreases invasion of human colorectal cancer cells in vitro

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World Journal of Gastroenterology 2008年第15期14卷 2308-2313页

作者： Ji-Kun li liang Yu Yun Shen li-sheng zhou Yi-Cheng Wang Jian-Hai Zhang Department of General Surgery Affiliated First People's Hospital Shanghai Jiaotong University Shanghai 200080 China Department of Pathology Affiliated First People's Hospital Shanghai Jiaotong University Shanghai 200080 China

AIM: To investigate the effect and mechanism of blockade of the CXC chemokine receptor-4 (CXCR4) signaling pathway by AMD3100, a small non-peptide CXCR4 inhibitor, on invasion and metastasis of colorectal cancer cells in vitro. METHODS: Human colorectal cancer cell line SW480 was treated with AMD3100 at different final concentrations. 3-(4,5-dimethylthiazole-2-yl)-2.5-dipheny-ltetrazolium bromide (MTT) assay was used to detect the effect of AMD3100 on cell proliferation. The invasion ability of SW480 cells was determined by cell invasion assay kit. In the presence of AMD3100, the CXCL12-mediated migratory response of SW480 cells was tested by classical chemotaxis assays. RT-PCR analysis and Western blotting were used to detect the expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in SW480 cells. RESULTS: Cell viability was significantly suppressed by AMD3100 in a dose-dependent manner. AMD3100 (100 and 1000 ng/mL) significantly inhibited the invasion ability of SW480 cells. Treatment with AMD3100 markedly reduced the expression of VEGF and MMP-9 but not MMP-2 in SW480 cells. CONCLUSION: The CXCL12/CXCR4 system is an important mediator of proliferation and invasion of CXCR4-expressing colorectal cancer cells. AMD3100 inhibited invasion and metastasis activity of the colorectalcancer cell line SW480 through down-regulation of VEGF and MMP-9 expression.

关键词： Colorectal cancer CXCR4 Vascular endothelial growth factor MMPs Invasion

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圆盘空化器航行体入水空泡实验研究

工程力学 2017年第3期34卷 241-246页

作者：蒋运华徐胜利周杰清华大学航天航空学院北京100084

针对圆盘空化器航行体入水空泡问题,开展约束航行体姿态的实验研究。实验研究了入水局部空泡、空泡正好闭合在航行体尾部及入水超空泡的生成、发展与倾斜入水下的空泡流动特性。分析了空泡尺寸与弗劳德数和欧拉数之间的关系,给出了入水... 详细信息

针对圆盘空化器航行体入水空泡问题,开展约束航行体姿态的实验研究。实验研究了入水局部空泡、空泡正好闭合在航行体尾部及入水超空泡的生成、发展与倾斜入水下的空泡流动特性。分析了空泡尺寸与弗劳德数和欧拉数之间的关系,给出了入水空泡长度的变化规律,探讨了实验获得各种空泡流动形式的流动机理。结果表明,入水局部空泡长度在深水闭合之后有微小增加,空泡最终以云状空泡形式脱落溃灭。当空泡正好闭合在航行体尾部时空泡极易形成回射流与航行体及空泡尾部相互作用,影响空泡尾部流动形式。入水超空泡有较好的稳定性。倾斜入水空泡易受重力影响,空泡尾部上飘,导致航行体尾部与空泡的相互作用下的空泡拉断。倾斜入水空泡内气体弹性效应更加明显,空泡壁面出现波形,空泡长度发生振荡。

关键词：航行体入水空泡实验局部空泡超空泡流动稳定性

地应力主导型突出危险煤巷水力扩孔卸压防突技术研究

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煤炭工程 2020年第4期52卷 97-102页

作者：李生舟瓦斯灾害监控与应急技术国家重点实验室重庆400037 中煤科工集团重庆研究院有限公司重庆400037

为了防治桑树坪煤矿松软3#煤层地应力主导型突出灾害,提出了采用水力扩孔卸压增透技术进行煤巷条带区域防突的防治措施。采用理论分析、FLAC3D数值模拟软件获得了扩孔后煤体破坏形态、塑性区范围及应力分布规律,据此确定水力扩孔合理布... 详细信息

为了防治桑树坪煤矿松软3#煤层地应力主导型突出灾害,提出了采用水力扩孔卸压增透技术进行煤巷条带区域防突的防治措施。采用理论分析、FLAC3D数值模拟软件获得了扩孔后煤体破坏形态、塑性区范围及应力分布规律,据此确定水力扩孔合理布孔参数。并提出以残余瓦斯含量、扩出煤屑率作为防突效果的双重评价指标,从而提出穿层钻孔水力扩孔卸压防突技术,并进行了现场应用。应用表明:扩孔后煤层卸压增透及防突效果显著,瓦斯流量衰减系数降低65%~74%,自然瓦斯涌出量提高2~3倍。残余瓦斯含量的临界值为8m3/t,煤层正常、异常区域扩出煤屑率的临界值分别为3%、5%,可实现煤巷安全高效掘进。

关键词：地应力主导水力扩孔松软煤层掘进防突煤层蠕变