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中医药通过NF-κB信号通路治疗骨关节炎的研究进展

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中国骨质疏松杂志 2024年第5期30卷 725-731页

作者：刘江燕张晓峰徐西林李朝霞段洪超黑龙江中医药大学黑龙江哈尔滨150040 黑龙江中医药大学附属第三医院黑龙江哈尔滨150016 黑龙江中医药大学附属第二医院黑龙江哈尔滨150001

随着全球人口老龄化的进展,骨关节炎的发病率也逐年上升,必将成为一大社会公共卫生问题。骨关节炎发病机制复杂,中药因其多成分、多途径、多靶点的特点在治疗骨关节炎方面具有巨大潜力。大量研究表明中医药可通过调节NF-κB信号通路抑... 详细信息

随着全球人口老龄化的进展,骨关节炎的发病率也逐年上升,必将成为一大社会公共卫生问题。骨关节炎发病机制复杂,中药因其多成分、多途径、多靶点的特点在治疗骨关节炎方面具有巨大潜力。大量研究表明中医药可通过调节NF-κB信号通路抑制炎症反应、氧化应激、基质降解、细胞凋亡等治疗骨关节炎。本文综述了中医药通过NF-κB通路治疗骨关节炎的研究进展,以期为未来的基础和临床研究提供参考。

关键词： NF-κB 骨关节炎氧化应激炎症反应发病机制

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焦化尾水资源化回用集成工艺中试

化工环保 2024年第5期44卷 736-743页

作者：张曼曼段锋石绍渊李玉平周玉生中国科学院过程工程研究所中国科学院化学化工科学数据中心北京100190 郑州中科新兴产业技术研究院河南郑州450000 战略金属资源绿色循环利用国家工程研究中心北京100190 新疆宣力环保能源股份有限公司新疆哈密839303

为实现焦化尾水的资源化回用,开发了以预处理、压力-电驱动膜组合及双极膜电渗析技术为核心的集成工艺,并进行了中试研究。集成工艺中,化学软化和臭氧-双氧水复合氧化工艺用于去除原水中的硬度和反渗透浓水中的难降解有机物,纳滤工艺完... 详细信息

为实现焦化尾水的资源化回用,开发了以预处理、压力-电驱动膜组合及双极膜电渗析技术为核心的集成工艺,并进行了中试研究。集成工艺中,化学软化和臭氧-双氧水复合氧化工艺用于去除原水中的硬度和反渗透浓水中的难降解有机物,纳滤工艺完成了一价离子与高价离子的分离,电渗析和双极膜电渗析工艺实现了焦化尾水的近零排放和酸碱资源再生。化学软化工艺对原水的硬度去除率可达64.2%;臭氧-双氧水复合氧化工艺对反渗透浓水的COD去除率可达35.0%;纳滤工艺的脱盐率可达30.2%,对氯离子、硫酸根、硬度和TOC去除率分别可达-6.8%、97.3%、78.4%和87.4%;双极膜电渗析工艺可得浓度均为2 mol/L以上的酸和碱,能耗为4.0 kW·h/kg。该集成工艺的水回用率大于90%,酸碱可短程循环利用。

关键词：焦化尾水资源化双极膜电渗析酸碱回用废水循环利用

A Predator-prey Particle Swarm Optimization Approach to Multiple UCAV Air Combat Modeled by Dynamic Game Theory

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IEEE/CAA Journal of Automatica Sinica 2015年第1期2卷 11-18页

作者： Haibin duan Pei Li Yaxiang Yu the Science and Technology on Aircraft Control Laboratory School of Automation Science and Electrical EngineeringBeihang University (BUAA)

Dynamic game theory has received considerable attention as a promising technique for formulating control actions for agents in an extended complex enterprise that involves an adversary. At each decision making step, each side seeks the best scheme with the purpose of maximizing its own objective function. In this paper, a game theoretic approach based on predatorprey particle swarm optimization (PP-PSO) is presented, and the dynamic task assignment problem for multiple unmanned combat aerial vehicles (UCAVs) in military operation is decomposed and modeled as a two-player game at each decision stage. The optimal assignment scheme of each stage is regarded as a mixed Nash equilibrium, which can be solved by using the PP-PSO. The effectiveness of our proposed methodology is verified by a typical example of an air military operation that involves two opposing forces: the attacking force Red and the defense force Blue. © 2014 Chinese Association of Automation.

关键词： Aircraft control Airships Combinatorial optimization Computation theory Decision making Military operations Military vehicles Particle swarm optimization (PSO)

Railway switch fault diagnosis based on Multi-heads Channel Self Attention,Residual Connection and Deep CNN

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Transportation Safety and Environment 2023年第1期5卷 58-65页

作者： Xirui Chen Hui Liu Zhu duan Institute of Artificial Intelligence&Robotics(IAIR) Key Laboratory of Traffic Safety on Track of Ministry of EducationSchool of Traffic and Transportation EngineeringCentral South UniversityChangsha 410075HunanChina.

A novel switch diagnosis method based on self-attention and residual deep convolutional neural networks(CNNs)is *** of the imbalanced dataset,the K-means synthetic minority oversampling technique(SMOTE)is applied to balancing the dataset at ***,the deep CNN is utilized to extract local features from long power curves,and the residual connection is performed to handle the performance *** the end,the multi-heads channel self attention focuses on those important local *** ablation and comparison experiments are applied to verifying the effectiveness of the proposed *** the residual connection and multi-heads channel self attention,the proposed method has achieved an impressive accuracy of 99.83%.The t-SNE based visualizations for features of the middle layers enhance the trustworthiness.

关键词： fault diagnosis railway switch residual connection channel self-attention deep convolutional neural network

基于AHP-VWT-TOPSIS的缓倾斜薄矿体采矿方法优选

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矿业研究与开发 2024年第2期44卷 1-5页

作者：潘征段文权刘敬智周科平杨春中南大学资源与安全工程学院湖南长沙410083 北方矿业有限责任公司北京100053

为满足缓倾斜薄矿体采矿方法科学优选要求,构建了基于AHP-VWT-TOPSIS的采矿方法多属性综合决策模型。采用VWT规避AHP法确定的常权权重向量可能出现的“状态失衡”问题﹐再结合TOPSIS逼近理想解排序法得到各方案优越度,选出最优采矿方法... 详细信息

为满足缓倾斜薄矿体采矿方法科学优选要求,构建了基于AHP-VWT-TOPSIS的采矿方法多属性综合决策模型。采用VWT规避AHP法确定的常权权重向量可能出现的“状态失衡”问题﹐再结合TOPSIS逼近理想解排序法得到各方案优越度,选出最优采矿方法。以贵州某金矿为例,结合矿山开采实际,提出了3种可行的采矿方案。从经济、技术和安全3个层面,选取了13个评价指标,构建了采矿方法优选多属性综合决策矩阵,通过建立的综合决策模型计算得到3种方案的贴近度分别为0.2132,0.4913和0.5802,推荐采用方案三(液压支柱护顶壁式崩落法)。优选结果符合工程实际,应用效果表明,该综合评判模型对采矿方案优选具有一定的工程应用价值。

关键词：采矿方法优选缓倾斜薄矿体 AHP 变权重理论 TOPSIS 液压支柱护顶壁式崩落法

基于改进YOLOv5s轻量化模型的红外场景目标检测方法研究

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兵器装备工程学报 2024年第3期45卷 323-330页

作者：刘芷汐周春桂崔俊杰段捷岳凯杰中北大学机电工程学院太原030051

红外技术在防备夜间作战和隐蔽作战中发挥的作用是至关重要的,针对如何平衡红外图像检测精度与轻量化的问题,提出一种基于红外场景下的轻量化目标检测模型M-YOLOv5。该网络模型采用改进的ShuffleBlock模块替换原有的CSP骨干网络。此外,... 详细信息

红外技术在防备夜间作战和隐蔽作战中发挥的作用是至关重要的,针对如何平衡红外图像检测精度与轻量化的问题,提出一种基于红外场景下的轻量化目标检测模型M-YOLOv5。该网络模型采用改进的ShuffleBlock模块替换原有的CSP骨干网络。此外,应用轻量级上采样算子CARAFE替换原有上采样模块,在C3模块中加入SE注意力机制,降低冗余信息,提高特征的区分性和表征能力,重新设计损失函数,E-IoU作为新的损失函数,加快模型收敛速度。在公开数据集FLIR上进行了实验,实验结果表明:改进之后网络模型的平均检测精度达到73.0%,仅降低2.9个百分点,而M-YOLOv5模型的网络参数数量、理论计算量分别减少40%、39%,模型的推理速度提高52%,满足部署于边缘设备的需求。

关键词：红外目标检测轻量化模型 YOLOv5s CARAFE 注意力机制损失函数

Numerical Simulation of a Class of Nonlinear Wave Equations by Lattice Boltzmann Method

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Communications in Mathematics and Statistics 2017年第1期5卷 13-35页

作者： Yali duan Linghua Kong Min Guo School of Mathematical sciences University of Science and Technology of ChinaHefei 230026.AnhuiPeople's Republic of China School of Mathematics and Information Science Jiangxi Normal UniversityNanchang 330022JiangxiPeople's Republic of China Department of Basic North China College of Mechanics and ElectricsChangzhi 046000ShanxiPeople's Republic of China

In this paper,we develop a lattice Boltzmann model for a class ofone-dimensional nonlinear wave equations,including the second-order hyperbolictelegraph equation,the nonlinear Klein-Gordon equation,the damped and undampedsine-Gordon equation and double sine-Gordon *** choosing properly theconservation condition between the macroscopic quantity u,and the distributionfunctions and applying the Chapman-Enskog expansion,the governing equation isrecovered correctly from the lattice Boltzmann ***,the local equilib-rium distribution function is *** results of numerical examples have beencompared with the analytical solutions to confirm the good accuracy and the applica-bility of our scheme.

关键词： Lattice Boltzmann method Second-order hyperbolic telegraph equation Klein-Gordon equation Sine-Gordon equation Chapman-Enskog expansion

Dynamic emulation based modeling and detection of polymorphic shellcode at the network level

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Science in China(Series F) 2008年第11期51卷 1883-1897页

作者： WANG LanJia duan HaiXin LI Xing Department of Electronic Engineering Tsinghua University Beijing 100084 China Network Research Center Tsinghua University Beijing 100084 China

It is a promising way to detect polymorphic shellcode using emulation method. However, previous emulation-based approaches are limited in their performance and resilience against evasions. A new enhanced emulation-based detection approach is proposed, including an automaton-based model of the dynamic behavior of polymorphic shellcode and a detection algorithm, the detection criterion of which is derived from that model and ensures high detection accuracy. The algorithm also contains several optimization techniques, highly improving the running performance and the resilience against detection evasion shellcode. We have implemented a prototype system for our approach. The advantages of our algorithm are validated by the experiments with real network data, polymorphic shellcode samples generated by available polymorphic engines and hand-crafted detection evasion shellcode.

关键词： polymorphic shellcode intrusion detection CPU emulation

骨疏方调节FoxO3a/Wnt信号通路对H_(2)O_(2)诱导成骨细胞损伤的影响

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中国骨质疏松杂志 2024年第10期30卷 1426-1431页

作者：段波陈丽川马志毅喻昭刘静王进军武汉市中医医院风湿病科湖北武汉430050 武汉市中医医院针灸科湖北武汉430050

目的探讨骨疏方调节FoxO3a/Wnt信号通路对过氧化氢(H_(2)O_(2))诱导成骨细胞损伤的影响。方法CCK-8法检测不同浓度(0.01、0.1、1、10、100μmol/L)的骨疏方对H_(2)O_(2)诱导的MC3T3-E1细胞活力。随后设置对照组、H_(2)O_(2)(150μmol/L H_(2)O_(2))组、骨疏方组、骨疏方+空载体组、骨疏方+FoxO3a过表达组。CCK-8法、ELISA分别检测细胞活力、超氧化物歧化酶(SOD)、丙二醛(MDA);成骨诱导分化后,碱性磷酸酶(ALP)试剂盒及茜素红分析ALP活性、细胞骨矿化结节;qRT-PCR检测成骨相关基因OPN mRNA、Runx2 mRNA以及FoxO3a mRNA表达水平;Western blot检测通路相关蛋白FoxO3a、Wnt2、β-连环蛋白(β-catenin)表达水平。结果与对照组比较,H_(2)O_(2)组MDA、FoxO3a表达显著增加,细胞活力、SOD、ALP活性、骨矿化结节数量、OPN mRNA、Runx2 mRNA、Wnt2、β-catenin表达显著降低(P<0.05);与H_(2)O_(2)组比较,骨疏方组MDA、FoxO3a表达显著降低,细胞活力、SOD、ALP活性、骨矿化结节数量、OPN mRNA、Runx2 mRNA、Wnt2、β-catenin表达显著增加(P<0.05);与骨疏方+空载体组比较,骨疏方+FoxO3a过表达组MDA、FoxO3a表达显著增加,细胞活力、SOD、ALP活性、骨矿化结节数量、OPN mRNA、Runx2 mRNA、Wnt2、β-catenin表达显著降低(P<0.05)。结论骨疏方可改善H_(2)O_(2)诱导成骨细胞损伤,可能与抑制FoxO3a/Wnt信号通路有关。

关键词：骨疏方过氧化氢成骨细胞 FoxO3a/Wnt信号通路骨质疏松症