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Participation of microbiota in the development of gastric cancer

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World Journal of Gastroenterology 2014年第17期20卷 4948-4952页

作者： Li-Li Wang Xin-Juan Yu Shu-Hui Zhan sheng-jiao jia Zi-Bin Tian Quan-jiang Dong Central Laboratories and Department of Gastroenterology Qingdao Municipal Hospital Department of Gastroenterology the Affiliated Hospital of Qingdao University

There are a large number of bacteria inhabiting the human body,which provide benefits for the *** of microbiota participate in the pathogenesis of *** gastric microbiota consists of bacteria from seven to eleven phyla,predominantly Proteobacteria,Firmicutes,Bacteroidetes,Actinobacteria and *** by Helicobacter pylori(***)does not remarkably interrupt the composition and structure of the gastric *** of bacterial commensal from the stomach delays the onset of ***-induced gastric cancer,while presence of artificial microbiota accelerates the *** gastric microbiota may increase the production of N-nitroso compounds,promoting the development of gastric *** investigation of the carcinogenic mechanisms of microbiota would benefit for the prevention and management of gastric cancer.

关键词： Microbiota Helicobacter pylori Gastric cancer Nitrite Metagenomics

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实际海浪环境中舰船大尺度模型试验研究进展

舰船科学技术 2017年第5期39卷 1-5页

作者：韩春生郭京焦甲龙孙树政中国人民解放军92941部队哈尔滨工程大学船舶工程学院

目前对舰船总体性能的研究主要是依靠数值计算、水池模型试验、实际海浪环境大尺度模型试验以及实船海试等方法,以上各种方法均有一定的适用范围。实际海浪环境中舰船大尺度模型试验技术是采用适当缩尺比的自航船模在自然水域环境中进... 详细信息

目前对舰船总体性能的研究主要是依靠数值计算、水池模型试验、实际海浪环境大尺度模型试验以及实船海试等方法,以上各种方法均有一定的适用范围。实际海浪环境中舰船大尺度模型试验技术是采用适当缩尺比的自航船模在自然水域环境中进行的试验,可以研究舰船在开阔海域自由航行状态下的各项航行性能。分析各种舰船总体性能研究方法的优缺点,针对目前舰船总体性能理论与试验研究存在的问题分析开展舰船大尺度模型海上试验研究的必要性,综述国内外大尺度模型试验技术的发展现状,最后针对该试验技术中的关键技术及热点问题进行总结与展望。

关键词：舰船试验技术船舶水动力学大尺度模型试验实际海浪

Evaluation of the therapeutic significance of Glehniae Radix polysaccharides on the ulcerative colitis through DSS-induced rat model

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Food Science and Human Wellness 2025年

作者： Jie Liu Xufang Geng Yuxin Yang jiao Xu Haoran Feng Tianshuo Zhang Guangzhao Zhou Man Wang Changshun Wang Dongsheng jia Yuting Chen Bin Cong Ding Zhao The Postdoctoral Mobile Station of Basic Medicine， Hebei Medical University The Department of Pharmacognosy， School of Pharmacy， Hebei Medical University Hebei Key Laboratory of Forensic Medicine， College of Forensic Medicine， Hebei Medical University

Glehniae Radix has a wide range of pharmaceutical applications， and research on its main components has mainly focused on coumarins， alkaloids， lignans， and flavonoids， while neglecting the research on polysaccharides. Literature reports and our previous studies have shown that polysaccharides have certain therapeutic significance in immune regulation， antioxidant， anti-inflammatory and other aspects. Herein， the rat model of ulcerative colitis (UC) was established to evaluate the anti-inflammatory efficacy of the prepared Glehniae Radix polysaccharide (GLP) from the perspectives of inflammatory factors， intestinal tissue morphology， and microflora changes. The polysaccharides are mainly composed of galacturonic acid， rhamnose， glucose， galactose， and arabinose in molar ratios of 1.4:9.2:33.3:2.5:2.9， and GLP could downregulate the expression pro-inflammatory factors (interleukin-6， tumor necrosis factor-α， and interferon-γ) and significantly upregulate the expression of anti-inflammatory factor (interleukin-10). In addition， Glehniae Radix aqueous extract (GLA)， GLP with low dosage (GLPL) and GLP with high dosage (GLPH) could increase the number of goblet cells， enhance the integrity of crypt structure， and reverse the status of inflammatory infiltrating cells. Moreover， GLA and GLPH could upregulate Lactobacillus and Lachnoclostridium in UC rats， and appropriately downregulate Lachnospiraceae＿NK4A136＿group， thereby optimizing the proportion of bacterial flora and improving the intestinal microbial environment. Our findings not only be valuable as theoretical materials for the further clinical applications of GLP， but the identified biomarkers and metabolic pathways also provide new clues for the diagnosis of UC.

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乙酰丙酮铱Ir(acac)_(3)电子结构及光学性质的理论研究

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原子与分子物理学报 2025年第1期42卷 1-7页

作者：樊依佳蔚娇娇郭家成陈扬尹杜恭贺西北工业大学伦敦玛丽女王大学工程学院西安710129 西安邮电大学理学院西安710121

乙酰丙酮铱是一种由过渡金属Ir与乙酰丙酮酸(acetylcaetonato)有机部分组成的过渡金属有机配合物,它是一种重要的绿光磷光材料,同时其也是多种铱系发光材料的组成部分.采用密度泛函理论(DFT)对Ir(acac)_(3)单体及其二聚物的基态几何结... 详细信息

乙酰丙酮铱是一种由过渡金属Ir与乙酰丙酮酸(acetylcaetonato)有机部分组成的过渡金属有机配合物,它是一种重要的绿光磷光材料,同时其也是多种铱系发光材料的组成部分.采用密度泛函理论(DFT)对Ir(acac)_(3)单体及其二聚物的基态几何结构进行了优化,在此基础上考察了它们的振动和红外光谱,并使用CIS方法对它们的激发态性质进行了理论研究.计算得到的单体和二聚物的吸收光谱均在紫外波段,单体的主要吸收峰有260 nm,350 nm,414 nm,二聚物的主要吸收峰有299 nm,353 nm,401 nm.计算得到了二者在乙腈CH_(3)CN溶液中的吸收光谱,与它们气相情况的结果相比,溶剂极性的影响使得电子吸收谱发生蓝移.计算结果表明Horst Kunkely和Arnd Vogler所得光谱中既含有单体的特征光谱,又含有二聚体的特征光谱,证明实验溶液中同时存在乙酰丙酮铱的低聚物,并且二者的组分比能被合理推算.最后,对多聚体的形成机理作了简单讨论.

关键词： Ir(acac)_(3) 密度泛函理论(DFT) CIS 电子吸收光谱溶液效应

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关于投影关系研究

山东科技大学学报（自然科学版） 2003年第2期22卷 75-77页

作者：张起生李蛟宗家富赵红雁燕山大学河北秦皇岛066000

将投影关系进一步细化、具体化 ,且提出了投影直接关系与投影间接关系 ,画物体视图时具有针对性、严谨性和科学性 ,并对GB4 4 5 8.1- 1984第 4 .

关键词：机械制图投影关系视图正投影图投影轴投影直接关系投影间接关系

Functional Analysis of MYB73 of Arabidopsis thaliana Against Bipolaris oryzae

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Agricultural Sciences in China 2011年第5期10卷 721-727页

作者： jia jiao XING Ji-hong DONG Jin-gao HAN jian-min LIU Jun-sheng Laboratory of Molecular Plant Pathology Agricultural University of Hebei Baoding 071001 P.R.China

Bipolaris oryzae is a severe rice disease,resulting in significant economic ***73 gene of Arabidopsis was isolated based on T-DNA insertion mutants whose lose-of-function mutant increased susceptibility to *** of staining for H2O2 revealed that infection of incompatible *** caused much more strong brown patches on the leaves of myb73 mutant than those on the leaves of wild *** of MYB73 gene was induced by *** increased expression was severely impaired in the myb73 *** of MYB73 was severely decreased in the npr1,jar1,eds5,and sid2 mutants,suggesting MYB73 gene participates in the jasmonate （JA） and salicylic acid （SA） signaling *** of MYB73 who encoded an R2R3 MYB transcription factor was increased by SA,JA,and ethylene （ET） *** cDNA full-length sequence of MYB73 was 960 bp and a protein with 320 amino acids was *** predicted molecular weight of MYB73 was 34.85 *** expression of MYB73 gene was induced within 24 h of the inoculation,however,the expression of PR1,PDF1.2 and NPR1 weren＇t *** *** successfully infected myb73 mutant plants,the expression of PR1,PDF1.2 and NPR1 were ***,our results suggested that MYB73 is involved in NPR1-mediated SA and JA signaling pathways.

关键词： Arabidopsis MYB73 RT-PCR Bipolaris oryzae

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen Yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Situation-adaptive neural network for fast pre-computing image enhancement

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Science China(Information Sciences) 2025年

作者： Xinyue LI Huiyu DUAN jia WANG Xiaohong LIU Yitong CHEN Guangtao ZHAI Institute of Image Communication and Network Engineering Department of Electronic EngineeringShanghai Jiao Tong University

As intelligent vision tasks become more widespread, enhancing image quality before further computational analysis is crucial. Recently, deep learning has shown potential for automated pre-computing enhancement, but it typically requires substantial computational resources and is hard to adapt to in multiple situations without *** practice, image enhancement often demands flexible adjustments based on different situations and subsequent computation devices, such as optical computing. Therefore,we propose SAEnhancer, a situation-adaptive neural network for fast pre-computing image enhancement. It learns from a small sample set to achieve personalized and adaptive enhancements for various situations without re-training,using semantic-aware embedding for precise color adjustments, surpassing traditional 3D lookup tables (LUTs), and enhancing computational effectiveness in intelligent vision applications.

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基于双目视觉和改进YOLOv8n的火灾检测及测距方法

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陕西科技大学学报 2025年第1期43卷 152-160页

作者：刘振董绍江罗家元孙世政潘学娇重庆交通大学机电与车辆工程学院重庆400074

针对火灾检测出现的漏检误检、模型参数量大及定位困难的问题,基于双目视觉和改进YOLOv8n提出了一种轻量化火灾检测及测距方法.通过双目相机拍摄图片,使用改进的检测算法YOLOv8n-AEM和现有的测距算法SGBM进行检测和测距.首先,在主干网... 详细信息

针对火灾检测出现的漏检误检、模型参数量大及定位困难的问题,基于双目视觉和改进YOLOv8n提出了一种轻量化火灾检测及测距方法.通过双目相机拍摄图片,使用改进的检测算法YOLOv8n-AEM和现有的测距算法SGBM进行检测和测距.首先,在主干网络中引入可变核卷积AKConv和EMA注意力机制,通过构建不规则卷积核有效提取火灾的特征;然后,在颈部网络中构建C2f-SCConv模块,通过特征重组降低模型参数,提高检测速度;其次,基于最小点距离改进损失函数,解决火源与光源重叠导致的漏检与误检问题;最后,增加小目标检测头,提高对小火苗的检测能力.实验结果表明,改进后的检测算法P、R、mAP分别为83.6%、76.4%、83.6%,分别提高了2.5%、3.6%、4.8%;参数量和模型大小分别为2.54 M和5.1 MB,分别降低了15.3%和15%;测距精度误差不超过2.5%,证明改进的方法能准确完成火灾的检测及测距.

关键词：火灾检测双目视觉测距 YOLOv8n 轻量化

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