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Nano-Bacillus Calmette-Guérin immunotherapies for improved bladder cancer treatment

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第7期25卷 557-567页

作者： sheng zeng Shaoqiang XING Yifei ZHANG Haifeng WANG Qian LIU Department of Urology Tianjin First Central HospitalTianjin 300192China Department of Urology First Central Clinical CollegeTianjin Medical UniversityTianjin 300192China

Cancer immunotherapy has rapidly become the fourth mainstream treatment alternative after surgery,radiotherapy,and chemotherapy,with some promising *** aims to kill tumor cells by mobilizing or stimulating cytotoxic immune ***,the clinical applications of tumor immunotherapies are limited owing to a lack of adequate delivery pathways and high ***,nanomaterials and genetic engineering have shown great potential in overcoming these limitations by protecting the delivery of antigens,activating targeted T cells,modulating the immunosuppressive tumor microenvironment,and improving the treatment *** Calmette-Gué;rin(BCG)is a live attenuated Mycobacterium bovis vaccine used to prevent tuberculosis,which was first reported to have antitumor activity in *** therapy can activate the immune system by inducing various cytokines and chemokines,and its specific immune and inflammatory responses exert antitumor *** was first used during the 1970s as an intravesical treatment agent for bladder cancer,which effectively improved immune antitumor activity and prevented tumor *** recently,nano-BCG and genetically engineered BCG have been proposed as treatment alternatives for bladder cancer due to their ability to induce stronger and more stable immune *** this study,we outline the development of nano-BCG and genetically engineered BCG for bladder cancer immunotherapy and review their potential and associated challenges.

关键词： Bladder cancer Bacillus Calmette-Gué rin vaccine Nanocarrier Genetic engineering Immunotherapy

Ultrathin surface coating of Cu enabling long-life Zn metal anodes

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Rare Metals 2024年第5期43卷 2125-2135页

作者： Sang-Sang Liu Ya-Ru Liang Wen-Long Chen Ze-Hua Wang Yi-Long Dai Fu-Gang Qi zeng-sheng Ma Xiao-Ping Ouyang School of Materials Science and Engineering Xiangtan UniversityXiangtan 411105China Key Laboratory of Low Dimensional Materials and Application Technology of Ministry of Education Xiangtan UniversityXiangtan 411105China

Aqueous zinc-ion batteries(AZIBs)are regarded as promising energy storage devices due to their low cost,high capacity,and ecological ***,the severe dendritic growth and side reactions hinder their practical applicability ***,an ultrathin Cu coating layer(~200 nm)is decorated on zinc foils via filtered cathodic vacuum arc deposition technology,aiming to achieve high-performance *** Cu layer effectively suppresses chemical corrosion and hydrogen evolution reactions and enables preferential(002)Zn deposition during the stripping/plating ***,the Cu@Zn anode represents an elongated cycle life over 4,000 h at 2 mA·cm^(-2)/2 mAh·cm^(-2).Even in conditions of high current density of 5 and 10 mA·cm^(-2),the Cu@Zn anode shows prolonged cycling stability exceeding 4000 and 2000 h,*** advantages also bring high Coulombic efficiency of 99.87%under 5 mAh·cm^(-2)in Cu@Ti||Zn half-cell over 1500 ***,the Cu@Zn||MnO_(2)full cell demonstrates a superior cyclability with a specific capacity of 203 mAh·g^(-1)after 500 cycles a1 A·g^(-1).

关键词： Zn ion battery Zn metal anode Zn(002)plane Cu coating

科技金融、经济高质量发展与共同富裕——基于门槛效应的实证分析

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西南大学学报（社会科学版） 2024年第4期50卷 141-154页

作者：曾胜赵雪姝何玲重庆工商大学成渝地区双城经济圈建设研究院重庆400067 重庆工商大学金融学院重庆400067

科技金融作为促进创新要素深度融合的一种新型经济范式,能够助推经济高质量发展与共同富裕的实现。在理论分析的基础上,运用熵值法计算我国2006—2021年的30个省区市的共同富裕指数与经济高质量发展水平,利用超效率DEA测算科技金融效率... 详细信息

科技金融作为促进创新要素深度融合的一种新型经济范式,能够助推经济高质量发展与共同富裕的实现。在理论分析的基础上,运用熵值法计算我国2006—2021年的30个省区市的共同富裕指数与经济高质量发展水平,利用超效率DEA测算科技金融效率值,并采用固定效应和门槛效应模型检验科技金融与共同富裕间的关系,研究表明:科技金融与共同富裕间存在着“U”型关系,0.438为科技金融效率的拐点值;经济高质量发展在科技金融与共同富裕的关系中呈现双门槛效应,当经济高质量发展水平跨越第二门槛值0.155,科技金融对共同富裕的影响由负转正。从优化科技金融投入、加快科技金融产出、提供差异化政策、合理调整产业结构、健全保障机制方面为实现共同富裕提出建议。

关键词：科技金融共同富裕经济高质量发展科技创新金融服务

维普期刊数据库博看期刊

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基于改进的蚁群算法的目标物流车辆路径优化

现代电子技术 2024年第7期47卷 181-186页

作者：曾胜王兵戴贤君皖江工学院电气信息工程学院安徽马鞍山243000 安徽工业大学电气与信息工程学院安徽马鞍山243000 中国计量大学生命科学学院浙江杭州310000

随着冷链物流发展,物流车的路径优化已逐渐显现在大众的视野中,但是运输成本与路径一直困扰着物流公司,针对此类情况,文中提出冷链物流车的路径优化。主要设计以下两个方面:通过建立冷链物流模型,从碳排放成本与车辆运输成本进行模型建... 详细信息

随着冷链物流发展,物流车的路径优化已逐渐显现在大众的视野中,但是运输成本与路径一直困扰着物流公司,针对此类情况,文中提出冷链物流车的路径优化。主要设计以下两个方面:通过建立冷链物流模型,从碳排放成本与车辆运输成本进行模型建立;通过改进的蚁群算法研究,引入最优最差蚁群算法与启发因子算法对其路径优化建立模型。通过传统蚁群算法的研究与改进后的蚁群算法可以缩短车辆行驶路径,改进后的蚁群算法可以提升收敛性,优化了车辆行驶路径。结果表明,基于改进的蚁群算法可以优化路线、降低运输成本,优于传统的蚁群算法路径优化,提高了公司运输效率。

关键词：冷链物流改进蚁群算法优化路线提升收敛性降低运输成本提高运输效率

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往复式天然气压缩机主驱动电机轴裂纹分析

压缩机技术 2024年第3期 57-61页

作者：曾胜中国石油集团济柴动力有限公司成都压缩机分公司四川成都610100

针对往复式天然气压缩机主驱动电机轴裂纹故障进行了失效分析,通过对该压缩机组在故障前的运行工况分析、扭振分析复核、外观分析、裂纹电镜扫描分析、金相分析、机械性能分析、化学分析等找出了引起电机轴产生裂纹的原因。分析结果表明... 详细信息

针对往复式天然气压缩机主驱动电机轴裂纹故障进行了失效分析,通过对该压缩机组在故障前的运行工况分析、扭振分析复核、外观分析、裂纹电镜扫描分析、金相分析、机械性能分析、化学分析等找出了引起电机轴产生裂纹的原因。分析结果表明:电机轴表面存在一层厚度1.7 mm左右的堆焊层,该电机轴表面的堆焊层是引起本次压缩机主驱动电机轴产生裂纹的直接原因。

关键词：往复式天然气压缩机电机轴裂纹失效分析扭振分析堆焊层

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某体育馆预制装配式清水混凝土看台设计实践

福建建设科技 2024年第1期 91-93页

作者：曾盛厦门上城建筑设计有限公司福建厦门361012

本文以某体育馆预制装配式清水混凝土看台设计实践为例,介绍了体育场馆看台采用预制装配式清水混凝土的总体设计方案、构件深化设计及连接设计等技术要点,并就BIM技术应用的要点进行了总结。

关键词：预制装配式清水混凝土看台板标准化设计 BIM技术应用

Curvature-enhanced multipartite coherence in the multiverse

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Chinese Physics C 2024年第7期48卷 259-272页

作者：吴树民王春旭王锐迪李金璇黄晓理曾浩生 Department of Physics Liaoning Normal UniversityDalian 116029China Department of Physics Hunan Normal UniversityChangsha 410081China

Here,we study the quantum coherence of N-partite Greenberger-Horne-Zeilinger(GHZ)and W states in the multiverse consisting of N causally disconnected de Sitter ***,N-partite coherence increases monotonically with curvature,whereas the curvature effect destroys quantum entanglement and discord,indicating that the curvature effect is beneficial to quantum coherence and harmful to quantum correlations in the *** find that with an increase in n expanding de Sitter spaces,the N-partite coherence of the GHZ state increases monotonically for any curvature,whereas the quantum coherence of the W state decreases or increases monotonically depending on the *** find a distribution relationship,which indicates that the correlated coherence of the N-partite W state is equal to the sum of all bipartite correlated coherence in the *** coherence exhibits unique properties in the multiverse,suggesting that it may provide some evidence for the existence of the multiverse.

关键词： multiverse curvature effect multipartite coherence

Integrin α6:a potential target for cancer molecular imaging and targeting therapy

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Malignancy Spectrum 2024年第1期1卷 30-45页

作者： Xin-Ling Li Zhuo-Lun Shen Qiao-Li Wang Jia-Cong Ye Wen-Biao Zhang Ying-He Li Guo-Kai Feng Mu-sheng zeng State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdongChina

As a major kind of cell surface adhesion molecules with signal transduction function,integrins play a major role in tumorigenesis and tumor *** role of integrins in tumor cells and the tumor microenvironment has been extensively *** the integrin family,integrinαvβ3 is the most studied integrin in the past 20 *** of preclinical and clinical studies have been conducted,which showed clinical benefits of targeting integrinαvβ3 in tumor imaging and ***,the focus of interest is gradually shifting from integrinαvβ3 toward other integrin ***α6 is expressed in many malignant tumors,such as colorectal cancer,head and neck squamous cell carcinoma,breast cancer,pancreatic cancer,and liver cancer,and its expression is correlated with poor survival of the *** studies have shown that tumor molecular imaging agents and therapeutic drugs targeting integrinα6 have excellent safety and efficacy in preclinical mouse models,encouraging clinical translation of this promising *** this review,we briefly overview the physiological and pathological function of integrinα6 and highlight the recent advances in integrinα6-targeted imaging and therapeutics in tumors.

关键词： tumor imaging tumor therapy tumor microenvironment molecular imaging integrin

The structure of HSV-1 gB bound to a potent neutralizing antibody reveals a conservative antigenic domain across herpesviruses

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hLife 2024年第3期2卷 141-146页

作者： Cong Sun Jia-Wen Yang Chu Xie Xin-Yan Fang Guo-Long Bu Ge-Xin Zhao Dan-Ling Dai Zheng Liu Mu-sheng zeng State Key Laboratory of Oncology in South China Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapyGuangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangdongChina Cryo-electron Microscopy Center Southern University of Science and TechnologyGuangdongChina Department of Biology Southern University of Science and TechnologyGuangdongChina

Human herpesviruses(HHV),including the alpha,beta,andgamma subfamilies,are enveloped viruses with broad prevalence,establishing life-time latent infections and inducing a variety of diseases[1].Among them,herpes simplex virus(HSV),consists of two HSV-1 and HSV-2 variants,ubiquitouslyaffecting global populations[2].As an enveloped virus,HSV features a repertoire of glycoproteins such as glycoproteins D(gD),glycoproteins H(gH),glycoproteins L(gL),and glycoproteins B(gB),to orchestrate host cell recognition and infection[3,4].

关键词： diseases neutral envelope