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High Expression of Fibronectin 1 Predicts a Poor Prognosis in Glioblastoma

Current Medical Science 2022年第5期42卷 1055-1065页

作者： Song WU Chang LIU xing WEI Wei-xia NONG Li-na LIN Feng LI Xiao-xun XIE xing-sheng LIAO Bin LUO Qing-mei ZHANG Shao-wen XIAO Department of Neurosurgery the First Affiliated HospitalGuangxi Medical UniversityNanning530021China Department of Histology and Embryology School of Pre-clinical MedicineGuangxi Medical UniversityNanning530021China Central Laboratory of Pre-Clinical Medicine(Key Laboratory of Guangxi Colleges and Universities) Guangxi Medical UniversityNanning530021China Key Laboratory of Early Prevention and Treatment of Regional High Frequency Tumor(Guangxi Medical University) Ministry of EducationNanning530021China Department of Neurology the First Affiliated HospitalGuangxi Medical UniversityNanning530021China

Objective Glioblastoma multiforme(GBM),the most malignant intracranial neoplasm,is associated with a high mortality and recurrence rate due to the aggressive nature and heterogeneity of the *** of the molecular markers involved in the tumorigenesis of GBM are essential in prognosis,diagnosis,and *** to the limitations of therapeutic effects,this study aims to explore novel biomarkers with prognostic value and to provide new insights into therapeutic *** The expression profile of mRNAs in GBM was detected by RNA-sequencing,and differentially expressed genes were identified by integrating the data from RNA-seq results and the GEPIA2 *** the total 40 hub genes,FN1,P4HB,and PPIB showed prognostic significance based on both GEPIA2 and CGGA *** validation of FN1,P4HB,and PPIB expression by qPCR and correlation analysis with clinicopathological features were performed in 41 GBM tissues from our *** Kaplan-Meier analysis revealed that FN1 and P4HB expressions levels were related to the overall survival(OS)of GBM patients(P<0.05).Multivariate analysis showed that FN1 overexpression(HR=9.199,P=0.002)was an independent and unfavorable prognostic factor for GBM *** median survival time was 8.5 months and 21 months for high and low expressions of FN1,*** It was suggested that FN1 could be an ideal target for prognosis and a potential therapeutic target in GBM.

关键词： glioblastoma FN1 overall survival prognosis

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不确定性条件下的生产调度

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华东理工大学学报（自然科学版） 2000年第5期26卷 441-446页

作者：顾幸生华东理工大学自动化研究所上海200237

综述了不确定性条件下生产调度的研究现状 ,分析了生产调度过程中所存在的各种不确定性 ,阐述了不确定性的分类 ,不确定性的数学描述 ,不确定性生产调度的数学模型 ,各种调度方法 ,处理不确定性生产调度的优化方法等 ,指出了解决不确定... 详细信息

综述了不确定性条件下生产调度的研究现状 ,分析了生产调度过程中所存在的各种不确定性 ,阐述了不确定性的分类 ,不确定性的数学描述 ,不确定性生产调度的数学模型 ,各种调度方法 ,处理不确定性生产调度的优化方法等 ,指出了解决不确定性生产调度的有关途径 ,并对存在不确定性条件下生产调度的进一步的研究内容作了展望。

关键词：生产调度优化不确定性在线调度

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陶瓷摩擦副磨损机理的研究

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华南理工大学学报（自然科学版） 2001年第4期29卷 94-97页

作者：童幸生江汉大学机电工程系湖北武汉430019

从陶瓷摩擦副的应用实例出发 ,叙述了Al2 O3陶瓷的结构和性能 ,分析了陶瓷材料的摩擦特性和磨损过程 ,在此基础上说明陶瓷材料的磨损率是很低的。

关键词：陶瓷摩擦副显微结构磨损机理磨损率工程陶瓷材料氧化铝陶瓷耐磨性能

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Occupational Mercury Exposure at a Thermometer Facility-Jiangsu Province, 2019

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China CDC weekly 2020年第42期2卷 827-831,I0001页

作者： Yanqiong Xu Xiaoling Zhang Yiliang Xin Xiaowen Liu xing sheng Enmin Ding Jingxin Xie Lei Han Hengdong Zhang Xin Liu Department of Occupational Disease Prevention and Control Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsuChina Department of Technique Service Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsuChina

Summary What is already known about this topic?Mercury is still used in the manufacture of some thermometers in *** may pose health risks if exposure is not properly prevented and *** is added by this report?An onsite investigation of a workplace at a thermometer facility in Jiangsu Province in 2019 found heavily elevated airborne and urinary mercury levels among a massive number of workers exposed to mercury.

关键词： Mercury mercury properly

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Endobiliary brush cytology during percutaneous transhepatic cholangiodrainage in patients with obstructive jaundice

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Hepatobiliary & Pancreatic Diseases International 2005年第1期4卷 98-103页

作者： Gu-sheng xing Jin-Chao Geng Xin-Wei Han Jin-Han Dai Chao-Yang Wu Department of Radiology First Hospital of Tsinghua University Beijing 100016 China. xgs1259@***

BACKGROUND: Nonsurgical pathologic diagnosis of malignant bile duct stricture with a high sensitivity and specificity is desirable for therapeutic scheme. Percutaneous transhepatic endobiliary brush cytology in detecting obstructive jaundice is evaluated.METHODS: Fifty-eight consecutive patients with obstructive jaundice underwent percutaneous transhepatic cholangiodrainage (PTCD). During the process, a brush was inserted into the bile duct through the preexisted percutaneous transhepatic 8-F sheath, then exfoliated cells were collected from the bile duct stenosis and sent for cytologic diagnosis. The suspicious results were considered of negative diagnosis. All patients had relevant clinical data and follow-up results (15 months to 3 years). Statistical analysis was performed with the chi-square test and Fisher's exact test of probabilities, and a P value0.05).CONCLUSION: The results of this study indicate that cytological brushing of biliary stricture during PTCD is a useful method to establish a diagnosis of malignant biliary stenosis with a high sensitivity, but the negative predictive value is not satisfied.

关键词： bile duct neoplasm brush cytology diagnosis pathology

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Advances in diastolic heart failure

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World Journal of Cardiology 2010年第3期2卷 58-63页

作者： xing sheng Yang Jing Ping Sun xing sheng Yang Jing Ping Sun Department of Caediology Emory University School of Medicine 6276 Courtside Drive Norcross GA 30092 United States.

More than 50% of people living with congestive heart failure have diastolic heart failure(DHF).Most of them are older than 70 years,and *** prevalence of DHF has increased with *** is caused by left ventricular(LV) diastolic dysfunction(DD) which is induced by diastolic *** and extracardiac factors play important roles in the development of heart failure(HF) *** diagnosis of DHF is generally based on typical symptoms and signs of HF,preserved or normal LV ejection fraction,DD and no valvular abnormalities on examination,using noninvasive and invasive *** outcomes with pharmacological therapy in patients with DHF are frequently neutral in clinical trials,and prognosis still remains poor with a 5-year mortality of 42.3% after hospitalization for *** trials are necessary.

关键词： B-type natriuretic peptide Diastolic dysfunction Diastolic dyssynchrony normal ejection fraction Diastolic heart failure Echocardiography Heart failure

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Light Extraction Enhancement of GaN LED with a Two-Dimensional Photonic Crystal Slab

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Chinese Physics Letters 2011年第5期28卷 161-163页

作者： LIU Hong-Wei KAN Qiang WANG Chun-Xia HU Hai-Yang XU xing-sheng CHEN Hong-Da School of Electronics and Information Engineering Tianjin Polytechnic UniversityTianjin 300160 Institute of Semiconductors Chinese Academy of SciencesBeijing 100083

Light extraction effects ora photonic crystal slab with a micrometer scale lattice constant are studied.A GaN light emitting diode(LED)with a photonic crystal slab is *** light extraction effects and the enhancement mechanism are *** theoretical analysis,it is found that the characteristics of LED light emission are modulated by the photonic crystal *** results show that the LED light emission intensity is enhanced by 38%due to guide mode extracting by the photonic crystal.

关键词： GaN Crystal light

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Effect of Different Irrigation Patterns on Transportation and Allocation of Carbohydrate During Grain Filling of Rice

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Agricultural Sciences in China 2005年第3期4卷 181-186页

作者： CHENHai-sheng TAOLong-xing WANGXi HUANGXiao-lin TANHui-juan CHENGShi-hua MINShao-kai StateKeyLaboratoryofRiceBiology／ChinaNationalRiceResearchInstitute Hangzhou310006P.R.China

Using intersubspecific hybrid rice Xieyou 9308 and Liangyou Peijiu as the tested materials, the effects of differentirrigation patterns on transportation and allocation of carbohydrate during grain filling stage was observed by the designwith three level of soil water content in irrigated field. The results showed that in the conventional flooding and thealternate dry-watering cultivations, the exported rate of stored carbohydrate from stem and photophate from the leaves were60 and 90 % respectively. The exported rate of carbohydrate was decreased significantly (P<0.01) in the non-floodingcultivation. There was no significant difference between the conventional flooding and dry-wet alternation treatments interm of the exported rate of carbohydrate. The filling grains were the major sinks for carbohydrate storage during grainfilling stage. Grains received nearly 50% of stored carbohydrate from leaf sheath and 80% of photophate from leaves. Atthe nonflooding condition the absorbing rates of grains were significantly decreased by 10 % from leaf sheath and 20 %from leaves photophate. Water stress leaded much decrease in absorbing ability for inferior grains, which might be one ofthe main causes for low seed-settling rate in non-flooding cultivation.

关键词： Rice Grain filling stage Irrigation mode Grain Photophate

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Role of D2 gastrectomy in gastric cancer with clinical para-aortic lymph node metastasis

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World Journal of Gastroenterology 2019年第19期25卷 2338-2353页

作者： Xiao-Hao Zheng Wen Zhang Lin Yang Chun-Xia Du Ning Li Gu-sheng xing Yan-Tao Tian Yi-Bin Xie Department of Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical College Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Department of Diagnostic Radiology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College

BACKGROUND Owing to the technical difficulty of pathological diagnosis, imaging is still the most commonly used method for clinical diagnosis of para-aortic lymph node metastasis(PALM) and evaluation of therapeutic effects in gastric cancer, which leads to inevitable false-positive findings in imaging. Patients with clinical PALM may have entirely different pathological stages(stage IV or not), which require completely different treatment strategies. There is no consensus on whether surgical intervention should be implemented for this group of patients. In particular, the value of D2 gastrectomy in a multidisciplinary treatment(MDT)approach for advanced gastric cancer with clinical PALM remains *** To investigate the value of D2 gastrectomy in a MDT approach for gastric cancer patients with clinical *** In this real-world study, clinico-pathological data of all gastric cancer patients treated at the Cancer Hospital, Chinese Academy of Medical Sciences between 2011 and 2016 were reviewed to identify those with clinically enlarged PALM. All the clinico-pathological data were prospectively documented in the patient medical record. For all the gastric cancer patients with advanced stage disease,especially those with suspicious distant metastasis, the treatment methods were determined by a multidisciplinary *** In total, 48 of 7077 primary gastric cancer patients were diagnosed as having clinical PALM without other distant metastases. All 48 patients received chemotherapy as the initial treatment. Complete or partial response was observed in 39.6%(19/48) of patients in overall and 52.1%(25/48) of patients in the primary tumor. Complete response of PALM was observed in 50.0%(24/48)of patients. After chemotherapy, 45.8%(22/48) of patients received D2 gastrectomy, and 12.5%(6/48) of patients received additional radiotherapy. The postoperative major complication rate and mortality were 27.3%(6/22) and 4.5%(1/22), respectively. The median overall sur

关键词： Gastric cancer Para-aortic lymph node Multidisciplinary Gastrectomy Conversion Neoadjuvant

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Diagnostic accuracy of transient elastography (Fibro Scan) in detection of esophageal varices in patients with cirrhosis: A meta-analysis

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World Journal of Gastroenterology 2017年第2期23卷 345-356页

作者： Ke Pu Jing-Hong Shi Xu Wang Qian Tang Xin-Jie Wang Kai-Lin Tang Zhong-Qi Long xing-sheng Hu School of Clinical Medicine Dazhou College of Chinese Medicine Department of Immunology Shaanxi University of Chinese Medicine Department of Hepatobiliary Surgery Dachuan Southern Hospital School of Nursing Georgia Southern University School of Life Science Northwest University General Surgery Department of Jinshan Hospital The First Affiliated Hospital of Chongqing Medical University Department of Oncology Nanchong Central Hospital(The Second Affiliated Hospital of North Sichuan Medical College)

AIM To investigate the diagnostic accuracy of Fibro Scan(FS) in detecting esophageal varices(EV) in cirrhotic *** Through a systemic literature search of multiple databases, we reviewed 15 studies using endoscopy as a reference standard, with the data necessary to calculate pooled sensitivity(SEN) and specificity(SPE), positive and negative LR, diagnostic odds ratio(DOR) and area under receiver operating characteristics(AUROC). The quality of the studies was rated by the Quality Assessment of Diagnostic Accuracy studies-2 tool. Clinical utility of FS for EV was evaluated by a Fagan plot. Heterogeneity was explored using meta-regression and subgroup analysis. All statistical analyses were conducted via Stata12.0, MetaD isc1.4 and RevM *** In 15 studies(n = 2697), FS detected the presence of EV with the summary sensitivities of 84%(95%CI: 81.0%-86.0%), specificities of 62%(95%CI: 58.0%-66.0%), a positive LR of 2.3(95%CI: 1.81-2.94), a negative LR of 0.26(95%CI: 0.19-0.35), a DOR of 9.33(95%CI: 5.84-14.92) and an AUROC of 0.8262. FS diagnosed the presence of large EV with the pooled SEN of 0.78(95%CI: 75.0%-81.0%), SPE of 0.76(95%CI: 73.0%-78.0%), a positive and negative LR of 3.03(95%CI: 2.38-3.86) and 0.30(95%CI: 0.23-0.39) respectively, a summary diagnostic OR of 10.69(95%CI: 6.81-16.78), and an AUROC of 0.8321. A meta-regression and subgroup analysis indicated different etiology could serve as a potential source of heterogeneity in the diagnosis of the presence of EV group. A Deek's funnel plot suggested a low probability for publication *** Using FS to measure liver stiffness cannot provide high accuracy for the size of EV due to the various cutoff and different etiologies. These limitations preclude widespread use in clinical practice at this time; therefore, the results should be interpreted cautiously given its SEN and SPE.

关键词： Transient elastography FibroScan Liver cirrhosis Meta-analysis Esophageal varices

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