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Single-cell transcriptomics reveals the ameliorative effect of rosmarinic acid on diabetic nephropathy-induced kidney injury by modulating oxidative stress and inflammation

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1661-1676页

作者： Junhui Chen Qian Zhang Jinan Guo Di Gu Jing Liu Piao Luo Yunmeng Bai Jiayun Chen Xinzhou Zhang sheng nie Chunbo Chen Yulin Feng Jigang Wang National Pharmaceutical Engineering Center for Solid Preparation of Chinese Herbal Medicine Jiangxi University of Chinese MedicineNanchang 330006China Department of Pulmonary and Critical Care Medicine Shenzhen Institute of Respiratory Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalFirst Affiliated Hospital of Southern University of Science and TechnologySecond Clinical Medical College of Jinan UniversityShenzhen 518020China School of Traditional Chinese Medicine and School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Urology the First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510230China Department of Nephrology Shenzhen Key Laboratory of Kidney Diseasesand Shenzhen Clinical Research Centre for GeriatricsShenzhen People's Hospitalthe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Nephrology Nanfang Hospitalthe First Affiliated Hospital of Southern Medical UniversityGuangzhou 510515China Department of Critical Care Medicine Shenzhen People's Hospital(the Second Clinical Medical CollegeJinan Universitythe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China State Key Laboratory for Quality Esurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China Department of Oncology the Affiliated Hospital of Southwest Medical UniversityLuzhou 646000China

Diabetic nephropathy(DN)is a severe complication of diabetes,characterized by changes in kidney structure and *** natural product rosmarinic acid(RA)has demonstrated therapeutic effects,including anti-inflammation and anti-oxidative-stress,in renal damage or *** this study,we characterized the heterogeneity of the cellular response in kidneys to DN-induced injury and RA treatment at single cell *** results demonstrated that RA significantly alleviated renal tubular epithelial injury,particularly in the proximal tubular S1 segment and on glomerular epithelial cells known as podocytes,while attenuating the inflammatory response of macrophages,oxidative stress,and cytotox-icity of natural killer *** findings provide a comprehensive understanding of the mechanisms by which RA alleviates kidney damage,oxidative stress,and inflammation,offering valuable guidance for the clinical application of RA in the treatment of DN.

关键词： Rosmarinic acid Diabetic nephropathy scRNA sequencing Injury Oxidative stress Infiammation Proteomics

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法经济学视角下教育法典编纂的方案设想

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理论月刊 2024年第5期 128-140页

作者：聂圣华中师范大学法学院

在中国式现代化视域下,教育法典编纂的本质是国家为保障公民公平优质受教育权和保证教育事业优先发展而供给高质量教育法律,应当符合办好人民满意教育的制度需求。引入法经济学视角,能够为教育法典编纂如何克服现实困境达致综合性、体... 详细信息

在中国式现代化视域下,教育法典编纂的本质是国家为保障公民公平优质受教育权和保证教育事业优先发展而供给高质量教育法律,应当符合办好人民满意教育的制度需求。引入法经济学视角,能够为教育法典编纂如何克服现实困境达致综合性、体系性、逻辑性和科学性的理论目标拓展方法论,但必须坚持教育立法的社会本位,注重教育公平性与经济效率性的法律权衡。基于我国教育立法的现状和教育事业改革发展的趋势,教育法典编纂必须坚持守正创新的法典化路径,采取开放性结构和汇编型模式以实现教育法典编纂的效益优化。教育法典编纂可以采取“制定教育法典总则—加快推进教育领域内重点立法工作—完成教育法典分则编纂”三步走进程,并运用整合式技术应对教育法典编纂进程中的路径依赖和连锁效应。

关键词：教育法典法经济学教育立法汇编型模式整合式技术

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Real-world effectiveness of early insulin therapy on the incidence of cardiovascular events in newly diagnosed type 2 diabetes

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2953-2959页

作者： Sihui Luo Xueying Zheng Wei Bao sheng nie Yu Ding Tong Yue Yilun Zhou Ying Hu Hua Li Qiongqiong Yang Qijun Wan Bicheng Liu Hong Xu Guisen Li Gang Xu Chunbo Chen Huafeng Liu Yongjun Shi Yan Zha Yaozhong Kong Guobin Su Ying Tang Mengchun Gong Linong Ji Fan Fan Hou Jianping Weng Department of Endocrinology First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHeifeiChina Institute of Public Health Sciences Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiChina Division of Nephrology National Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Nephrology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina The Second Affiliated Hospital of Zhejiang University School of Medicine HangzhouChina Sir Run Run Shaw Hospital Zhejiang University School of MedicineHangzhouChina Department of Nephrology Sun Yat-Sen Memorial HospitalSun Yat-Sen UniversityGuangzhouChina The Second People’s Hospital of Shenzhen Shenzhen UniversityShenzhenChina Institute of Nephrology Zhongda HospitalSoutheast University School of MedicineNanjingChina Children’s Hospital of Fudan University ShanghaiChina Renal Department and Institute of Nephrology Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaSichuan Clinical Research Center for Kidney DiseasesChengduChina Division of Nephrology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Critical Care Medicine Maoming People’s HospitalMaomingChina Key Laboratory of Prevention and Management of Chronic Kidney Disease of Zhanjiang City Institute of NephrologyAffiliated Hospital of Guangdong Medical UniversityZhanjiangChina Huizhou Central People’s Hospital Sun Yat-Sen UniversityHuizhouChina Guizhou Provincial People’s Hospital Guizhou UniversityGuiyangChina Department of Nephrology the First People’s Hospital of FoshanFoshanChina Department of Nephrology Guangdong Provincial Hospital of Chinese Medicinethe Second Affiliated Hospitalthe Second Clinical CollegeGuangzhou University of Chinese Medicin

Early insulin therapy is capable to achieve glycemic control and restoreβ-cell function in newly diagnosed type 2 diabetes(T2D),but its effect on cardiovascular outcomes in these patients remains *** this nationwide real-world study,we analyzed electronic health record data from 19 medical centers across China between 1 January 2000,and 26 May *** included 5424 eligible patients(mean age 56 years,2176 women/3248 men)who were diagnosed T2D within six months and did not have prior cardiovascular *** Cox regression models were used to estimate the associations of early insulin therapy(defined as the first-line therapy for at least two weeks in newly diagnosed T2D patients)with the incidence of major cardiovascular events including coronary heart disease(CHD),stroke,and hospitalization for heart failure(HF).During 17,158 persons years of observation,we documented 834 incident CHD cases,719 stroke cases,and 230 hospitalized cases for *** diagnosed T2D patients who received early insulin therapy,compared with those who did not receive such treatment,had 31%lower risk of incident stroke,and 28%lower risk of hospitalization for *** significant difference in the risk of CHD was *** found similar results when repeating the aforesaid analysis in a propensity-score matched population of 4578 patients and with inverse probability of treatment weighting *** findings suggest that early insulin therapy in newly diagnosed T2D may have cardiovascular benefits by reducing the risk of incident stroke and hospitalization for HF.

关键词： cardiovascular treatment nationwide

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一种稳健的激光点云拟合空间圆柱面方法

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测绘地理信息 2024年第3期49卷 31-34页

作者：罗成文黎东聂胜隋立春中国科学院空天信息创新研究院数字地球重点实验室北京100094 中国科学院大学北京100049 长安大学地质工程与测绘学院陕西西安710061

针对激光点云三维建模应用中完整圆柱面及局部圆柱面拟合结果稳健性问题,提出一种稳健的空间圆柱面拟合方法。首先采用RANSAC(random sample consensus)算法拟合直线和圆,确定圆柱模型参数的初值,然后将RANSAC算法结合最小二乘法(least ... 详细信息

针对激光点云三维建模应用中完整圆柱面及局部圆柱面拟合结果稳健性问题,提出一种稳健的空间圆柱面拟合方法。首先采用RANSAC(random sample consensus)算法拟合直线和圆,确定圆柱模型参数的初值,然后将RANSAC算法结合最小二乘法(least square,LS)实现空间圆柱面拟合。利用仿真实验测试了圆柱面完整度在100%、50%及25%3种情况下且包含各种水平噪声的圆柱面点云,拟合的圆柱半径最大误差仅为0.2 mm。结果表明,与传统RANSAC算法和LS法相比,所提方法不仅具有非常高的拟合精度,而且对数据完整性、噪声等具有较高的稳健性。

关键词：激光点云圆柱面拟合 RANSAC算法最小二乘法稳健性

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Integrated data mining and network pharmacology to discover a novel traditional Chinese medicine prescription against diabetic retinopathy and reveal its mechanism

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TMR Modern Herbal Medicine 2024年第2期7卷 41-55页

作者： Kai-Lun Zhang Xu Wang Xiang-Wei Chang Jun-Fei Gu Bo-Yang Zhu Shi-Bing Wei Bo Wu Can Peng Jiu-sheng nie De-Ling Wu College of Pharmacy Anhui University of Chinese MedicineHefei 230012China School of Traditional Chinese Medicine and School of Integrated Chinese and Western Medicine Nanjing University of Chinese MedicineNanjing 210023China MOE-Anhui Joint Collaborative Innovation Center for Quality Improvement of Anhui Genuine Chinese Medicinal Materials Anhui University of Chinese MedicineHefei 230012China Institute of Pharmaceutics Anhui Academy of Chinese MedicineHefei 230012China Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Anhui University of Chinese MedicineHefei 230012China Engineering Technology Research Center of Modernized Pharmaceutics Anhui Education Department(AUCM)Hefei 230012China The First Clinical Medical College Anhui University of Chinese MedicineHefei 230012China

Background:Diabetic retinopathy(DR)is currently the leading cause of blindness in elderly individuals with *** Chinese medicine(TCM)prescriptions have shown remarkable effectiveness for treating *** study aimed to screen a novel TCM prescription against DR from patents and elucidate its medication rule and molecular mechanism using data mining,network pharmacology,molecular docking and molecular dynamics(MD)***:TCM prescriptions for treating DR was collected from patents and a novel TCM prescription was identified using data ***,the mechanism of the novel TCM prescription against DR was explored by constructing a network of core TCMs-core active ingredients-core targets-core ***,molecular docking and MD simulation were employed to validate the findings from network ***:The TCMs of the collected prescriptions primarily possessed bitter and cold properties with heat-clearing and supplementing effects,attributed to the liver,lung and kidney ***,a novel TCM prescription for treating DR was identified,composed of Lycii Fructus,Chrysanthemi Flos,Astragali Radix and Angelicae Sinensis *** core active ingredients and ten core targets of the novel TCM prescription for treating DR were ***,the novel TCM prescription played a crucial role for treating DR by inhibiting inflammatory response,oxidative stress,retinal pigment epithelium cell apoptosis and retinal neovascularization through various pathways,such as the AGE-RAGE signaling pathway in diabetic complications and the MAPK signaling ***,molecular docking and MD simulation demonstrated that almost all core active ingredients exhibited satisfactory binding energies to core ***:This study identified a novel TCM prescription and unveiled its multi-component,multi-target and multi-pathway characteristics for treating *** findings provide a scientific basis and novel insights into

关键词： TCM prescriptions diabetic retinopathy medication rule molecular mechanism data mining network pharmacology molecular docking

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基于图优化的激光SLAM点云整体配准方法

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激光与光电子学进展 2024年第10期61卷 273-281页

作者：唐浩黎东王成聂胜刘佳音段烨昆明理工大学国土资源工程学院云南昆明650093 中国科学院空天信息创新研究院数字地球重点实验室北京100094

针对激光同步定位与制图(SLAM)算法在扫描轨迹过长时,获得的点云容易出现漂移误差且精度变差的问题,提出一种基于图优化的激光SLAM点云整体配准方法。对于有一定漂移误差的激光SLAM点云,先后构建初始位姿图和迭代位姿图进行级联优化。... 详细信息

针对激光同步定位与制图(SLAM)算法在扫描轨迹过长时,获得的点云容易出现漂移误差且精度变差的问题,提出一种基于图优化的激光SLAM点云整体配准方法。对于有一定漂移误差的激光SLAM点云,先后构建初始位姿图和迭代位姿图进行级联优化。首先基于分段点云相似性和形心距离,构建初始位姿图进行优化,以减小轨迹漂移误差,获得漂移误差较小的SLAM点云。然后基于分段点云重叠度构建迭代位姿图,依次进行点云迭代粗优化和精优化,获得更高精度的SLAM点云。使用一组手持和三组车载激光SLAM数据进行实验。优化后,4组实验数据的各自重复扫描点云很好地重叠在一起,匹配关键点之间的距离的均方根误差(RMSE)分别由优化前的2.667 m、10.348 m、19.018 m和3.412 m降为0.158 m、0.211 m、0.218 m和0.157 m。实验结果表明,所提算法可以有效解决激光SLAM点云长轨迹扫描的漂移误差问题,提升点云数据精度。

关键词：点云整体配准同步定位与制图图优化 K-means算法

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中国非透析慢性肾脏病患者高磷血症的流行病学概况及其预后分析

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中华肾脏病杂志 2024年第4期40卷 261-269页

作者：粟立聪高齐周世煜庞铭祯聂晟南方医科大学南方医院肾内科、南方医科大学南方医院国家肾脏病临床医学研究中心广州510515

目的了解中国成人非透析慢性肾脏病(chronic kidney disease,CKD)患者高磷血症的患病率和降磷药物使用率,探索高磷血症及降磷治疗与临床结局的相关性。方法该研究为大型回顾性、多中心队列研究,研究人群来源于中国肾脏病大数据协作网,纳... 详细信息

目的了解中国成人非透析慢性肾脏病(chronic kidney disease,CKD)患者高磷血症的患病率和降磷药物使用率,探索高磷血症及降磷治疗与临床结局的相关性。方法该研究为大型回顾性、多中心队列研究,研究人群来源于中国肾脏病大数据协作网,纳入2013—2020年诊断为CKD的≥18岁的非透析且有血磷检测结果的首次住院患者。高磷血症定义为住院期间首次检测的血磷>1.45 mmol/L,正常血磷定义为0.97 mmol/L≤血磷≤1.45 mmol/L。使用Cox回归模型分析高磷血症与全因死亡、心血管事件死亡和CKD进展的关系,以及使用降磷药物与全因死亡和心血管事件死亡的关系。结果该研究共纳入157987例有血磷检测结果的成人非透析CKD患者,年龄60(47,72)岁,男性91453例(57.89%),估算肾小球滤过率为63.49(39.12,92.90)ml·min^(-1)·(1.73 m^(2))^(-1),常见的合并症为高脂血症84497例(53.48%)、高血压58818例(37.23%)和心力衰竭42686例(27.02%)。高磷血症的患病率为14.83%(23431/157987)。在合并高磷血症的CKD 3~5期患者中,降磷药物的使用率为13.34%(3962/29705)。多因素Cox回归分析结果显示,在64662例随访时间≥90 d的患者中,随访时间为3.3(1.5,5.4)年,高磷血症与全因死亡(高磷血症/正常血磷,HR=1.13,95%CI 1.06~1.22,P=0.001)及心血管事件死亡(高磷血症/正常血磷,HR=1.28,95%CI 1.04~1.56,P=0.018)风险增加均显著相关。在47581例随访时间≥90 d且基线估算肾小球滤过率>30 ml·min^(-1)·(1.73 m^(2))^(-1)的患者中,随访时间为1.8(0.9,3.2)年,高磷血症与CKD进展风险增加显著相关(高磷血症/正常血磷,HR=1.08,95%CI 1.00~1.17,P=0.038)。在8856例有死亡随访资料且有高磷血症患者中,随访时间为3.3(1.5,5.4)年,使用降磷药物与全因死亡(HR=0.88,95%CI 0.82~0.95,P<0.001)和心血管事件死亡(HR=0.84,95%CI 0.72~0.97,P=0.022)风险降低均显著相关。结论中国成人非透析CKD患者高磷血症患病率较高,但降磷药物使用率较低。高磷血症是非透析CKD患者全因死亡、心血管事件死亡及肾功能进展的独立危险因素,使用降磷药物可能降低上述风险。定期监测非透析CKD患者血磷水平并对高磷血症患者启动降磷治疗可能有利于改善其临床预后。

关键词：肾功能不全慢性高磷血症患病率成人基线特征临床结局

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基于ICESat-2和Sentinel-2A数据的森林蓄积量反演

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自然资源遥感 2024年第1期36卷 210-216页

作者：刘美艳聂胜王成习晓环程峰冯宝坤云南师范大学地理学部昆明650500 中国科学院空天信息创新研究院数字地球重点实验室北京100094

森林蓄积量是林业调查的重要指标,在衡量森林健康状况和评价森林固碳能力等方面发挥重要作用,协同主被动遥感是当前反演大区域森林蓄积量的主要手段。以云南香格里拉森林为研究区,分别提取ICESat-2/ATLAS和Sentinel-2A影像的特征变量,... 详细信息

森林蓄积量是林业调查的重要指标,在衡量森林健康状况和评价森林固碳能力等方面发挥重要作用,协同主被动遥感是当前反演大区域森林蓄积量的主要手段。以云南香格里拉森林为研究区,分别提取ICESat-2/ATLAS和Sentinel-2A影像的特征变量,并通过相关性分析和共线性诊断方法筛选特征变量,构建Sentinel-2A变量集和ICESat-2/ATLAS变量集,以及二者联合的变量集,然后结合样地实测数据与3个特征变量集,采用逐步线性回归和随机森林方法分别建立线性和非线性回归模型,反演森林蓄积量,并对结果进行精度验证及对比分析。研究结果表明:对3个变量集,随机森林方法精度均优于逐步线性回归;ICESat-2/ATLAS变量集在2种回归方法下的反演精度均高于Sentinel-2A变量集;联合Sentinel-2A和ICESat-2/ATLAS变量集,随机森林方法的反演精度最高,其R 2,RMSE和rRMSE分别为0.7034,84.78 m^(3)/hm^(2)和36.46%。整体来说,与Sentinel-2A数据相比,基于ICESat-2/ATLAS数据及其与多源数据联合的反演模型均可以提高森林蓄积量反演精度和模型稳定性。

关键词：森林蓄积量特征变量随机森林多元回归 ICESat-2/ATLAS Sentinel-2A

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Segmentation of the communication tower and its accessory equipment based on geometrical shape context from 3D point cloud

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International Journal of Digital Earth 2022年第1期15卷 1547-1566页

作者： Jingru Wang Cheng Wang Xiaohuan Xi Meng Du Pu Wang sheng nie Key Laboratory of Digital Earth Science Aerospace Information Research InstituteChinese Academy of SciencesBeijingPeople’s Republic of China College of Resources and Environment University of Chinese Academy of SciencesBeijingPeople’s Republic of China International Research Center of Big Data for Sustainable Development Goals Key Laboratory of Digital Earth ScienceAerospace Information Research InstituteChinese Academy of SciencesBeijingPeople’s Republic of China

Communication tower(CT)and its accessory equipment(AE)such as radio frequency equipment(RFE)and antenna,are essential in providing highspeed and stable mobile network *** is necessary to routinely monitor the security and stability of CT and AE for seamless *** is limited research on fine segmentation of communication base station *** paper proposes a method for accurately segmenting the point cloud of the CT and AE from Terrestrial Laser Scanning(TLS)*** first,the CT point cloud is accurately segmented based on region growing and Random Sample Consensus(RANSAC).Then,the point cloud of pole-shaped apart is extended to a certain distance to obtain the buffer point cloud containing *** Differential(ND)clustering is employed to obtain several groups of clusters containing planes,and calculate each plane's filling rate and ***,the cluster type(such as antenna,RFE,or other)is *** experimental results demonstrate that the point-based average F1-score of CTs is 98.70%,the point-based and object-based average F1-scores of antennas are 96.09%and 97.93%,and the corresponding values for the RFE are 89.89%and 90.00%,respectively,indicating the optimal performance of the proposed method.

关键词： Communication tower(CT) radio frequency equipment(RFE) antenna segmentation point cloud

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RECAT-CN间隔下点融合系统进场航班排序研究

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航空计算技术 2024年第2期54卷 1-5页

作者：段炼孙永鹏聂胜楠张杨中国民用航空飞行学院四川广汉618000 民航大连空管站辽宁大连116000 广安职业技术学院四川广安638000

为提升终端区进场航班运行效率,针对大连机场终端区点融合系统设计进场航班排序模型,改进遗传算法求解实际航班流的最优排序并提出了一种航班换序运行模式。通过分别对比在RECAT-CN间隔和CAAC间隔下航班换序运行模式与先到先服务(FCFS)... 详细信息

为提升终端区进场航班运行效率,针对大连机场终端区点融合系统设计进场航班排序模型,改进遗传算法求解实际航班流的最优排序并提出了一种航班换序运行模式。通过分别对比在RECAT-CN间隔和CAAC间隔下航班换序运行模式与先到先服务(FCFS)运行模式的运行效率,得出了如下结论:1)CAAC间隔下实施航班换序运行模式较FCFS运行模式对航班总等待时间、总飞行时间、航班流总运行时间均有优化;2)在航班换序运行模式下采用RECAT-CN间隔可进一步提升运行效率;3)采用航班换序运行模式可以一定程度上缓解FCFS原则下航班延误逐渐累积的问题。

关键词：点融合系统进场航班排序遗传算法 RECAT-CN间隔

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