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RNase P:Beyond Precursor tRNA Processing

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 19-28页

作者： Peipei wang Juntao lin Xiangyang Zheng Xingzhi xu Guangdong Key Laboratory for Genome Stability&Disease Prevention and Marshall Laboratory of Biomedical Engineering Shenzhen University Medical SchoolShenzhen UniversityShenzhen 518060China Department of Urology The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000China Shenzhen University General Hospital-Dehua Hospital Joint Research Center on Precision Medicine Dehua HospitalDehua 362500China

Ribonuclease P(RNase P)was first described in the 1970’s as an endoribonuclease acting in the maturation of precursor transfer RNAs(tRNAs).More recent studies,however,have uncovered non-canonical roles for RNase P and its ***,we review the recent progress of its involvement in chromatin assembly,DNA damage response,and maintenance of genome stability with implications in *** possibility of RNase P as a therapeutic target in cancer is also discussed.

关键词： RNase P Chromatin assembly DNA damage response Genome stability Tumorigenesis

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 458-474页

作者： Wei Ding Wei-Wei Chen Yi-Qin wang xue-zhong xu Yi-Bo wang Yong-Min Yan Yu-lin Tan Department of General Surgery Wujin Hospital Affiliated with Jiangsu UniversityChangzhou 213003Jiangsu ProvinceChina Changzhou Medical Center Nanjing Medical UniversityChangzhou 213017Jiangsu ProvinceChina Department of General Surgery The Wujin Clinical College of Xuzhou Medical UniversityChangzhou 213003Jiangsu ProvinceChina

BACKGROUND Gastric cancer(GC)is a prevalent malignant tumor of the gastrointestinal ***710 is a transcription factor(TF),and zinc finger protein 710(ZNF710)-AS1-201 is an immune-related long noncoding RNA(lncRNA)that is upregulated in GC *** To assess the correlation between ZNF710-AS1-201 and immune microenvir-onment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC *** We obtained data from The Cancer Genome Atlas and Wujin *** assessed cell growth,migration,invasion,and programmed cell death using cell counting kit-8,EdU,scratch,Transwell,and flow cytometry *** real-time polymerase chain reaction(qRT-PCR)was used to identify the potential downstream targets of *** In GC tissues with low ZNF710-AS1-201 expression,immunoassays detected significant infiltration of various antitumor immune cells,such as memory CD8 T cells and activated CD4 T *** the low-expression group,the half-maximal inhibitory concentrations(IC_(50)s)of 5-fluorouracil,cisplatin,gemcitabine,and trametinib were lower,whereas the IC_(50)s of dasatinib and vorinostat were *** malignant degree of GC was higher and the stage was later in the high-expression ***,patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival *** vitro,the overexpression of ZNF710-AS1-201 greatly enhanced growth,metastasis,and infiltration while suppressing cell death in HGC-27 *** contrast,the reduced expression of ZNF710-AS1-201 greatly hindered cell growth,enhanced apoptosis,and suppressed the metastasis and invasion of MKN-45 *** expression changes in ZNF710 were significant,but the corresponding changes in isocitrate dehydrogenase-2,Semaphorin 4B,ARHGAP10,RGMB,hsa-miR-93-5p,and ZNF710-AS1-202 were not consistent or statistically significant after overexpression or knockdown of ZNF710-AS1-201,as determined by ***

关键词： Gastric cancer ZNF710-AS1-201 Proliferation Metastasis Invasion Apoptosis

The m^(6)A regulator KIAA1429 stabilizes RAB27B mRNA and promotes the progression of chronic myeloid leukemia and resistance to targeted therapy

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Genes & Diseases 2024年第2期11卷 993-1008页

作者： Fangyi Yao Fangmin zhong Junyao Jiang Ying Cheng Shuai xu Jing Liu Jin lin Jing Zhang Shuqi Li Meiyong Li Yanmei xu Bo Huang Xiaozhong wang Jiangxi Province Key Laboratory of Laboratory Medicine Jiangxi Provincial Clinical Research Center for Laboratory MedicineDepartment of Clinical LaboratoryThe Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi 330006China

Chronic myeloid leukemia(CML)is a common adult *** the acute phase of the disease and the adverse effects of anti-cancer treatments can lead to a poor *** N6-methyladenine(m^(6)A)modification plays an important regulatory role in various physiological and pathological ***1429 is a known m^(6)A regulator,but the biological role of KIAA1429 in CML is *** this study,we observed that the m^(6)A levels and KIAA1429 expression were significantly up-regulated in patients with blast phase ***,KIAA1429 regulated the total level of RNA m^(6)A modification in the CML cells and promoted the malignant biological behaviors of CML cells,including proliferation,migration,and imatinib *** KIAA1429 in CML cells reduced the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis,consequently inhibiting CML proliferation and drug efflux,ultimately increasing the sensitivity of CML cells to ***,the knockdown of RAB27B also inhibited the proliferation and drug resistance of CML cells and promoted their ***,a recently developed anti-cancer agent,suppressed the expression of KIAA1429 and CML cell proliferation and promoted cell *** also inhibited the tumorigenesis of CML cells in *** combined use of rucaparib and imatinib enhanced the sensitivity of CML cells to *** study provides evidence that elevated KIAA1429 expression in the blast phase of CML enhances the stability of RAB27B mRNA through the m^(6)A/YTHDF1 axis to up-regulate RAB27B expression,thereby promoting CML *** exerts inhibitory effects on KIAA1429 expression and thus reduces CML progression.

关键词： Chronic myeloid leukemia KIAA1429 N6-methyladenine RAB27B Rucaparib YTHDF1

Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma

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World Journal of Gastroenterology 2024年第17期30卷 2321-2331页

作者： Zhi-Peng lin Xiao-Long Hu Du Chen Da-Bei Huang xu-Gong Zou Hai zhong sheng-Xiang xu Yuan Chen Xiao-Qun Li Jian Zhang Department of Interventional Medicine Zhongshan People’s HospitalZhongshan 528400Guangdong ProvinceChina

BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more efficacious than ***,the mechanisms underlying this innovative treatment modality have not been *** To evaluate the clinical efficacy of targeted therapy plus immunotherapy combined with hepatic arterial infusion chemotherapy(HAIC)of FOLFOX in patients with unresectable *** We enrolled 53 patients with unresectable HCC who received a combination of targeted therapy,immunotherapy,and HAIC of FOLFOX between December 2020 and June 2021 and assessed the efficacy and safety of the treatment *** The objective response rate was 60.4%(32/53),complete response was 24.5%(13/53),partial response was 35.9%(19/53),and stable disease was 39.6%(21/53).The median duration of response and median progression-free survival were 9.1 and 13.9 months,*** surgical conversion rate was 34.0%(18/53),and 1-year overall survival was 83.0%without critical complicating diseases or adverse events(AEs).CONCLUSION The regimen of HAIC of FOLFOX,targeted therapy,and immunotherapy was curative for patients with unresectable HCC,with no serious AEs and a high rate of surgical conversion.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Targeted therapy Immunotherapy Adverse events

Triboelectric nanogenerator integrated with a simple controlled switch for regularized water wave energy harvesting

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Nano Research 2024年第8期17卷 7585-7592页

作者： Hongbo Yang Xi Liang Junwu Kan zhong lin wang Tao Jiang Zhanyong Hong College of Engineering Zhejiang Normal UniversityJinhua 321004China Beijing Key Laboratory of Micro-Nano Energy and Sensor Center for High-Entropy Energy and SystemsBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China The Beijing Key Laboratory for Nano-Photonics and Nano-Structure Department of PhysicsCapital Normal UniversityBeijing 100048China Guangzhou Institute of Blue Energy Guangzhou 510555China Georgia Institute of Technology AtlantaGA 30332-0245USA Yonsei Frontier Lab Yonsei UniversitySeoul 03722Republic of Korea

Ocean is full of low-frequency,irregular,and widely distributed wave energy,which is suitable as the energy source for maritime Internet of Things(IoTs).Utilizing triboelectric nanogenerators(TENGs)to harvest ocean wave energy and power sensors is proven to be an effective ***,in random ocean waves,the irregular electrical energy output by general TENGs restricts the *** present,achieving regularized water wave energy harvesting relies on rather complex mechanical structure designs,which is not conducive to *** this work,we proposed a novel mechanical controlled TENG(MCTENG)with a simple controlled switch to realize the regularization *** structural parameters of the MC-TENG are optimized,and the optimal output voltage,output current,and transferred charge respectively reach 1684.2 V,85.4μA,and 389.9 nC,generating a peak power density of 38.46 W·m^(−3)·Hz^(−1).Under real water wave environment,the output of the MC-TENG is regularized and keeps stable regardless of any wave ***,the potential applications of the MC-TENG are demonstrated in powering environmental temperature,humidity,and wind speed *** work renders a simple approach to achieve effective regularized ocean wave energy harvesting,promoting the TENG industrialization toward practical application of maritime IoTs.

关键词： water wave energy harvesting triboelectric nanogenerators random excitation mechanical control regular output

Transient Analysis of a Reactor Coolant Pump Rotor Seizure Nuclear Accident

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Fluid Dynamics & Materials Processing 2024年第6期20卷 1331-1349页

作者： Mengdong An Weiyuan zhong Wei xu Xiuli wang Research Center of Fluid Machinery Engineering and Technology Zhenjiang212013China School of Energy and Power Engineering Jiangsu UniversityZhenjiang212013China

The reactor coolant pump(RCP)rotor seizure accident is defined as a short-time seizure of the RCP *** event typically leads to an abrupt flow decrease in the corresponding loop and an ensuing reactor and turbine *** significant reduction of core coolant flow while the reactor is being operated at full load can have very negative *** potentially dangerous event is typically characterized by a complex transient behavior in terms of flow conditions and energy transformation,which need to be analyzed and *** study constructed transient flow and rotational speed mathematical models under various degrees of rotor seizure using the test data collected from a dedicated transient rotor seizure test ***,bidirectional fluid-solid coupling simulations were conducted to investigate the flow evolution *** is found that the influence of the impeller structure size and transient braking acceleration on the unsteady head(Hu)is dominant in rotor seizure accident ***,the present results also show that the rotational acceleration additional head(Hu1)is much higher than the instantaneous head(Hu2).

关键词： Reactor coolant pump bidirectional fluid-solid coupling rotor seizure nuclear accident

Spatiotemporal Variability and Environmental Controls of Temperature Sensitivity of Ecosystem Respiration across the Tibetan Plateau

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Advances in Atmospheric Sciences 2024年第9期41卷 1821-1842页

作者： Danrui sheng Xianhong MENG Shaoying wang Zhaoguo LI Lunyu SHANG Hao CHEN lin ZHAO Mingshan DENG Hanlin NIU Pengfei xu Xiaohu WEN Key Laboratory of Land Surface Process and Climate Change in Cold and Arid Regions Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Zoige Plateau Wetlands Ecosystem Research Station Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beijing 100049China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Northwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China

Warming-induced carbon loss via ecosystem respiration(R_(e))is probably intensifying in the alpine grassland ecosystem of the Tibetan Plateau owing to more accelerated warming and the higher temperature sensitivity of R_(e)(Q_(10)).However,little is known about the patterns and controlling factors of Q_(10)on the plateau,impeding the comprehension of the intensity of terrestrial carbon-climate feedbacks for these sensitive and vulnerable ***,we synthesized and analyzed multiyear observations from 14 sites to systematically compare the spatiotemporal variations of Q_(10)values in diverse climate zones and ecosystems,and further explore the relationships between Q_(10)and environmental ***,structural equation modeling was utilized to identify the direct and indirect factors predicting Q_(10)values during the annual,growing,and non-growing *** results indicated that the estimated Q_(10)values were strongly dependent on temperature,generally,with the average Q_(10)during different time periods increasing with air temperature and soil temperature at different measurement depths(5 cm,10 cm,20 cm).The Q_(10)values differentiated among ecosystems and climatic zones,with warming-induced Q_(10)declines being stronger in colder regions than elsewhere based on spatial *** was the most cardinal factor in predicting annual Q_(10)values,significantly and positively correlated with Q_(10).Soil temperature(Ts)was identified as the other powerful predictor for Q_(10),and the negative Q_(10)-Ts relationship demonstrates a larger terrestrial carbon loss potentiality in colder than in warmer regions in response to global *** that the interpretations of the effect of soil moisture on Q_(10)were complicated,reflected in a significant positive relationship between Q_(10)and soil moisture during the growing season and a strong quadratic correlation between the two during the annual and non-growing *** findings are conducive to imp

关键词： carbon cycle eddy covariance measurements ecosystem respiration Q_(10)value Tibetan Plateau climate change

Nonlinear Impact Damage Evolution of Charpy Type and Analysis of Its Key Influencing Factors

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Chinese Journal of Mechanical Engineering 2024年第1期37卷 254-264页

作者： Jianfeng Mao Qian xu Jiadong Yang Chi Cao Dasheng wang Fengping zhong Mingya Chen Institute of Process Equipment and Control Engineering Zhejiang University of TechnologyHangzhou 310032China Taizhou Key Laboratory of Advanced Manufacturing Technology Taizhou InstituteZhejiang University of TechnologyTaizhou 318014China State Key Laboratory of Nuclear Power Safety Monitoring Technology and Equipment Shenzhen 518172China Zhejiang Academy of Special Equipment Science Hangzhou 310020China Suzhou Nuclear Power Research Institute Suzhou 215004China

The current research of Charpy impact mainly focuses on obtaining the ductile brittle transition temperature of materials by *** with experiments,numerical simulation can study many problems with harsh ***,there are still few studies on the influence of geometric factors such as side *** this paper,the geometry of standard Charpy impact test is *** with different widths and side grooves are *** finite element model of Charpy impact was established by ABAQUS *** test results and simulation results to verify each *** effects of sample width,side groove depth and side groove bottom fillet on the impact fracture resistance of the sample were *** results show that the specimen width is positively correlated with the impact toughness of the *** side groove greatly reduces the impact toughness of the material;the toughness of side groove decreases with the increase of depth;the fracture toughness of side groove decreases with the increase of fillet at the bottom of side *** proportion of toughness energy to impact energy of samples was *** results show that the toughness energy accounts for about 70%of the impact energy of the sample,which has little to do with the geometric characteristics of the *** study presents a reliable method for studying Charpy impact *** influence of geometric parameters is obtained,which provides a reference method for the study of impact toughness of high toughness materials.

关键词： Johnson-Cook model Impact toughness Charpy impact

Satellite glial cells in sensory ganglia play a wider role in chronic pain via multiple mechanisms

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Neural Regeneration Research 2024年第5期19卷 1056-1063页

作者： Xiaoyun Qiu Yuanzhi Yang Xiaoli Da Yi wang zhong Chen Cenglin xu Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical ScienceZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina

Satellite glial cells are unique glial cells that surround the cell body of primary sensory *** increasing body of evidence suggests that in the presence of inflammation and nerve damage,a significant number of satellite glial cells become activated,thus triggering a series of functional *** suggests that satellite glial cells are closely related to the occurrence of chronic *** this review,we first summarize the morphological structure,molecular markers,and physiological functions of satellite glial ***,we clarify the multiple key roles of satellite glial cells in chronic pain,including gap junction hemichannel Cx43,membrane channel Pannexin1,K channel subunit 4.1,ATP,purinergic P2 receptors,and a series of additional factors and their receptors,including tumor necrosis factor,glutamate,endothelin,and ***,we propose that future research should focus on the specific sorting of satellite glial cells,and identify genomic differences between physiological and pathological *** review provides an important perspective for clarifying mechanisms underlying the peripheral regulation of chronic pain and will facilitate the formulation of new treatment plans for chronic pain.

关键词： chronic pain primary sensory neurons satellite glial cells sensory ganglia