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A new fluorinated poly(ether amide) bearing xanthene group

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Chinese Chemical Letters 2010年第10期21卷 1247-1250页

作者： Ting Li Shou Ri sheng Mei Hong Wei Cheng Chen Cai sheng song College of Chemistry and Chemical Engineering Jiangxi Normal UniversityNanchang 330022China

A new fluorinated poly(ether amide) bearing xanthene group was prepared from 9,9-bis[4-(2-trifluoromethyl-4-aminophenox- y)phenyl]xanthene (BTFAPX) with 9,9-bis[4-(4-carboxyphenoxy)phenyl]xanthene (BCAPX) in the presence of triphenyl phos- phate and pyridine (Py). The polymer had the weight-average molecular weight (Mw) of 69,000 and number-average molecular weight (Mn) of 39,000, showed the glass transition temperature (Tg) of 267 ℃, 5% weight loss temperature (Tds) over 460 ℃ both in N2 and air, and char yield of 62% at 800 ℃ in N2. This polymer was amorphous and readily soluble in amide-type solvents such as N,N-dimethylacetamide (DMAc), and even in m-cressol, Py and tetrahydrofuran (THF) at room temperature, and exhibited tensile strength of 74 MPa, elongation at break of 6%, tensile moduli of 2.2 GPa. The polymer had low dielectric constant of 3.69 (100 Hz), low moisture absorption of 0.56%, and high transparency with an ultraviolet-visible absorption cut-off wavelength at 334 nm.

关键词： Fluorinated polyamide Xanthene group Trifluoromethyl substituents

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过伸与非过伸型胫骨平台骨折的比较

中国矫形外科杂志 2024年第2期32卷 133-138页

作者：李松生宗淑君胡明鑫张保龙河南中医药大学第五临床医学院(郑州人民医院)骨科河南郑州450003

[目的]探讨过伸型胫骨平台骨折手术方式选择及对预后的影响。[方法]回顾性分析2016年1月—2021年1月本院采用开放复位内固定治疗53例胫骨平台骨折患者。参照Firoozabadi标准分为过伸型组19例,非过伸组34例。比较两组围手术期、随访及影... 详细信息

[目的]探讨过伸型胫骨平台骨折手术方式选择及对预后的影响。[方法]回顾性分析2016年1月—2021年1月本院采用开放复位内固定治疗53例胫骨平台骨折患者。参照Firoozabadi标准分为过伸型组19例,非过伸组34例。比较两组围手术期、随访及影像结果。[结果]过伸组在合并伤的总发生率(63.1%vs 23.4%,P0.05)。随访时间平均(14.3±1.1)个月,两组术后完全负重活动时间的差异无统计学意义(P>0.05)。随时间推移,两组KSS临床评分、KSS功能评分均显著增加(P0.05)。术前过伸型组PTS显著小于非过伸组(P0.05)。[结论]与非过伸型骨折相比,过伸型胫骨平台骨折常合并其他结构损伤,手术治疗复杂,预后较差。

关键词：过伸型胫骨平台骨折合并损伤切开复位内固定预后

Effects of Electron Flow Current Density on Flow Impedance of Magnetically Insulated Transmission Lines

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Chinese Physics Letters 2011年第8期28卷 65-67页

作者： HE Yong ZOU Wen-Kang song sheng-Yi Institute of Fluid physics China Academy of Engineering PhysicsMianyang 621900

In modern pulsed power systems,magnetically insulated transmission lines(MITLs)are used to couple power between the driver and the *** circuit parameters of MITLs are well understood by employing the concept of flow impedance derived from Maxwell’s equations and pressure balance across the ***,the electron density in an MITL is always taken as constant in the application of flow *** effects of electron flow current density(product of electron density and drift velocity)in an MITL are *** calculate the flow impedances of an MITL and compare them under three classical MITL theories,in which the electron density profile and electron flow current density are different from each *** is found that the assumption of constant electron density profile in the calculation of the flow impedance is not always *** electron density profile and the electron flow current density have significant effects on flow impedance of the *** details of the electron flow current density and its effects on the operation impedance of the MITL should be addressed more explicitly by experiments and theories in the future.

关键词： impedance flow Density

新型sGC刺激剂维立西呱在心衰治疗中的价值

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四川生理科学杂志 2024年第2期46卷 276-278页

作者：潘靖梅易异许盛松上饶市人民医院心血管内科江西上饶334000

目的:探讨新型可溶性鸟苷酸环化酶(sGC)刺激剂维立西呱在心衰(HF)治疗中的价值。方法:2022年10月~2023年6月本院收治的60例HF患者,随机数字表法分为维立西呱组和对照组,每组各30例。对照组采用常规抗HF治疗,维立西呱组在对照组基础上给... 详细信息

目的:探讨新型可溶性鸟苷酸环化酶(sGC)刺激剂维立西呱在心衰(HF)治疗中的价值。方法:2022年10月~2023年6月本院收治的60例HF患者,随机数字表法分为维立西呱组和对照组,每组各30例。对照组采用常规抗HF治疗,维立西呱组在对照组基础上给予维立西呱口服,均持续3 m。比较两组的心功能改善疗效和治心室重构指标、心功能及不良反应发生率。结果:维立西呱组心功能改善疗效为93.33%,高于对照组的73.33%(P<0.05)。维立西呱组LVEF、6MWT高于对照组,LVESV、LVEDD和NT-ProBNP低于对照组(P<0.05)。结论:新型sGC刺激剂维立西呱治疗可改善HF患者心功能和运动耐力,降低NT-ProBNP水平。

关键词：可溶性鸟苷酸环化酶刺激剂维立西呱心衰心功能改善疗效

基于网络药理学探讨小儿止哮平喘颗粒治疗支气管哮喘的作用机制

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中医儿科杂志 2024年第3期20卷 32-40页

作者：张丽高蕊芮娜刘昆盛松中国中医科学院西苑医院儿科北京100091

目的运用网络药理学探讨小儿止哮平喘颗粒治疗支气管哮喘的作用机制。方法通过TCMSP和SymMap数据库筛选小儿止哮平喘颗粒的活性成分及其作用靶点,通过NCBI Gene、GeneCards、TTD、KEGG、MalaCards、PharmGKB、OMIM等数据库筛选支气管哮... 详细信息

目的运用网络药理学探讨小儿止哮平喘颗粒治疗支气管哮喘的作用机制。方法通过TCMSP和SymMap数据库筛选小儿止哮平喘颗粒的活性成分及其作用靶点,通过NCBI Gene、GeneCards、TTD、KEGG、MalaCards、PharmGKB、OMIM等数据库筛选支气管哮喘的疾病相关靶点,获取活性成分作用靶点与疾病相关靶点的交集靶点(共同靶点),即小儿止哮平喘颗粒治疗支气管哮喘的潜在作用靶点。运用Cytoscape3.2.1软件构建“中药-成分-靶点-疾病”网络,将上述共同靶点导入String数据库,获取数据后在Cytoscape3.2.1软件中构建“成分靶点-疾病靶点”(T-D)网络,利用Metascape数据库进行GO和KEGG通路富集分析。结果共筛选得到289个活性成分及470个潜在作用靶点;获得豆甾-4-烯-3-酮、白矢车菊素、丹参醌酚I、飞燕草素、(E)-(4-甲基亚苄基)-(4-苯基三唑-1-基)胺、油酸等核心活性成分;RAC-α丝氨酸/苏氨酸蛋白激酶(RAC-alpha serine/threonine-protein kinase,AKT1)、p53蛋白(cellular tumor antigen p53,TP53)、黏着连接蛋白β1(cateninβ1,CTNNβ1)、转录因子激活蛋白-1(transcription factor AP-1,JUN)、Harvery鼠肉瘤病毒癌基因(GTPase HRas,HRAS)、生长因子受体结合蛋白2(growth factor receptor-bound protein 2,GRB2)、过氧化物酶体增殖激活受体γ(peroxisome proliferator-activated receptor gamma,PPARG)等核心靶点;筛选得到AGE-RAGE信号通路、钙信号通路、cAMP信号通路、TNF信号通路、PI3K-Akt信号通路等关键信号通路。结论小儿止哮平喘颗粒可通过多成分、多靶点调控多种通路达到治疗小儿支气管哮喘的作用,为其分子机制研究奠定了一定的基础。

关键词：小儿止哮平喘颗粒支气管哮喘网络药理学作用机制

Comparison of bilateral/unilateral lateral rectus recession and unilateral recession-resection for intermittent exotropia:a Meta-analysis

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International Journal of Ophthalmology(English edition) 2018年第12期11卷 1984-1993页

作者： De-sheng song Zhi-Jun Chen Jing Qian Department of Ophthalmology Children's Hospital of Nanjing Medical University

AIM: To compare the effectiveness of unilateral recession-resection(R&R) and bilateral/unilateral recession(BLR/ULR) for treatment of basic type of intermittent exotropia [IX(T)].METHODS: A comprehensive literature search was performed using PubMed, EMBASE, and the Cochrane Library, to identify randomized controlled trials and comparative studies regarding the effectiveness of R&R and BLR/ULR for IX(T). Based on which, a Meta-analysis was then performed in terms of long-term success rate, overcorrection rate, and recurrence ***: Nine studies in total satisfy the specified eligibility criteria. BLR is at disadvantage to R&R at a short-term follow-up [2 y). There is no significant difference was found in overcorrection rate, regardless of the length of follow-up time [OR 0.85(0.41, 1.75)]. In the treatment for small-angle IX(T), the final outcome was significantly different between the groups, demonstrating a more successful alignment [OR 0.37(0.18, 0.74)] and a lower undercorrection [OR 3.50(1.28, 7.26)] in the R&R group than in the ULR group. While for moderate-angle IX(T)(20 PD-25 PD), the effectiveness of R&R and ULR is quite equivalent with similar success rate [OR 1.08(0.65, 1.79)] and undercorrection rate [OR 0.89(0.54, 1.48)]. CONCLUSION: As regard to the effect of BLR and R&R, R&R shows an advantage over BLR at short term. But, BLR is more effective in the long term for the basic typeIX(T) in children. R&R surgery should be a better choice for the treatment of small-angle IX(T) of ≤20 PD than ULR. However, both of ULR and R&R are recommended for moderate-angle IX(T) from 20 PD to 25 PD.

关键词： intermittent exotropia unilateral lateral rectus recession recess-resect moderate-angle exotropia

FAM160A2功能缺失性突变可能诱发心房颤动

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中国生物化学与分子生物学报 2024年第5期40卷 721-730页

作者：彭钊张梓铭陈松生叶嘉豪王鹏珍张少衡贵州医科大学研究生院贵阳550000 暨南大学附属广州红十字会医院心内科广州510220 南方医科大学临床医学系广州528305

心房颤动(atrial fibrillation,AF)是临床最常见的心律失常,对AF致病基因的研究,有助于AF早期筛查。本文旨在家族性AF人群和散发性AF人群中筛选具有潜在发病意义的易感基因,并对其在AF发生机制进行初步探讨。首先对4名家族性AF进行全外... 详细信息

心房颤动(atrial fibrillation,AF)是临床最常见的心律失常,对AF致病基因的研究,有助于AF早期筛查。本文旨在家族性AF人群和散发性AF人群中筛选具有潜在发病意义的易感基因,并对其在AF发生机制进行初步探讨。首先对4名家族性AF进行全外显子组测序(WES),鉴定AF相关基因。然后用Sanger测序在非家族性AF人群和健康人群中证实易感基因突变情况,应用Western印迹分析其蛋白质表达情况,利用膜片钳技术分析突变基因对外向钾离子电流的影响。家族共有39人,其中有4人发生AF,这4名AF患者存在2个共有的突变基因FAM160A 2(纯合突变,rs77726581 c.1375C>T)和MUC5B(杂合突变,rs199736618 c.12272C>T)。在52例非家族性AF患者中,有5例存在FAM160A2相同位点杂合突变,在健康人群中未发现此突变;而MUC5B在非家族性AF人群和健康人群中均发生杂合突变。FAM160A2蛋白在非家族性AF散发人群和健康人群中表达水平并无显著性差异。FAM160A 2基因突变明显降低外向钾离子电流(与野生型比较,P<0.001)。由此可见,FAM160A 2基因功能缺失性突变可能是AF发生的新分子生物学机制,可用于AF早期筛查。

关键词：心房颤动基因突变 FAM160A2

Apoptosis of pancreatic cancer BXPC-3 cells induced by indole-3-acetic acid in combination with horseradish peroxidase

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World Journal of Gastroenterology 2005年第29期11卷 4519-4523页

作者： Chen Huang Li-Ying Liu Tu-sheng song Lei Ni Ling Yang Xiao-Yan Hu Jing-song Hu Li-Ping song Yu Luo Lu-sheng Si Department of Cytobiology and Medical Genetics Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China College of Life Science and Technology Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM： To explore the mechanisms underlying the apoptosis of human pancreatic cancer BXPC-3 cells induced by indole-3-acetic acid （IAA） in combination with horseradish peroxidase （HRP）. METHODS： BXPC-3 cells derived from human pancreatic cancer were exposed to 40 or 80 μmol/L IAA and 1.2 μg/mL HRP at different times. Then, Mn- assay was used to detect the cell proliferation. Flow cytometry was performed to analyze cell cycle. Terminal deoxynucleotidyl transferasemediated dUTP nick end labeling assay was used to detect apoptosis. 2,7-Dichlorofluorescin diacetate uptake was measured by confocal microscopy to determine free radicals. Level of malondialdehyde （MDA） and activity of superoxide dismutase （SOD） were measured by biochemical methods. RESULTS： IAA/HRP initiated growth inhibition of BXPC-3 cells in a dose- and time-dependent manner. Flow cytometry revealed that the cells treated for 48 h were arrested at G1/G0. After exposure to 80 μmol/L IAA plus 1.2 μg/mL HRP for 72 h, the apoptosis rate increased to 72.5‰, which was nine times that of control. Content of MDA and activity of SOD increased respectively after treatment compared to control. Meanwhile, IAA/HRP stimulated the formation of free radicals. CONCLUSION： The combination of IAA and HRP can inhibit the growth of human pancreatic cancer BXPC-3 cells in vitro by inducing apoptosis.

关键词： Indole-3-acetic acid Horseradish peroxidase BXPC-3 cells Apoptosis Free radical

Nanoceria Supported Gold Catalysts for CO Oxidation

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Chinese Journal of Chemistry 2018年第7期36卷 639-643页

作者： Zhao Jin Yang-Yang song Xin-Pu Fu Qi-sheng song Chun-Jiang Jia Key Laboratory for Colloid and interface Chemistry Key Laboratory of Special Aggregated Materials School of Chemistry and Chemical Engineering Shandong University Jinan Shandong 250100 China

Two types of CeO2 nanocubes （average size of 5 and 20 nm, respectively） prepared via the hydrothermal process were selected to load gold species via a deposition-precipitation （DP） method. Various measurements, including X-ray diffraction （XRD）, Raman spectra, high resolution transmission electron microscopy （HRTEM）, in situ diffuse reflectance infrared Fourier transform spectroscopy （in situ DRIFTS）, and temperature-programmed reduction by hydrogen （H2-TPR）, were applied to characterize the catalysts. It is found that the sample with ceria size of 20 nm （Au/CeO2-20） was covered by well dis ersed both Au^3＋ and Au^δ＋（0〈δ〈1）. For the other sample with ceria size of 5 nm （Au/CEO2-5）, Au^3＋ is the dominant gold species. Au/CeO2-20 performed better catalytic activity for CO oxidation because of the strong CO adsorption of Au^δ＋ in the catalysts. The catalytic activity of Au/CeO2-5 was improved due to the transformation of Au^3＋ to Au^δ＋. Based on the CO oxidation and in situ DRIFTS results, Au^δ＋ is likely to play a more important role in catalyzing CO oxidation reaction.

关键词： gold catalysts nanoceria CO oxidation active species