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^(131)I-labeled metuximab combined with chemoembolization for unresectable hepatocellular carcinoma

World Journal of Gastroenterology 2013年第47期19卷 9104-9110页

作者： Qing He Wu-sheng lu Yang Liu Yong-Song Guan An-Ren Kuang Oncology Department West China Hospital of Sichuan University Department of Vascular Surgery West China Hospital of Sichuan University Department of Psychiatry West China Hospital of Sichuan University Department of Nuclear Medicine West China Hospital of Sichuan University

AIM:To investigate the safety and effectiveness of combined131I-metuximab and transcatheter arterial chemoembolization(TACE)for hepatocellular carcinoma(HCC).METHODS:One hundred and eighty-five patients(159men and 26 women)with advanced HCC were enrolled in this study from February 2009 to July *** were 95 patients in the combined metuximab and TACE group,and 90 patients in the TACE only *** patients were followed for 12 *** symptoms,blood cell counts,Karnofsky Performance Score(KPS)evaluation and therapeutic effects according to the Response Evaluation Criteria in Solid Tumors were recorded and ***:The 1-mo effective rates(complete response+partial response+stable disease)of the test group and control group were 71.23%and 38.89%,respectively(P<0.001).The 6-,9-and 12-mo survival rates were 86.42%,74.07%and 60.49%for the test group and 60.0%,42.22%and 34.44%for the control group(P<0.001).The incidence of adverse events(gastrointestinal symptoms,fever and pain)and blood cell toxicity were significantly higher for the test group than for the control group(P<0.001).No severe131Imetuximab-related complications were *** respect to efficacy,patients in the test group had greater improvement in tumor-related pain(P=0.014)and increase in KPS(P<0.001)than those in the control ***:Combination of131I-metuximab and TACE prolonged the survival time in patients with HCC compared with TACE *** combination treatment was safe and effective.

关键词： Hepatocellular carcinoma 131 I-metuximab Transcatheter arterial chemoembolization Radioimmunotherapy

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LARGE EDDY SIMULATION OF FREE SURFACE TURBULENT CHANNEL FLOW WITH HEAT TRANSFER

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Journal of Hydrodynamics 2002年第1期14卷 16-22页

作者： Zhong, Feng-Quan Liu, Nan-sheng lu, Xi-Yun Zhuang, Li-Xian Dept. of Modern Mech. Univ. of Sci. and Technol. of China Hefei 230026 China

The Large Eddy Simulation (LES) was used to study the free-surface turbulent channel flow with passive heat transfer. The three-dimensional filtered incompressible Navier-Stokes equations and energy equation were numerically solved with dynamic Subgrid Scale (SGS) models for modeling turbulent stresses and heat flux. To compare the turbulent behavior of the free-surface and two-walled channel flows, the LES of two-walled turbulent channel flow was performed. The statistical quantities and flow structures of the free-surface turbulence with heat transfer in the vicinity of the free-surface were investigated. The results are also in good agreement with theoretical analysis and available results by Direct Numerical Simulation (DNS).

关键词： Computer simulation Heat transfer Mathematical models

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Effects of oxygen vacancies on polarization stability of barium titanate

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Science China(Physics,Mechanics & Astronomy) 2016年第3期59卷 96-99页

作者： Jun Wang Yao Gen Shen Fan Song Fu Jiu Ke Yi Long Bai Chun sheng lu State Key Laboratory of Nonlinear Mechanics (LNM) Institute of Mechanics Chinese Academy of Sciences Department of Mechanical and Biomedical Engineering City University of Hong Kong School of Physics and Nuclear Energy Engineering Beihang University Department of Mechanical Engineering Curtin University

Oxygen vacancy, a kind of native point defects in ferroelectric ceramics, usually causes an increase of the dielectric loss. Based on experimental observations, it is believed that all of the oxygen vacancies are an unfavorable factor for energy saving. By using molecular dynamics simulations, we show that the increase of coercive and saturated electric fields is due to the difficulty to switch local polarization near an oxygen vacancy, and so that a ferroelectric device has to sustain the rising consumption of energy. The simulation results also uncover how oxygen vacancies influence ferroelectric properties.

关键词： ferroelectricity hysteresis oxygen vacancy molecular dynamics simulation

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Characteristics of black carbon aerosol in Jiaxing,China during autumn 2013

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Particuology 2015年第3期13卷 10-15页

作者： Lijuan Shen Li Li sheng lu Xiaohan Zhang Jie Liu Junlin An Guojun Zhang Bo Wu Fei Wang Jiaxing Environmental Monitoring Station Zhejiang Institute of Meteorological Sciences Key Laboratory of Meteorological Disaster of Ministry of Education Nanjing University of Information Science and Technology

We conducted measurements of black carbon （BC） aerosol in Jiaxing, China during autumn from September 26 to November 30, 2013. We investigated temporal and diurnal variations of BC, and its cor relations with meteorological parameters and other major pollutants. Results showed that hourly mass concentrations of BC ranged from 0.2 to 22.0 μg/m3, with an average of 5.1 μg/ms. The diurnal variation of BC exhibited a bimodal distribution, with peaks at 07：00 and 18：00. The morning peak was larger than the evening peak. The mass percentages of BC in PM2.s and PM10 were 7.1%and 4.8g, respectively. The absorption coefficient of BC was calculated to be 44.4 Mm-1, which accounted for 11.1% of the total aerosol extinction. BC was mainly emitted from local sources in southwestern Jiaxing where BC concentrations were generally greater than 11μg/m3 during the measurement period. Correlation analysis indicated that the main sources of BC were motor vehicle exhaust, and domestic and industrial combustion.

关键词： Black carbonDiurnal variationAbsorption coefficientCorrelation analysisJiaxing

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Effects of SO_2 and SO_3 on the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans by de novo synthesis

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2010年第5期11卷 363-369页

作者： Ke SHAO Jian-hua YAN Xiao-dong LI sheng-yong lu Mu-xing FU Ying-lei WEI State Key Laboratory of Clean Energy Utilization Zhejiang University Hangzhou 310027 China

The effects of SO2,SO3 on de novo synthesis of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) were studied using model fly ashes incorporating copper oxide and activated carbon. It was found that the inhibitive effect of SO2 on PCDD/Fs formation is similar to that of SO3. To investigate the inhibition mechanism,CuSO4 formations from both CuO and CuCl2 were examined. The ability of SO3 to convert CuCl2 and CuO on a silica support into sulfate is much stronger than that of SO2. However,replacing silica by activated carbon leads to a much high conversion of CuCl2 to CuSO4 in the presence of SO2. The promotion by activated carbon is explained by the reduction of CuCl2 to Cu2Cl2 and the eventual conversion of Cu2Cl2 into CuSO4 is the main inhibition mechanism of SO2 on de novo synthesis of PCDD/Fs.

关键词： Cuprous chloride Model fly ash Sulfation Cupric chloride

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A preliminary study on the teratogenesis of dexamethasone and the preventive effect of vitamin B_(12 )on murine embryonic palatal shelf fusion in vitro

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第4期9卷 306-312页

作者： sheng-jun lu Wei HE Bing SHI Tian MENG Xiao-yu LI Yu-rong LIU State Key Laboratory of Oral Disease West China College of Stomatology Sichuan University Chengdu 610041 China Department of Cleft Lip and Palate Surgery West China Stomatological Hospital Sichuan University Chengdu 610041 China

Excessive dexamethasone (Dex) administrated into pregnant mice during critical periods of palatal development can produce a high incidence of cleft palate. Its mechanisms remain unknown. Vitamin B12 has been shown to antagonize the tera- togenic effects of Dex, which, however, remains controversial. In this study, we investigated the effects of Dex and vitamin B12 on murine embryonic palatal shelf fusion using organ culture of murine embryonic shelves. The explanted palatal shelves on em- bryonic day 14 (E14) were cultured for 24, 48, 72 or 96 h in different concentrations of Dex and/or vitamin B12. The palatal shelves were examined histologically for the morphological alterations on the medial edge epithelium (MEE) and fusion rates among different groups. It was found that the palatal shelves were not fused at 72 h or less of culture in Dex group, while they were completely fused in the control and vitamin B12-treated groups at 72 and 96 h, respectively. The MEE still existed and proliferated. In Dex+vitamin B12 group the palatal shelves were fused at each time point in a similar rate to controls. These results may suggest that Dex causes teratogenesis of murine embryonic palatal shelves and vitamin B12 prevents the teratogenic effect of Dex on palatogenesis on murine embryos in vitro.

关键词： Dexamethasone Vitamin B12 Organ culture Cleft oalate Medial edge epithelial cells

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Therapeutic strategies for peripheral nerve injury: decellularized nerve conduits and Schwann cell transplantation

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Neural Regeneration Research 2019年第8期14卷 1343-1351页

作者： Gong-Hai Han Jiang Peng Ping Liu Xiao Ding Shuai Wei sheng lu Yu Wang Kunming Medical University Kunming Yunnan Province China Institute of Orthopedics Chinese PLA General Hospital Beijing China Shanxi Medical Univers让y Taiyuan Shanxi Province China Shihezi University Medical College Shihezi Xinjiang Uygur Autonomous Region China 920^th Hospital of Joint Service Support Force Kunming Yunnan Province China

In recent years, the use of Schwann cell transplantation to repair peripheral nerve injury has attracted much attention. Animal-based studies show that the transplantation of Schwann cells in combination with nerve scaffolds promotes the repair of injured peripheral nerves. Autologous Schwann cell transplantation in humans has been reported recently. This article reviews current methods for removing the extracellular matrix and analyzes its composition and function. The development and secretory products of Schwann cells are also reviewed. The methods for the repair of peripheral nerve injuries that use myelin and Schwann cell transplantation are assessed. This survey of the literature data shows that using a decellularized nerve conduit combined with Schwann cells represents an effective strategy for the treatment of peripheral nerve injury. This analysis provides a comprehensive basis on which to make clinical decisions for the repair of peripheral nerve injury.

关键词： nerve regeneration peripheral nerve injury nerve conduits decellularization extracellular matrix Schwann cell neural regeneration

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Harmonic Inversion of Recurrence Spectra of Nonhydrogen Atom in an Electric Field

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Communications in Theoretical Physics 2008年第5期49卷 1291-1294页

作者： GAO Song XU Xue-You LI Hong-Yun ZHANG Yan-Hui LIN sheng-lu College of Physics and Electronics Shandong Normal University Jinan 250014 China

An extended harmonic inversion method is analytically continued to approach bifurcation region of the dosed orbits thus to obtain highly resolved spectra of lithium atom in external field. The suitable band-limited signal is generated by a semielassieal uniform approximation. By decimating the selected signal window and solving the algebraic set of nonlinear equations the quantum eigenvalues are properly fitted, which reveal the fine resonance structure hidden in low resolution spectrum. The study is made at the sealed energy ε= -2.7, relevant bifurcation effects and corescattered impacts have to be taken into account. It is demonstrated that the present method is a useful technique for the semiclassieal quantization of system with mixed regular-chaotic classical dynamics.

关键词： harmonic inversion Stark effects recurrence spectrum

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Soil Organic Carbon Transformation and Related Properties in Urban Soil Under Impervious Surfaces

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Pedosphere 2014年第1期24卷 56-64页

作者： WEI Zong-Qiang WU Shao-Hua ZHOU sheng-lu LI Jing-Tao ZHAO Qi-Guo School of Geographic and Oceanographic Science Nanjing University Institute of Soil Science Chinese Academy of Sciences

Installation of impervious surface in urban area prevents the exchange of material and energy between soil and other environmental counterparts,thereby resulting in negative effects on soil function and urban *** samples were collected at 0-20cm depth in Nanjing City,China,in which seven sites were selected for urban open soils,and fourteen sites with similar parent material were selected for the impervious-covered soils,to examine the effect of impervious surface on soil properties and microbial activities,and to determine the most important soil properties associated with soil organic carbon(SOC)transformation in the urban soils covered by impervious *** organic carbon and water-soluble organic carbon(WSOC)concentrations,potential carbon(C)and nitrogen(N)mineralization rates,basal respiration,and physicochemical properties with respect to C transformation were *** of impervious surface severely affected soil physicochemical properties and microbial activities,e.g.,it significantly decreased total N contents,potential C mineralization and basal respiration rate(Plue of 4.52 kg m^(-2)in the open soils(P<0.05).Canonical correlation analysis showed WSOC played a major role in determining SOC transformation in the impervious-covered soil,and it was highly correlated with total N content and potential C mineralization *** findings demonstrate that installation of impervious surface in urban area,which will result in decreases of SOC and total N concentrations and soil microbial activities,has certain negative consequences for soil fertility and long-term storage of SOC.

关键词： carbon mineralization microbial activity soil fertility soil sealing water-soluble organic carbon

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Three-dimensional finite element analysis with different internal fixation methods through the anterior approach

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World Journal of Clinical Cases 2021年第8期9卷 1814-1826页

作者： Xian-Jin Xie sheng-lu Cao Kai Tong Zi-Yi Zhong Gang Wang Department of Orthopaedic Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Orthopaedic Surgery Zhongnan HospitalWuhan UniversityWuhan 430000Hubei ProvinceChina

BACKGROUND With the modernization of society and transportation in the last decades in China,the incidence of high-energy trauma increased sharply in China,including that of acetabular *** To establish different finite element models for acetabular posterior column fractures involving the quadrilateral area of the *** The three-dimensional models of the normal and fractured pelvis and the five internal fixations were established using the computed tomography data of the pelvis of a living *** the vertebral body model was inserted in the way of origin matching and all cancellous bones were copied using the duplicated cancellous bone model as the subtractive entity,the Boolean operation was performed on the pelvis model to obtain the model of the complete pelvis cortical and cancellous *** In the standing position,the maximum stress was 46.21 *** the sitting position,the sacrum bore the simulated gravity load at the upper *** comparing the five fixations,there were no significant differences in the stress mean values among groups(sitting:P=0.9794;standing:P=0.9741).In terms of displacement,the average displacement of the internal iliac plate group was smaller than that of the spring plate group(P=0.002),and no differences were observed between the other pairs of groups(all P>0.05).In the standing position,there were no significant differences in the mean value of displacement among the groups(P=0.2985).It can be seen from the stress nephogram of the internal fixations in different positions that the stress of the internal fixation was mainly concentrated in the fracture *** There were no significant differences among the fixations for acetabular posterior column fractures involving the quadrilateral area of the acetabulum.

关键词： Acetabulum Hip fractures Analysis Finite element Fracture fixation Orthopedic fixation devices

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