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Polysiloxane with Pendant [60]Fulleropyrrolidines as Stationary Phase for Capillary Gas Chromatography

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Chinese Chemical Letters 1998年第9期9卷 847-850页

作者： ying LIU Xun Gao ZhanG han ying YE (Department of Analysis and Measurement Science, Wuhan University, Wuhan 430072),Yuan Yin chen zhao Rui ZENG (Department of Chemistry, Wuhan University, Wuhan 430072),Rong sheng sheng (Wuhan Broadcasting and TV Univer Wuhan Univ Dept Anal & Measurement Sci Wuhan 430072 Peoples R China Wuhan Univ Dept Chem Wuhan 430072 Peoples R China Wuhan Broadcasting & TV Univ Wuhan 430030 Peoples R China

Polysiloxane with pendant [60] fulleropyrrolidines was synthesized and used as the stationary phase for capillary gas chromatography for the first time. A preliminary investigation of its property shows that it has an... 详细信息

关键词： polysiloxane fulleropyrrolidine stationary phase capillary gas chromatography

Comparative analysis of primate and pig cells reveals primate-specific PINK1 expression and phosphorylation

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Zoological Research 2024年第2期45卷 242-252页

作者： Xiu-sheng chen Rui han Yan-Ting Liu Wei Huang Qi Wang Xin Xiong ying Zhang Jian-Guo zhao Shi-Hua Li Xiao-Jiang Li Wei-Li Yang Guangdong Key Laboratory of Non-human Primate Research Key Laboratory of CNS Regeneration(Ministry of Education)GHM Institute of CNS RegenerationJinan UniversityGuangzhouGuangdong 510632China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China University of Chinese Academy of Sciences Beijing 100049China

PTEN-induced putative kinase 1(PINK1),a mitochondrial kinase that phosphorylates Parkin and other proteins,plays a crucial role in mitophagy and protection against *** in PINK1 and Parkin can lead to loss of function and early onset Parkinson's ***,there is a lack of strong in vivo evidence in rodent models to support the theory that loss of PINK1 affects mitophagy and induces ***,PINK1 knockout pigs(Sus scrofa)do not appear to exhibit *** our recent work involving non-human primates,we found that PINK1 is selectively expressed in primate brains,while absent in rodent *** extend this to other species,we used multiple antibodies to examine the expression of PINK1 in pig *** contrast to tissues from cynomolgus monkeys(Macaca fascicularis),our data did not convincingly demonstrate detectable PINK1expression in pig *** of PINK1 in cultured pig cells did not result in altered Parkin and BAD phosphorylation,as observed in cultured monkey cells.A comparison of monkey and pig striatum revealed more PINK1-phosphorylated substrates in the monkey ***,PINK1 knockout in pigs did not lead to obvious changes in the phosphorylation of Parkin and *** findings provide new evidence that PINK1expression is specific to primates,underscoring the importance of non-human primates in investigating PINK1function and pathology related to PINK1 deficiency.

关键词： PINK1 Parkin Mitochondria Phosphorylation Non-human primates Pigs

Microstructure evolution and passivation quality of hydrogenated amorphous silicon oxide(a-SiOx:H) on〈100〉- and 〈111〉-orientated c-Si wafers

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Chinese Physics B 2020年第3期29卷 480-487页

作者： Jun-Fan chen sheng-sheng zhao Ling-Ling Yan Hui-Zhi Ren Can han De-Kun Zhang Chang-Chun Wei Guang-Cai Wang Guo-Fu Hou § ying zhao Xiao-Dan Zhang Institute of Photoelectronic Thin Film Devices and Technology of Nankai University Tianjin 300350China Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Tianjin 300350China Engineering Center of Thin Film Photoelectronic Technology of Ministry of Education Tianjin 300350China Sino-Euro Joint Research Center for Photovoltaic Power Generation of Tianjin Tianjin 300350China

Hydrogenated amorphous silicon oxide(a-SiOx:H) is an attractive passivation material to suppress epitaxial growth and reduce the parasitic absorption loss in silicon heterojunction(SHJ) solar cells. In this paper, a-SiOx:H layers on different orientated c-Si substrates are fabricated. An optimal effective lifetime(τ(eff)) of 4743 μs and corresponding implied opencircuit voltage(iV(oc)) of 724 mV are obtained on〈100〉-orientated c-Si wafers. While τ(eff) of 2429 μs and iV_(oc) of 699 mV are achieved on 111-orientated substrate. The FTIR and XPS results indicate that the a-SiOx:H network consists of SiOx(Si-rich), Si–OH, Si–O–SiHx, SiO2 ≡ Si–Si, and O3 ≡ Si–Si. A passivation evolution mechanism is proposed to explain the different passivation results on different c-Si wafers. By modulating the a-SiOx:H layer, the planar silicon heterojunction solar cell can achieve an efficiency of 18.15%.

关键词： a-SiO_x:H orientated wafers silicon heterojunction

Pien Tze Huang Inhibits Migration and Invasion of Hepatocellular Carcinoma Cells by Repressing PDGFRB/YAP/CCN2 Axis Activity

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Chinese Journal of Integrative Medicine 2024年第2期30卷 115-124页

作者： LUO Zhi-yi TIAN Qi chenG Niang-mei LIU Wen-han YANG Ye chen Wei ZhanG Xiang-zhi ZHENG Xiao-yuan chen Ming-sheng ZHUANG Qiu-yu zhao Bi-xing LIU Cong-sheng LIU Xiao-long LI Qin WANG ying-chao The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China Fujian Pien Tze Huang Enterprise Key Laboratory of Natural Medicine Research and Development Zhangzhou Pien Tze Huang Pharmaceutical Co.Ltd.ZhangzhouFujian Province(363099)China College of Biological Science and Engineering and Mengchao Med-X Center Fuzhou UniversityFuzhou(350116)China Department of Internal Medicine Mengchao Hepatobiliary Hospital of Fujian Medical UniversityFuzhou(350025)China

Objective:To investigate the effects of Pien Tze Huang(PZH) on the migration and invasion of HCC cells and underlying molecular ***:Cell counting kit-8(CCK-8) was applied to evaluate the cell viabilities of SMMC-7721,SK-Hep-1,C3A and HL-7702(6 × 10^(3)cells/well) co-incubated with different concentrations of PZH(0,0.2,0.4,0.6,0.8 mg/mL) for 24 ***,wound healing assay,CCK-8and Annexin V-FITC/PI staining were conducted to investigate the effects of PZH on the migration,invasion,proliferation and apoptosis of SK-Hep-1 and SMMC-7721 cells(650 μg/mL for SK-Hep-1 cells and 330 μg/mL for SMMC-7721 cells),*** vivo,lung metastasis mouse model constructed by tail vein injection of HCC cells was used for evaluating the anti-metastasis function of ***-Hep-1 cells(10^(6)cells/200 μL per mice) were injected into B-NDG mice via tail *** 8 mice were randomly divided into PZH and control groups,4 mice in each *** 2-d inoculation,mice in the PZH group were administered with PZH(250 mg/kg,daily) and mice in the control group received only vehicle(PBS) from the 2nd day after xenograft to day *** analysis based on RNA-seq was subsequently used for deciphering anti-tumor mechanism of *** real-time polymerase chain reaction(qRT-PCR) and Western blot were applied to verify RNA-seq *** reporter assay was performed to examine the transcriptional activity of yes-associated protein(YAP).Results:PZH treatment significantly inhibited the migration,invasion,proliferation and promoted the apoptosis of HCC cells in vitro and in vivo(P<0.01).Transcriptome analysis indicated that Hippo signaling pathway was associated with anti-metastasis function of *** study showed PZH significantly inhibited the expressions of platelet derived growth factor receptor beta(PDGFRB),YAP,connective tissue growth factor(CCN2),N-cadherin,vimentin and matrix metallopeptidase 2(MMP2,P<0.01).Meanwhile,the phosphorylatio

关键词： PienTzeHuang hepatocellular carcinoma RNA-seq Hippo yes-associated protein

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Agent动作信念模型中的信念更新

系统工程理论与实践 2007年第5期27卷 135-141页

作者：陈胜赵林度韩莹东南大学系统工程研究所南京210096

采用世界贴近函数方法解决了动作信念更新的问题,并讨论了这种信念更新方法的更新成功条件、更新结果有限性这两个方面的性质,最后以定理的形式给出其是FORBUS更新方法一种扩展的结论.

关键词：动作信念模型区间值模糊逻辑信念更新世界贴近度函数

A Novel AGRN Mutation Leads to Congenital Myasthenic Syndrome Only Affecting Limb？girdle Muscle

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Chinese Medical Journal 2017年第19期130卷 2279-2282页

作者： ying Zhang Yi Dai Jing-Na han zhao-Hui chen Li Ling Chuan-Qiang Pu Li-ying Cui Xu-sheng Huang Department of Neurology Chinese People's Liberation Army General Hospital Beijing 100853 China Cadre Ward Two The First Affiliated Hospital of Chinese People's Liberation Army General Hospital Beijing 100843 China Department of Neurology Peking Union Medical College Hospital Beijing 100730 China Neuroscience Center Chinese Academy of Medical Sciences Beijing 100730 China

Background： Congenital myasthenic syndromes （CMSs） are a group of clinically and genetically heterogeneous disorders caused by impaired neuromuscular transmission. The defect of AGRN was one of the causes of CMS through influencing the development and maintenance of neuromuscular transmission. However, CMS reports about this gene mutation were rare. Here, we report a novel homozygous missense mutation （c.5302G〉C） of AGRN in a Chinese CMS pedigree. Methods： We performed a detailed clinical assessment of a Chinese family with three affected members. We screened for pathogenic mutations using a disease-related gene panel containing 519 genes associated with genetic myopathy （including 17 CMS genes）. Results： In the family, the proband showed limb-girdle pattern of weakness with sparing of ocular, facial, bulbar, and respiratory muscles. Repetitive nerve stimulation showed a clear decrement of the compound muscle action potentials at 3 Hz only. Pathological analysis of the left tibialis anterior muscle showed predominance of type I fiber and the presence of scattered small angular fibers. The proband＇s two elder sisters shared a similar but more severe phenotype. By gene analysis, the same novel homozygous mutation （c.5302G〉C, p.A1768P） of AGRN was identified in all three affected members, whereas the same heterozygous mutation was found in both parents, revealing an autosomal recessive transmission pattern. All patients showed beneficial responses to adrenergic agonists. Conclusions： This study reports a Chinese pedigree in which all three children carried the same novel AGRN mutation have CMS only affecting limb-girdle muscle. These findings might expand the spectrum of mutation in AGRN and enrich the phenotype of CMS.

关键词： AGRN Congenital Myasthenic Syndrome Gene Mutation

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区间值语义下的Agent信念模型

系统工程理论与实践 2005年第5期25卷 118-122页

作者：陈胜赵林度韩莹东南大学系统工程研究所江苏南京210096

　从实际应用出发,在逻辑系统基础上,结合二维区间值语义,构建Agent模糊信念模型,并研究该模型语义的数理基础,分析系统可靠性、完备性以及重言式结构等特性,最后给出一些应用,这些研究不仅为Agent信念复杂性研究,而且也为Agent认知、... 详细信息

　从实际应用出发,在逻辑系统基础上,结合二维区间值语义,构建Agent模糊信念模型,并研究该模型语义的数理基础,分析系统可靠性、完备性以及重言式结构等特性,最后给出一些应用,这些研究不仅为Agent信念复杂性研究,而且也为Agent认知、决策等研究提供一定的逻辑理论基础.

关键词：模糊信念模型区间值语义系统特性

Tobacco carcinogen induces tryptophan metabolism and immune suppression via induction of indoleamine 2,3-dioxygenase 1

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3911-3924页

作者： Fan Liang Gui-Zhen Wang Yan Wang Ya-Ning Yang Zhe-sheng Wen Dong-Ni chen Wen-Feng Fang Bin Zhang Lu Yang chen Zhang Si-Chong han Fu-ying Yang Di Wang Li-Jun Liang Zheng Wang Yong zhao Chang-Li Wang Li Zhang Guang-Biao Zhou State Key Laboratory of Molecular Oncology National Cancer CenterNational Clinical Research Center for CancerCancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesUniversity of Chinese Academy of SciencesBeijingChina Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouChina Department of Lung Cancer Tianjin Lung Cancer CenterNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin’s Clinical Research Center for CancerTianjin Medical University Cancer Institute and HospitalTianjinChina Department of Medical Oncology and Radiation Sickness Peking University Third HospitalBeijingChina

Indoleamine 2,3-dioxygenase 1(IDO1),the enzyme that catabolizes tryptophan(Trp)metabolism to promote regulatory T cells(Tregs)and suppress CD8+T cells,is regulated by several intrinsic signaling ***,we found that tobacco smoke,a major public health concern that kills 8 million people each year worldwide,induced IDO1 in normal and malignant lung epithelial cells in vitro and in *** carcinogen nicotine-derived nitrosaminoketone(NNK)was the tobacco compound that upregulated IDO1 via activation of the transcription factor c-Jun,which has a binding site for the IDO1 *** NNK receptorα7 nicotinic acetylcholine receptor(α7nAChR)was required for NNK-induced c-Jun activation and IDO1 *** A/J mice,NNK reduced CD8+T cells and increased ***,smoker patients with non-small-cell lung cancer(NSCLC)exhibited high IDO1 levels and low Trp/kynurenine(Kyn)*** NSCLC patients,smokers with lower IDO1 responded better to anti-PD1 antibody treatment than those with higher *** data indicate that tobacco smoke induces IDO1 to catabolize Trp metabolism and immune suppression to promote carcinogenesis,and lower IDO1 might be a potential biomarker for anti-PD1 antibodies in smoker patients,whereas IDO1-high smoker patients might benefit from IDO1 inhibitors in combination with anti-PD1 antibodies.

关键词： PD1 metabolism lung

酚氧树脂/聚(4-乙烯基吡啶)高分子复合物的制备及表征

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高等学校化学学报 1998年第7期19卷 1157-1161页

作者：徐胜清赵汉英陈斌黄葆同中国科学院长春应用化学研究所

采用元素分析、ＤＳＣ、ＦＴＩＲ、紫外光谱及ＸＰＳ等手段对酚氧树脂和聚（４－乙烯基吡啶）在氯仿中溶液共混形成的高分子复合物的组成及结构进行了研究，并与相应的共混物作了比较．结果表明，所得的各复合物的组成相同，其值与组分... 详细信息

采用元素分析、ＤＳＣ、ＦＴＩＲ、紫外光谱及ＸＰＳ等手段对酚氧树脂和聚（４－乙烯基吡啶）在氯仿中溶液共混形成的高分子复合物的组成及结构进行了研究，并与相应的共混物作了比较．结果表明，所得的各复合物的组成相同，其值与组分分子中的链节等摩尔比一致；而共混物也为相容体系，其组成与两高分子组分的投料比对应．基于实验结果，揭示了复合物的形成过程．

关键词：高分子复合物共混物酚氧树脂聚乙烯基吡啶