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Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer

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Genes & Diseases 2024年第1期11卷 218-233页

作者： Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu yuping shen Qizhang Li Lei Zhang Innovative Drug R&D Center College of Life SciencesHuaibei Normal UniversityHuaibeiAnhui 235000China National"111"Center for Cellular Regulation and Molecular Pharmaceutics Key Laboratory of Fermentation Engineering(Ministry of Education)Hubei Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)and School of Food and Biological EngineeringHubei University of TechnologyWuhanHubei 430068China Department of Biomedical Informatics The Ohio State UniversityColumbusOH 43210USA School of Agriculture and Biology and Engineering Research Center of Cell&Therapeutic AntibodyMinistry of EducationShanghai Jiao Tong UniversityShanghai 200240China College of Chemistry and Bioengineering Hunan University of Science and EngineeringYongzhouHunan425199China Department of Pharmaceutical Botany School of PharmacyNaval Medical UniversityShanghai 200433China

Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and ***2 performs a critical role in the malignant biological behaviors of *** structure,regulation,and function of RRM2 and its inhibitors were ***2 gene can produce two transcripts encoding the same ***2 expression is regulated at multiple levels during the processes from transcription to ***,this gene is associated with resistance,regulated cell death,and tumor *** order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different ***,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor ***,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关键词： Function Inhibition Regulation Resistance RRM2

Multidisciplinary strategies to enhance therapeutic effects of flavonoids from Epimedii Folium:Integration of herbal medicine,enzyme engineering,and nanotechnology

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Journal of Pharmaceutical Analysis 2023年第3期13卷 239-254页

作者： Yi Lu Qiulan Luo Xiaobin Jia James P.Tam Huan Yang yuping shen Xin Li School of Pharmacy Jiangsu UniversityZhenjiangJiangsu212013China College of Fashion&Design Jiaxing Nanhu UniversityJiaxingZhejiang314001China School of Traditional Chinese Pharmacy China Pharmaceutical UniversityNanjing211198China School of Biological Sciences Nanyang Technological University637551SingaporeSingapore DWI-Leibniz-Institute for Interactive Materials e.V. 52056AachenGermany Institute for Technical and Macromolecular Chemistry RWTH Aachen University52074AachenGermany

Flavonoids such as baohuoside I and icaritin are the major active compounds in Epimedii Folium(EF)and possess excellent therapeutic effects on various ***,in 2022,icaritin soft capsules were approved to reach the market for the treatment of hepatocellular carcinoma(HCC)by National Medical Products Administration(NMPA)of ***,recent studies demonstrate that icaritin can serve as immune-modulating agent to exert anti-tumor ***,both production efficiency and clinical applications of epimedium flavonoids have been restrained because of their low content,poor bioavailability,and unfavorable in vivo delivery ***,various strategies,including enzyme engineering and nanotechnology,have been developed to increase productivity and activity,improve delivery efficiency,and enhance therapeutic effects of epimedium *** this review,the structure-activity relationship of epimedium flavonoids is ***,enzymatic engineering strategies for increasing the productivity of highly active baohuoside I and icaritin are *** nanomedicines for overcoming in vivo delivery barriers and improving therapeutic effects of various diseases are ***,the challenges and an outlook on clinical translation of epimedium flavonoids are proposed.

关键词： Flavonoids Enzymatic hydrolysis Nanomedicine Therapeutic effects Clinical translation Epimedii Folium

Modal identification based on Hilbert-Huang Transform of structural response with S VD preprocessing

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Acta Mechanica Sinica 2009年第6期25卷 883-888页

作者： Min Zheng Fan shen yuping Dou Xiaoyan Yan College of Civil Aviation,Nanjing University of Aeronautics and Astronautics,210016 Nanjing. China College of Civil Aviation Nanjing University of Aeronautics and Astronautics 210016 Nanjing China

In recent years, Empirical mode decomposition and Hilbert spectral analysis have been combined to identify system parameters. Singular-Value Decomposition is pro- posed as a signal preprocessing technique of Hilbert-Huang Transform to extract modal parameters for closely spaced modes and low-energy components. The proposed method is applied to a simulated airplane model built in Automatic Dynamic Analysis of Mechanical Systems software. The results demonstrate that the identified modal parameters are in good agreement with the baseline model.

关键词： Modal identification . Hilbert-Huang Transforms - Singular-value decomposition . Signal processing

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有关《西域土地人物略》作者的考察

西北民族研究 2009年第4期 129-140页

作者：沈玉萍南京大学历史系元史室

《西域土地人物略》是现存少数记述明代西域史地的最重要历史文献之一,其作者和材料来源,学界迄今尚未有一致意见。本文在前人研究的基础上,对该书的作者和材料来源做了探析和考证,认为该书中所记述的是一条明代中国穆斯林去天方朝觐的... 详细信息

《西域土地人物略》是现存少数记述明代西域史地的最重要历史文献之一,其作者和材料来源,学界迄今尚未有一致意见。本文在前人研究的基础上,对该书的作者和材料来源做了探析和考证,认为该书中所记述的是一条明代中国穆斯林去天方朝觐的路线,其材料来源于穆斯林朝觐者。

关键词：《西域土地人物略》作者材料来源考证

税延政策下不同收入层人群养老保险模式选择——基于累进税制和比例税制的综合实证研究

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财经论丛 2017年第3期 18-30页

作者：沈玉平沈凯豪浙江财经大学财政税务学院浙江杭州310018

个税递延型商业养老保险政策的实施将对不同收入层次和不同收入来源人群的养老保险模式选择产生重大影响,而我国现行以累进型为主的个人所得税制度在这一影响发生的过程中发挥着根本性作用。基于这一影响机制,本文重点研究EET模式商业... 详细信息

个税递延型商业养老保险政策的实施将对不同收入层次和不同收入来源人群的养老保险模式选择产生重大影响,而我国现行以累进型为主的个人所得税制度在这一影响发生的过程中发挥着根本性作用。基于这一影响机制,本文重点研究EET模式商业养老保险的受益群体范围,以不同收入水平和不同收入来源的杭州市居民为研究对象,以包含社会养老保险和商业养老保险的动态养老金总替代率期望值为调节目标,构建包含个人所得税的累进税率和比例税率变量的保险精算模型,设计和测算了投保期内的下临界点S1和上临界点S2。在此基础上,从居民购买商业养老保险意愿度和社会公平的角度出发,探讨对两个临界点的进一步调整,分析EET模式商业养老保险受益群体范围以外人群的行为决策,并最终提出政策性建议。

关键词：个税递延养老保险累进税制比例税制行为决策模式

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马欢和马德新朝觐比较研究

青海社会科学 2009年第2期 108-113页

作者：沈玉萍南京大学历史系元史室博士研究生

马欢和马德新是明清两代到伊斯兰教圣地天方——今沙特阿拉伯麦加进行朝觐活动的古代中国穆斯林的代表人物。他们生活的时代相隔四百多年,其朝觐活动也各具特色,马欢的朝觐活动带有官方色彩,而马德新的朝觐活动带有个人性和学术性的色... 详细信息

马欢和马德新是明清两代到伊斯兰教圣地天方——今沙特阿拉伯麦加进行朝觐活动的古代中国穆斯林的代表人物。他们生活的时代相隔四百多年,其朝觐活动也各具特色,马欢的朝觐活动带有官方色彩,而马德新的朝觐活动带有个人性和学术性的色彩。本文从他们的朝觐活动、他们对克尔白的描述、他们对麦地那的描述及朝觐外的活动和朝觐的行程等几个方面对马欢和马德新的朝觐活动做了比较研究。

关键词：马欢马德新朝觐比较研究

IBI310(anti-CTLA-4 antibody)monotherapy or in combination with sintilimab in advanced melanoma or urothelial carcinoma

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The Innovation 2024年第4期5卷 34-40,33页

作者： Chuanliang Cui Juan Li Yue Yang Lu Si Zhihong Chi Lili Mao Xuan Wang Bixia Tang Xieqiao Yan Siming Li Li Zhou Xiaoting Wei yuping shen Qun Guo Shirui Zheng Jun Guo Bin Lian Department of Renal Cancer and Melanoma Peking University Cancer Hospital&InstituteKey laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Beijing 100142China Innovent Biologics Inc.Suzhou 215123China

IBI310 is a recombinant fully human IgG1 antibody against cytotoxic T lymphocyte antigen *** study was conducted to evaluate IBI310 monotherapy or combination therapy with sintilimab in the patients with advanced melanoma or urothelial carcinoma(UC).Patients in phase 1a received IBI310 at 0.3/1/2/3 mg/kg intravenously(IV)every 3 weeks(Q3W)following the accelerated titration and 3+3 escalation *** in phase 1b received IBI310(1/2/3 mg/kg IV,Q3W)plus sintilimab(200 mg IV,Q3W)for four cycles,followed by sintilimab maintenance *** phase 1b expansion of IBI310 plus sintilimab was performed in patients with advanced melanoma or ***,53 patients were enrolled,including 10 patients with melanoma in phase 1a,34 with melanoma,and 9 with UC in phase ***,94.3%of patients(50/53)experienced at least one treatment-related adverse event(TRAE)with most being grade 1–2;26.4%of patients(14/53)experienced grade 3 or higher *** phase 1a,the disease control rate(DCR)was 50.0%(95%confidence interval[CI],18.7%–81.3%).In phase 1b,the objective response rate(ORR)and DCR were 17.6%(95%CI,6.8%–34.5%)and 44.1%(95%CI,27.2%–62.1%),respectively,for melanoma,and were 22.2%(95%CI,2.8%–60.0%)and 66.7%(95%CI,29.9%–92.5%),respectively,for ***310 monotherapy or combination therapy with sintilimab was well tolerated with favorable antitumor activity across patients with advanced melanoma and UC.

关键词： melanoma mono experienced

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芝麻素酚生理活性功能研究进展

食品与发酵工业 2024年第15期50卷 381-388页

作者：张祖姣沈玉平湖南科技学院化学与生物工程学院湖南永州425199 湖南省银杏工程技术研究中心湖南永州425199 湖南南岭地区植物资源研究开发湖南省工程研究中心湖南永州425199

芝麻素酚是一种主要来源于芝麻的多酚类天然产物,具有多种生理活性功能以及很强的热稳定性,可作为药品、营养保健品以及化妆品添加剂,具有重要的应用和开发价值。近年来,研究者针对芝麻素酚开展了大量的研究。该文从抗氧化、抗炎、抗肿... 详细信息

芝麻素酚是一种主要来源于芝麻的多酚类天然产物,具有多种生理活性功能以及很强的热稳定性,可作为药品、营养保健品以及化妆品添加剂,具有重要的应用和开发价值。近年来,研究者针对芝麻素酚开展了大量的研究。该文从抗氧化、抗炎、抗肿瘤、心血管保护、预防肥胖、神经保护和延缓皮肤衰老7个方面,综述了其最新研究进展,发现芝麻素酚生理活性功能和药理机制研究大多处于体外细胞模型或动物模型阶段,距离临床应用以及转化为市场产品仍有很长的距离,因此亟需深入推进研究。借助生命科学、现代医学和现代仪器分析技术的发展成果,深入研究药理作用机制,完善安全评价,发掘新的生理活性功能,将有助于促进芝麻素酚生理活性功能研究和相关产品开发。

关键词：芝麻素酚生理活性功能抗氧化制备方式研究进展

转移支付与地方财政收支决策——基于省级面板数据的实证研究

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管理世界 2009年第11期25卷 41-53页

作者：李永友沈玉平浙江财经学院南京大学博士后流动站

大规模转移支付将会对地方财政收支决策产生何种影响?本文通过构建地方财政收支决策对大规模转移支付的反应函数,并利用省级面板数据对此进行了研究。结论显示:(1)地方财政收支决策对大规模转移支付的反应存在明显差异,支出决策反应显... 详细信息

大规模转移支付将会对地方财政收支决策产生何种影响?本文通过构建地方财政收支决策对大规模转移支付的反应函数,并利用省级面板数据对此进行了研究。结论显示:(1)地方财政收支决策对大规模转移支付的反应存在明显差异,支出决策反应显著性要高于收入决策;(2)地方财政支出决策对大规模转移支付的周期变化反应并不对称,支出决策对转移支付增加的反应要弱于对转移支付减少的反应;(3)对总量转移支付做进一步分解后,研究发现,地方财政收支决策对专项转移支付和非特定用途转移支付的反应存在显著差异,支出决策对前者的反应强于后者,而收入决策对前者的反应却弱于后者;(4)地方财政收支决策对转移支付的反应显著受到地区间竞争程度和地区开放程度的影响,地区间竞争程度增加了地方财政收支决策对转移支付变化的反应程度,而地区开放程度却一定程度上减缓了上述反应。

关键词：转移支付收支决策反应函数