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MicroRNA-298 determines the radio-resistance of colorectal cancer cells by directly targeting human dual-specificity tyrosine(Y)-regulated kinase 1A

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1453-1464页

作者： Mei-Zhu shen yong Zhang Fang Wu Mei-Zhen shen Jun-Lin Liang Xiao-Long Zhang Xiao-Jian Liu Xin-Shu Li Ren-sheng Wang Department of Radiotherapy The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Radiotherapy People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Colorectal Anal Surgery The First Affiliated Hospital of Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina Department of Clinical Medicine Guangxi Medical UniversityNanning 530021Guangxi Zhuang Autonomous RegionChina

BACKGROUND Radiotherapy stands as a promising therapeutic modality for colorectal cancer(CRC);yet,the formidable challenge posed by radio-resistance significantly undermines its efficacy in achieving CRC *** To elucidate the role played by microRNA-298(miR-298)in CRC *** To establish a radio-resistant CRC cell line,HT-29 cells underwent exposure to 5 gray ionizing radiation that was followed by a 7-d recovery *** quantification of miR-298 levels within CRC cells was conducted through quantitative RT-PCR,and protein expression determination was realized through Western *** viability was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and proliferation by clonogenic ***-induced apoptosis was discerned through flow cytometry *** We observed a marked upregulation of miR-298 in radio-resistant CRC ***-298 emerged as a key determinant of cell survival following radiation exposure,as its overexpression led to a notable reduction in radiation-induced ***,miR-298 expression exhibited a strong correlation with CRC cell *** investigation unveiled human dual-specificity tyrosine(Y)-regulated kinase 1A(DYRK1A)as miR-298’s direct *** Taken together,our findings underline the role played by miR-298 in bolstering radio-resistance in CRC cells by means of DYRK1A downregulation,thereby positioning miR-298 as a promising candidate for mitigating radioresistance in CRC.

关键词： MicroRNA-298 Human dual-specificity tyrosine(Y)-regulated kinase 1A Colorectal cancer Radio-resistance p53 binding protein 1

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Monolithic integrated optoelectronic chip for vector force detection

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Microsystems & Nanoengineering 2024年第3期10卷 245-257页

作者： Jiansong Feng Zhongqi Wang Mengyuan Zhanghu Xu Zhang yong shen Jing Yang Zhibin Li Bin Chen Taihong Wang Xiaolong Chen Zhaojun Liu Department of Electrical and Electronic Engineering Southern University of Science and TechnologyShenzhen 518055China Department of Electrical and Electronic Engineering The University of Hong KongHong KongChina

Sensors with a small footprint and real-time detection capabilities are crucial in robotic surgery and smart wearable *** device footprint while maintaining its high performance is a major challenge and a significant limitation to their ***,we proposed a monolithic integrated micro-scale sensor,which can be used for vector force *** sensor combines an optical source,four photodetectors,and a hemispherical silicone elastomer component on the same sapphire-based AlGaInP *** chip-scale optical coupling is achieved by employing the laser lift-off techniques and the flip-chip bonding to a processed sapphire *** hemispherical structure device can detect normal and shear forces as low as 1mN within a measurement range of 0–220 mN for normal force and 0–15 mN for shear *** packaging,the sensor is capable of detecting forces over a broader range,with measurement capabilities extending up to 10 N for normal forces and 0.2 N for shear *** has an accuracy of detecting a minimum normal force of 25 mN and a minimum shear force of 20 ***,this sensor has been validated to have a compact footprint of approximately 1.5 mm^(2),while maintaining high real-time *** also demonstrate its promising potential by combining this sensor with fine surface texture perception in the fields of compact medical robot interaction and wearable devices.

关键词： robot force smart

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Transient Characteristics and Accommodative Current Limiting Strategy for Bidirectional Interlinking Converters in Hybrid AC/DC Microgrids

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CSEE Journal of Power and Energy Systems 2024年第4期10卷 1575-1588页

作者： Xia shen Zhikang Shuai Wen Huang Chao shen Yang shen Z.John shen College of Electrical and Information Engineering Hunan UniversityChangsha 410082China Department of Electrical and Computer Engineering Illinois Institute of TechnologyChicagoIL 60616 USA

Bidirectional interlinking converter(BIC)is the core equipment in a hybrid AC/DC microgrid connected between AC and DC ***,the variety of control modes and flexible bidirectional power flow complicate the influence of AC faults on BIC itself and on DC sub-grid,which potentially threaten both converter safety and system *** study first investigates AC fault influence on the BIC and DC bus voltage under different BIC control modes and different pre-fault operation states,by developing a mathematical model and equivalent sequence ***,based on the analysis results,a general accommodative current limiting strategy is proposed for BIC without limitations to specific mode or operation *** amplitude is predicted and constrained according to the critical requirements to protect the BIC and relieving the AC fault influence on the DC bus *** with conventional methods,potential current limit failure and distortions under asymmetric faults can also be ***,experiments verify feasibility of the proposed method.

关键词： Bidirectional interlinking converter current limiting fault characteristic hybrid AC/DC microgrid variation/oscillation of DC bus voltage

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Rational Solutions of First Order Algebraic Ordinary Differential Equations

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Journal of Systems Science & Complexity 2024年第2期37卷 567-580页

作者： FENG Shuang shen Liyong School of Physical and Mathematical Sciences Nanjing Tech UniversityNanjing 211816China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China

Let f(t,y,y')=∑ _(i=0)^(n )a_(i)(t,y)y'^(i)=0 be an irreducible first order ordinary differential equation with polynomial *** in 1998 proved that there exists a constant C such that every rational solution of f(t,y,y')=0 is of degree not greater than *** show that this degree bound C depends not only on the degrees of f in t,y,y' but also on the coefficients of f viewed as the polynomial in t,y,y'.In this paper,the authors show that if f satisfies deg(f,y)0,then the degree bound C only depends on the degrees of f in t,y,y',and furthermore we present an explicit expression for C in terms of the degrees of f in t,y,y'.

关键词： Degree bound first order AODE height rational solution

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基于MODIS资料的2000—2004年江河源区陆地植被净初级生产力分析

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冰川冻土 2006年第4期28卷 512-518页

作者：郭晓寅何勇沈永平冯丁中国气象科学研究院北京100081 国家气候中心气候研究开放实验室北京100081

基于EOS/MODIS卫星遥感资料的分析表明,2000-2004年江河源地区陆地植被平均年NPP为82.04 gC.m-2,相当于同期全国陆地植被年NPP的23%,其中2001年的年NPP最小,只有78.04gC.m-2,2002年最大,为85.44 gC.m-2.根据年NPP分布显示,黄河源区的植... 详细信息

基于EOS/MODIS卫星遥感资料的分析表明,2000-2004年江河源地区陆地植被平均年NPP为82.04 gC.m-2,相当于同期全国陆地植被年NPP的23%,其中2001年的年NPP最小,只有78.04gC.m-2,2002年最大,为85.44 gC.m-2.根据年NPP分布显示,黄河源区的植被生长状况要好于长江源区,其中在黄河源东南部陆地植被的年NPP>250 gC.m-2,为江河源区植被年生长最大的区域;该地区的植被年NPP最小值的区域分布在长江源的西北部地区,年NPP大部分<50 gC.m-2.江河源地区植被的年NPP表现为显著的年际变化特征,不同地区年NPP的变化特征各不相同;高寒草甸的年NPP为该地区所有陆地植被年NPP中最大,其5 a平均值为89.38 gC.m-2,其次为高寒草原和灌木及草本植被;由于地处高寒地区,温度成为影响该地区陆地植被净初级生产力的主要因素.

关键词：江河源区 MODIS 净初级生产力生态环境

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Using Copula functions to predict climatic change impacts on floods in river source regions

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Advances in Climate Change Research 2024年第3期15卷 406-418页

作者： Ting-Xing CHEN Hai-shen LYU Robert HORTON yong-Hua ZHU Ren-sheng CHEN Ming-Yue SUN Ming-Wen LIU Yu LIN The National Key Laboratory of Water Disaster Prevention College of Hydrology and Water ResourcesHohai UniversityNanjing 2098China College of Hydrology and Water Resources Hohai UniversityNanjing 210098China Departmentof Agronomy lowa State UniversityAmes IA5oollUSA Qilian Alpine Eology and Hydrology Research Station Northwest Instiuteof Eco-Environmentand ReourcesChinese Academy of SciencesLanzhou0000 China

Flood frequency in river source regions is significantly affected by rainfall and snowmelt as part of climatic changes.A traditional univariate flood frequency analysis cannot reflect the complexity of floods,and when used in isolation,it can only underestimate flood *** effective flood prevention and mitigation,it is essential to consider the combined effects of precipitation and *** functions can effectively quantify the joint distribution relationship between floods and their associated variables without restrictions on their distribution *** study uses copula functions to consider a multivariate probability distribution model of flood peak flow(Q)with cumulative snowmelt(CSm)and cumulative precipitation(CPr)for the Hutubi River basin located in northern Xinjiang,*** joint frequencies of rainfall and snowmelt floods are predicted using copula models based on the Coupled Model Intercomparison Project Phase 6 *** results show that Q has a significant positive correlation with 24-d CSm(r=0.559,p=0.002)and 23-d CPr(r=0.965,p<0.05).Flood frequency will increase in the future,and mid-(2050e2074)and long-term(2075e2099)floods will be more severe than those in the near-term(2025e2049).The probability of flood occurrence is higher under the SSP2-4.5 and SSP1-2.6 scenarios than under *** during the historical period(1990e2014)led to extreme floods,and increasing future precipitation trends are found to be *** increases with rising temperatures and occurs earlier than estimated,leading to an earlier flood period in the basin and more frequent snowmelt *** Q under the joint return period is larger than that during the same univariate return *** difference indicates that neglecting the interaction between precipitation and snowmelt for floods leads to an underestimation of the flood risk(with underestimations ranging from 0.3%to 22%).The underestimations decrease with an increase

关键词： Climate change Flood frequency Copula CMIP6 River source regions

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Grain boundary engineering for enhancing intergranular damage resistance of ferritic/martensitic steel P92

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Nuclear Science and Techniques 2024年第5期35卷 186-199页

作者： Lei Peng Shang-Ming Chen Jing-Yi Shi yong-Jie Sun Yi-Fei Liu Yin-Zhong shen Hong-Ya He Hui-Juan Wang Jie Tian State Key Laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China School of Materials Engineering Shanghai University of Engineering Science333 Long Teng RoadShanghai 201620China Experimental Center of Engineering and Material Science University of Science and Technology of ChinaHefei 230026China

Ferritic/martensitic(F/M)steel is widely used as a structural material in thermal and nuclear power ***,it is susceptible to intergranular damage,which is a critical issue,under service *** this study,to improve the resistance to intergranular damage of F/M steel,a thermomechanical process(TMP)was employed to achieve a grain boundary engineering(GBE)microstructure in F/M steel *** TMP,including cold-rolling thickness reduction of 6%,9%,and 12%,followed by austenitization at 1323 K for 40 min and tempering at 1053 K for 45 min,was applied to the as-received(AR)P92 *** prior austenite grain(PAG)size,prior austenite grain boundary character distribution(GBCD),and connectivity of prior austenite grain boundaries(PAGBs)were *** to the AR specimen,the PAG size did not change *** fraction of coincident site lattice boundaries(CSLBs,3≤Σ≤29)and Σ3^(n) boundaries along PAGBs decreased with increasing reduction ratio because the recrystallization fraction increased with increasing reduction *** PAGB connectivity of the 6%deformed specimen slightly deteriorated compared with that of the AR ***,potentiodynamic polarization studies revealed that the intergranular damage resistance of the studied steel could be improved by increasing the fraction of CSLBs along the PAGBs,indicating that the TMP,which involves low deformation,could enhance the intergranular damage resistance.

关键词： Grain boundary engineering Ferritic/martensitic steel Prior austenite grain boundary character distribution Grain boundary connectivity Intergranular damage resistance

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Winter extreme precipitation over the Tibetan Plateau influenced by Arctic sea ice on interdecadal timescale

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Advances in Climate Change Research 2024年第4期15卷 42-51页

作者： Qing-Quan LI Miao BI Song YANG Qing-Yuan WU Yi-Hui DING Xin-yong shen Xiao-Ting SUN Meng-Chu ZHAO China Meteorological Administration Key Laboratory for Climate Prediction Studies National Climate CentreBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China CMA Key Open Laboratory of Transforming Climate Resources to Economy Chongqing Institute of Meteorological SciencesChongqing 401147China School of Atmospheric Sciences and Guangdong Province Key Laboratory for Climate Change and Natural Disaster Studies Sun Yat-sen University Zhuhai 519082China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519082China

The Tibetan Plateau(TP)and the Arctic are the most sensitive regions to global climate ***,the interdecadal varibility of winter extreme precipitation over the TP and its linkage with Arctic sea ice are still *** this study,the characteristics and mechisnems of the TP extreme precipitation(TPEP)influenced by Arctic sea ice on interdecadal timescale are studied based on the daily precipitation,monthly sea ice concentration and ERA5 reanalysis data from 1980 to *** found that the dominant mode of the TPEP in winter mostly exhibits a uniform spatial variation on the interdecadal timescale,with an opposite weak variation in the southeastern TP,and the Arctic sea ice concentration(SIC)before 2002 are larger than that after *** interdecadal variation of TPEP is affected by two teleconnection wave trains regulated by the Barents and Kara Sea *** the light ice years,a remarkable positive geopotential height(HGT)anomaly appears over the Barents-Kara Sea and a remarkable negative HGT anomaly is located over the Lake *** wave trains originating over the Barents-Kara Sea can be *** southern branch forms a wave train through the North Atlantic along the subtropical westerly jet stream,showing a‘+-+-+'pattern of HGT anomalies from Arctic to the *** HGT anomaly controls the western TP,which creates dynamic and water vapor conditions for the *** northern branch forms a wave train through the Lake Baikal and the southeast of the TP,showing a‘+-+'HGT anomaly *** HGT anomaly controls the southeastern TP,which is not conducive to precipitation in the *** the SIC in the Barents-Kara Sea increases,the situation is *** above analysis also reveals the reason for the difference in the east-west distribution of the TPEP.

关键词： Arctic sea ice Tibetan Plateau Winter extreme precipitation Rossby wave activity Interdecadal variation

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基于支持向量机的智能决策方法

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系统工程 2005年第10期23卷 111-116页

作者：王强沈永平陈英武国防科技大学信息系统与管理学院湖南长沙410073

分析多属性决策问题及现有方法,提出了基于支持向量机的智能多属性决策方法。首先,介绍了支持向量回归估计的学习算法。其次,探讨了基于支持向量机的智能决策原理。然后,提出了多属性决策支持向量机方法的实现算法。最后给出了一个算例。

关键词：多属性决策效用函数支持向量机

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草鱼不同养殖模式实验围隔内沉积物-水界面营养盐通量的研究

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水生生物学报 2013年第4期37卷 595-605页

作者：郭永坚沈勇平王芳张振东中国海洋大学教育部海水养殖重点实验室青岛266003 中国水产科学研究院南海水产研究所广州510300 无锡市农业委员会无锡214131

于2009年6—10月采用围隔实验法开展草鱼(Ctenopharyngodon idellus)、鲢鱼(Hypophythalmichthysmolitrix)和凡纳滨对虾(Litopenaeus vannamei)不同混养模式的养殖实验,并在实验室培养条件下,测定了草鱼不同养殖模式实验围隔内沉积物-... 详细信息

于2009年6—10月采用围隔实验法开展草鱼(Ctenopharyngodon idellus)、鲢鱼(Hypophythalmichthysmolitrix)和凡纳滨对虾(Litopenaeus vannamei)不同混养模式的养殖实验,并在实验室培养条件下,测定了草鱼不同养殖模式实验围隔内沉积物-水界面营养盐交换通量,并探讨了影响营养盐交换通量的因素。实验设置7个处理组,分别为草鱼单养组(G),草鱼和鲢鱼二元混养组(GS),草鱼和凡纳滨对虾二元混养组(GL),草鱼、鲢鱼和凡纳滨对虾按照不同比例放养的三元混养组(GSL1、GSL2、GSL3和GSL4),每组3个重复。结果显示:(1)草鱼不同养殖模式下沉积物-水界面呈现较高的营养盐通量,其水平高于湖泊、鱼类网箱区和青蟹、刺参养殖池塘,其中氨氮通量为87.87—229.67 mmol/(m2.d),硝酸盐通量为32.95—27.13 mmol/(m2.d),DIP通量500.2—10.25 mmol/(m2.d),且在不同养殖模式下,硝酸盐通量、氨氮通量、无机磷通量均以8月份最高;(2)养殖期间沉积物对氨氮的释放和吸收呈交替变化趋势,7、8月份沉积物对NO3+NO2主要表现为吸收,而沉积物对可溶性无机磷(DIP)的吸收主要出现在8、9两月;(3)在不同养殖模式下,养殖中后期的硝酸盐通量、氨氮通量、无机磷通量多表现为差异显著(P<0.05),三元混养组中营养盐的通量值明显高于单养组和二元混养组;(4)结合水环境指标来看,GSL2组(放养0.58 ind./m2的草鱼、0.23 ind./m2的鲢鱼、48.9 ind./m2的凡纳滨对虾)是较优的养殖模式。

关键词：草鱼混养沉积物-水界面氨氮通量硝酸盐通量磷酸盐通量

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