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Potential active compounds and mechanisms of shen-Qi-yi-Chang granule for the treatment of colorectal cancer:an analysis of network pharmacology and molecular docking

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Drug Combination Therapy 2021年第3期3卷 1-9页

作者： Jia-Lin Gu Jia-Lin Yu Zi-Wei Song Guo-Li Wei yi Ji Ling-Chang Li Can-Hong Hu Jie-Ge Huo Department of Oncology Affiliated Hospital of Integrated Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjingJiangsu 210028China The Third Clinical Medical College Nanjing University of Chinese MedicineNanjingJiangsu 210046China Department of Oncology Jiangsu Province Academy of Traditional Chinese MedicineNanjingJiangsu 210028China.

Background:In recent years,herbal formulations have assumed an influential part in preventing and treating *** yichang granules(SQYCG)have proven effective in the adjuvant treatment of colorectal cancer(CRC),but their mechanism has not been *** study aimed to explore the potential active compounds and mechanisms of SQYCG in the treatment of CRC using network pharmacology and molecular ***:The active compounds and targets of SQYCG and the CRC genes were found using the Traditional Chinese Medicine Systems Pharmacology,DrugBank,and DisGeNET *** intersected targets of disease genes and drug targets were depicted using a Venn *** protein-protein interaction(PPI)network of these targets was obtained by String platform and visualized using *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis were carried using the DAVID database to obtain the core molecular mechanism of SQYCG in CRC *** docking techniques were used to validate the ***:A total of 63 compounds and 245 targets were obtained from the herbal prescription after the screening,of which 122 targets crossed with CRC *** showed that the core regulatory targets include MAPK1,TNF,TP53,JUN,RELA,MAPK14,and MAPK *** GO analysis indicated regulation of drug response,apoptotic process,response to hypoxia,angiogenesis,and response to *** pathway enrichment analysis mainly involves TNF,T cell receptor,Toll-like receptor,PI3K-Akt,and MAPK signal ***:Through network pharmacology,we havedemonstrated that SQYCG has multiple targets,components,and pathways in treating CRC,with anti inflammation and inhibition of cell proliferation being critical components of its mechanism.

关键词： pharmacology shenqi yichang granule treatment of post-operative and advanced CRC.The efficacy(SQYCG) Colorectal cancer Molecular Docking

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Fuzzy c-means clustering based on spatial neighborhood information for image segmentation

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Journal of Systems Engineering and Electronics 2010年第2期21卷 323-328页

作者： Yanling Li yi shen Institute of Systems Engineering Department of Control Science and EngineeringHuazhong University of Science and Technology Wuhan 430074 P. R. China College of Computer and Information Technology Xinyang Normal University Xinyang 464000 P. R. China

Fuzzy c-means （FCM） algorithm is one of the most popular methods for image segmentation. However, the standard FCM algorithm is sensitive to noise because of not taking into account the spatial information in the image. An improved FCM algorithm is proposed to improve the antinoise performance of FCM algorithm. The new algorithm is formulated by incorporating the spatial neighborhood information into the membership function for clustering. The distribution statistics of the neighborhood pixels and the prior probability are used to form a new membership func- tion. It is not only effective to remove the noise spots but also can reduce the misclassified pixels. Experimental results indicate that the proposed algorithm is more accurate and robust to noise than the standard FCM algorithm.

关键词： image segmentation fuzzy c-means spatial informa- tion. robust.

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Transdisciplinary Convergence:Intelligent Infrastructure for Sustainable Development

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Data Intelligence 2021年第2期3卷 261-273页

作者： yi shen Virginia Tech BlacksburgVA 24061USA

The fast-developing intelligent infrastructure landscape catalyzes transformative new relationships of human,technology,and environment and requires new socio-technical configurations of information practice and knowledge *** a focus on data as the source of intelligence,this paper aims to explore the shifting scenarios and indicative features of data science solutions for intelligent system applications and identify the evolving knowledge spaces and integrative learning practices in the“smart”*** projects and discusses the democratization of data science platforms,the distribution of data intelligence on the edge,and the transition from vertical to horizontal data solutions in solving intelligent system *** mapping the changing data research landscape,this work further reveals essential new roles of knowledge architects and social engineers in enabling dynamic data linking,interaction,and exploration for transdisciplinary data convergence.

关键词： Intelligent infrastructure Data intelligence and decision sciences Convergent research Integrative learning Transdisciplinary practice Information work

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Attitude sensor fault diagnosis based on Kalman filter of discrete-time descriptor system

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Journal of Systems Engineering and Electronics 2012年第6期23卷 914-920页

作者： ZhenhuaWang yi shen Xiaolei Zhang School of Astronautics Harbin Institute of Technology Harbin 150001 P. R. China

To diagnose the fault of attitude sensors in satellites, this paper proposes a novel approach based on the Kalman filter of the discrete-time descriptor system. By regarding the sensor fault term as the auxiliary state vector, the attitude measurement system subjected to the attitude sensor fault is modeled by the discrete-time descriptor system. The condition of estimability of such systems is given. And then a Kalman filter of the discrete-time descriptor system is established based on the methodology of the maximum likelihood estimation. With the descriptor Kalman filter, the state vector of the original system and sensor fault can be estimated simultaneously. The proposed method is able to esti-mate an abrupt sensor fault as well as the incipient one. Moreover, it is also effective in the multiple faults scenario. Simulations are conducted to confirm the effectiveness of the proposed method.

关键词： discrete-time descriptor system Kalman filter satel-lite attitude sensor fault estimation.

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Unraveling structure and performance of protein a ligands at liquid–solid interfaces: A multi-techniques analysis

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Chinese Journal of Chemical Engineering 2023年第2期54卷 232-239页

作者： yi shen Xinshuang Chu Qinghong Shi Department of Biochemical Engineering School of Chemical Engineering and TechnologyTianjin UniversityTianjin 300350China Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology(Ministry of Education) Tianjin UniversityTianjin 300350China

Oriented ligand immobilization is one of the most effective strategies used in the design and construction of a high-capacity protein A chromatography. In this work, cysteine was introduced as anchoring sites by substituting a specific residue on Helix Ⅰ, Ⅱ, and at C-terminus of antibody binding domain Z from protein A, respectively, to investigate structural evolution and binding behavior of protein A ligands at liquid-solid interfaces. Among the three affinity dextran-coated Fe_(3)O_(4) magnetic nanoparticles(Fe_(3)O_(4)@Dx MNPs), affinity MNPs with the immobilized ligand via N11C on Helix Ⅰ(Fe_(3)O_(4)@Dx-Z_(1) MNPs) had the highest helical content, and MNPs with the immobilized ligand via G29C on Helix Ⅱ(Fe_(3)O_(4)@Dx-Z_(2) MNPs) had the lowest helical content at the same pHs. It was attributed to less electrostatic attraction of ligand to negatively charged surface on Fe_(3)O_(4)@Dx-Z_(1) MNPs because of less positive charged residues on Helix Ⅰ(K6) than Helix Ⅱ(R27/K35). Among the three affinity MNPs, moreover, the highest affinity to immunoglobulin G(IgG) binding was observed on Fe_(3)O_(4)@Dx-Z_(1) MNPs in isothermal titration calorimetry measurement, further validating greater structural integrity of the ligand on Fe_(3)O_(4)@Dx-Z_(1) MNPs. Finally,the study of IgG binding on MNPs and 96-well plates showed that anchoring sites for ligand immobilization had distinct influences on IgG binding and IgG-mediated antigen binding. This work illustrated that anchoring sites of the ligands had a striking significance for the molecular structure of the ligand at liquid-solid interfaces and raised an important implication for the design and optimization of protein A chromatography and protein A-based immunoassay analysis.

关键词： Adsorption Interface Thermodynamics Protein A ligand Immobilization Molecular structure

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A NOTE ON STABILITY OF THE SPLIT-STEP BACKWARD EULER METHOD FOR LINEAR STOCHASTIC DELAY INTEGRO-DIFFERENTIAL EQUATIONS

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Journal of Systems Science & Complexity 2012年第5期25卷 873-879页

作者： Feng JIANG yi shen Xiaoxin LIAO Department of Control Science and Engineering Huazhong University of Science and Technology School of Statistics and Mathematics Zhongnan University of Economics and Law Department of Control Science and Engineering the Key Laboratory of Ministry of Eduction for Image Processing and Intelligent ControlHuazhong University of Science and Technology

In the literature （Tan and Wang, 2010）, Tan and Wang investigated the convergence of the split-step backward Euler （SSBE） method for linear stochastic delay integro-differential equations （SDIDEs） and proved the mean-square stability of SSBE method under some condition. Unfortu- nately, the main result of stability derived by the condition is somewhat restrictive to be applied for practical application. This paper improves the corresponding results. The authors not only prove the mean-square stability of the numerical method but also prove the general mean-square stability of the numerical method. Furthermore, an example is given to illustrate the theory.

关键词： General mean-square stability mean-square stability split-step backward Euler method stochastic delay integro-differential equations.

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Thermodynamics and kinetics of extracting zinc from zinc oxide ore by the ammonium sulfate roasting method

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International Journal of Minerals,Metallurgy and Materials 2015年第5期22卷 467-475页

作者： yi Sun Xiao-yi shen Yu-chun Zhai School of Materials and Metallurgy Northeastern University

Thermodynamic analyses and kinetic studies were performed on zinc oxide ore treatment by （NH4）2SO4 roasting technology. The results show that it is theoretically feasible to realize a roasting reaction between the zinc oxide ore and （NH4）2SO4 in a temperature range of 573-723 K. The effects of reaction temperature and particle size on the extraction rate of zinc were also examined. It is found that a surface chemical reaction is the rate-controlling step in roasting kinetics. The calculated activation energy of this process is about 45.57 kJ/mol, and the kinetic model can be expressed as follows： 1 - （1 - α）1/3 = 30.85 exp（-45.57/RT）·t. An extraction ratio of zinc as high as 92% could be achieved under the optimum conditions.

关键词： zinc metallurgy extraction ammonium sulfate ore roasting thermodynamics kinetics

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The Support of a Refinable Vector Satisfying an Inhomogeneous Refinement Equation

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Acta Mathematica Sinica,English Series 2010年第4期26卷 691-698页

作者： Song LI yi shen Department of Mathematics Zhejiang University Hangzhou 310027 P. R. China

In this paper, we investigate the support of a refinable vector satisfying an inhomoge- neous refinement equation. By using some methods introduced by So and Wang, an estimate is given for the support of each component function of a compactly supported refinable vector satisfying an inhomogeneous matrix refinement equation with finitely supported masks.

关键词： support inhomogeneous refnement equation refinable vector

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Modified MUSIC estimation for correlated signals with compressive sampling arrays

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Journal of Systems Engineering and Electronics 2014年第5期25卷 755-760页

作者： Yan Jing Naizhang Feng yi shen School of Astronautics Harbin Institute of Technology School of Information and Electrical Engineering Harbin Institute of Technology in Weihai

This paper addresses the issue of the direction of arrival （DOA） estimation under the compressive sampling （CS） framework. A novel approach, modified multiple signal classification （MMUSIC） based on the CS array （CSA-MMUSIC）, is proposed to resolve the DOA estimation of correlated signals and two closely adjacent signals. By using two random CS matrices, a large size array is compressed into a small size array, which effectively reduces the number of the front end circuit. The theoretical analysis demonstrates that the proposed approach has the advantages of low computational complexity and hardware structure compared to other MMUSIC approaches. Simulation results show that CSAMMUSIC can possess similar angular resolution as MMUSIC.

关键词： direction of arrival (DOA) compressive sampling array (CSA) modified multiple signal classification (MMUSIC) correlated signal.

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H_-/H_∞ fault detection filter design for interval time-varying delays switched systems

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Journal of Systems Engineering and Electronics 2016年第4期27卷 878-886页

作者： Jiawei Wang yi shen Zhenhua Wang Department of Control Science and Engineering Harbin Institute of Technology

The problem of the robust fault detection filter design for time-varying delays switched systems is considered in the framework of mixed H-/H∞. Firstly, the weighted H∞ performance index is utilized as the robustness performance, and the H- index is used as the sensitivity performance for obtaining the robust fault detection filter. Then a novel multiple Lyapunov-Krasovskii function is proposed for deriving sufficient existence conditions of the robust fault detection filter based on the average dwell time technique. By introducing slack matrix variable, the coupling between the Lyapunov matrix and system matrix is removed, and the conservatism of results is reduced. Based on the robust fault detection filter, residual is generated and evaluated for detecting faults. In addition, the results of this paper are dependent on time delays,and represented in the form of linear matrix inequalities. Finally,the simulation example verifies the effectiveness of the proposed method.

关键词： switched system average dwell time mixed H-/H∞ robust fault detection filter time-varying delay

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