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糖皮质激素口服给药和经鼻腔雾化吸入用于慢性鼻窦炎患者功能性鼻窦内镜手术后的效果

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中国药物经济学 2024年第1期19卷 63-65,70页

作者：申丽萍苏州平江医院耳鼻咽喉科江苏苏州215031

目的探讨糖皮质激素口服给药和经鼻腔雾化吸入用于慢性鼻窦炎患者功能性鼻窦内镜手术后的效果。方法选取2019年12月至2022年12月于苏州平江医院确诊的慢性鼻窦炎患者60例作为研究对象,根据就诊先后顺序将患者进行编号(1~60号),1~30号... 详细信息

目的探讨糖皮质激素口服给药和经鼻腔雾化吸入用于慢性鼻窦炎患者功能性鼻窦内镜手术后的效果。方法选取2019年12月至2022年12月于苏州平江医院确诊的慢性鼻窦炎患者60例作为研究对象,根据就诊先后顺序将患者进行编号(1~60号),1~30号口服醋酸泼尼松片(口服组),31~60号采用丙酸氟替卡松雾化吸入用混悬液经鼻腔雾化吸入(雾化组),比较两组的治疗效果。结果雾化组治愈率略高于口服组,但组间比较差异无统计学意义(P>0.05)。治疗2周后,两组鼻内镜Lnud-Kenndry评分降低,且雾化组低于口服组,差异有统计学意义(P0.05),雾化组血清糖皮质激素水平明显高于口服组(P<0.05)。雾化组不良反应发生率低于口服组,差异有统计学意义(P<0.05)。结论糖皮质激素经鼻腔雾化吸入应用于慢性鼻窦炎行功能性鼻窦内镜手术患者,更有利于术后鼻窦黏膜恢复,且安全性更高。

关键词：慢性鼻窦炎功能性鼻窦内镜手术糖皮质激素口服给药经鼻腔雾化吸入治疗临床效果

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大语言模型在中学历史学科中的应用测评分析

现代教育技术 2024年第2期34卷 62-71页

作者：申丽萍何朝帆曹东旭朱云彬吴永和上海交通大学计算机科学与工程系上海200240 上海交大附属中学上海200439 上海交大第二附属中学上海200240 华东师范大学教育信息技术学系上海200062

大语言模型一经发布便获得广泛关注,但其在实际应用特别是教育领域的应用还存在诸多局限与挑战,因此需要对大语言模型在中文语境下的能力与风险进行测评。基于此,文章首先收集整理了一个包括10万条客观选择题与10套中学主观题测试卷的... 详细信息

大语言模型一经发布便获得广泛关注,但其在实际应用特别是教育领域的应用还存在诸多局限与挑战,因此需要对大语言模型在中文语境下的能力与风险进行测评。基于此,文章首先收集整理了一个包括10万条客观选择题与10套中学主观题测试卷的中学历史数据集,并在以ChatGPT、GPT-4和讯飞星火为代表的大语言模型上测试了该数据集中题目的回答表现。然后,文章详细分析了测试结果,发现虽然当前大语言模型的突出能力在于能够产生完整且流畅的表达,但其在中学历史知识测试中仍远低于适龄学生的平均水平,大语言模型应用于教育领域仍存在可靠性较差、可信度较低、具有偏见与歧视、推理能力不足、无法自动更新知识等问题。最后,文章针对大语言模型在中文语境下教育领域的应用提出建议,以期助力大语言模型在教育领域发挥更大的作用,为学生、教师带来更好的学习和教学体验。

关键词：大语言模型 ChatGPT 讯飞星火教育应用测评

Investigation of the cross-reaction mechanism of C_6H_5F-HNO_2 aqueous solution irradiated at 355 nm by transient absorbance spectrum technique

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Chinese Science Bulletin 2008年第7期53卷 998-1003页

作者： ZHANG RenXi shen Yan li ping HUANG li DONG WenBo HOU HuiQi Institute of Environmental Science Fudan University Shanghai 200433 China

The transient absorption spectrum technique was employed to investigate the cross-reaction mecha-nism of C6H5F-HNO2 aqueous solution irradiated at 355 nm. The characteristic and the kinetic parame-ters of transient species were also detected. Hydroxyl radical derived from the photolysis of HNO2 was added to monofluorobenzene with a second-order rate constant of (5.83±0.17)×109 L·mol-1·s-1 to form an adduct, C6H5F···OH, which was able to react with HNO2 as the main reaction pathway with a rate constant of (8.3±0.1)×107 L·mol-1·s-1. The C6F6···OH adduct can also be decayed by elimination of H2O to yield monofluorophenyl radical C6H4F·. By GC-MS technique, the final products were identified to be monofluorophenol, nitro-monofluorobenzene, nitro-monofluorophenol and para-fluorobiphenyl.

关键词：溶液作用瞬变现象吸收率光谱学

Persistent subretinal fluid after successful scleral buckle surgery for macula-off retinal detachment

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Chinese Medical Journal 2011年第23期124卷 4007-4011页

作者： WANG Xiao-yu shen li-ping HU Rong-rong XU Wei Department of Ophthalmology First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

Background After successful scleral buckle and cryotherapy for macular-off retinal detachment （RD）, some patients have poor visual acuity without any clinically detected macular change, and the unsatisfactory postoperative visual acuity is difficult to explain. The purpose of this study was to determine the characteristics of subretinal fluid （SRF） after successful scleral buckle surgery for macula-off RD. Methods Twenty-eight eyes from 28 patients were included in this study. The patients underwent scleral buckle surgery combined with cryopexy for macular-off RD. After surgery, all eyes underwent thorough ophthalmologic examinations including slit-lamp biomicroscopy, best-corrected visual acuity （BCVA） test, and binocular indirect ophthalmoscopy. The BCVA prior to the operation, duration of RD, the duration of postoperative retinal reattachment, BCVA when SRF was observed, period required for the SRF to become undetectable, and the BCVA at the final follow-up were included in the clinical data for this study. Optical coherence tomography （OCT） and B-ultrasonography were used to confirm SRF, and fluorescein angiography （FFA） was carried out in several patients. BCVA when SRF was observed and BCVA at the final follow-up were evaluated using a paired t test. Correlations between BCVA before the operation and duration of RD and BCVA at the final follow-up were analyzed using the Pearson correlation test. The type of SRF under OCT and BCVA at the final follow-up were compared using one-way analysis of variance （ANOVA）. Results Postoperative retinal reattachment was achieved in 1.0-7.0 days （average, （2.7±.2.1） days）. After retinal reattachment, SRF was detected in all eyes by OCT 2 weeks postoperative, while B ultrasonography found no changes. The mean IogMAR BCVA was 0.35±0.27 at the time of the detection of SRF. The period for SRF to become undetectable ranged from 2.0 to 11.0 months （average, （6.3±2.3） months）. The time of follow-up ranged from 24.0 to 36.0 months （a

关键词： subretinal fluid retinal detachment macula-off surgery

Synthesis and Antiproliferative Activity of Novel [1,2,4]Triazolo[1,5-a]pyrimidine-7-amine Derivatives

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Chemical Research in Chinese Universities 2009年第4期25卷 474-479页

作者： ZHAI Xin ZHANG Cun-long HE Lei li Qi WANG Jiu-liang shen Xiao-li GONG ping Key Laboratory of New Drugs Design and Discovery of liaoning Province School of Pharmaceutical Engineering Shenyang Pharmaceutical University Shenyang 110016 P. R. China

A series of novel N-anilino-2-substituted-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine-7-amine derivatives was prepared and evaluated for their in vitro antiproliferative activity against two cancer cell lines,Bel-7402 and *** of the compounds inhibited the cell proliferation at a low *** compounds,VI5,VI7,VI10,and VI12―VI15,possessed marked antiproliferative activity superior to that of *** these seven initial hits,compound VI10 was the most active.

关键词： Triazolo[ 1,5-a]pyrimidines Antiproliferative activity Anticancer

Combined trabeculectomy and vitrectomy for intractable glaucoma with severe ocular contusion involving the posterior segment

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Chinese Medical Journal 2011年第15期124卷 2316-2320页

作者： WANG Xiao-yu HU Rong-rong shen li-ping LU Hong GU Yang-shun Department of Ophthalmology the First Affiliated Hospital of College of Medicine Zhejiang University Hangzhou Zhejiang 310003 China

Background Intractable secondary glaucoma with severe ocular contusion involving the posterior segment is difficult to treat. In this study, we evaluated the safety and efficacy of combined trabeculectomy and vitrectomy for intractable glaucoma with severe ocular contusion involving the posterior segment. Methods This retrospective interventional study enrolled 18 eyes from 18 consecutive cases with uncontrolled intraocular pressure, angle recession exceeding 180°, dense vitreous hemorrhage, and/or limited retinal detachment after severe ocular contusion. Combined trabeculectomy and vitrectomy was performed after giving the patient sufficient anti-inflammatory and intraocular pressure （IOP）-Iowering medication. Follow-up averaged 26.2 （range, 6.0-48.0） months. Results The mean lOP decreased from （36.4±10.0） mmHg on maximum lOP-lowering medications to （14.6±4.4） mmHg on （0.7±1.2） topical medications at the final follow-up （P 〈0.0001）. During the first postoperative month, four eyes （22%） had a short hypertensive phase and six eyes （33%） had early hypotony, including one case （5.6%） of bleb leakage Seven eyes （39%） developed recurrent hypertension 3-6 months postoperatively, five of which were controlled by topical medications. Ten （55.6%） eyes were classified as a complete success, five （27.8%） as a qualified success, and three eyes （16.7%） as failures. Kaplan-Meier survival analysis for complete and cumulative success showed 53.5% and 80.0% survival at 48 months, respectively. Visual acuity was improved in 15 eyes （83.3%）. Three eyes （16.7%） had unchanged visual acuity, one （5.6%） of which developed atrophia bulbi despite a normal intraocular pressure. No recurrent retinal detachment or vitreous hemorrhage developed. Conclusion Combined trabeculectomy and vitrectomy is a viable surgical procedure for the management of intractable glaucoma with severe ocular contusion involving the posterior segment in selected cases.

关键词： trabeculectomy vitrectomy glaucoma ocular trauma

AB_(2)-type rare earth-based compounds with C-15 structure:Looking for reversible hydrogen storage materials

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Journal of Rare Earths 2024年第5期42卷 803-816,I0001页

作者： Hao shen Junxian Zhang Valerie Paul-Boncour ping li Zhinian li Yuanfang Wu lijun Jiang National Engineering Research Center of Nonferrous Metals Materias and Products for New Energy GRINM Group Co.LtdBeijing00088China Univ Paris Est Creteil CNRSICMPEUMR 71822 rue Henri Dunant94320ThiaisFrance Institute for Advanced Materials and Technology University of Science and TechnologyBeijing100083China GRIMAT Engineering Institute Co. Ltd.Beijing101407China

AB_(2)-type(A=rare earth,B=transition metal)intermetallic compounds with C15 structure can easily absorb large amount of hydrogen,showing their potential use as hydrogen storage *** crucial problem hindering their application is hydrogen induced amorphization(HIA),which leads to the irreversible hydrogen sorption *** stability of the AB_2 Laves phase compounds,the structural properties,the hydrogenation properties and the controlling factors of HIA are discussed in this *** with other factors,the atomic radii ratio r_A/r_B is the most important one influencing the ***-element substitution is an efficient way to suppress or limit HIA and may enable AB_2 compounds to be suitable for hydrogen storage.

关键词： Rare earth-based AB_2-type compounds Hydrogenation properties Hydrogen induced amorphization Elemental substitution

Architecture Design of Protocol Controller Based on Traffic-Driven Software Defined Interconnection

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Chinese Journal of Electronics 2024年第2期33卷 362-370页

作者： Peijie li Jianliang shen ping LYU Chunlei DONG Ting CHEN Information Engineering University

To solve the problems of redundant logic resources and poor scalability in protocol controller circuits among communication networks, we propose a traffic-driven software defined interconnection(TSDI) *** unified software defined interconnection interface standards and the normalized interconnection topology are designed to implement the architecture of TSDI-based protocol controller. The key indicators of power, performance and area(PPA) can be realized while resolving the flexible interconnection of the controller. We designed a TSDI-based Rapid IO controller as an example. Compared to traditional designs, the design could achieve more protocol scalability,and Rapid IO protocol standards of Gen4 could be supported directly. The key PPA indicators, such as a lower delay of 56.1 ns and more than twice throughput of 98.1 Gbps, were achieved at the cost of a 23.4% area increase.

关键词： Protocols Software design Scalability Integrated circuit interconnections Process control Computer architecture Throughput

Failure mechanism and simulation for long run-out of the catastrophic rock landslide in the Shanyang Vanadium Mine,China

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Journal of Mountain Science 2024年第9期21卷 2905-2917页

作者： liU Yinpeng Mumtaz HAIDER David-darnor LAWRENCE li Tonglu shen Wei li ping College of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Observation and Research Station of Water Cycle and Geological Environment for the Chinese Loess Plateau Ministry of EducationZhengning 745399China

On 12th August 2015,a massive rapid long run-out rock landslide occurred in the Shanyang Vanadium Mine in Shaanxi Province,China,which claimed the lives of 65 *** heavy rainfalls,earthquakes,and mining blasts were recorded before the ***,the failure mechanism and the cause of the long run-out movement are always in *** this paper,we conducted a detailed field investigation,laboratory tests,block theory analysis,and numerical simulation to investigate the failure and long run-out mechanisms of the *** field investigation results show that the source material of the rock landslide is a huge dolomite wedge block bedding on siliceous shale *** compression tests indicate that the uniaxial compression strength of the intact dolomite is 130-140MPa and the dolomite shows a brittle failure *** to the progressive downward erosion of the gully,the dolomite rock bridge at the slope toe became *** the compression stress in the dolomite bridge increased to surpass its strength,the brittle failure of the bridge *** huge potential energy was released following the disintegration of the landslide,which led to the high acceleration of this rock *** 3D discrete element simulation results suggest that the low intergranular friction contributes to the long run-out movement of this rock landslide.

关键词： Rock landslide Gully erosion Long run-out Wedge block Discrete element method