检索结果-南通市图书馆

Xiao Tan San Jie Fang Hampers the Growth of Colon Cancer Stem Cells through the Wnt/β-catenin Signaling Pathway

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Traditional Chinese Medicine 2024年第2期10卷 171-179页

作者： Yu-Qi Zhou Jun-Fei Yuan hong-Shi shen Ya-Ping Wang Han-Fei Shi De-Jian Pan Min Ye Department of Hematology and Oncology The 904^(th) Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Clinical Laboratory The 904^(th)Hospital of PLA Joint Logistic Support ForceWuxiJiangsuChina Department of Traditional Chinese Medicine Second Affiliated Hospital of Naval Medical UniversityShanghaiChina

Objective: The purpose of this research was to examine the potential anticancer properties of Xiao Tan San Jie Fang(XTSJF) and its potential mechanism of action against colorectal cancer. Materials and Methods: HCT116 cells were induced into HCT116 spheres in DMEM/F12 medium by treatment with epidermal growth factor + fibroblast growth factor + leukemia inhibitory factor + B27. The proliferation ability and stemness of HCT116 spheres was examined. Various concentrations of XTSJF were used to treat HCT116 spheres to observe the impact on proliferation, apoptosis, and expression of stem cell markers. Next, Wnt/β-catenin pathway-related factor proteins were detected. Results: The findings revealed that XTSJF suppressed cell growth and induced cell death in HCT116 cells in a dosage-dependent manner. Similarly, XTSJF promotes apoptosis, inhibits cell proliferation, prolongs survival, and maintains the expression of stem cells through the Wnt/-catenin/TCF4 axis. XTSJF also inhibits AKT activity and subsequently activates glycogen synthesis kinase-3β expression, inhibiting Wnt/beta-catenin pathway activity and downstream target gene transcript expression. The Wnt/β-catenin signaling pathway is inhibited by the XTSJF, leading to the suppression of colon cancer stem cell proliferation. Conclusion: Xiaotan Sanjie Prescription inhibited colon cancer stem cell growth through Wnt/β-catenin signaling pathway.

关键词： Apoptosis colorectal cancer proliferation traditional Chinese medicine Wnt/β-catenin signaling

Bimetallic NiCoP catalysts anchored on phosphorus-doped lignin-based carbon for robust oxygen evolution performance

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2024年第7期43卷 3084-3095页

作者： Ling-Ying-Zi Xiong Bo-Wen Liu Lei Du Yue-kuan Zhou Xu-Liang Lin Huan Wang Guangdong Engineering Technology Research Center for Sensing Materials&Devices Guangzhou Key Laboratory of Sensing Materials&DevicesSchool of Chemistry and Chemical EngineeringGuangzhou UniversityGuangzhou 510006China School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Guangdong Provincial Laboratory of Chemistry and Fine Chemical Engineering Jieyang Center Jieyang 515200China Sustainable Energy and Environment Thrust Function HubThe Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Emerging Interdisciplinary Areas Department of Mechanical and Aerospace EngineeringThe Hong Kong University of Science and TechnologyHong Kong 999077China State Key Lab of Pulp and Paper Engineering South China University of TechnologyGuangzhou 510640China

Oxygen evolution reaction(OER)catalysts are the key core materials that determine the performance of fuel cells,metal-air batteries,electrolytic water decomposition,and other *** this work,a green lignin-based non-precious metal OER catalyst was prepared by a simple ***,c arboxylated lignin was used to complex Ni and Co in situ,and then they were placed with sodium hypophosphite in the same tube furnace for upstream and downstream high-temperature calcination to construct a lignin carbon-based Ni-Co bimetallic OER catalyst(NiCoP@C).The synthesized catalyst is a porous bimetallic phosphide with a three-dimensional network structure and high-density electrochemical active ***@C exhibited favorable catalytic activity for the oxygen evolution reaction(OER)with overpotential of 280 mV at 10 mA·cm~(-2)and a Tafel slope of 77 mV·dec~(-1).Additionally,it exhibited remarkable durability during *** functional theory(DFT)calculations revealed that by leveraging the distinctive structure of transition metal phosphide nanoparticles incorporated into a reticulated substrate,the NiCoP@C catalyst offered an increased number of active sites for OER catalysis,significantly enhancing its stability during practical *** present study broadens the utilization pathways of biomass to"turn waste into treasure,"aligning the development concept of green sustainable development.

关键词： Oxygen evolution reaction Lignin Carbon-based catalyst Nickel-cobalt bimetal Metal phosphide

在线全文

学校读者我要写书评

暂无评论

金钱草颗粒剂的药效学研究

黑龙江医药科学 2009年第3期32卷 8-9页

作者：沈德凤焦艳沈洪宽宋岳佳木斯大学化学与药学院黑龙江佳木斯154007 佳木斯市药品检验所黑龙江佳木斯154007

目的:探讨金钱草颗粒剂的药理作用。方法:建立动物实验模型,抗炎实验:通过小鼠耳廓二甲苯致炎,以左右耳片重量差为肿胀程度,计算各组肿胀度;利胆实验:采用胆管引流法测定金钱草颗粒对大鼠胆汁流量变化的影响。结果:金钱草颗粒可抑制由... 详细信息

目的:探讨金钱草颗粒剂的药理作用。方法:建立动物实验模型,抗炎实验:通过小鼠耳廓二甲苯致炎,以左右耳片重量差为肿胀程度,计算各组肿胀度;利胆实验:采用胆管引流法测定金钱草颗粒对大鼠胆汁流量变化的影响。结果:金钱草颗粒可抑制由二甲苯所致小鼠耳廓肿胀,且各剂量组与空白对照组比较均有显著性差异(P<0.01);能明显增加胆汁分泌量,且中剂量组效果最佳,3h累积胆汁量为(1.68±0.02)mL,与空白对照组比有显著性差异(P<0.05,P<0.01)。结论:金钱草颗粒有显著的消炎利胆作用,对胆囊炎有很好的治疗作用。

关键词：金钱草颗粒剂抗炎利胆胆囊炎

Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En Chen Yu-Yang Lu Ruei-Yu Su hong-Hau Wang Chao-Yang Chen Je-Ming Hu Jung-Cheng Kang kuan-Hsun Lin Ta-Wei Pu Department of Surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** SUMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report

A lithium–tin fluoride anode enabled by ionic/electronic conductive paths for garnet-based solid-state lithium metal batteries

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2024年第2期43卷 575-587页

作者： Lei Zhang Qian-Kun Meng Xiang-Ping Feng Ming shen Yu-Qing Zhang Quan-Chao Zhuang Run-Guo Zheng Zhi-Yuan Wang Yan-Hua Cui hong-Yu Sun Yan-Guo Liu School of Materials Science and Engineering Northeastern UniversityShenyang110819China School of Resources and Materials Northeastern University at QinhuangdaoQinhuangdao066004China School of Materials and Physics China University of Mining&TechnologyXuzhou221116China Institute of Electronic Engineering China Academy of Engineering PhysicsMianyang621900China

The high energy density and stability of solid-state lithium metal batteries(SSLMBs)have garnered great ***-type oxides,especially Li_(6.4)La_(3)Zr_(1.4)Ta_(0.6)O_(12)(LLZTO),with high ionic conductivity,wide electrochemical window,and stability to Li metal anode,are promising solid-state electrolyte(SSEs)materials for ***,Li/LLZTO interface issues including high interface resistance,inhomogeneous Li deposition,and Li dendrite growth have hindered the practical application of ***,a multi-functional Li–SnF_(2) composite anode with Li,LiF,and Li-Sn alloy was specifically designed and *** composite anode improves the wettability to LLZTO,constructing an intimate contact interface between it and ***,ionic/electronic conductive paths in situ formed at the interface can effectively uniform Li deposition and suppress Li *** solid-state symmetric cell exhibits low interface resistance(11Ω·cm^(2)) and high critical current density(1.3 mA·cm^(−2))at 25℃.The full SSLMB based on LiFePO_(4) or LiNi_(0.5)Co_(0.2)Mn_(0.3)O_(2) cathode also shows stable cycling performance and high rate *** work provides a new composite anode strategy for achieving high-energy density and high-safety SSLMBs.

关键词： Solid-state lithium metal batteries(SSLMBs) Lithium-tin fluoride anode Ionic/electronic conductive Interface resistance Lithium dendrite

在线全文

学校读者我要写书评

暂无评论

内在特征与新型研究型大学的持续发展

中国高教研究 2024年第7期 25-33页

作者：沈红南方科技大学高等教育研究中心广东深圳518055

新型研究型大学已在国内兴起,相关研究不少,但在某些理论问题和建设成效的研究上仍显不足。首先辨析如新、型、内在特征、持续发展等主要概念;研究新型研究型大学体现在教学、科研、服务三项职能上的内在特征:培养学生为创新者,开展三... 详细信息

新型研究型大学已在国内兴起,相关研究不少,但在某些理论问题和建设成效的研究上仍显不足。首先辨析如新、型、内在特征、持续发展等主要概念;研究新型研究型大学体现在教学、科研、服务三项职能上的内在特征:培养学生为创新者,开展三导向下的三类研究,以培养的创新者和三类研究成果贡献社会;然后分析新型研究型大学持续发展面临的挑战,如创新者的培养过程有待贯通,以战略为导向的开创研究尚未推动,社会服务并未起到引领作用,大学内外部都难以坚持办学初心;最后提出,将培养创新者落实到教育教学全过程,将成为“国之重器”落实到科研行动中,将办学初心融入世界一流大学的日常建设里,作为新型研究型大学持续独特的战略与策略选择。

关键词：新型研究型大学持续发展内在特征培养创新者开创研究

Endoscopic polidocanol foam sclerobanding for the treatment of grade Ⅱ-Ⅲ internal hemorrhoids:A prospective,multi-center,randomized study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第38期30卷 3326-3335页

作者： Chun-Ying Qu Fei-Yu Zhang Yi Zhang Ming-Ming Li Zheng-hong Li Mei-hong Cai Lei-Ming Xu Feng shen Wen Wang Wu-Lian Lin Feng-Yu Gao Hao Zhang Guang-Yu Chen Department of Gastroenterology&Endoscopy Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Gastroenterology The 900th Hospital of the People’s Liberation Army Joint Service Support ForceFuzhou 350025Fujian ProvinceChina Department of Endoscopy Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao UniversityJinan 250014Shandong ProvinceChina Department of Endoscopy Baoshan People’s Hospital of Yunnan ProvinceBaoshan 678000Yunnan ProvinceChina Department of Gastroenterology Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

BACKGROUND Endoscopic rubber band ligation(ERBL)is a nonsurgical technique for the treatment of symptomatic internal hemorrhoids but is limited by recurrence and post-procedural *** To evaluate satisfaction,long-term recurrence,and post-procedural pain in managing internal hemorrhoids using a combination of polidocanol foam sclerotherapy and *** This was a prospective,multicenter,randomized study.A total of 195 consecutive patients diagnosed with grade II-III internal hemorrhoids were enrolled from four tertiary hospitals and randomly divided into a cap-assisted endoscopic polidocanol foam sclerobanding(EFSB)or an ERBL *** patients were followed-up for 12 ***-based severity and post-procedural pain were assessed using a hemorrhoid severity score(HSS)and a visual analog scale(VAS).Continuous variables were reported as medians and interquartile *** One hundred and ninety-five patients were enrolled,with 98 in the EFSB *** was lower in the EFSB group than in the ERBL group at 8 weeks[4.0(3.0-5.0)vs 5.0(4.0-6.0),P=0.003]and 12-month[2.0(1.0-3.0)vs 3.0(2.0-3.0),P<0.001]of *** prolapse recurrence rate was lower in the EFSB group at 12 months(11.2%vs 21.6%,P=0.038).Multiple linear regression analysis demonstrated that EFSB treatment[B=-0.915,95%confidence interval(CI):−1.301 to−0.530,P=0.001]and rubber band number(B=0.843,95%CI:0.595-1.092,P<0.001)were negatively and independently associated with the VAS score 24 hours *** median VAS was lower in the EFSB group than in the ERBL[2.0(1.0-3.0)vs 3.0(2.0-4.0),P<0.001].CONCLUSION Cap-assisted EFSB provided long-term satisfaction and effective relief from the recurrence of prolapse and pain 24 hours post-procedure.

关键词： Internal hemorrhoids Endoscopic therapy Polidocanol foam Sclerotherapy Rubber band ligation Sclerobanding

钛粒硅镁石:冷俯冲带蛇纹岩超高压变质的特征变质矿物

在线全文

学校读者我要写书评

暂无评论

岩石矿物学杂志 2024年第2期43卷 427-449页

作者：杨文宽申婷婷自然资源部深地动力学重点实验室中国地质科学院地质研究所北京100037 中国地质大学(北京)地球科学与资源学院北京100083

蛇纹岩矿物组合简单,主要组成矿物蛇纹石的温压稳定范围很大,这导致确定蛇纹岩的变质温压条件存在困难。本文通过实验岩石学模拟的方法,确定了钛粒硅镁石是蛇纹岩经历超高压变质的特征变质矿物。根据实验观察,压力达到3.0~3.5 GPa条件下... 详细信息

蛇纹岩矿物组合简单,主要组成矿物蛇纹石的温压稳定范围很大,这导致确定蛇纹岩的变质温压条件存在困难。本文通过实验岩石学模拟的方法,确定了钛粒硅镁石是蛇纹岩经历超高压变质的特征变质矿物。根据实验观察,压力达到3.0~3.5 GPa条件下,600~700℃范围内均存在钛粒硅镁石的生成反应,说明钛粒硅镁石在压力大于3.0~3.5 GPa条件下才能稳定;温度高于750℃,钛粒硅镁石开始减少直至消失。至于钛粒硅镁石的压力上限,由于实验条件所限,本次实验并未得出。钛斜硅镁石先于钛粒硅镁石出现,晚于钛粒硅镁石消失,稳定的温压范围更大。对实验样品观察发现,普遍存在钛粒硅镁石、钛斜硅镁石和橄榄石互为核边、互相交生的现象,这些实验现象与自然界中观察到的现象一致。低温高压条件下,由于这3类矿物结构的相似性,钛斜硅镁石与橄榄石通常出现互为核边的现象;随着温度升高,钛斜硅镁石以斑块或者片晶出现在橄榄石中,直至最终分解消失。钛粒硅镁石的出现与否取决于温压条件:低温低压条件下,钛粒硅镁石不稳定,发生分解产生钛斜硅镁石,出现钛斜硅镁石包裹钛粒硅镁石的现象;低温高压条件下,钛粒硅镁石稳定生长,出现钛粒硅镁石发育于钛斜硅镁石边部的现象;高温条件下,钛粒硅镁石不稳定,以片晶形式存在于橄榄石或钛斜硅镁石中。研究表明,钛粒硅镁石稳定于低温高压条件,确定其为冷俯冲带蛇纹岩超高压变质的标志。同时详细的岩相学显示了钛硅镁石矿物在高压变质过程中的行为,从而为俯冲带超基性岩变质研究提供理论依据。

关键词：高温高压实验蛇纹岩钛粒硅镁石钛斜硅镁石变质反应

Cetuximab combined with chemotherapy for simultaneous esophageal squamous cell carcinoma and colon adenocarcinoma:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2024年第15期12卷 2649-2654页

作者： Xin-Xin Luo Yu-Xuan Du Qi-Qing Zhang Lin Zhang Shu-Ying Zeng Zhi-hong Yu Peng shen Zheng-Quan Feng The Second School of Clinical Medicine Zhejiang Chinese Medical UniversityHangzhou310053Zhejiang ProvinceChina Department of Oncology Tongde Hospital of Zhejiang ProvinceHangzhou 310012Zhejiang ProvinceChina Department of Medical Oncology The First Affiliated HospitalMedical College of Zhejiang UniversityHangzhou 310003Zhejiang ProvinceChina

BACKGROUND Multiple primary carcinomas(MPCs)are defined as two or more independent primary cancers that occur simultaneously or sequentially in the same *** MPCs are rarer than solitary cancers or metachronous *** diagnoses of synchronous MPCs and the choice of treatment are critical for successful outcomes in these *** SUMMARY A 64-year-old patient presented with dysphagia,without obvious cause.A diagnosis of synchronous esophageal squamous cell carcinoma and colon adenocarcinoma with liver metastasis was confirmed based on examination and laboratory *** multi-disciplinary consultations,combination chemotherapy(a 3-wk cycle with oxaliplatin 212 mg administered on day 1 and capecitabine 1.5 g twice daily on days 1-14)and esophageal cancer radiotherapy were *** on the results of genetic testing,we switched to a regimen of leucovorin+fluorouracil+oxaliplatin and cetuximab regimen for 8 ***,capecitabine and bevacizumab were administered until the most recent follow-up,at which the tumor remained *** Successful cetuximab chemotherapy treatment provides a reference for the nonoperative and homogeneous treatment of different pathological types of synchronous MCPs.

关键词： Synchronous multiple primary carcinoma Esophageal squamous cell carcinoma Colon adenocarcinoma Cetuximab Chemotherapy Case report