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Tree‑Inspired Structurally Graded Aerogel with Synergistic Water,Salt,and Thermal Transport for High‑Salinity Solar‑Powered Evaporation

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Nano-Micro Letters 2024年第11期16卷 19-37页

作者： Xiaomeng Zhao Heng Zhang Kit‑Ying Chan Xinyue Huang Yunfei Yang Xi shen Department of Aeronautical and Aviation Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Sports Science and Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China Research Institute for Advanced Manufacturing The Hong Kong Polytechnic UniversityHung HomKowloonHong Kong SARPeople’s Republic of China

Solar-powered interfacial evaporation is an energy-efficient solution for water *** requires solar absorbers to facilitate upward water transport and limit the heat to the surface for efficient ***,downward salt ion transport is also desired to prevent salt ***,achieving simultaneously fast water uptake,downward salt transport,and heat localization is challenging due to highly coupled water,mass,and thermal ***,we develop a structurally graded aerogel inspired by tree transport systems to collectively optimize water,salt,and thermal *** arched aerogel features root-like,fan-shaped microchannels for rapid water uptake and downward salt diffusion,and horizontally aligned pores near the surface for heat localization through maximizing solar absorption and minimizing conductive heat *** structural characteristics gave rise to consistent evaporation rates of 2.09 kg m^(-2) h^(-1) under one-sun illumination in a 3.5 wt%NaCl solution for 7 days without *** in a high-salinity solution of 20 wt%NaCl,the evaporation rates maintained stable at 1.94 kg m^(-2) h^(-1) for 8 h without salt crystal *** work offers a novel microstructural design to address the complex interplay of water,salt,and thermal transport.

关键词： Composite aerogel Graded structure Solar-powered evaporation Thermal insulation Salt rejection

Interplay between the glymphatic system and neurotoxic proteins in Parkinson’s disease and related disorders:current knowledge and future directions

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Neural Regeneration Research 2024年第9期19卷 1973-1980页

作者： Yumei Yue Xiaodan Zhang Wen Lv Hsin-Yi Lai Ting shen Department of Neurology of Sir Run Run Shaw Hospital Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Emergency Medicine The University of Hong KongHong Kong Special Administrative RegionChina Department of Neurology of the Second Affiliated Hospital and School of Brain Science and Brain Medicine Interdisciplinary Institute of Neuroscience and TechnologyKey Laboratory of Medical Neurobiology of Zhejiang ProvinceZhejiang University School of MedicineHangzhouZhejiang ProvinceChina College of Biomedical Engineering and Instrument Science Zhejiang UniversityHangzhouZhejiang ProvinceChina MOE Frontier Science Center for Brain Science and Brain-Machine Integration State Key Laboratory of Brain-machine IntelligenceSchool of Brain Science and Brain MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina

Parkinson’s disease is a common neurodegenerative disorder that is associated with abnormal aggregation and accumulation of neurotoxic proteins,includingα-synuclein,amyloid-β,and tau,in addition to the impaired elimination of these neurotoxic *** parkinsonism,which has the same clinical presentation and neuropathology as Parkinson’s disease,expands the disease landscape within the continuum of Parkinson’s disease and related *** glymphatic system is a waste clearance system in the brain,which is responsible for eliminating the neurotoxic proteins from the interstitial *** of the glymphatic system has been proposed as a significant contributor to the development and progression of neurodegenerative disease,as it exacerbates the aggregation of neurotoxic proteins and deteriorates neuronal ***,impairment of the glymphatic system could be considered as the final common pathway to *** evidence has provided initial insights into the potential effect of the impaired glymphatic system on Parkinson’s disease and related disorders;however,many unanswered questions *** review aims to provide a comprehensive summary of the growing literature on the glymphatic system in Parkinson’s disease and related *** focus of this review is on identifying the manifestations and mechanisms of interplay between the glymphatic system and neurotoxic proteins,including loss of polarization of aquaporin-4 in astrocytic endfeet,sleep and circadian rhythms,neuroinflammation,astrogliosis,and *** review further delves into the underlying pathophysiology of the glymphatic system in Parkinson’s disease and related disorders,and the potential implications of targeting the glymphatic system as a novel and promising therapeutic strategy.

关键词： atypical parkinsonism glymphatic system magnetic resonance imaging neurotoxic proteins Parkinson’s disease

IGFBP1在胃癌组织中的表达特点及其预后作用与机制的生物信息学分析

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中国医学物理学杂志 2024年第5期41卷 628-639页

作者：熊珊申洪华南理工大学医学院广东广州510006 南方医科大学基础医学院病理学系广东广州510515

目的:通过综合方法分析IGFBP1在胃癌表达、预后以及参与的生物学功能,探讨其在胃癌中的诊断和治疗价值。方法:基于TCGA数据分析IGFBP1在胃癌中的表达水平,以及不同临床病理分期和生存状态下的表达差异;采用Kaplan-Meier曲线描述IGFBP1... 详细信息

目的:通过综合方法分析IGFBP1在胃癌表达、预后以及参与的生物学功能,探讨其在胃癌中的诊断和治疗价值。方法:基于TCGA数据分析IGFBP1在胃癌中的表达水平,以及不同临床病理分期和生存状态下的表达差异;采用Kaplan-Meier曲线描述IGFBP1表达和胃癌患者预后的关系;采用ROC曲线、Cox回归及Meta分析评价IGFBP1在胃癌中诊断及预后价值,利用LASSO回归分析建立与IGFBP1相关的预后模型,并通过PPI网络筛选IGFBP1相关的核心基因;利用GO、KEGG及CIBERSORT等分析方法分析IGFBP1在胃癌中涉及的潜在致病通路及肿瘤免疫浸润;通过Cell Miner数据库预测IGFBP1与抗肿瘤药物敏感性的相关性。结果:IGFBP1在多种癌症中异常表达,包括胃癌,其中在III~IV期胃癌患者中表达显著上调;Cox回归证实IGFBP1是独立危险因素,预后分析提示IGFBP1与预后不良密切相关;GO分析提示IGFBP1相关差异基因在细胞粘附的正向调节、囊泡管腔和丝氨酸水解酶活性富集,KEGG分析提示其在IL-17信号通路中富集;肿瘤免疫浸润分析提示IGFBP1高低表达组间免疫细胞浸润显著差异;单因素Cox和LASSO回归分析构建了IGFBP1相关的胃癌预后模型,PPI网络从中筛选出7个核心基因,这些基因在胆固醇代谢、嘧啶代谢和PPAR信号通路中富集;IGFBP1的表达水平与Dasatinib等药物的敏感性相关。结论:IGFBP1在胃癌中表达上调并导致患者预后不良,可能通过影响IL-17信号通路和M0巨噬细胞浸润等机制调控胃癌发生发展。

关键词：胃癌 IGFBP1 免疫细胞浸润生物信息预后

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胆痛消炎片质量标准研究

中国实用医药 2012年第12期7卷 262-263页

作者：沈洪宽宋岳白立红刘晓凤黑龙江省佳木斯市药品检验所 154007

目的建立了胆痛消炎片的质量标准。方法采用显微鉴别法对大黄进行了定性鉴别,用TLC法对方中延胡索与白芍进行了薄层定性鉴别,采用TLC法鉴别土大黄苷。结果 TLC定性鉴别分离度好,专属性强。结论本方法简便易行、重现性好,可用于胆痛消炎... 详细信息

目的建立了胆痛消炎片的质量标准。方法采用显微鉴别法对大黄进行了定性鉴别,用TLC法对方中延胡索与白芍进行了薄层定性鉴别,采用TLC法鉴别土大黄苷。结果 TLC定性鉴别分离度好,专属性强。结论本方法简便易行、重现性好,可用于胆痛消炎片的质量标准。

关键词：胆痛消炎片 TLC 土大黄苷

Global epidemiology of mental disorder in atrial fibrillation between 1998-2021:A systematic review and meta-analysis

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World Journal of Psychiatry 2024年第1期14卷 179-193页

作者： Shuai Zhang Na Zhang Liu Liu Wang Zheng Zi-Lin Ma Si-Yu Qiao Ying-Li Zhao Yi-hong Wei Gang Wu Qiu-Ting Yu Bing Deng Lin shen Department of Cardiology LongHua Hospital Shanghai University of Traditional Chinese MedicineShanghai 200032China Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China

BACKGROUND As the burden of mental disorders among patients with atrial fibrillation(AF)increases,researchers are beginning to pay close attention to the risk and prevalence of these *** studies have independently analyzed the risk of comorbidity with depression and anxiety in patients with AF,no study has systematically focused on the global epidemiology of these two mental *** To explore the prevalence of depression and anxiety in patients with *** Five databases were searched from their date of establishment until January *** studies reporting the comorbidity of AF with depression and anxiety,were included in this *** information,such as the first author/publication year,study year,study type,and prevalence of depression and anxiety,were *** SE 15.1 was used to analyze the ***,meta-regression,and sensitivity analyses were performed to estimate study *** After a thorough search,26 studies were identified and included in this *** prevalence rates of depression and anxiety in adults with AF were 24.3%and 14.5%,*** adult males with AF,the prevalence was 11.7%and 8.7%,respectively,whereas in females it was 19.8%and 10.1%,*** older adults with AF,the prevalence rates of depression and anxiety were 40.3%and 33.6%,*** highest regional prevalence of depression and anxiety was observed in European(30.2%)and North American(19.8%)patients with *** In this study,we found that the prevalence of depression and anxiety among patients with AF varies with sex,region,and evaluation scales,suggesting the need for psychological interventions for patients with AF in clinical practice.

关键词： Atrial fibrillation Depression Anxiety Prevalence

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祛湿护肝胶囊质量标准

中国实用医药 2012年第19期7卷 254-255页

作者：宋岳谷继卜沈洪宽张亚娟黑龙江省佳木斯市药品检验所 154007 黑龙江省佳木斯大学附属第一医院药剂科

目的建立祛湿护肝胶囊的质量标准。方法采用显微鉴别法对砂仁、白术进行定性鉴别。采用TLC法对牡丹皮、柴胡、黄芩、黄连进行了定性鉴别。结果 TLC定性鉴别分离度好,专属性强。结论本方法简单易行、重现性好,可用于祛湿护肝胶囊的质量... 详细信息

目的建立祛湿护肝胶囊的质量标准。方法采用显微鉴别法对砂仁、白术进行定性鉴别。采用TLC法对牡丹皮、柴胡、黄芩、黄连进行了定性鉴别。结果 TLC定性鉴别分离度好,专属性强。结论本方法简单易行、重现性好,可用于祛湿护肝胶囊的质量标准。

关键词：护肝祛湿胶囊显微鉴别薄层鉴别

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质量参数对空爆荷载梁构件振动位移的影响

爆炸与冲击 2024年第5期44卷 108-118页

作者：耿少波洪欣郑毅沈新月中北大学环境与安全工程学院土木工程学科部山西太原030051

为研究质量参数对空爆荷载梁构件振动位移的影响,以等效单自由度法为基本方法,理论推导了柔性及刚性2类梁构件含质量参数在弹性、塑性各阶段的振动位移解,选择矩形截面、圆截面为梁构件典型截面,设计并计算了质量参数在1.00~1.20范围内... 详细信息

为研究质量参数对空爆荷载梁构件振动位移的影响,以等效单自由度法为基本方法,理论推导了柔性及刚性2类梁构件含质量参数在弹性、塑性各阶段的振动位移解,选择矩形截面、圆截面为梁构件典型截面,设计并计算了质量参数在1.00~1.20范围内的13种典型工况。结果表明:对于空爆荷载柔性及刚性2类梁构件,增大其截面面积后,仅考虑质量参数计算振动位移时误差较大,应按质量参数及产生的附加刚度参数耦合效应分析;对于矩形截面梁构件,采用质量参数与刚度参数耦合计算时,其最大弹性位移、最大弹塑性位移和残余变形降低幅度分别约为仅采用质量参数计算结果的4.75、3.28和2.96倍;对于圆截面梁构件,则分别为3.57、2.56和2.32倍;该结论在柔性梁构件及刚性梁构件均适用且无明显差异。

关键词：空爆荷载质量参数梁构件动力响应刚度残余变形

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Flexible,efficient,and accurate tests for epidemics

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Science China Mathematics 2024年第8期67卷 1881-1898页

作者： Linjiajie Fang Bing-Yi Jing shen Ling Qiyue Wang Qing Yang Data Science and Analytics Thrust The Hong Kong University of Science and TechnologyHong KongChina Department of Statistics and Data Science Southern University of Science and TechnologyShenzhen 518055China Department of Mathematics and Statistics Dalhousie UniversityHalifaxNS B 3H 4R 2Canada Department of Mathematics The Hong Kong University of Science and TechnologyHong KongChina

Group testing involves discovering a small subset of distinguished subjects from a large population while efficiently reducing the total number of *** has been widely used for industrial testing,information technology,and biology,especially epidemic ***,in reality,are noisy for the presence of false *** tests are accurate but time-consuming,while others are cheaper but less *** which test to use is constrained by various considerations,such as availability,cost,accuracy,and *** this paper,we propose flexible,efficient,and accurate tests(FEATs).FEATs are based on group testing with simple but careful designs by incorporating ideas such as close contact cliques and repeated *** could dramatically improve the efficiency or accuracy of existing *** example,for accurate but slow tests,the FEAT can improve efficiency multiple times without compromising *** the other hand,for fast but inaccurate tests,the FEAT can sharply reduce the false-negative rate(FNR)and significantly increase *** justifications are *** point out some scenarios where the FEAT can be effectively employed.

关键词： epidemiology control blood testing testing efficiency testing accuracy

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： shengyang Zhou Ting Li Wei Zhang Jian Wu Hui hong Wei Quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon