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用Al-CaO复合发热剂对钢液升温的实验研究

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东北大学学报（自然科学版） 2001年第3期22卷 295-298页

作者：于赋志沈峰满刘恒昌陈永范东北大学材料与冶金学院辽宁沈阳110004 鞍山钢铁学院辽宁鞍山114002

使用Al CaO作发热剂在中频感应炉内进行了钢液升温的实验研究·对实验中影响升温热效率的因素进行了分析 ,在工业生产中本复合发热剂中铝的升温热效率可达 87% ·在实验基础上 ,针对升温过程中钢液化学成分的变化还对Al CaO复合发热剂... 详细信息

使用Al CaO作发热剂在中频感应炉内进行了钢液升温的实验研究·对实验中影响升温热效率的因素进行了分析 ,在工业生产中本复合发热剂中铝的升温热效率可达 87% ·在实验基础上 ,针对升温过程中钢液化学成分的变化还对Al CaO复合发热剂的辅助效果进行了分析 ,得出了使用Al CaO作发热剂对钢液进行升温是可行的 ,升温同时兼具脱硫效果 ,可有效防止连铸时中间包水口阻塞·

关键词：连铸钢液升温复合发热剂热效率脱硫水口阻塞

Metal-Organic Framework Nanozyme Enabling Dual-Functional Photo-lnduced Charge Transfer and Biomimetic Precipitation for Advanced Organic Photoelectrochemical Transistor Bioanalysis

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Chinese Journal of Chemistry 2024年第17期42卷 1999-2004页

作者： Ke-Xin Xu Cheng Yuan Hao Lou feng-Zao Chen Ling Zhang Guangxu Chen De-man Han Wei-Wei Zhao state Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjingJiangsu210023China School of Pharmaceutical and Chemical Engineering Taizhou UniversityTaizhouJjiangsu 318000China School of Environment and Energy State Key Laboratory of Luminescent Materials and DevicesGuangdong Provincial Key Laboratory of Atmospheric Environment and Pollution ControlSouth China University of TechnologyGuangzhouGuangdong 510006China

We report herein the first observation of MoF nanozyme enabling dual-functional photo-induced charge transfer and biomimetic precipitation for advanced organic photoelectrochemical transistor(OPECT)***,Fe/Co-MIL-88,serving simultaneously as the semiconductor and nanozyme,was explored as a dual-functional gating module in *** light llumination,it could accelerate the charge transfer of the photogate to produce enhanced photo-induced ***,its catalytic property could efficiently produce biomimetic precipitation to block the nanopores in Fe/Co-MIL-88 and thus alter the device characteristics.

关键词： Metal-organic frameworks Nanozymes Organic transistor Photoelectrochemical Biosensing Electrodes

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烧结矿粘结相的熔化特性

东北大学学报（自然科学版） 2008年第5期29卷 697-700页

作者：李光森金明芳姜鑫沈峰满东北大学材料与冶金学院辽宁沈阳110004

以高碱度烧结矿中的铁酸盐粘结相为研究对象,考察了粘结相的熔化特性随粘结相组成的变化规律.通过试验探讨了不同nCaO∶nFe2O3以及不同的w(Mg),w(MgO2),w(SiO2)和w(Al2O3)铁酸盐粘结相的熔化特性.结果表明,nCaO∶nFe2O3=1∶1时,粘结相... 详细信息

以高碱度烧结矿中的铁酸盐粘结相为研究对象,考察了粘结相的熔化特性随粘结相组成的变化规律.通过试验探讨了不同nCaO∶nFe2O3以及不同的w(Mg),w(MgO2),w(SiO2)和w(Al2O3)铁酸盐粘结相的熔化特性.结果表明,nCaO∶nFe2O3=1∶1时,粘结相的熔化温度最低,熔化时间最短;添加MgO粘结相的熔化温度升高,熔化时间变长;当w(SiO2)或w(Al2O3)为3%时,粘结相的熔化温度最低,熔化最快.

关键词：烧结矿粘结相熔化温度熔化时间熔化特性

Melatonin improves synapse development by PI3K/Akt signaling in a mouse model of autism spectrum disorder

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Neural Regeneration Research 2024年第7期19卷 1618-1624页

作者： Luyi Wang man Xu Yan Wang Feifei Wang Jing Deng Xiaoya Wang Yu Zhao Ailing Liao feng Yang Shali Wang Yingbo Li Institute of Neuroscience Department of PhysiologySchool of Basic Medical ScienceChongqing Medical UniversityChongqingChina Department of Pediatric Chongqing University Fuling HospitalChongqingChina Department of Neurosurgery Xinqiao HospitalArmy Medical UniversityChongqingChina Department of Pathology Affiliated Hospital of North Sichuan Medical CollegeNanchongSichuan ProvinceChina NHC Key Laboratory of Birth Defects and Reproductive Health Chongqing Population and Family Planning Science and Technology Research InstituteChongqingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Advanced Innovation Center for Human Brain Protection Capital Medical UniversityBeijingChina

Autism spectrum disorders are a group of neurodevelopmental disorders involving more than 1100 genes,including Ctnnd2 as a candidate ***2knockout mice,serving as an animal model of autis m,have been demonstrated to exhibit decreased density of dendritic *** role of melatonin,as a neuro hormone capable of effectively alleviating social interaction deficits and regulating the development of dendritic spines,in Ctnnd2 deletion-induced nerve injury remains unclea *** the present study,we discove red that the deletion of exon 2 of the Ctnnd2 gene was linked to social interaction deficits,spine loss,impaired inhibitory neurons,and suppressed phosphatidylinositol-3-kinase(PI3K)/protein kinase B(Akt) signal pathway in the prefrontal *** findings demonstrated that the long-term oral administration of melatonin for 28 days effectively alleviated the aforementioned abnormalities in Ctnnd2 gene-knockout ***,the administration of melatonin in the prefro ntal cortex was found to improve synaptic function and activate the PI3K/Akt signal pathway in this *** pharmacological blockade of the PI3K/Akt signal pathway with a PI3K/Akt inhibitor,wo rtmannin,and melatonin receptor antagonists,luzindole and 4-phenyl-2-propionamidotetralin,prevented the melatonin-induced enhancement of GABAergic synaptic *** findings suggest that melatonin treatment can ameliorate GABAe rgic synaptic function by activating the PI3K/Akt signal pathway,which may contribute to the improvement of dendritic spine abnormalities in autism spectrum disorders.

关键词： autism Ctnnd2 deletion GABAergic neurons melatonin PI3K/Akt signal pathway prefrontal cortex social behavior spine density synaptic-associated proteins

CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： Yue Ding Zheng Ye Bo Ding Songwei feng Furong Du Xuejiao Ma Xiaoxuan Wang Yang shen Department of Obstetrics and Gynaecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recently,immune checkpoint inhibitors(ICIs)and poly(ADP-ribose)polymerase inhibitors(PARPi)have played a pivotal role in prolonging the recurrence-free survival of patients with ovarian cancer(OC).1,2 Although PARPi have revolutionized the treatment of OC,the absence of reliable predictive biomarkers limits the broad application of ICIs for patients with homologous recombination(HR)deficiency(HRD).3 CXC-chemokine ligand 13(CXCL13)is a cytokine constitutively secreted in the stromal cells of the B-cell region of secondary lymphoid tissue.4 It exclusively binds to the chemokine receptor CXCR5,which is abundantly expressed in subsets of mature circulating B lymphocytes,follicular helper T cells,and skin-derived dendritic cells,and governs the migration of these cells into secondary lymphoid organs in response to the CXCL13 gradient.5 In this study,we aimed to elucidate the role of CXCL13 in shaping the tumor immune microenvironment(TIME)in HR-deficient OC and to explore its relationship with the cGAS-STING signaling pathway.

关键词： CXCL13 cancer organs

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高炉炉缸三维稳态出铁模型

东北大学学报（自然科学版） 2009年第5期30卷 692-695页

作者：李玉陈良玉沈峰满张克文东北大学机械工程与自动化学院辽宁沈阳110004 东北大学材料与冶金学院辽宁沈阳110004

根据热流体力学原理和计算流体力学热焓-多孔介质方法,建立了包含铁水凝固相变的高炉炉缸三维稳态出铁数值计算模型.计算中采用等效对流换热系数的方法对炉缸、炉底的冷却条件进行了合理转化.结合实际高炉炉缸对其流场、温度场和渣皮形... 详细信息

根据热流体力学原理和计算流体力学热焓-多孔介质方法,建立了包含铁水凝固相变的高炉炉缸三维稳态出铁数值计算模型.计算中采用等效对流换热系数的方法对炉缸、炉底的冷却条件进行了合理转化.结合实际高炉炉缸对其流场、温度场和渣皮形貌进行了数值计算和分析.给出了不同高炉容积利用系数和冷却条件下的炉缸铁水流动特征和结渣情况数据,可为现场操作提供技术参考.

关键词：高炉炉缸稳态出铁渣皮等效对流换热系数

Preparation of meter-scale Cu foils with decimeter grains and the use for the synthesis of graphene films

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Journal of Materiomics 2024年第1期10卷 1-6页

作者： Ruitao Jia Fangzhu Qing Shurong Wang Yuting Hou Changqing shen feng Hao Yang Yang Hongwei Zhu Xuesong Li School of Integrated Circuit Science and Engineering(Exemplary School of Microelectronics) University of Electronic Science and Technology of ChinaChengdu610054China State Key Laboratory of Electronic Thin Films and Integrated Devices University of Electronic Science and Technology of ChinaChengdu610054China shenzhen Institute for Advanced Study University of Electronic Science and Technology of ChinaShenzhen518110China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu610054China PipeChina Southwest Pipeline Co. Ltd.Chengdu610041China State Key Lab of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing100084China

Chemical vapor deposition(CVD)is the most promising method for the preparation of high-quality and large-area graphene films,especially the epitaxial growth of graphene on large-area single-crystal Cu *** single-crystal Cu foils are normally achieved by thermally annealing the commercial poly-crystalline Cu foils,their size and therefore the size of graphene films grown on them are limited to the size of the reaction *** report a simple and feasible method to prepare large-area Cu foils with decimeter grains by thermally annealing the rolled-up Cu foils,where the Cu layers are separated by thin porous carbon fiber *** carbon fiber cloths prevent Cu layers from sticking to each other at high temperatures while do not block the gas *** such a way,the utilization efficiency of the reaction chamber is significantly improved,e.g.,0.2 m×(1e2)m Cu foils can be processed even in a 5 cm diameter quartz tube ***-quality graphene films grown on such Cu foils are then *** method may be suitable for the annealing of other metal foils to enlarge grain size and the synthesis of other two-dimensional materials on them such as h-BN.

关键词： Graphene Single-crystal Cu Chemical vapor deposition Synthesis

轻烧菱镁石制备与表征及其对球团生球质量的影响

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东北大学学报（自然科学版） 2017年第3期38卷 370-374页

作者：高强健姜鑫沈峰满刘常升东北大学冶金学院辽宁沈阳110819

以轻烧菱镁石作为造球用添加剂,考察了不同制备条件下轻烧菱镁石性质的变化以及其活性对球团生球质量的影响.研究表明:焙烧温度过低或时间过短,菱镁石分解不完全,水化活性相对较低,焙烧温度过高或时间过长同样容易破坏轻烧菱镁石活性.其... 详细信息

以轻烧菱镁石作为造球用添加剂,考察了不同制备条件下轻烧菱镁石性质的变化以及其活性对球团生球质量的影响.研究表明:焙烧温度过低或时间过短,菱镁石分解不完全,水化活性相对较低,焙烧温度过高或时间过长同样容易破坏轻烧菱镁石活性.其中,800~850℃下焙烧获得的轻烧菱镁石具有较好的性质(活性、粒级、比表面积以及晶粒尺寸);高活性的轻烧菱镁石对改善生球抗压强度(CSGP/N)、生球落下强度(DS/次数),提高生球爆裂温度(t_b/℃)效果明显,其中,爆裂温度(t_b/℃)最大增幅可达150℃.

关键词：菱镁石添加剂生球活性比表面积

3'-Deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome

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Neural Regeneration Research 2024年第10期19卷 2270-2280页

作者： Yize Qi Yao Zhou Jiyang Li Fangyuan Zhu Gengni Guo Can Wang man Yu Yijie Wang Tengfei Ma Shanwu feng Li Zhou Institute for Stem Cell and Neural Regeneration and Key Laboratory of Cardiovascular&Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Anesthesiology The Second People’s Hospital of LianyungangLianyungangJiangsu ProvinceChina Department of Anesthesiology Women’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health Care HospitalNanjingJiangsu ProvinceChina

Methamphetamine addiction is a brain disorder characterized by persistent drug-seeking behavior, which has been linked with aberrant synaptic plasticity. An increasing body of evidence suggests that aberrant synaptic plasticity is associated with the activation of the NOD-like receptor family pyrin domain containing-3(NLRP3) inflammasome. 3′-Deoxyadenosin, an active component of the Chinese fungus Cordyceps militaris, has strong anti-inflammatory effects. However, whether 3′-deoxyadenosin attenuates methamphetamine-induced aberrant synaptic plasticity via an NLRP3-mediated inflammatory mechanism remains unclear. We first observed that 3′-deoxyadenosin attenuated conditioned place preference scores in methamphetamine-treated mice and decreased the expression of c-fos in hippocampal neurons. Furthermore, we found that 3′-deoxyadenosin reduced the aberrant potentiation of glutamatergic transmission and restored the methamphetamine-induced impairment of synaptic plasticity. We also found that 3′-deoxyadenosin decreased the expression of NLRP3 and neuronal injury. Importantly, a direct NLRP3 deficiency reduced methamphetamine-induced seeking behavior, attenuated the impaired synaptic plasticity, and prevented neuronal damage. Finally, NLRP3 activation reversed the effect of 3′-deoxyadenosin on behavior and synaptic plasticity, suggesting that the anti-neuroinflammatory mechanism of 3′-deoxyadenosin on aberrant synaptic plasticity reduces methamphetamine-induced seeking behavior. Taken together, 3′-deoxyadenosin alleviates methamphetamine-induced aberrant synaptic plasticity and seeking behavior by inhibiting the NLRP3 inflammasome.

关键词： 3′-deoxyadenosin hippocampus long-term potentiation methamphetamine NOD-like receptor family pyrin domain containing-3(NLRP3)inflammasome synaptic plasticity