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DNA vaccine prime and replicating vaccinia vaccine boost induce robust humoral and cellular immune responses against MERS-CoV in mice

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VIROLOGICA SINICA 2024年第3期39卷 490-500页

作者： shen, xiuli Wang, Shuhui Hao, Yanling Fu, Yuyu Ren, Li Li, Dan Tang, Wenqi Li, Jing Chen, Ran Zhu, Meiling Wang, Shuo Liu, Ying Shao, Yiming Chinese Ctr Dis Control & Prevent Natl Ctr AIDS STD Control & Prevent Natl Key Lab Intelligent Tracking & Forecasting In Beijing 102206 Peoples R China Changping Lab Yard 28Sci Pk Rd Beijing 102206 Peoples R China Zhejiang Univ Affiliated Hosp 1Sch Med Natl Clin Res Ctr Infect DisState Key Lab Diag & Collaborat Innovat Ctr Diag & Treatment Infect Dis Hangzhou 310003 Peoples R China

As of December 2022, 2603 laboratory-identi fied Middle East respiratory syndrome coronavirus (MERS-CoV) infections and 935 associated deaths, with a mortality rate of 36%, had been reported to the World Health Organization (WHO). However, there are still no vaccines for MERS-CoV, which makes the prevention and control of MERS-CoV dif ficult. In this study, we generated two DNA vaccine candidates by integrating MERS-CoV Spike (S) gene into a replicating Vaccinia Tian Tan (VTT) vector. Compared to homologous immunization with either vaccine, mice immunized with DNA vaccine prime and VTT vaccine boost exhibited much stronger and durable humoral and cellular immune responses. The immunized mice produced robust binding antibodies and broad neutralizing antibodies against the EMC2012, England1 and KNIH strains of MERS-CoV. Prime-Boost immunization also induced strong MERS-S speci fic T cells responses, with high memory and poly-functional (CD107aIFN- gamma-TNF- alpha) effector CD8 & thorn; T cells. In conclusion, the research demonstrated that DNA-Prime/VTT-Boost strategy could elicit robust and balanced humoral and cellular immune responses against MERS-CoV-S. This study not only provides a promising set of MERS-CoV vaccine candidates, but also proposes a heterologous sequential immunization strategy worthy of further development.

关键词： MERS-CoV VTT vaccine DNA vaccine Humoral and cellular immune responses Prime/boost strategy

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基于声发射技术的T800碳纤维复合材料拉伸失效机制分析

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固体火箭技术 2024年第3期47卷 411-420页

作者：董少静李凯丁文辉王立强申秀丽北京航空航天大学能源与动力工程学院北京100191 航天动力技术研究院西安710025 西安航天动力技术研究所西安710025

为揭示固体火箭发动机碳纤维缠绕复合材料壳体多载荷工况下的失效机理,开展了单向T800碳纤维复合材料试件不同偏轴角度下的拉伸实验。利用声发射(AE)无损测试技术获得了试件完整波形信号,结合Pearson相关系数选取了AE信号的特征参数,通... 详细信息

为揭示固体火箭发动机碳纤维缠绕复合材料壳体多载荷工况下的失效机理,开展了单向T800碳纤维复合材料试件不同偏轴角度下的拉伸实验。利用声发射(AE)无损测试技术获得了试件完整波形信号,结合Pearson相关系数选取了AE信号的特征参数,通过K-means聚类算法对AE信号进行了聚类分析,同时结合扫描电镜(SEM)拍摄的微观断口形貌将不同的损伤机制与声发射聚类组对应。进一步利用代表性体积单元并结合渐进损伤方法,实现了单向复合材料损伤过程的数值模拟。分析结果表明,AE信号的峰值频率与幅值两类参数的相关系数低于0.2。采用二者对AE信号进行聚类分析,同时结合数值仿真获得的应力-应变曲线,发现纤维断裂峰值频率最高,基体开裂峰值频率居中,界面脱粘峰值频率最低,试件宏观破坏时的AE信号幅值最高。

关键词：碳纤维复合材料固体火箭发动机纤维缠绕壳体声发射偏轴拉伸聚类分析渐进损伤

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Multi-scale thermodynamic analysis method for 2D SiC/SiC composite turbine guide vanes

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Chinese Journal of Aeronautics 2018年第1期31卷 117-125页

作者： Xin LIU xiuli shen Longdong GONG Peng LI School of Energy and Power Engineering Beihang University Beijing 100083 China Navigation and Control Technology Research Institute of China Ordnance Industries Beijing 100089 China

Ceramic Matrix Composite （CMC） turbine guide vanes possess multi-scale stress and strain with inhomogeneity at the microscopic scale. Given that the macroscopic distribution cannot reflect the microscopic stress fluctuation, the macroscopic method fails to meet the requirements of stress and strain analysis of CMC turbine guide vanes. Furthermore, the complete thermodynamic properties of 2D woven SiC/SiC-CMC cannot be obtained through experimentation, Accordingly, a method to calculate the thermodynamic properties of CMC and analyze multi-scale stress and strain of the turbine guide vanes should be established. In this study, the multi-scale thermodynamic analysis is investigated. The thermodynamic properties of Chemical Vapor Infiltration （CVI） pro- cessed SiC/SiC-CMC are predicted by a Representative Volume Element （RVE） model with porosity, leading to the result that the relative error between the calculated in-plane tensile modulus and the experimental value is 4.2%. The macroscopic response of a guide vane under given conditions is predicted. The relative error between the predicted strain on the trailing edge and the experimental value is 9.7%. The calculation of the stress distribution of micro-scale RVE shows that the maximum value of microscopic stress, which is located in the interlayer matrix, is more than 1.5 times that of macroscopic stress in the same direction and the microscopic stress distribution of the interlayer matrix is related to the pore distribution of the composite.

关键词： Ceramic matrix composites Multi-scale Representative volume element Thermal-mechanical coupling Turbine guide vane

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Macro-phenomenological high-strain-rate elastic fracture model for ice-impact simulations

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Chinese Journal of Aeronautics 2023年第3期36卷 146-160页

作者： Jiang FAN Qinghao YUAN Fulei JING Guangchen BAI xiuli shen School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory of Aero-Engine Structure and Strength Beijing 100191China Collaborative Innovation Center of Advanced Aero-Engine Beijing 100191China Aero-Engine Academy of China Aero Engine(Group)Corporation of ChinaBeijing 101304China

The ice impact can cause a severe damage to an aircraft’s exposed structure,thus,requiring its *** numerical simulation represents an effective method to overcome this *** establishment of the ice material model is ***,ice is not a common structural material and exhibits an extremely complex material *** material models of ice reported so far are not able to accurately simulate the ice behavior at high strain *** study proposes a novel high-precision macro-phenomenological elastic fracture model based on the brittle behavior of ice at high strain *** developed model has been compared with five reported models by using the smoothed particle hydrodynamics method so as to simulate the ice-impact process with respect to the impact speeds and ice *** important metrics and phenomena(impact force history,deformation and fragmentation of the ice projectile and deflection of the target)were compared with the experimental data reported in the *** findings obtained from the developed model are observed to be most consistent with the experimental data,which demonstrates that the model represents the basic physics and phenomena governing the ice impact at high strain *** developed model includes a relatively fewer number of material ***,the used parameters have a clear physical meaning and can be directly obtained through ***,no adjustment of any material parameter is needed,and the consumption duration is also *** advantages indicate that the developed model is suitable for simulating the iceimpact process and can be applied for the anti-ice impact design in aviation.

关键词： Crack propagation Elastic fracture High strain rate Ice impact Impact force Material model

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Integration of nanoindentation and finite element method for interpretable tensile properties:A crossscale calculation method of uneven joints

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Chinese Journal of Aeronautics 2023年第6期36卷 233-248页

作者： Kun GAO Zhiying LIU xiuli shen Lizhong LANG Shaojing DONG School of Energy and Power Engineering Beihang UniversityBeijing100191China Department of Materials Science and Engineering University of TorontoTorontoON M5S 3E4Canada

Nanoindentation testing and its Reverse Analysis Method(RAM)show great potential in understanding the tensile properties of metallic alloys with various ***,the tensile properties of heterogeneous materials such as nickel-based superalloy welded joints have not been well interpreted by combining the microstructures and nanoindentation results,due to their diverse and complex microscopic zones,which throws shade on the properties of separated zones in the *** we demonstrated a new method of implanting nanoindentation results into Finite Element Method(FEM)and applied the method to the welded joints with the zones of various microstructure *** local properties are calculated by the nanoindentation data using RAM,and used as input of Finite Element(FE)simulation of an identical indentation process,to in turn verify the accuracy and reliability of the reverse *** simulation results reveal that the global mechanical behaviors,such as Young's modulus,yield strength and strain hardening exponent,are related to the local properties to a great ***,the global properties can be verified by simulation straight after experiments,taking consideration of local properties and dimension parameters of different *** is shown that the maximum error between calculation of RAM and testing is within 5.1%in different zones,and the errors of maximum indentation depth and residual depth obtained by FE simulation are less than 2.4%,which indicates that the method provides a reliable prediction of mechanical properties of superalloy welded joints.

关键词： Finite element method Nanoindentation Reverse analysis method Tensile properties Welded joints

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Research on disruptive design pre-identification in the preliminary design phase of aero engine flow pass multidisciplinary optimization

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Chinese Journal of Aeronautics 2022年第11期35卷 264-276页

作者： Shaojing DONG Yufan FANG Wentong HU xiuli shen Gaoxiang CHEN School of Energyand Power Engineering Beihang UniversityBeijing 10083China Beijing Key Laboratory of Aero-Engine Structure and Strength Beihang UniversityBejing 100083China Jiangxi Research Institute Beihang UniversityNanchang 330096China Navigation and Control Technology Research Institute of China Ordnance Industries Beijing 100089China Research Institute of Aero-engine Beihang UniversityBeijing 100083China

In aero engine design, determining whether the preliminary design will have disruptive effects on the detailed design is the key to multidisciplinary design optimization in the preliminary design stage. In order to adapt to the non-orthogonal parameter value range caused by the selfconstrained parametric modeling method, a non-orthogonal space mapping method that maps the optimal Latin hypercube sampling points of the traditional orthogonal design space to the non-orthogonal design space is proposed. Based on the logical regression method in machine learning field, a kind of feasible domain boundary identification method is employed to identify whether the sample spatial response meets the relevant criteria. The method proposed in this paper is used to identify and analyze the key technologies of the high-pressure turbine mortise joint structure. It is found that the preliminary design of the aero engine may lead to the failure to obtain a mortise joint structure meeting the design requirements in the detailed design stage. The mortise joint structure needs to be pre-optimized in the preliminary design stage.

关键词： Aero engine Disruptive design Flow pass multidisciplinary optimization Pre-identification Preliminary design phase

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Structural design and optimization for vent holes of an industrial turbine sealing disk

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Chinese Journal of Aeronautics 2021年第5期34卷 265-277页

作者： Cheng YAN Jianfeng ZHU xiuli shen Jun FAN Zhigang JIA Tiefeng CHEN School of Aerospace Engineering Xiamen UniversityXiamen 361005China School of Energy and Power Engineering Beihang UniversityBeijing 100083China Army Aviation Institute Beijing 100000China Aero Engine Academy of China Beijing 101300China AECC Commercial Aircraft Engine Co LtdShanghai 200241China

Severe stress concentration occurs around circular vent holes of an industrial turbine sealing *** paper investigates the structural design and optimization for the vent holes to effectively reduce the maximum von Mises stress and improve the fatigue life of the turbine sealing *** efficient integrated design optimization method is presented based on a novel non-circular vent hole design method in combination with a variable dimension sub-model method,a self-developed modeling and meshing tool,and the Multi-Island Genetic *** proposed non-circular vent hole is biaxial symmetric and consists of four smoothly connected *** variable dimension sub-model method is utilized to obtain accurate results in the fields around the vent holes within the computationally acceptable *** modeling and meshing tool is developed by using the Tcl/Tk Scripts to rebuild the geometry and generate the high-quality hexahedral mesh *** Multi-Island Genetic Algorithm is adopted to solve the studied constrained optimization *** optimization,the maximum von Mises stress is reduced from 1305.644 MPa to 963.435 MPa,and the fatigue life is increased from 3091 cycles to 30,297 *** results show that the proposed design and optimization methods can significantly improve the performance of the turbine sealing disk along with the remarkable drop in stress concentration.

关键词： Multi Island Genetic Algorithm Stress concentration Structural optimization Sub-model method Vent hole

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Investigation on experimental load spectrum for high and low cycle combined fatigue test

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Propulsion and Power Research 2013年第4期2卷 235-242页

作者： Rongqiao Wang Jiaming Wei Dianyin Hu xiuli shen Jiang Fan School of Energy and Power Engineering Beihang UniversityBeijing 100191China

As the outfield load spectrum is so complicated that it cannot be used directly for test study in *** paper presents a method to determine load spectrum for high and low cycle combined fatigue of turbine mortise at elevated temperature through experimental and numerical *** of all,the low cycle load spectrum with duration time is determined through cumulative damage *** rain flow counting method is applied to obtain main cycles and sub cycles,and then the stress cycle is converted into pulsation cycle(stress ratio=0)based on the S-N curve and the Goodman curve;Secondly,three groups of different amplitudes tests are established to determine the high cycle ***,another three groups of the high-low combined cycle fatigue(HLCCF)tests for turbine mortise of a certain type engine are carried *** results show that the macro and micro failure modes are identical with outfield's,which verifies the accuracy of the conversion method.

关键词： High-low combined cycle fatigue Load spectrum Turbine mortise Rain flow counting method Fracture analysis

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航空发动机中“W”形金属密封环的设计方法

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航空动力学报 2018年第10期33卷 2305-2314页

作者：申秀丽翟宇北京航空航天大学能源与动力工程学院北京100191 先进航空发动机协同创新中心北京100191

针对密封性和强度,对"W"形金属密封环的压缩率选取范围进行研究。在压缩率确定的基础上,优化"W"形金属密封环所在处机匣的轴向间隙,探究"W"形金属密封环关键结构参数对强度的影响,基于灵敏度分析对"W"形金属密封环的结构参数进一步优化... 详细信息

针对密封性和强度,对"W"形金属密封环的压缩率选取范围进行研究。在压缩率确定的基础上,优化"W"形金属密封环所在处机匣的轴向间隙,探究"W"形金属密封环关键结构参数对强度的影响,基于灵敏度分析对"W"形金属密封环的结构参数进一步优化;研究"W"形金属密封环屈曲及轴向刚度间的关系,并采用刚度实验校核模拟结果,为评估屈曲临界载荷提供支持。结果表明:在该典型工况下,"W"形金属密封环的压缩率合理范围为3.2%~6.08%;壁厚对最大等效应力影响最大,最终优化结果为壁厚增大5.0%,波峰、波谷半径增大9.0%,接触半径增大7.7%,圆环外径减小5.8%,最大等效应力减小5.7%;屈曲"W"形金属密封环载荷与轴向刚度线性相关。

关键词： “W”形金属密封环强度结构优化设计灵敏度轴向刚度

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Prediction of subsurface settlement induced by shield tunnelling in sandy cobble stratum

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第1期16卷 192-212页

作者： Fan Wang xiuli Du Pengfei Li Key Laboratory of Urban Security and Disaster Engineering Ministry of EducationBeijing University of TechnologyBeijing100124China

This study focuses on the analytical prediction of subsurface settlement induced by shield tunnelling in sandy cobble stratum considering the volumetric deformation modes of the soil above the tunnel crown.A series of numerical analyses is performed to examine the effects of cover depth ratio(C/D),tunnel volume loss rate(h t)and volumetric block proportion(VBP)on the characteristics of subsurface settle-ment trough and soil volume *** the ground loss variation with depth,three modes are deduced from the volumetric deformation responses of the soil above the tunnel ***,analytical solutions to predict subsurface settlement for each mode are presented using stochastic medium *** influences of C/D,h t and VBP on the key parameters(i.e.B and N)in the analytical expressions are discussed to determine the fitting formulae of B and ***,the proposed analytical solutions are validated by the comparisons with the results of model test and numerical *** show that the fitting formulae provide a convenient and reliable way to evaluate the key ***,the analytical solutions are reasonable and available in predicting the subsurface settlement induced by shield tunnelling in sandy cobble stratum.

关键词： Shield tunnelling Sandy cobble stratum Subsurface settlement Volumetric deformation mode Stochastic medium theory

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