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Evaluation of Anxiolytic and Sedative-Like Activities of Methanolic Extract of <i>Euphorbia hirta</i>Leaves in Mice

Pharmacology & Pharmacy 2019年第6期10卷 283-297页

作者： S. M. Mushiur Rahman sohel Rana Md. Nahinul islam Alok Kumer Md. Mehedi Hassan Tonmoy Kumar Biswas Md. Atikullah Department of Pharmacy Jashore University of Science and Technology Jashore Bangladesh Department of Pharmacy State University of Bangladesh Dhaka Bangladesh Department of Pharmacy University of Asia Pacific Dhaka Bangladesh

In indigenous or folk medicine, Euphorbia hirta is a very popular herb and used as a palliative to treat various ailments including intestinal parasites, diarrhoea, vomiting, amoebic dysentery, asthma, bronchitis, emphysema, coughs, kidney stones, menstrual problems etc. The objective of this study is to evaluate the anxiolytic and sedative-like effects of the methanol extract from the leaves of Euphorbia hirta (Euphorbiaceae). Methanolic extract of Euphorbia hirta was evaluated for its CNS depression effect using mice behavioral models such as, elevated plus maze and hole board test for its anxiolytic potential where hole cross and pentobarbital-induced sleeping time tests were performed for its sedative properties, respectively. The test group received three different doses of the MEHL (100 mg/kg, 200 mg/kg and 300 mg/kg) orally. The positive control group received diazepam (1 mg/kg) orally where the negative control group received distilled water (10 ml/kg) orally. In elevated plus maze test, the extract exhibited significant (p d the number of open arm entry and time spent in open arm by mice compared to control group. In addition, the number of head dips and hole crosses significantly (p < 0.05) decreased by mice in hole board and hole cross tests respectively, compared to control group. Moreover, mice treated with MEHL significantly decrease the onset of sleep and increase the duration of sleep in pentobarbital-induced sleeping time test in mice compared to control group. The data obtained from the present study clearly demonstrate that the methanolic extract of Euphorbia hirta has potential anxiolytic and sedative-like activity in the animal behavioral models. And the findings represent a rational explanation for its use in traditional medicine for the management of neurological disorder.

关键词： Euphorbia hirta Anxiolytic Sedative Elevated Plus Maze Hole Board Hole Cross

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The Central Cattle Breeding and Dairy Farm, Bangladesh waste contributes in emergence and spread of aminoglycoside-resistant bacteria

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Advances in Bioscience and Biotechnology 2013年第2期4卷 278-282页

作者： sohel Ahmed M. Ibrahim Hossain Tareq Hossan K. M. Rokibul islam orhan Uddin M. Badier Rahman M. Anwar Hossain Central Cattle Breeding and Dairy Farm (CCBDF) Dhaka Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar University Dhaka Bangladesh Department of Microbiology University of Dhaka Dhaka Bangladesh

Aminoglycosides are one of the categories of antibiotics most frequently used in treating several cattle diseases at the Central Cattle Breeding and Dairy Farm (CCBDF), Savar,Dhaka,Bangladesh. Untreated veterinary clinical healthcare waste (VCHW) of diseased cattle at CCBDF which directly disposed to surrounding may contribute to the antibiotic resistant bacteria pollution (ARB) pollution. The investigation analyses the role of VCHW of CCBDF in spreading ARB. Here we studied:1) veterinary clinical data and antibiotics treatment history;2) total and resistant bacteria counts in fecal samples of healthy and diseased cattles as well as VCHW of CCBDF;and 3) finally, data analysis to estimate the burden of VCHW of CCBDF in the pollution of environment with aminoglycoside antibiotics resistant bacteria. The results conclusively demonstrate the spread of 3 different aminoglycoside antibiotics, namely genta- mycin, kanamycin and streptomycin resistant bacte- ria in the surrounding environment alarmingly with high significant value (p < 0.01 - 0.05). This study re- veals the risks to the cattle as well as public health posed by the random VCHW disposal at the CCBDF, Bangladesh.

关键词： Aminoglycosides Resistant Bacteria Cattle Diseases Veterinary Clinical Healthcare Waste

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Serum Vitamin D Associated with Insulin Secretory Function in Impaired Fasting Glucose Subjects

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Journal of Biosciences and Medicines 2019年第1期7卷 83-98页

作者： A. K. M. Shahidur Rahman Md. Arifuzzaman sohel Farjana Rahman Bhuiyan Fahad Al Shatil Ashrafee Md. Kabir Hossain Syed Fazlul islam Mohammad Ibrahim Ali Rahelee Zinnat Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh Department of Biochemistry & Cell Biology Bangladesh University of Health Sciences (BUHS) Dhaka Bangladesh Department of Urology Dhaka Medical College Hospital Dhaka Bangladesh

Background: Impaired fasting glucose (IFG) is a prediabetic condition and is a high-risk state for developing diabetes and associated complications. The aim of this study was to explore the association of vitamin D with insulin secretory function among the IFG subjects. Materials and Methods: This was a prospective cross-sectional study conducted in the Department of Biochemistry and Cell Biology, Bangladesh University of Health Sciences (BUHS), Dhaka, Bangladesh;from June 2016 to May 2017, on forty-six (46) IFG subjects. Serum blood glucose was measured by glucose-oxidase method, Fasting serum lipid profile (Total cholesterol, TG and HDL-c);liver enzyme like alanine aminotransferase (ALT) was measured by enzymatic-colorimetric method;Serum creatinine was measured by colorimetric kinetic method;Serum Insulin and vitamin D [25(OH)D] were measured by ELISA method;insulin secretory capacity (HOMA%B) and insulin sensitivity (HOMA%S) were calculated by Homeostasis Model Assessment (HOMA) using HOMA-CIGMA software. Results: Among 46 IFG subjects, 22 (47.8%) were male and rest 24 (52.2%) were female and their mean age was 40 (±8) years. Mean fasting serum glucose level of the study subjects was 6.33 (±0.23) mmol/l and mean postprandial serum glucose level was 7.23 (±0.41) mmol/l. Mean serum vitamin D level of the study subjects was 26.54 (±8.83) ng/ml. Mean HOMA%S, HOMA%B and HOMA%IR of the total study subjects were 48.34 (±16.70), 102.16 (±23.13) and 2.28 (±0.70) respectively. Insulin secretory capacity (HOMA%B) was significantly higher (p = 0.047) in the subjects having higher vitamin D [25(OH)D level ≥ 20 ng/ml] compared to the subjects having lower vitamin D [25(OH)D levels Conclusion: High prevalence of hypovitaminosis D exists among IFG subjects. Vitamin D is associated with insulin secretory function in IFG subjects. Population based prospective studies using larger sample size should be done to confirm the results.

关键词： Impaired Fasting Glucose (IFG) Insulin Secretory Capacity Insulin Sensitivity Prediabetes Vitamin D

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Dielectric or plasmonic Mie object at air–liquid interface: The transferred and the traveling momenta of photon

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Chinese Physics B 2020年第1期29卷 311-323页

作者： M R C Mahdy Hamim Mahmud Rivy Ziaur Rahman Jony Nabila Binte Alam Nabila Masud Golam Dastegir Al Quaderi Ibraheem Muhammad Moosa Chowdhury Mofizur Rahman M sohel Rahman Department of Electrical&Computer Engineering North South UniversityBashundharaDhaka 1229Bangladesh Pi Labs Bangladesh LTD ARA Bhaban39Kazi Nazrul Islam AvenueKawran BazarDhaka 1215Bangladesh Department of Computer Science&Engineering Military Institute of Science and TechnologyDhakaBangladesh Department of Physics University of DhakaDhakaBangladesh Department of Computer Science&Engineering Bangladesh University of Engineering and Technology ECE BuildingWest PalasiDhaka-1205 Department of Computer Science&Engineering United International UniversityDhakaBangladesh

Considering the inhomogeneous or heterogeneous background, we have demonstrated that if the background and the half-immersed object are both non-absorbing, the transferred photon momentum to the pulled object can be considered as the one of Minkowski exactly at the interface. In contrast, the presence of loss inside matter, either in the half-immersed object or in the background, causes optical pushing of the object. Our analysis suggests that for half-immersed plasmonic or lossy dielectric, the transferred momentum of photon can mathematically be modeled as the type of Minkowski and also of Abraham. However, according to a final critical analysis, the idea of Abraham momentum transfer has been rejected. Hence,an obvious question arises: whence the Abraham momentum? It is demonstrated that though the transferred momentum to a half-immersed Mie object(lossy or lossless) can better be considered as the Minkowski momentum, Lorentz force analysis suggests that the momentum of a photon traveling through the continuous background, however, can be modeled as the type of Abraham. Finally, as an interesting sidewalk, a machine learning based system has been developed to predict the time-averaged force within a very short time avoiding time-consuming full wave simulation.

关键词： Abraham–Minkowski controversy dielectric interface machine learning optical force laws optical pulling force optical tractor beams

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