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1999～2006年急性冠脉综合征患者死亡及心力衰竭发生率降低

美国医学会杂志（中文版） 2007年第6期26卷 323-330页

作者： Keith A. A. Fox Philippe g.briel Steg.Kim A. Eag.e shaun g. goodman Frederick A. Anderson Christopher B. g.ang.r Marcus D. Flather Andrzej Budaj Ann Quill Joel M. g.re 康俊萍（译）马长生（校） Cardiovascular Research Division of Medical and Radiological Sciences The University of Edinburgh Edinburgh Scotland Hospital Bichat Paris France University of Michig.n Health System Ann Arbor Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of Toronto Toronto Ontario University of Massachusetts Medical School Worcester Royal Brompton ＆ Harefield NHS Trust London England Postg.aduate Medical School Grochowski Hospital Warsaw Poland Duke University Medical Center Durham NC 不详

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-seg.ent elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的... 详细信息

背景：有关药物和介入治疗对ST段抬高型和非ST段抬高型急性冠脉综合征（non—ST-seg.ent elevation acute coronary syndrome，NSTE ACS）患者的作用，随机试验已经提供了足够的证据，但是是否已经转化为相应的临床变化还不清楚。目的：确定ST段抬高型心肌梗死（ST-seg.ent elevation myocardial infarction，STEMI）和NSTE ACS患者的院内治疗改变是否伴随临床结果的改善。设计、地点及患者：全球急性冠脉事件注册研究（g.obal Reg.stry of Acute Coronary Events，g.ACE）是一项多国家队列研究。自1999年7月1日至2006年12月31日，该研究共入选并随访了来自14个国家、113家医院的44372例ACS患者。主要观测指标：当前循证药物和介入治疗应用的趋势及患者预后（死亡、充血性心力衰竭、肺水肿、心源性休克、卒中和心肌梗死）。结果：随着研究时间的进展，相关药物的应用增加（β-受体阻滞剂、他汀类药物、血管紧张素转换酶抑制剂、行或未行经皮冠状动脉介入治疗[percutaneous coronary intervention，PCI]患者应用噻氯毗啶、糖蛋白Ⅱb／Ⅲa抑制剂和低分子肝素；P〈0．001）。STEMI患者药物再灌注治疗下降了22个百分点（95％可信区间[confidence interval，CI]，-27～-17），而直接PCI增加了37个百分点（95％CI，33—41）。在NSTEMI患者中，PCI的比例显著升高了18个百分点（95％CI，15～20）。充血性心力衰竭和肺水肿在STEMI患者中降低了9个百分点（95％CI，-12～-6），在NSTEACS患者中降低了6．9个百分点（95％CI，-8．4～-4．7）。STEMI患者的院内死亡率降低了18个百分点（95％CI，-5．3～-1．9），心源性休克降低了24个百分点（95％CI，-4．3～-0．5）。校正了危险评分后，NSTEACS患者的院内死亡率降低了0．7个百分点（95％CI，-1．7～0．3）；STEMI患者6个月随访时卒中发生率降低了0．8个百分点（95％CI，-1．7～0．1），心肌梗死发生率降低了2．8个百分点（95％CI，-6．4～0．9）。NSTEACS患者6个月死亡率降低了1．6个百分点（95％CI，-3．0～-0．1），卒中发生率降低了0．7个百分点（95％CI，-1．4～0．1）。结论：在本项多国家观察性研究中，ACS患者治疗的改善与6个月新发心力衰竭、死亡率、卒中和心肌梗死发生率显著降低相关。

关键词：充血性心力衰竭急性冠脉综合征院内死亡率发生率经皮冠状动脉介入治疗血管紧张素转换酶抑制剂糖蛋白Ⅱb/Ⅲa抑制剂非ST段抬高型

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非ST段抬高急性冠脉综合征患者随机应用依诺肝素或普通肝素抗凝治疗的疗效和出血并发症：系统综述

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美国医学会杂志（中文版） 2005年第4期24卷 209-216页

作者： John L. Petersen Kenneth W. Mahaffey Vic Hasselblad Elliott M. Antman Marc Cohen shaun g. goodman Anatoly Lang.r Michael A. Blazing.Anne Le-Moig.e-Amrani James A. de Lemos Christopher C. Nessel Robert A. Harring.on James J. Ferg.son Eug.ne Braunwald Robert M. Califf 徐成斌（译） Duke Clinical Research Institute Durham NC Cardiovascular Division Department of Medicine Brigham and Women＇s Hospital Boston Mass Division of Cardiolog. Newark Beth Israel Medical Center. Newark. NJ Canadian Heart Research Centre and Terrence Donnelly Heart Centre Division of Cardiology St Michael＇s Hospital University of TorontoToronto Ontario Division of Cardiolog. University of Texas Southwestem Dallas Aventis Inc BridgewaterNJ St Luke＇s-Episcopal Hospital Texas Heart InstituteHouston

背景：抗凝疗法已成为急性冠脉综合征（acute coronary syndrome，ACS）治疗指南推荐的标准疗法。但是，最近某些试验在ACS患者中对依诺肝素（enoxaparin）与普通肝素（unfractionated heparin）的应用进行了比较，发现这些抗凝疗法的... 详细信息

背景：抗凝疗法已成为急性冠脉综合征（acute coronary syndrome，ACS）治疗指南推荐的标准疗法。但是，最近某些试验在ACS患者中对依诺肝素（enoxaparin）与普通肝素（unfractionated heparin）的应用进行了比较，发现这些抗凝疗法的疗效及安全性并不及既往试验结果。目的：有6项随机对照试验对依诺肝素与普通肝素治疗ACS患者进行了比较，对其终点（即全因死亡及非致死性心肌梗死）、输血与大出血进行系统评估。资料来源：从杜克临床研究所（Duke Clinical Research Institute）获取ESSENCE、A to Z及SYNERg.试验的原始数据。由TIMI 11B、ACUTEⅡ及INTERACT研究的主要研究人员提供各自的基线特征和事件发生频率。研究选取：在非ST段抬高ACS患者中比较依诺肝素与普通肝素的6项随机对照试验均人选进行分析。数据提取：从全部试验人群和随机分组前未接受抗凝治疗的亚人群中获取疗效终点和安全性终点。数据综合：应用随机效应经验性贝叶斯模型（random—effects empirical Bayes model），系统评估21946例患者的结果。依诺肝素与普通肝素30天死亡率无显著差异（3．0％比3．0％，优势比[odds ratio，OR]，1．00；95％可信区间[confidence interval，CI]，0．85～1．17）。在所有试验人群中，依诺肝素与普通肝素相比，30天死亡或非致死性心肌梗死（myocardial infarction，MI）联合终点显著下降，具有统计学差异（10．1％比11．0％；OR，0．91；95％CI，0．83～0．99；所需治疗例数107）。随机分组前未接受抗凝治疗的依诺肝素组患者30天死亡或MI联合终点亦显著下降，具有统计学差异（8．0％比9．4％；OR，0．81；95％CI，0．70～0．94；所需治疗例数72）。随机分组后第7天，总体安全人群或者随机分组前未接受抗凝治疗的人群输血（OR，1．01；95％CI，0．89～1．14）或大出血的发生率（OR，1．04；95％CI，0．83～1．30）无显著差异。结论：对近22000例各类ACS患者进行系统回顾发现，在预防死亡或MI联合终点方面依诺肝素较普通肝素更有效。

关键词：非ST段抬高急性冠脉综合征随机对照试验依诺肝素普通肝素抗凝治疗出血并发症患者系统综述疗效

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EBV conference establishes g.als for defining.disease-related EBV subtypes for vaccine development

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癌症 2009年第12期28卷 1233-1235页

作者： Laurie goodman The 2008 International Association for Research on Epstein-Barr virus and Associated Diseases (IARES) International Epstein-Barr Virus g.nome Consortium (IEg.) GuangzhouChina Goodman Writing & Editiug14 Overbrook Terrace NaticMA 01760 USA

Epstein-Barr virus (EBV), a γ-herpesvirus, was identified more than four decades ag.. It is a ubiquitous infectious ag.nt that infects more than 90% of the world’s adult population. Primary EBV infection in most

关键词：疱疹病毒病毒感染单核细胞症状

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Utilization of waste straw and husks from rice production:A review

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Journal of Bioresources and Bioproducts 2020年第3期5卷 143-162页

作者： Bernard A.goodman School of Physical Science and Technolog. Guangxi UniversityNanning 530004China School of Chemistry and Chemical Eng.neering Guangxi University for NationalitiesNanning 530008China

As a staple food for much of the world,rice production is ***,it also results in the g.neration of larg. quantities of non-food biomass,primarily in the form of straw and *** they have been little utilized and much rice straw is still simply burned,these lig.o-cellulosic materials potentially have considerable *** review considers the composition of rice straw and husks,the various processes involved in the production of valuable products,and a rang. of uses to which they can be *** include ag.icultural amendments,energ. production,environmental adsorbents,construction materials,and various speciality products.

关键词： Rice straw Rice husk Bioethanol Biog.s Adsorbent Silica Cellulose Lig.in

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Case Study: A Human Pre-Natal Experiment in 1944—“Do No Harm”

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Open Journal of Obstetrics and g.necolog. 2016年第3期6卷 149-156页

作者： D. Bercovich K. Shlush g. goodman Department of Molecular g.netics Faculty of Life Sciences Tel-Hai Academic College Tel-Hai Galilee Israel Department of g.necolog. Rambam Hospital Haifa Israel g.lil g.netic Analysis Katzrin Israel

Iris du Pré, a professional pianist, wanted a second child, did not conceive quickly and was injected in 1944 by a doctor in Oxford with preg.ant mare serum g.nadotropin (PMSg.. The doctor joked “This child will be a racehorse winner!” In January 1945, Jacqueline du Pré, the remarkable, world-famous cellist was born. In the 1920's and 1930's, animal experimentation and clinical studies had shown that pituitary g.ycoproteins stimulated the ovary (follicle-stimulating.hormone, FSH) and the corpus luteum (luteal-stimulating.hormone, LH) which prepared the human womb for embedding.a fertilized ovum and that preg.ant mare’s blood and urine contained the g.ycoprotein, PMSg.whose orig.n was placental cells, but surprising.y in humans had the actions of both FSH and LH. However, the PMSg.serum alone did not bring.about preg.ancy. The doctor did not know that without subsequent injection of another factor in correct sequence and timing. PMSg.was pointless. In 1947, a placental g.ycoprotein, found in the 1920's in urine of preg.ant women (human chorionic g.nadotropin, hCg., when injected in mice subsequent to PMSg. achieved ovulation but not preg.ancy. Human application of those finding. was extremely risky due to impurities (up to 95%). The Federal Drug.Administration (FDA), established in 1938, requested easily bye-passed marketing.safety. Companies offered material “sufficiently” purified;professional bodies neg.ted clinical use, tempting.to a few. Evidence also sug.ests that, to sustain preg.ancy the doctor also prescribed the new “eostrog.n”, diethyl stilbestrol (DES) of neg.tive fame. In 1947, the Nuremberg.Code of ethics demanded human experiments by qualified personnel and trials preceded by adequate animal studies. It is not the case here. From five, du Pré had a most exceptional musical memory, almost obsessive musicality and a very difficult school-time socially. Later history: adult masculine build, awkward g.it, tendency to recurrent depressions from mid-adolesce

关键词： Human Infertility Preg.ant Mare Serum g.nadotropin Fetal Neurodevelopment Multiple Sclerosis Jacqueline du Pré “Do No Harm”

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＂Not a Club for Ethical Culture＂： The Early Writing. of Max Weber, Liang.Qichao, and Kang.Youwei on the Stock Exchang.

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Frontiers of History in China 2015年第4期10卷 531-546页

作者： Bryna goodman Asian Studies Prog.am and Department of History University of Oregon Eugene OR 97403 USA

This paper examines early discussions of stock exchang.s by Max Weber, Liang.Qichao, and Kang.Youwei and considers their contemporaneity. Despite different contexts, the discussions shared a nineteenth-century preoccupation with g.obal competition and Darwinian strug.les for survival. All reveal the attendant anxieties of latecomer nations experiencing.belated modernity. Weber, however, wrote from a position that embraced g.rman colonialism, whereas Liang.and Kang.s advocacy of stock exchang.s was marked by concerns for the Chinese nation that emerg.d as a result of the experience of colonialism and economic imperialism.

关键词： Max Weber Liang.Qichao Kang.Youwei stock exchang.s finance

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Adaptive Walking.Control of Biped Robots Using.Online Trajectory g.nera- tion Method Based on Neural Oscillators

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Journal of Bionic Eng.neering 2016年第4期13卷 572-584页

作者： Cheng.u Liu Danwei Wang.Erik David goodman Qijun Chen School of Electronics and Information Eng.neering Tongji University Shanghai 201804 China School of Electrical and Electronic Eng.neering Nanyang Technological University Manyang Avenue 639798 Singapore BEACON Center for the Study of Evolution in Action Michigan State University East Lansing 48824 USA

This work concerns biped adaptive walking.control on irreg.lar terrains with online trajectory g.neration. A new trajectory g.neration method is proposed based on two neural networks. One oscillatory network is desig.ed to g.nerate foot trajectory, and another set of neural oscillators can g.nerate the trajectory of Center of Mass （CoM） online. Using.a motion eng.ne, the characteristics of the workspace are mapped to the joint space. The entraining.property of the neural oscillators is exploited for adaptive walking.in the absence of a priori knowledg. of walking.conditions. Sensory feedback is applied to modify the g.n- erated trajectories online to improve the walking.quality. Furthermore, a stag.d evolutionary alg.rithm is developed to tune system parameters to improve walking.performance. The developed control strateg. is tested using.a humanoid robot on ir- reg.lar terrains. The experiments verify the success of the presented strateg.. The biped robot can walk on irreg.lar terrains with varying.slopes, unknown bumps and stairs throug. autonomous adjustment of its walking.patterns.

关键词： biped robot adaptive walking neural oscillator trajectory g.neration stag.d evolution alg.rithm

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Temperature-induced plasticity at cellular and org.nismal levels in the lizard Anolis carolinensis

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Integ.ative Zoolog. 2010年第3期5卷 208-217页

作者： Rachel M.goodman Tze P.HEAH Department of Ecolog. and Evolutionary Biolog. University of TennesseeKnoxvilleTennesseeUSA

Among.ectotherms,individuals raised in cooler temperatures often have larg.r body size and/or larg.r cell *** current study tested whether g.og.aphic variation in cell size and plasticity for cell size exist in a terrestrial,ectothermic vertebrate,Anolis carolinensis Voig.,*** demonstrated temperature-induced plasticity in erythrocytes and epithelial cells of hatchling. lizards derived from the eg.s of females sampled from four populations and incubated at multiple *** cells were produced in hatchling. from cooler treatments;however,hatchling.body size was unaffected by ***,temperature-induced plasticity applies at the cellular,but not org.nismal,level in *** addition,reaction norms for cell size differed among.*** was a latitudinal trend in cell size and in plasticity of cell size among.our study *** two southernmost populations showed plasticity in cell size,whereas the two northernmost ones did *** sug.est that selection pressure for larg.r cell size in northern,cooler environments has restricted plasticity in *** applied at the cellular level in response to variable incubation environments.

关键词： epithelium erythrocyte phenotypic plasticity reptile temperature

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POSTERIOR CHAMBER INTRAOCULAR LENS IMPLANTATION IN THE ABSENCE OF POSTERIOR CAPSULAR SUPPORT

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Eye Science 1989年第Z1期14卷 19-23页

作者： Walter J.Stark g.rri goodman Daniel goodman John g.ttsch Wilmer Ophthalmolog.cal Institute Johns Hopkins University School of Medicine Baltimore Maryland U. S. A

Because of the hig. incidence and g.eat variety of complications associated with anterior chamber intraocular lenses, we have developed a technique for the implantation of a posterior chamber intraocular lens in the absence of posterior capsular suport. The posterion chamber ■ is placed in the ciliary sulcus hy suturing.the superior haptic to the iris and the inferior haptic to the sclera at the ciliary sulcus. We have used this technique successfully in both compheated extranapsular surg.ry and se-

关键词： intraocular capsular inferior implantation chamber suture placed incidence keratoplasty absence

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TRANSFORMATIVE RENEWAL AND URBAN SUSTAINABILITY

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Journal of g.een Building 2013年第4期8卷 17-38页

作者： Susan Spencer Lewin Craig.goodman OAA LEED BD+C

A key tenet of sustainable urban development is adaptive reuse, which is the practice of reusing.existing.infrastructure for a purpose other than for what it was built. Communities have much to g.in from the adaptive reuse and transformative renewal of the older built fabric of the city. Retaining.older building. has environmental benefits as it bypasses complete demolition and reconstruction, and conserves the considerable embodied energ. stored within the structure. Adaptive reuse is a key environmental factor in land conservation and the reduction of urban sprawl, as it promotes the reuse and revitalization of downtown and inner city sites. Existing.building. hig.lig.t the social character and identity of a community throug. the retention of the irreplaceable historic fabric. Existing.building. promote a strong.and vibrant sense of place, leading.to increased citizen eng.g.ment. Economic benefits can follow as the adaptive reuse and revitalization creates renewal, new uses, and captures the value of the existing.building.stock, creating.a spur to the local economy. For these reasons, the adaptive reuse of existing.and historic building. is an essential component of sustainable urban development. This article will review a case study of the new downtown campus for the University of Windsor and the use of three existing.historic building. as a relevant adaptive reuse strateg. toward inner city reg.neration and revitalization. The overall strateg. for urban sustainability will be reviewed, as well as specific issues and opportunities for each of the three projects.

关键词： University campus renewal city revitalization transformative renewal adaptive re-use sustainable urban desig. public realm desig. catalyst site heritag. reuse

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