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Comparative Analysis of Adaptive Vessel Segmentation—Cerebral Arteriovenous Malformation

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Journal of Biomedical Science and Engineering 2015年第12期8卷 797-804页

作者： Yadalam k.ran k.mar shashi Bhushan Mehta Manjunath Ramachandra Manipal University Manipal India Philips Research Philips Innovation Campus Bangalore India

Aim: Neurovascular abnormalities are extremely complex, due to the multitude of factors acting simultaneously on cerebral hemodynamics. Cerebral Arteriovenous Malformation (CAVM) hemo-dynamic in one of the vascular abnormality condition results changes in the vessels structures and hemodynamics in blood vessels. The challenge is segmenting accurate vessel region to measure hemodynamics of CAVM patients. The clinical procedure is in-vivo method to measure hemodynamics. The catheter-based procedure is difficult, as it is sometimes difficult to reach vessels sub-structures. Methods: In this paper, we have proposed adaptive vessel segmentation based on threshold technique for CAVM patients. We have compared different adaptive methods for vessel segmentation of CAVM structures. The sub-structures are modeled using lumped model to measure hemodynamics non-invasively. Results: Twenty-three CAVM patients with 150 different vessel locations of DSA datasets were studied as part of the adaptive segmentation. 30 simulated data has been evaluated for more than 150 vessels locations for sub-segmentation of vessels. The segmentation results are evaluated with accuracy of 93%. The computed p-value is smaller than the significance level 0.05. Conclusion: The adaptive segmentation using threshold based produces accurate vessel segmentation, results in better accuracy of hemodynamic measurements for DSA images for CAVM patients. The proposed adaptive segmentation helps clinicians to measure hemodynamic non-invasively for the segmented sub-structures of vessels.

关键词： Adaptive Segmentation AVM Lumped Model

A Review of Epilepsy Diagnosis Using PET Parameters

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Journal of Behavioral and Brain Science 2012年第3期2卷 415-425页

作者： Yadalam k.ran k.mar shashi Bhushan Mehta Uday Patil Manipal Hospital Bangalore India Philips Electronics India Ltd Bangalore India

Epilepsy is caused by abnormal excessive electric discharges from the neurons in the brain. Epileptic seizures are non- specific responses of the brain to many types of insults. The structural abnormalities causing epilepsy can be identified using various state of art imaging methods. Through a combination of brain activity monitoring, imaging and mapping techniques, physicians can locate the specific area in the brain causing epileptic discharges and identify its location in relation to those areas in the brain controlling vital functions. Positron Emission Tomography (PET) has emerged as a useful tool to identify abnormal metabolic activity of the epileptogenic foci. Parameters lik. asymmetric index, stan- dard uptak. value (SUV) etc obtained by PET are processed and analyzed for identifying the origin of epileptic sei- zures. This paper discuss the techniques used to diagnose in general and to localize the epileptogenic regions using post-processing other features on PET imaging.

关键词： Epilepsy PET Asymmetric Index Standard Uptak. Value

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应用修正的PVT数据优化原油生产装置设计

油气储运 1996年第3期15卷 56-60页

作者： shashi Dharmadhik.ri 林玉萍辽河石油勘察设计研究院

常规色谱分析法得出的油层PVT物性分析数据,若直接应用于原油地面生产装置模拟计算,则其饱和泡点压力偏差为20％,油气比偏差为40％。提出需修正一些物性参数,完善PVT物性数据,以便较准确地确定油层流体组分,获取溶解气含量和残油密度等... 详细信息

常规色谱分析法得出的油层PVT物性分析数据,若直接应用于原油地面生产装置模拟计算,则其饱和泡点压力偏差为20％,油气比偏差为40％。提出需修正一些物性参数,完善PVT物性数据,以便较准确地确定油层流体组分,获取溶解气含量和残油密度等特性,更有效地应用修正的PVT物性分析数据优化原油生产装置的设计。

关键词：压力油层体积温度原油 PVT物性分析

维多株单抗治疗老年炎症性肠病患者的有效性和安全性:一项匹配病例对照研究

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Gastroenterology Report 2020年第4期8卷 306-311,I0002页

作者： Preeti shashi Dharmesh Gopalak.ishnan Malav P.Parik. Bo Shen Gursimran k.chhar Center for Inflammatory Bowel Disease Digestive Diseases and Surgery InstituteThe Cleveland Clinic FoundationClevelandOHUSA Department of Internal Medicine The Cleveland Clinic FoundationClevelandOHUSA Department of Gastroenterology Allegheny General HospitalPittsburghPAUSA

背景:多个临床研究显示,维多株单抗治疗成人中重度活动期炎症性肠病(IBD)安全有效。但其用于老年患者的安全性和有效性相关数据甚是有限。方法:本研究为病例对照研究,比较维多株单抗用于老年组(≥65岁)和对照组(0.05)。结论:在真实世界... 详细信息

背景:多个临床研究显示,维多株单抗治疗成人中重度活动期炎症性肠病(IBD)安全有效。但其用于老年患者的安全性和有效性相关数据甚是有限。方法:本研究为病例对照研究,比较维多株单抗用于老年组(≥65岁)和对照组(0.05)。结论:在真实世界中,维多株单抗用于老年IBD患者的治疗同样安全有效。

关键词： inflammatory bowel disease vedolizumab elderly patients mucosal healing safety

Venous Ulcer: Review Article

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Surgical Science 2013年第2期4卷 144-150页

作者： shashi Prak.sh Satyendra k.mar Tiwary Manjaree Mishra Ajay k.mar k.anna Department of General Surgery Institute of Medical Sciences Banaras Hindu University Varanasi India

Venous ulceration is the most severe and debilitating outcome of chronic venous insufficiency in the lower limbs and accounts for 80 percent of lower extremity ulcerations. The morbidity caused by them has a serious impact on the quality of life. Sustained venous hypertension, caused by venous insufficiency leads to venous ulceration. The diagnosis is mainly clinical but needs to be differentiated from other causes of lower limb ulcers. Doppler ultrasound is the diagnostic investigation. Treatment options for venous ulcers include conservative management, mechanical treatment, medications, and surgical options. The goals of treatment are to reduce edema, improve ulcer healing, and prevent recurrence. The achievement of good long term results depends on continuous care, ulcer care clinics, home health nursing and regular evaluation by the doctor. They have a crucial role to play for the amelioration of this common and morbid condition.

关键词： Venous Ulcer Chronic Venous Insufficiency

苯硼酸衍生物的晶体工程:用能量较高的syn,syn-构象设计共晶(英文)

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中国科学：化学 2012年第1期42卷 95-96页

作者： VARUGHESE Sunil SINHA shashi Bhushan DESIRAJU Gautam R olid State and Structural Chemistry Unit Indian Institute of Science

研苯硼酸衍生物有3种不同构象(syn,syn-;syn,anti-和anti,anti-构象),这3种构象能量非常不同.苯硼酸衍生物通常是采用能量最低的syn,anti-构象存在.然而在配合物中,苯硼酸衍生物展现了硼酸功能团的构象多样性.在本文中,我们采用syn,syn... 详细信息

研苯硼酸衍生物有3种不同构象(syn,syn-;syn,anti-和anti,anti-构象),这3种构象能量非常不同.苯硼酸衍生物通常是采用能量最低的syn,anti-构象存在.然而在配合物中,苯硼酸衍生物展现了硼酸功能团的构象多样性.在本文中,我们采用syn,syn-构象的硼酸衍生物作为结构单元,与含氮给体化合物反应,合成了一系列共晶配合物.采用的含氮给体化合物包括含1,2-重氮片段的化合物(阿普唑仑,1H-四唑,乙酰唑胺和苯并三唑)、邻菲罗啉和2,2′-联吡啶.结果表明,只有1,2-重氮片段不一定能与syn,syn-构象的硼酸及衍生物生成共晶.

关键词：晶体工程苯硼酸衍生物超分子结构单元构象的灵活性

A Systematic Review to Explore the Factors Related to Parent to Child Transmission of HIV, Survival and Treatment Provision of Children with HIV in India

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World Journal of AIDS 2015年第3期5卷 245-255页

作者： Arvind k.mar Singh Partha Haldar Sanjay k.mar Rai shashi k.nt Centre for Community Medicine All India Institute of Medical Sciences New Delhi India

Introduction: There are a multitude of factors that impact the transmission of HIV from parent to child and the subsequent survival of infected children. Changing dynamics in HIV transmission have led to an increase in the number of children living with HIV in India. This review synthesizes the evidence related to transmission of HIV to children, survival and treatment provision among children living with HIV. Methods: A systematic search was conducted in MEDLINE, IndMed, Web of Science, Google Scholar and major journals related to HIV/AIDS to identify relevant studies published between 1992 and 2015. Inclusion criteria included studies related to parent to child transmission of HIV, treatment of children living with HIV and survival of children living with HIV. One of the authors reviewed the studies and extracted the data in a pre-coded extraction sheet. Results: Thirty-three studies were included in the review. HIV transmission rate from parent to Child who received nevirapine prophylaxis ranged from 2.1% to 27.3%. Extended dose regimen of nevirapine prophylaxis was found to be more effective than the single dose regimen. Adherence to ART ranged from 65% to 95%. Adherence varied depending upon the level of health care facility. Both social and medical factors were associated with non-adherence. CD 4 count at the time of diagnosis and delayed age at HIV diagnosis were important predictors of survival. Conclusion: Shift in policy to provide option B regimen is yielding better results. If the age at diagnosis could be reduced further, it would increase the survival of children living with HIV. The program needs to increase access to the health care facilities.

关键词： PPTCT1 ART Children India Adherence Prophylaxis

TIDAL FLAT STORM DEPOSITS OF MIDDLE CAMBRIAN IN SHIMEN DISTRICT,HUNAN PROVINCE

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Scientia Geologica Sinica 1997年第2期 93-99页

作者： Hu Mingyi, Guo Chengxian and Zhu Zhongde(Jianghan Petroleum Institute, shashi 434102)

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Multimodality Vessel Modeling Analysis for Cerebral Arteriovenous Malformation

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Journal of Behavioral and Brain Science 2014年第1期4卷 23-26页

作者： Y. k.ran k.mar shashi B. Mehta Manjunath Ramachandra Philips Health Care Philips Innovation Campus Manipal University Bangalore India Philips IP&S Philips Innovation campus Bangalore India Philips Research Philips Innovation Campus Bangalore India

Cerebral arteriovenous malformations (AVMs) are a type of vascular anomaly consisting of large intertwined vascular growth (Nidus) that is prone to serious hemorrhaging and can result in patient death if left untreated. Intervention through surgical clipping of feeding and draining vessels to the Nidus is a common treatment. However, identification of which vessels to clip is challenging even to experienced surgeons aided by conventional image guidance systems. The lumped modeling for the Cerebral Arteriovenous Malformation (CAVM) hemodynamic analysis is of high importance in clinical world. As part of the treatment planning for CAVM, it is difficult for doctors to assess the NIDUS part, which may get rupture while inserting catheter. In this paper, we have proposed a non-invasive method for assessing the hemodynamic condition of AVM. The measurement of flow and pressure without intervention along the vessel is a big challenge due to occlusion, bending and thinning of the vessel in Arteriovenous Malformation patients. In this paper, we analyzed a lumped model for the vascular malformation using various imaging multi-modalities that help to analyze CAVM Structures.

关键词： Vessel Deformation AVM Lumped Model