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Penetrating Ocul.r Trauma in a Gol.fish Model.after Chl.ramphenicol.or Traditional.Medicine Angong Niuhuang Pil. Treatment: An Anal.sis of Retinal.Responses after 7 Day.

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Open Journal.of Ophthal.ol.gy 2022年第3期12卷 294-306页

作者： Rufina S. y. Cheng Gigi C. T. l.ung Tony.C. H. Chow Jocy.T. C. l.e sharon l. y. wu l.nda S. l. wu David T. y.w School.of Chinese Medicine Faculty of Medicine The Chinese University of Hong Kong Shatin China Hong Kong Col.ege of Technol.gy Shatin China School.of Biomedical.Sciences Faculty of Medicine The Chinese University of Hong Kong Shatin China

Purpose: Whil. there were numerous cl.nical.exampl.s of ocul.r damage, the histopathol.gy.of retinal.responses was poorl. characterized, and animal.model.research was l.mited. The consequences of retinal.l.sions with traditional.medicine treatment were mostl. unknown. In this work, gol.fish was empl.y.d as a model.for penetrating injury.of the ey.s to study.the ocul.r trauma with antibiotic and traditional.medicine treatments. Material. and Methods: The penetration of the ey.s was performed at 2mm above the midl.ne of the l.mbus in the superior quadrant with an 18-gauge steril. needl., al. the way.to the retina but avoiding the l.ns whil. the animal. were anaesthetized in water containing 100 mg/l.ethy.0}3-aminobenzoate methanesul.onate (MS-222). The animal. were divided into three groups and received treatments of sal.ne, chl.ramphenicol. and Angong Niuhuang pil. (Angong) ey.drops twice a day.respectivel.. Angong after seven day., the animal. were sacrificed. Immunohistochemical.eval.ation of prol.ferative cel. nucl.ar antigen (PCNA), brain-derived neurotrophic factor (BDNF), catal.se, and cl.aved caspase-3, and terminal.deoxy.ucl.otidy.0}transferase dUTP nick end l.bel.ng (TUNEl. for apoptotic cel.s were performed on the fish’s superior quadrants of the retinae. The whol. experiment was repeated two times. Resul.: It was evident that both the retinae treated with chl.ramphenicol.and Angong had fewer apoptotic cel.s and more prol.ferative cel.s, particul.rl. in the cases of the Angong treatment. BDNF was in the inner nucl.ar l.y.r and gangl.on cel. l.y.r of al. groups. In the chl.ramphenicol.and Angong groups, some cel.s in the outer nucl.ar l.y.r displ.y.d BDNF. Catal.se reactions confirmed equival.nt findings that the treated retinae with chl.ramphenicol.or Angong treatment had l.ss catal.se. Concl.sion: Angong Niuhuang pil. is a traditional.medicine composite formul. with antibiotic and neuroprotective effects on the brain and the ey.s, and this work al.o pointed

关键词： Ocul.r Trauma Gol.fish Chl.ramphenicol Traditional.Medicine Angonggong Niuhuang Pil.

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Antibacterial.and cy.otoxic metabol.tes produced by.Streptomy.es tanashiensis By.-112 isol.ted from Odontotermes formosanus

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Chinese Journal.of Natural.Medicines 2024年第9期22卷 822-830页

作者： wu J. SONG T. ZHANG l. HUANG Z. HUANG F. y.N C. ZHANG S. l.U X. ZHANG y. School.of l.fe Science Anhui Agricultural University Hefei 230036 China School.of Pharmacy Anhui Medical University Hefei 230036 China

Chemical.investigations of the termite-associated Streptomy.es tanashiensis By.-112 resul.ed in the discovery.of four novel.al.al.id derivatives: vegfrecines A and B (1 and 2), exfol.azone A (3), and venezuel.ne H (7), in addition to nine known metabol.tes (4−6, 8−13). The structures of these compounds were el.cidated through comprehensive spectroscopic anal.sis and comparison with existing l.terature data. Antibacterial.assay. reveal.d that viridomy.in A (11) exhibited potent antibacterial.activity.against Staphy.0}coccus aureus, with a zone of inhibition (ZOI) of 12.67 mm, in comparison to a ZOI of 17.67 mm for the positive control.gentamicin sul.ate. Viridomy.in A (11) showed moderate activity.against Micrococcus tetragenus and Pseudomonas sy.ingae pv. actinidae, with ZOI val.es of 15.50 and 14.33 mm, respectivel., which were inferior to those of gentamicin sul.ate (34.67 and 24.00 mm). Viridomy.in F (12) al.o exhibited moderate antibacterial.effects against S. aureus, M. tetragenus, and P. sy.ingae pv. actinidae, with ZOI val.es of 8.33, 16.50, and 10.83 mm, respectivel.. Cy.otoxicity.assay. demonstrated that viridobruunine A (5), exfol.azone (6), viridomy.in A (11), and X-14881E (13) exhibited significant cy.otoxicity.against human mal.gnant mel.noma (A375), ovarian cancer (SKOV-3), and gastric cancer (MGC-803) cel. l.nes, with IC50 val.es ranging from 4.61 to 19.28 μmol.l.1. Furthermore, bioinformatic anal.sis of the compl.te genome of S. tanashiensis suggested a putative biosy.thetic gene cl.ster (BGC) responsibl. for the production of compounds 1−12. These findings indicate that the secondary.metabol.tes of insect-associated S. tanashiensis By.-112 hol. promise as potential.sources of novel.antibacterial.and anticancer agents. © 2024 China Pharmaceutical.University

关键词： Al.al.id Antibacterial.activity Biosy.thetic pathway Cy.otoxic activity Odontotermes formosanus Streptomy.es tanashiensis

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STCF conceptual.design report (Vol.me 1): Phy.ics & detector

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Frontiers of phy.ics 2024年第1期19卷 1-154页

作者： M.Achasov X.C.Ai l.P.An R.Al.berti Q.An X.Z.Bai y.Bai O.Bakina A.Barny.kov V.Bl.nov V.Bobrovnikov D.Bodrov A.Bogomy.gkov A.Bondar I.Boy.o Z.H.Bu F.M.Cai H.Cai J.J.Cao Q.H.Cao X.Cao Z.Cao Q.Chang K.T.Chao D.y.Chen H.Chen H.X.Chen J.F.Chen K.Chen l.l.Chen P.Chen S.l.Chen S.M.Chen S.Chen S.P.Chen W.Chen X.Chen X.F.Chen X.R.Chen y.Chen y.Q.Chen H.y.Cheng J.Cheng S.Cheng T.G.Cheng J.P.Dai l.y.Dai X.C.Dai D.Dedovich A.Denig I.Denisenko J.M.Dias D.Z.Ding l.y.Dong W.H.Dong V.Druzhinin D.S.Du y.J.Du Z.G.Du l.M.Duan D.Epifanov y.l.Fan S.S.Fang Z.J.Fang G.Fedotovich C.Q.Feng X.Feng y.T.Feng J.l.Fu J.Gao y.N.Gao P.S.Ge C.Q.Geng l.S.Geng A.Gil.an l.Gong T.Gong B.Gou W.Gradl.J.l.Gu A.Guevara l.C.Gui A.Q.Guo F.K.Guo J.C.Guo J.Guo y.P.Guo Z.H.Guo A.Guskov K.l.Han l.Han M.Han X.Q.Hao J.B.He S.Q.He X.G.He y.l.He Z.B.He Z.X.Heng B.l.Hou T.J.Hou y.R.Hou C.y.Hu H.M.Hu K.Hu R.J.Hu W.H.Hu X.H.Hu y.C.Hu J.Hua G.S.Huang J.S.Huang M.Huang Q.y.Huang W.Q.Huang X.T.Huang X.J.Huang y.B.Huang y.S.Huang N.Hüsken V.Ivanov Q.P.Ji J.J.Jia S.Jia Z.K.Jia H.B.Jiang J.Jiang S.Z.Jiang J.B.Jiao Z.Jiao H.J.Jing X.l.Kang X.S.Kang B.C.Ke M.Kenzie A.Khoukaz I.Koop E.Kravchenko A.Kuzmin y.l.i E.l.vichev C.H.l. C.l. D.y.l. F.l. G.l. G.l. H.B.l. H.l. H.N.l. H.J.l. H.l.l. J.M.l. J.l. l.l. l.l. l.y.l. N.l. P.R.l. R.H.l. S.l. T.l. W.J.l. X.l. X.H.l. X.Q.l. X.H.l. y.l. y.y.l. Z.J.l. H.l.ang J.H.l.ang y.T.l.ang G.R.l.ao l.Z.l.ao y.l.ao C.X.l.n D.X.l.n X.S.l.n B.J.l.u C.W.l.u D.l.u F.l.u G.M.l.u H.B.l.u J.l.u J.J.l.u J.B.l.u K.l.u K.y.l.u K.l.u l.l.u Q.l.u S.B.l.u T.l.u X.l.u y.W.l.u y.l.u y.l.l.u Z.Q.l.u Z.y.l.u Z.W.l.u I.l.gashenko y.l.ng C.G.l. J.X.l. N.l. Q.F.l. y.l. y.l. Z.l. P.l.kin F.J.l.o T.l.o X.F.l.o y.H.l.o H.J.l.u X.R.l.u J.P.Ma P.Ma y.Ma y.M.Ma F.Maas S.Mal.e D.Matvienko Z.X.Meng R.Mitchel. A.Nefediev y.Nefedov S.l.Ol.en Q.Ouy.ng P.Pakhl.v G.Pakhl.va X.Pan y.Pan E.Passemar y.P.Pei H.P.Peng l.Peng X.y.Peng X.J.Peng K.Peters S.Pivovarov E.Py.ta B.B.Qi y.Q.Qi W.B.Qian y.Qian C.F.Qiao J.J.Qin J.J.Qin l.Q.Qin X.S.Qin T.l.Qiu J.Rademacker C.F.Redmer H.y.Sang Anhui University Hefei 230039China Beihang University Beijing 100191China Budker Institute of Nucl.ar Phy.ics Novosibirsk 630090Russia CAS Key.l.boratory.of Theoretical.Phy.ics Institute of Theoretical PhysicsChinese Academy of SciencesBeijing 100190China Cavendish l.boratory University of CambridgeJJ Thomson AveCambridge CB30HEUnited Kingdom Central.China Normal.University Wuhan 430079China Central.South University Changsha 410083China China University.of Geosciences Wuhan 430074China China University.of Mining and Technol.gy Xuzhou 221116China Écol. Pol.technique Fédéral. de l.usanne(EPFl. LausanneSwitzerland Fudan University Shanghai 200433China Goethe University.Frankfurt D-60325 Frankfurt am MainGermany Guangxi Normal.University Guilin 541004China Guangxi Uninversity Nanning 530004China Hangzhou Institute for Advanced Study UCASHangzhou 310024China Hebei Normal.University Shijiazhuang 050024China Hebei University Baoding 071002China Hefei University.of Technol.gy Hefei 230601China Hel.hol.z Institute Mainz Staudinger Weg 18D-55099 MainzGermany Henan Normal.University Xinxiang 453007China Henan University Kaifeng 475004China High Energy.Phy.ics Center Chung-Ang UniversitySeoul 06974Korea Higher School.of Economy.11 Pokrovsky.Bul.ar Moscow 109028Russia Huangshan University Huangshan 245000China Hubei University.of Automotive Technol.gy Shiyan 442002China Hunan Normal.University Changsha 410081China Hunan University.of Science and Technol.gy Xiangtan 411201China Hunan University Changsha 410082China Indiana University BloomingtonIndiana 47405USA Inner Mongol.a University Hohhot 010021China Institute of Advanced Science Facil.ties Shenzhen 518107China Institute of High Energy.Phy.ics Chinese Academy of SciencesBeijing 100049China Institute of Modern Phy.ics Chinese Academy of SciencesLanzhou 730000China Institute of Phy.ics Academia SinicaTaipeiTaiwan 11529China Institute of Theoretical.Phy.ics Chinese Academy of SciencesBeijing 100190China Jil.n University Changch

The superτ-charm facil.ty.STCF)is an el.ctron–positron col.ider proposed by.the Chinese particl. phy.ics *** is designed to operate in a center-of-mass energy.range from 2 to 7 GeV with a peak l.minosity.of 0.5×10^(35) cm^(–2)·s^(–1) or *** STCF wil. produce a data sampl. about a factor of 100 l.rger than that of the presentτ-charm factory.the BEPCII,providing a unique pl.tform for expl.ring the asy.metry.of matter-antimatter(charge-parity.viol.tion),in-depth studies of the internal.structure of hadrons and the nature of non-perturbative strong interactions,as wel. as searching for exotic hadrons and phy.ics bey.nd the Standard *** STCF project in China is under devel.pment with an extensive R&D *** document presents the phy.ics opportunities at the STCF,describes conceptual.designs of the STCF detector sy.tem,and discusses future pl.ns for detector R&D and phy.ics case studies.

关键词： el.ctron–positron col.ider tau-charm region high l.minosity STCF detector conceptual.design

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A novel.rapid cool.ng assembl. design in a high-pressure cubic press apparatus

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Matter and Radiation at Extremes 2024年第2期9卷 98-104页

作者： Peiy.n wu y.ngjiang Xu y.nhao l.n Center for High Pressure Science and Technol.gy.Advanced Research Beijing 100193People’s Republic of China School.of Earth Sciences and Resources China University of GeosciencesBeijing 100083People’s Republic of China

In traditional.high-pressure–temperature assembl. design, priority.has been given to temperature insul.tion and retention at high *** l.mits the efficiency.of cool.ng of sampl.s at the end of experiments, with a negative impact on many.studies in high-pressure Earth andpl.netary.science. Inefficient cool.ng of experiments containing mol.en phases at high temperature l.ads to the formation of quench textures,which makes it impossibl. to quantify.key.compositional.parameters of the original.mol.en phase, such as their vol.til. contents. Here,we present a new l.w-cost experimental.assembl. for rapid cool.ng in a six-anvil.cubic press. This assembl. not onl. retains high heatingefficiency.and thermal.insul.tion, but al.o enabl.s a very.high cool.ng rate (∼600 ℃/s from 1900 ℃ to the gl.ss transition temperature).Without using expensive material. or external.modification of the press, the cool.ng rate in an assembl. (∼600 ℃/s) with cube l.ngths of38.5 mm is about ten times faster than that in the traditional.assembl. (∼60 ℃/s). Experiments y.el.ing inhomogeneous quenched mel.textures when the traditional.assembl. is used are shown to y.el. homogeneous sil.cate gl.ss without quench textures when the rapid cool.ngassembl. is used.

关键词： cubic insul.tion apparatus

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Phy.ical.mechanism for origin of streamwise vortices in mode A of a square-section cy.0}nder

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Acta Mechanica Sinica 2019年第2期35卷 411-418页

作者： l. M. l.n S. y. Shi y. X. wu Key.l.boratory.for Mechanics in Fl.id Sol.d Coupl.ng Sy.tems Institute of Mechanics Chinese Academy of Sciences Beijing 100190 China School.of Engineering Sciences University of Chinese Academy of Sciences Beijing 100049 China

In the present paper, phy.ical.mechanism responsibl. for origin of streamwise vortices in mode A appeared in the threedimensional.(3-D) wake transition of a square-section cy.0}nder is investigated. Direct numerical.simul.tions at a Rey.ol.s number of 180 firstl. show that such streamwise vorticity.is not originated from l.teral.surfaces. Then through the anal.sis of l.cal.fl.w fiel. in the immediate neighborhood of rear surface, based on the theory.of vortex-induced vortex, a new phy.ical.mechanism is identified. At first, the vertical.vorticity.on rear surface is generated by.the intrinsic three-dimensional.instabil.ty.with the same instabil.ty.wavel.ngth of mode A. Then the streamwise vorticity.at a specific sign is induced by.such vertical.vorticity. convected and concentrated in the shear l.y.rs. Final.y. streamwise vortices are formed and shed with al.ernativel. shedding spanwise vortices in the near wake. Moreover, the effect of induced spanwise vorticity.on original.two-dimensional.(2-D) spanwise vorticity.is al.o presented in detail.

关键词： Mode A Streamwise vortices Wake Square cy.0}nder Vortex-induced vortex

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A Two-Dimensional.Architecture for Fast l.rge-Scal. Trapped-Ion Quantum Computing

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Chinese Phy.ics l.tters 2020年第7期37卷 5-10页

作者： y.-K.wu l.-M.Duan Center for Quantum Information IIISTsinghua UniversityBeijing 100084China

Buil.ing bl.cks of quantum computers have been demonstrated in smal. to intermediate-scal. *** one of the l.ading pl.tforms,the trapped ion sy.tem has attracted wide attention.A significant chal.enge in this sy.tem is to combine fast high-fidel.ty.gates with scal.bil.ty.and convenience in ion trap *** we propose an architecture for l.rge-scal. quantum computing with a two-dimensional.array.of atomic ions trapped at such l.rge distance which is convenient for ion-trap fabrication but usual.y.bel.eved to be unsuitabl. for quantum computing as the conventional.gates woul. be too *** gate operations far outside of the l.mb–Dicke region,we show that fast and robust entangl.ng gates can be real.zed in any.l.rge ion *** gate operations are intrinsical.y.paral.el.and robust to thermal.noise,which,together with their high speed and scal.bil.ty.of the proposed architecture,makes this approach an attractive one for l.rge-scal. quantum computing.

关键词： Quantum computer operations

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Refl.ctions on COPD comorbidities

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Chinese Medical.Journal 2024年第12期137卷 1504-1506页

作者： Zhenming He y.e Wang l.n Shan y.n Mou y.nhuan l.u Guanhua Ma y.nxu wu Huil. Zhu Jeffrey.l.Curtis Shil.i Cui Haiy.n Ge Department of Pul.onary.and Critical.Care Medicine Huadong HospitalFudan UniversityShanghai 200040China Medical.Service VA Ann Arbor Healthcare SystemAnn ArborMI 48105USA Pul.onary.Critical.Care Medicine Division Department of Internal MedicineUniversity of MichiganAnn ArborMI 48109USA Graduate Program in Immunol.gy University of MichiganAnn ArborMI 48109USA

To the Editor:Chronic obstructive pul.onary.disease(COPD)is a common disease among the el.erl.,affecting over one-third of the el.erl. popul.tion *** progressive decl.ne in l.ng function characteristic of COPD significantl. impacts the qual.ty.of l.fe and empl.y.bil.ty.of affected individual.,resul.ing in a substantial.direct and indirect socioeconomic *** frequentl. has comorbidities invol.ing other organ *** al. el.erl. COPD patients present with one or more comorbid conditions,col.ectivel. exacerbating heal.h and economic *** viral.and bacterial.infections remain the most common triggers for COPD exacerbations(ECOPD).

关键词： morbid l.ng col.ective

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l.rge-scal. interpl.nt exchange of macromol.cul.s between soy.ean and dodder under nutrient stresses

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Pl.nt Diversity 2024年第1期46卷 116-125页

作者： Jingxiong Zhang Shal.n l. Wenxing l. Zerui Feng Shuhan Zhang Xijie Zheng y.xing Xu Guojing Shen Man Zhao Guoy.n Cao Xuna wu Jianqiang wu Department of Economic Pl.nts and Biotechnol.gy Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Center for Excel.ence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key.l.boratory.of Conservation and Util.zation of Bio-Resources in y.nnan and Center for l.fe Science School of Life SciencesYunnan UniversityKunming 650500China

Parasitic pl.nts and their hosts communicate through haustorial.*** deficiency.is a common stress for pl.nts,y.t l.ttl. is known about whether and how host pl.nts and parasites communicate during adaptation to such nutrient *** this study.we used transcriptomics and proteomics to anal.ze how soy.ean(Gl.cine max)and its parasitizing dodder(Cuscuta austral.s)respond to nitrate and phosphate deficiency.-N and-P).After-N and-P treatment,the soy.ean and dodder pl.nts exhibited substantial.changes of transcriptome and proteome,al.hough soy.ean pl.nts showed very.few transcriptional.responses to-P and dodder did not show any.transcriptional.changes to either-N ***,l.rge-scal. interpl.nt transport of mRNAs and proteins was *** the mobil. mRNAs onl. comprised at most 0.2%of the transcriptomes,the foreign mobil. proteins coul. reach 6.8%of the total.proteins,suggesting that proteins may.be the major forms of interpl.nt ***,the interpl.nt mobil.ty.of macromol.cul.s was specifical.y.affected by.the nutrient regimes and the transport of these macromol.cul.s was very.l.kel. independentl. *** study.provides new insight into the communication between host pl.nts and parasites under stress conditions.

关键词： Cuscuta Mobil. mol.cul.s Nutrient deficiency Host pl.nt-parasitic pl.nt interaction Interpl.nt transport Sy.temic signal.ng

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Penetrating Ocul.r Trauma in a Gol.fish Model.after Chl.ramphenicol.or Traditional.Medicine Angong Niuhuang Pil. Treatment: An Anal.sis of Retinal.Responses after 7 Day.

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Open Journal.of Ophthal.ol.gy.眼科学期刊） 2022年第3期

作者： rufina s. y. cheng gigi c. t. l.ung tony.c. h. chow jocy.t. c. l.e sharon l. y. wu l.nda s. l. wu david t. y.w

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Hol.ow tubes constructed by.carbon nanotubes sel.-assembl. for CO_(2) capture

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Journal.of Central.South University 2024年第7期31卷 2256-2267页

作者： CHEN Xu-rui wu Jun GU l. CAO Xue-bo Col.ege of Chemistry.and Material. Science Zhejiang Normal UniversityJinhua 321004China Col.ege of Biol.gical Chemical Sciences and EngineeringJiaxing UniversityJiaxing 314001China Col.ege of Material. and Textil. Engineering Jiaxing UniversityJiaxing 314001China Col.ege of Advanced Material. Engineering Jiaxing Nanhu UniversityJiaxing 314001China

Carbon nanotubes(CNTs)have garnered significant attention in the fiel.s of science,engineering,and medicine due to their numerous *** initial.step towards harnessing the potential.of CNTs invol.es their macroscopic *** present study.empl.y.d a gentl. and direct sel.-assembl. technique,wherein control.ed growth of CNT sheaths occurred on the metal.wire’s surface,fol.owed by.etching of the remaining metal.to obtain the hol.ow tubes composed of *** control.ing the growth time and temperature,it is possibl. to al.er the thickness of the CNTs *** immersing in a sol.tion containing 1 g/l.of CNTs at 60℃for 24 h,the resul.ing CNTs l.y.r achieved a thickness of up to 60μ*** hol.ow CNTs tubes with vary.ng inner diameters were prepared through surface reinforcement using pol.mers and sacrificing metal.wires,thereby.exhibiting exceptional.attributes such as robustness,fl.xibil.ty.air tightness,and high adsorption capacity.that effectivel. capture CO_(2) from the gas mixture.

关键词： carbon nanotubes sel.-assembl. hol.ow tubes CO_(2)capture

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