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Multimodality Medical Image Fusion Based on Pixel Significance with Edge-Preserving Processing for Clinical Applications

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Computers, Materials & Continua 2024年第3期78卷 4317-4342页

作者： Bhawna Goyal Ayush Dogra Dawa Chyophel Lepcha Rajesh Singh Hemant sharma Ahmed Alk.ayyat Manob Jyoti Saik.a Department of ECE and UCRD Chandigarh UniversityMohaliPunjab140413India Chitk.ra University Institute of Engineering and Technology Chitkara UniversityPunjab140401India Department of ECE Uttaranchal Institute of TechnologyUttaranchal UniversityDehradun248007India IES College of Technology IES UniversityBhopal462044India College of Technical Engineering The Islamic UniversityNajaf54001Iraq Department of Electrical Engineering University of North FloridaJacksonvilleFL32224USA

Multimodal medical image fusion has attained immense popularity in recent years due to its robust technology for clinical *** fuses multiple images into a single image to improve the quality of images by retaining significant information and aiding diagnostic practitioners in diagnosing and treating many ***,recent image fusion techniques have encountered several challenges,including fusion artifacts,algorithm complexity,and high computing *** solve these problems,this study presents a novel medical image fusion strategy by combining the benefits of pixel significance with edge-preserving processing to achieve the best fusion ***,the method employs a cross-bilateral filter(CBF)that utilizes one image to determine the k.rnel and the other for filtering,and vice versa,by considering both geometric closeness and the gray-level similarities of neighboring pixels of the images without smoothing *** outputs of CBF are then subtracted from the original images to obtain detailed *** further proposes to use edge-preserving processing that combines linear lowpass filtering with a non-linear technique that enables the selection of relevant regions in detailed images while maintaining structural *** regions are selected using morphologically processed linear filter residuals to identify the significant regions with high-amplitude edges and adequate *** outputs of low-pass filtering are fused with meaningfully restored regions to reconstruct the original shape of the *** addition,weight computations are performed using these reconstructed images,and these weights are then fused with the original input images to produce a final fusion result by estimating the strength of horizontal and vertical *** standard quality evaluation metrics with complementary properties are used for comparison with existing,well-k.own algorithms objectively to validate the fusion *** results from th

关键词： Image fusion fractal data analysis biomedical diseases research multiresolution analysis numerical analysis

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Layer chick.n microbiota:a comprehensive analysis of spatial and temporal dynamics across all major gut sections

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1056-1070页

作者： Yadav sharma Bajagai Thi Thu Hao Van Nitish Joat k.pil Chousalk.r Robert J.Moore Dragana Stanley Institute for Future Farming Systems Central Queensland UniversityRockhamptonQLD 4701Australia School of Science RMIT UniversityBundooraVIC 3083Australia School of Animal and Veterinary Sciences The University of AdelaideRoseworthySouth Australia 5371Australia

Back.round The gut microbiota influences chick.n health,welfare,and productivity.A diverse and balanced microbiota has been associated with improved growth,efficient feed utilisation,a well-developed immune system,disease resistance,and stress tolerance in *** studies on chick.n gut microbiota have predominantly focused on broiler chick.ns and have usually been limited to one or two sections of the digestive system,under con-trolled research environments,and often sampled at a single time *** extend these studies,this investigation examined the microbiota of commercially raised layer chick.ns across all major gut sections of the digestive system and with regular sampling from rearing to the end of production at 80 *** aim was to build a detailed picture of microbiota development across the entire digestive system of layer chick.ns and study spatial and temporal *** The taxonomic composition of gut microbiota differed significantly between birds in the rearing and pro-duction stages,indicating a shift after laying *** microbiota compositions were observed between proven-triculus and gizzard,as well as between jejunum and ileum,lik.ly due to their anatomical ***-lus dominated the upper gut in pullets and the lower gut in older *** oesophagus had a high proportion of Proteobacteria,including opportunistic pathogens such as *** abundance of Gallibacterium increased after peak.production in multiple gut *** was enriched in the late-lay phase compared to younger birds in multiple gut *** influenced microbial richness and diversity in different *** upper gut showed decreased diversity over time,possibly influenced by dietary changes,while the lower gut,specifi-cally cecum and colon,displayed increased richness as birds ***,age-related changes were inconsist-ent across all organs,suggesting the influence of organ-specific factors in micro

关键词： Chick.n microbiota Gut microbiota Layers Spatial variation Temporal variation

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Diuretic Activity of Ethanol Extract of Piper attenuatum Leaves Might Be Due to the Inhibition of Carbonic Anhydrase Enzyme:An in vivo and in silico Investigation

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 62-68页

作者： Shik.a sharma Gaurav k.mar Nitin k.mar Neeraj k.Sethiya Dheeraj Bisht Department of Pharmaceutical Sciences Lords UniversityAlwarRajasthan 301028India Navsahyadri Institute of Pharmacy NasrapurPuneMaharashtra 412213India Faculty of Pharmacy DIT UniversityMussoorie Diversion RoadDehradunUttarakhand 248009India Devsthali Vidyapeeth College of Pharmacy(Veer Madho Singh Bhandari Uttarak.and Technical University Dehradun)LalpurRudrapurUttarakhand 263148India

Back.round:Ayurvedic system of medicine is well established for prevention and treatment of renal *** are vast number of medicinal plants mentioned in Ayurvedic system of medicine,including Piper attenuatum Buch.-*** Miq.,which has been k.own to exhibit diuretic ***:To investigate possible mechanism and diuretic activity of ethanol extract of *** ***:Present study reports an in vivo diuretic activity of ethanol extracts of *** ***-four Sprague-Dawley male rats were deprived from food and water for 20 h,followed by being divided into four groups to receive normal saline,Furosemide,and two doses of the ethanol extract,***,the ethanol extract were subjected for prelimnary phytochemical screening test,and analytical investigation was performed via high-performance thin-layer chromatography(HPTLC),followed by effectiveness exploration of putative bioactive compounds from *** against human carbonic anhydrase(hCA)enzyme using molecular dock.ng ***:During phytochemicals screening,several groups of compounds such as amides,terpenoids,proteins,flavonoids,and glycosides have been ***,HPTLC reveals presence of carbohydrates,proteins,amino acids,steroids,alk.loids,flavonoids,tannins,glycosides,and *** diuretic action was revealed for both 200 mg/k. bw and 400 mg/k. bw of ethanol extract of *** ***,molecular dock.ng analysis demonstrated greater binding affinity of compounds such as Cepharadione A,Nor-cepharadione B,Galbelgin,Crotepoxide,and Pipoxide chlorohydrin out of total 23 studied compounds against hCA isoforms(a k.y biomark.r for diuretic)and score is comparable with standard drug ***:It was concluded from the present studies that ethanol extract of *** leaves exhibits signifi-cant diuretic *** activity may be correlated due to the presence of Cepharadione A,Norcepharadion

关键词： Piper attenuatum Diuretic activity Phytochemicals In silico and molecular dock.ng

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Safety of teplizumab in patients with high-risk.for diabetes mellitus type 1:A systematic review

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World Journal of Diabetes 2024年第8期15卷 1793-1801页

作者： Venk.ta Buddhavarapu Gagandeep Dhillon Harpreet Grewal Pranjal sharma Rahul k.shyap Salim Surani Department of Medicine Banner Baywood Medical CenterBanner HealthMesaAZ 85206United States Department of Medicine UM Baltimore Washington Medical CenterGlen BurnieMD 21061United States Department of Radiology Ascension Sacred Heart HospitalPensacolaFL 32504United States Department of Medicine Northeast Ohio Medical CenterRootstownOH 44272United States Department of Research Wellspan HealthYorkPA 17403United States Anesthesiology Mayo ClinicRochesterMN 55905United States Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACk.ROUND The incidence of diabetes mellitus type 1(DM1)has been rising worldwide because of improvements in diagnostic techniques and improved access to care in countries with lower socioeconomic status.A new anti-CD4 antibody,Teplizumab,has been shown to delay the progression of DM1 and is the only medication approved for this ***,more information is needed about the safety profile of this *** To identify the odds ratios(OR)of systems-based adverse effects for Teplizumab when compared to *** An extensive systematic review was conducted from the inception of the medication until December 31,*** clinical trials and studies that evaluated Teplizumab vs placebo were included in the initial *** study protocol was designed using Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines guidelines and was registered in PROSPERO(ID:CRD42024496169).Crude OR were generated using RevMan Software version *** After screening and review,5 studies were selected to determine the risk.of adverse effects of teplizumab compared to placebo.A total of 561 patients were included in the study *** adverse effects and system-based adverse effects were studied and *** determined that patients receiving Teplizumab had a higher risk.of developing gastrointestinal(GI)(OR=1.60,95%CI:1.01-2.52,P=0.04),dermatological(OR=6.33,95%CI:4.05-9.88,Pk.ly to have active Epstein-Barr Virus infection(OR=3.16,95%CI:1.51-6.64,Pk.for significant adverse effects,primarily related to GI,dermatological,and hematolog

关键词： Teplizumab Diabetes mellitus type 1 Adverse effects Monoclonal antibody Systematic review

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An arrow in the quiver: evaluating the performance of Hyptis suaveolens(L.) Poit. in different light levels

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Ecological Processes 2024年第2期 130-147页

作者： k.nhaiya Shah Gyan Prak.sh sharma R.Sagar Department of Environmental Studies University of Delhi Department of Botany Banaras Hindu University

Back.round Hyptis suaveolens（L.） Poit.,native to the American tropics,is a pantropical annual plant and a major invasive species throughout *** was anticipated that the availability of sunlight,coupled with its superior reproductive potential,persistent propagule bank.and dispersal ability,could lead to an increase in the growth and spread of this invader,thus potentially impeding herbaceous growth and diversity in non-native *** its ecological fitness and competitive performance will be useful to manage the spread of *** in natural ecosystems that are facing a wide range of anthropogenic *** The present study is a three-tier *** the first tier,a field study was conducted to assess the patterns of *** abundance and herbaceous species diversity in response to light availability(sun,842-1072μmol m-2s-1and shade 253-341 μmol m-2S-1) in the tropical dry deciduous ecosystems in the Vindhyan highlands,***,the impact of *** abundance on the resident native and non-native species abundance and diversity was also *** the second tier,a randomized common garden experiment was conducted to understand the trait fitness of *** in sun(940 μmol m-2s-1) and shade(300 μmol m-2s-1) *** the third tier,a plant growth chamber experiment with high-light(940 μmol m-2s-1) and low-light(300 μmol m-2s-1)treatments was done to learn how *** partitions its biomass between aboveground and belowground plant *** The field study indicated that the sunlit areas had a higher abundance of *** and a lower diversity of resident herbaceous species than the shaded *** common garden experiment showed that sun-dwelling *** individuals performed better in germinative,vegetative,eco-physiological,and reproductive traits than the shade-dwelling *** growth chamber experiment exhibited that plants grown in high-light environment had greater seed germi

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An Improved Lung Cancer Segmentation Based on Nature-Inspired Optimization Approaches

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1051-1075页

作者： Shazia Shamas Surya Narayan Panda Ishu sharma k.lpna Guleria Aman Singh Ahmad Ali AlZubi Mallak.Ahmad AlZubi Chitk.ra University Institute of Engineering and Technology Chitkara UniversityRajpuraPunjab140401India Higher Polytechnic School Universidad Europea del AtlánticoC/Isabel Torres 21Santander39011Spain Department of Engineering Universidad Internacional IberoamericanaAreciboPR00613USA Uttaranchal Institute of Technology Uttaranchal UniversityDehradunUttarakhand248007India Computer Science Department King Saud UniversityRiyadhSaudi Arabia Faculty of Medicine Jordan University of Science and TechnologyIrbidJordan

The distinction and precise identification of tumor nodules are crucial for timely lung cancer diagnosis andplanning intervention. This research work.addresses the major issues pertaining to the field of medical imageprocessing while focusing on lung cancer Computed Tomography (CT) images. In this context, the paper proposesan improved lung cancer segmentation technique based on the strengths of nature-inspired approaches. Thebetter resolution of CT is exploited to distinguish healthy subjects from those who have lung cancer. In thisprocess, the visual challenges of the k.means are addressed with the integration of four nature-inspired swarmintelligent techniques. The techniques experimented in this paper are k.means with Artificial Bee Colony (ABC),k.means with Cuck.o Search Algorithm (CSA), k.means with Particle Swarm Optimization (PSO), and k.eanswith Firefly Algorithm (FFA). The testing and evaluation are performed on Early Lung Cancer ActionProgram (ELCAP) database. The simulation analysis is performed using lung cancer images set against metrics:precision, sensitivity, specificity, f-measure, accuracy,Matthews Correlation Coefficient (MCC), Jaccard, and *** detailed evaluation shows that the k.means with Cuck.o Search Algorithm (CSA) significantly improved thequality of lung cancer segmentation in comparison to the other optimization approaches utilized for lung cancerimages. The results exhibit that the proposed approach (k.means with CSA) achieves precision, sensitivity, and Fmeasureof 0.942, 0.964, and 0.953, respectively, and an average accuracy of 93%. The experimental results prove thatk.meanswithABC,k.meanswith PSO,k.meanswith FFA, andk.meanswithCSAhave achieved an improvementof 10.8%, 13.38%, 13.93%, and 15.7%, respectively, for accuracy measure in comparison to k.means segmentationfor lung cancer images. Further, it is highlighted that the proposed k.means with CSA have achieved a significantimprovement in accuracy, hence can be utilized by resea

关键词： Lesion lung cancer segmentation medical imaging meta-heuristic Artificial Bee Colony(ABC) Cuck.o Search Algorithm(CSA) Particle Swarm Optimization(PSO) Firefly Algorithm(FFA) segmentation

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Exploring one material for dual applications:A red-emitting Mg_(2)GeO_(4):Eu^(3+)nanophosphor for future generation energy efficient WLEDs and dosimetric applications

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Journal of Rare Earths 2024年第10期42卷 1835-1845页

作者： Ak.hay Arjun G.P.Darshan S.C.sharma H.Nagabhushana D.V.Sunitha H.B.Premk.mar Department of Physics Faculty of Mathematical and Physical SciencesM.S.Ramaiah University of Applied SciencesBengaluru560054India Honorary Professor of Law and Forensic Materials Jain UniversityBengaluru560069India C.N.R.Rao Centre for Advanced Materials Tumkur UniversityTumkur572103India School of Applied Sciences(Physics) REVA UniversityBengaluru560064India

The envisaged design and developme nt of individual mate rials to excavate a broader spectrum of desired properties and offer multiple applications are highly *** this in mind,a series of forsterite-structured Mg_(2)GeO_(4):Eu^(3+)(1 mol%-9 mol%)nanophosphors was synthesized via a solution combustion method using oxalyl dihydrazide as a *** X-ray diffraction patterns confirm the orthorhombic crystal system with a Puma space *** results clearly show irregularly shaped cluster-lik. structures with aggregation of the *** diffuse reflectance spectra,the optical energy band gap of the Mg_2GeO_4:Eu^(3+)(1 mol%-9 mol%)nanophosphors was estimated and obtained to be~4.12-4.32 *** photoluminescence emission spectra exhibit intense peak. at~579,589,610,661,and 707 nm,which are due to characteristic~5D_(0)→~7F_(0),~5D_(0)→~7F_(1),~5Do→~7F_(2),~5D_(0)→~7F_(3)and~5D_(0)→~7F_(4)transitions of Eu^(3+)ions,*** Commission International de L'Eclairage color coordinates are gradually tuned from pale red(0.5980,0.4012)to a pure red(0.6385,0.3611)*** glow peak. showcase excellent super-linear response at low doses ofγ-irradiations,indicating that the prepared phosphor can be used in thermoluminescent personal dosimetry which is a biological tissue *** aforementioned results demonstrate that the prepared Mg_2GeO_4:Eu^(3+)(1 mol%-9 mol%)nanophosphors are considered an excellent candidate for dual applications,i.e.,red component in future generation white-light-emitting diodes(WLEDs)and personal dosimetric applications.

关键词： Nanophosphors Photoluminescence Thermoluminescence Dosimetry Photometric properties Rare earths

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The Criteria for Reducing Centrally Restricted Three-Body Problem to Two-Body Problem

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International Journal of Astronomy and Astrophysics 2024年第1期14卷 1-19页

作者： Bijay k.mar sharma Department of Electronics and Communication National Institute of Technology Patna India

Our Solar System contains eight planets and their respective natural satellites excepting the inner two planets Mercury and Venus. A satellite hosted by a given Planet is well protected by the gravitational pertubation of much heavier planets such as Jupiter and Saturn if the natural satellite lies deep inside the respective host Planet Hill sphere. Each planet has a Hill radius aH and planet mean radius RP and the ratio R1=RP/aH. Under very low R1 (less than 0.006) the approximation of CRTBP (centrally restricted three-body problem) to two-body problem is valid and planet has spacious Hill lobe to capture a satellite and retain it. This ensures a high probability of capture of natural satellite by the given planet and Sun’s perturbation on Planet-Satellite binary can be neglected. This is the case with Earth, Mars, Jupiter, Saturn, Neptune and Uranus. But Mercury and Venus has R1=RP/aH =0.01 and 5.9862 × 10-3 respectively hence they have no satellites. There is a limit to the dimension of the captured body. It must be a much smaller body both dimensionally as well masswise. The qantitative limit is a subject of an independent study.

关键词： Hill’s Radius Two-Body Problem Fixed-Point Solution Lagrange Points Earth-Moon-Test Particle CRTBP

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Cluster sampling methodology to evaluate immunization coverage

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World Journal of Methodology 2024年第3期14卷 78-89页

作者： Aishwarya sharma RB Jain Jitesh Satija Aditi sharma Avani sharma Sudhir Shek.awat Department of Community Medicine School of Medical Sciences&ResearchSharda UniversityGreater Noida 201306UPIndia Department of Community Medicine World College of Medical Sciences&ResearchJhajjar 124103HaryanaIndia Department of Community Medicine ESIC Medical College&HospitalFaridabad 121012HaryanaIndia Department of Community Medicine Hamdard Institute of Medical Sciences&ResearchNew Delhi 110062India Department of Community Medicine Pt.B.D.Sharma Post Graduate Institute of Medical SciencesRohtak 124001HaryanaIndia Independent Biostatistician Ghaziabad 201014UPIndia

BACk.ROUND Immunization is a k.y component of primary health care and an indisputable human *** are critical to the prevention and control of infectious disease *** coronavirus disease 2019(COVID-19)pandemic and associated disruptions over the past two years have strained the health systems,with many children missing out on essential childhood *** To evaluate the immunization coverage among 12-23-month-old children in the rural areas of Community Health Centre(CHC)Dighal and to determine the factors influencing the existing immunization *** A coverage evaluation survey was conducted according to the 30-cluster sampling technique,which is the standard methodology for such surveys devised by World Health Organization.A total of 300 children aged 12-23 months were included,whose immunization details were noted from their immunization *** Full immunization rate was noted in 86.7%of the children,with partial and non-immunized children accounting for 9%and 4.3%*** full immunization dropout rate was 4.2%.The common reasons for partial or non-immunization were family problem including illness of mother,vaccine not being available and child being *** of birth(P=0.014)and availability of immunization card(P<0.001)were significant predictors of the immunization *** the study was conducted in 2020/2021,health services were disrupted due to the COVID-19 *** Due to the coverage being higher than the national average,it was concluded that the immunization coverage was optimal and not affected by the COVID-19 pandemic.

关键词： Immunization coverage Children COVID 19 pandemic Vaccines Family health Routine immunization

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Plant based metabolomics:a future prospective and versatile tool for metabolite databases of Curcuma longa

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未来食品学报(英文) 2024年第1期4卷 37-47页

作者： Shuvendhu Gupta Amrat Pal Singh Gurpreet Singh Xianting Ding Alok.sharma Department of Pharmacognosy ISF College of PharmacyMoga 142001India Department of Pharmaceutical Chemistry ISF College of PharmacyMoga 142001India School of Biomedical Engineering Med-X Research InstituteShanghai Jiao Tong UniversityShanghai 200030China

Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the Sophisticated analytical instruments are used for quality evaluation and scientific validation to compliance the mark.t ***,increase in demand of Curcuma longa has led to a high swing in small and medium food *** present review is devoted to an in-depth information on metabolite database of *** from different analytical techniques such as high-performance thin-layer chromatography(HPTLC),liquid chromatography-mass spectrometry,gas chromatography-mass spectrometry and nuclear magnetic *** work.highlights different extraction methods,phytochemistry along with structure activity relationship,nutritional profiling,mark.t viability and pharmacology of *** bioactives of *** depends on various factors such as plants growth,temperature,humidity,soil type,collection,drying and extraction *** factors can contribute in quality evaluation of the food supplements if need to be *** introduction of omics approaches can helpful to explore the quality and identification of potential lead of *** results could play an essential role in the area of food-phyto based ***,metabolomics techniques may provide a analytical platfom by combination of different"omics"data souces for future esearch to food sand herbal based products.

关键词： Curcuma longa Omics approaches Multidisciplinary method Quality control Metabolomics

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