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Dissecting novel mechanisms of hepatitis B virus related hepatocellular carcinoma using meta-analysis of public data

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1856-1873页

作者： Jihad Aljabban Michael Rohr Saad syed Eli Cohen Naima Hashi sharjeel syed Kamal Khorfan Hisham Aljabban Vincent Borkowski Michael Segal Mohamed Mukhtar Mohammed Mohammed Emmanuel Boateng Mary Nemer Maryam Panahiazar Dexter Hadley Sajid Jalil Khalid Mumtaz Department of Medicine University of Wisconsin Hospital and ClinicsMadisonWI 53792United States Department of Medicine University of Central Florida College of MedicineOrlandoFL 32827United States Department of Medicine Northwestern Memorial HospitalChicagoIL 60611United States Department of Medicine Vanderbilt Medical CenterNashvilleTN 37232United States Department of Medicine Mayo ClinicRochesterMN 55905United States Department of Medicine University of Chicago HospitalsChicagoIL 60637United States Department of Gastroenterology and Hepatology University of California San Francisco-FresnoFresnoCA 93701United States Department of Medicine Barry UniversityMiamiFL 33161United States Department of Medicine Michigan State University College of Human MedicineLansingMI 49503United States Department of Medicine Windsor University School of MedicineFrankfortIL 60423United States Department of Surgery University of California San FranciscoSan FranciscoCA 94143United States Department of Pathology University of Central Florida College of MedicineOrlandoFL 32827United States Department of Gastroenterology and Hepatology Ohio State University Wexner Medical CenterColumbusOH 43210United States

BACKGROUND Hepatitis B virus(HBV) is a cause of hepatocellular carcinoma(HCC). Interestingly, this process is not necessarily mediated through cirrhosis and may in fact involve oncogenic processes. Prior studies have suggested specific oncogenic gene expression pathways were affected by viral regulatory proteins. Thus, identifying these genes and associated pathways could highlight predictive factors for HCC transformation and has implications in early diagnosis and *** To elucidate HBV oncogenesis in HCC and identify potential therapeutic *** We employed our Search, Tag, Analyze, Resource platform to conduct a meta-analysis of public data from National Center for Biotechnology Information’s Gene Expression Omnibus. We performed meta-analysis consisting of 155 tumor samples compared against 185 adjacent nontumor samples and analyzed results with ingenuity pathway *** Our analysis revealed liver X receptors/retinoid X receptor(RXR) activation and farnesoid X receptor/RXR activation as top canonical pathways amongst others. Top upstream regulators identified included the Ras family gene rab-like protein 6(RABL6). The role of RABL6 in oncogenesis is beginning to unfold but its specific role in HBV-related HCC remains undefined. Our causal analysis suggests RABL6 mediates pathogenesis of HBV-related HCC through promotion of genes related to cell division, epigenetic regulation, and Akt signaling. We conducted survival analysis that demonstrated increased mortality with higher RABL6 expression. Additionally, homeobox A10(HOXA10) was a top upstream regulator and was strongly upregulated in our analysis. HOXA10 has recently been demonstrated to contribute to HCC pathogenesis in vitro. Our causal analysis suggests an in vivo role through downregulation of tumor suppressors and other *** This meta-analysis describes possible roles of RABL6 and HOXA10 in the pathogenesis of HBV-related HCC. RABL6 and HOXA10 represent potent

关键词： Hepatitis B virus Hepatocellular carcinoma Genomics Meta-analysis

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Drug eluting biliary stents to decrease stent failure rates:Areview of the literature

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World Journal of Gastrointestinal Endoscopy 2016年第2期8卷 77-85页

作者： Joseph Shatzel Jisoo Kim Kartik Sampath sharjeel syed Jennifer Saad Zilla H Hussain Kabir Mody J Marc Pipas Stuart Gordon Timothy Gardner Richard I Rothstein Section of Hematology-Oncology Dartmouth Hitchcock Medical CenterLebanonNH 03756United States Geisel School of Medicine at Dartmouth HanoverNH 03755United States Section of Gastroenterology Dartmouth Hitchcock Medical CenterLebanonNH 03756United States Section of Internal Medicine Dartmouth Hitchcock Medical CenterLebanonNH 03756United States Mayo Clinic Cancer Center Section of Hematology/OncologyMayo Clinic FloridaJacksonvilleFL 32224United States

Biliary stenting is clinically effective in relieving both malignant and non-malignant obstructions. However, there are high failure rates associated with tumor ingrowth and epithelial overgrowth as well as internally from biofilm development and subsequent clogging. Within the last decade, the use of prophylactic drug eluting stents as a means to reduce stent failure has been investigated. In this review we provide an overview of the current research on drug eluting biliary stents. While there is limited human trial data regarding the clinical benefit of drug eluting biliary stents in preventing stent obstruction, recent research suggests promise regarding their safety and potential efficacy.

关键词： Bile ducts Cholangiocarcinoma Endoscopy Pancreas

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