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Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease

World Journal of Gastroenterology 2015年第4期21卷 1189-1196页

作者： Christopher Leung Sern Wei Yeoh Desmond Patrick shara ket Kaye Marion Paul Gow Peter W Angus Liver Transplant Unit Austin HospitalHeidelbergVictoria 3084Australia Department of Medicine The University of MelbourneAustin CampusHeidelbergVictoria 3084Australia Statistics and Operations Research Group School of Mathematical and Geospatial Sciences College of ScienceEngineering and HealthRMIT UniversityMelbourneVictoria 3000Australia

AIM: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).METHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BMI), and the presence of diabetes, hypertension, or ***: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of < 25 kg/m2, 25-29 kg/m2 and ≥ 30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of ***: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis.

关键词： Hepatocellular carcinoma Non-alcoholic fatty liver

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