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In situ injectable hydrogel encapsulating Mn/NO-based immune nano-activator for prevention of postoperative tumor recurrence

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Asian Journal of Pharmaceutical Sciences 2024年第2期19卷 102-119页

作者： Shengnan Huang Chenyang Zhou Chengzhi Song Xiali Zhu Mingsan Miao Chunming Li shaofeng duan Yurong Hu Academy of Chinese Medical Sciences Henan University of Chinese MedicineZhengzhou 450046China School of Pharmaceutical Sciences Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical DiseasesZhengzhou UniversityZhengzhou 450001China Center for Quantitative Biology Peking UniversityBeijing 100871China School of Pharmaceutical Sciences Henan University of Chinese MedicineZhengzhou 450046China Department of Pharmacy Chongqing University Cancer HospitalChongqing 400030China School of Pharmaceutical Sciences Henan UniversityZhengzhou 450046China

Postoperative tumor recurrence remains a predominant cause of treatment failure. In this study, we developed an in situ injectable hydrogel, termed MPB-NO@DOX + ATRA gel, which was locally formed within the tumor resection cavity. The MPB-NO@DOX + ATRA gel was fabricated by mixing a thrombin solution, a fibrinogen solution containing all-trans retinoic acid (ATRA), and a Mn/NO-based immune nano-activator termed MPB-NO@DOX. ATRA promoted the differentiation of cancer stem cells, inhibited cancer cell migration, and affected the polarization of tumor-associated macrophages. The outer MnO2 shell disintegrated due to its reaction with glutathione and hydrogen peroxide in the cytoplasm to release Mn2+ and produce O2, resulting in the release of doxorubicin (DOX). The released DOX entered the nucleus and destroyed DNA, and the fragmented DNA cooperated with Mn2+ to activate the cGAS-STING pathway and stimulate an anti-tumor immune response. In addition, when MPB-NO@DOX was exposed to 808 nm laser irradiation, the Fe-NO bond was broken to release NO, which downregulated the expression of PD-L1 on the surface of tumor cells and reversed the immunosuppressive tumor microenvironment. In conclusion, the MPB-NO@DOX + ATRA gel exhibited excellent anti-tumor efficacy. The results of this study demonstrated the great potential of in situ injectable hydrogels in preventing postoperative tumor recurrence.

关键词： Post-sur gical tumor recurrence In situl hydrogel Immunotherapy Tumor micr oenvir onment Manganese(Ⅱ) Nitic oxide

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Biosynthetic pathway of prescription cucurbitacin IIa and high-level production of key triterpenoid intermediates in engineered yeast and tobacco

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Plant Communications 2024年第6期5卷 154-172页

作者： Geng Chen Zhaokuan Guo Yanyu Shu Yan Zhao Lei Qiu shaofeng duan Yuan Lin Simei He Xiaobo Li Xiaolin Feng Guisheng Xiang Bo Nian Yina Wang Zhiyuan Li Chongkang Yang Yang Shi Yingchun Lu Guanze Liu Shengchao Yang Guanghui Zhang Bing Hao State Key Laboratory of Conservation and Utilization of Bio-resources in Yunnan The Key Laboratory of Medicinal Plant Biology of Yunnan ProvinceNational&Local Joint Engineering Research Center on Germplasms Innovation&Utilization of Chinese Medicinal Materials in Southwest ChinaYunnan Agricultural UniversityKunming 650201China Yunnan Characteristic Plant Extraction Laboratory KunmingYunnan 650106China

Cucurbitacin IIa is a triterpenoid isolated exclusively from Hemsleya plants and a non-steroidal anti-inflammatory drug that functions as the main ingredient of prescription Hemslecin capsules and tablets in *** biology provides new strategies for production of such valuable cucurbitacins at a large scale;however,the biosynthetic pathway of cucurbitacin IIa has been unknown,and the heterologous production of cucurbitacins in galactose medium has been expensive and low *** this study,we characterized the functions of genes encoding two squalene epoxidases(HcSE1-2),six oxidosqualene cyclases(HcOSC1-6),two CYP450s(HcCYP87D20 and HcCYP81Q59),and an acyltransferase(HcAT1)in cucurbitacin IIa biosynthesis by heterologous expression in Saccharomyces cerevisiae and Nicotiana *** achieved high-level production of the key cucurbitacin precursor 11-carbonyl-20b-hydroxy-Cuol from glucose in yeast via modular engineering of the mevalonate pathway and optimization of P450 expression *** resulting yields of 46.41 mg/l 11-carbonyl-20b-hydroxy-Cuol and 126.47 mg/l total cucurbitacin triterpenoids in shake flasks are the highest yields yet reported from engineered ***,production of 11-carbonyl-20b-hydroxy-Cuol by transient gene expression in tobacco resulted in yields of 1.28 mg/g dry weight in *** work reveals the key genes involved in biosynthesis of prescription cucurbitacin IIa and demonstrates that engineered yeast cultivated with glucose can produce high yields of key triterpenoid *** describe a low-cost and highly efficient platform for rapid screening of candidate genes and high-yield production of pharmacological triterpenoids.

关键词： cucurbitacin IIa oxidosqualene cyclase OSC 11-carbonyl-20b-hydroxy-Cuol Saccharomyces cerevisiae Nicotiana benthamiana Hemsleya chinensis

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基于定量磁敏感图的纹理分析对帕金森病的诊断价值

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中国医学影像学杂志 2024年第1期32卷 48-53页

作者：顾惠芳孟宪平王旭段绍峰南通大学附属江阴医院放射科江苏江阴214400 GE医疗(中国) 上海210000

目的通过定量磁敏感图(QSM)序列分析大脑灰质核团和脑白质的纹理特征,探讨纹理分析在帕金森病(PD)的诊断及病程评估方面的价值。资料与方法前瞻性纳入2019年7月—2020年11月于南通大学附属江阴医院ESWAN序列扫描的30例PD患者与22例正常... 详细信息

目的通过定量磁敏感图(QSM)序列分析大脑灰质核团和脑白质的纹理特征,探讨纹理分析在帕金森病(PD)的诊断及病程评估方面的价值。资料与方法前瞻性纳入2019年7月—2020年11月于南通大学附属江阴医院ESWAN序列扫描的30例PD患者与22例正常对照者,通过后处理得到两组的QSM图,手动获取双侧尾状核头、苍白球、壳核、黑质、红核、小脑齿状核及半卵圆中心白质的感兴趣区并提取纹理特征,对其降维筛选后得到一组最佳纹理特征构建随机森林预测模型。对模型的诊断效能及可靠性进行评价,并对筛选出的纹理特征与PD患者的临床量表进行相关性分析。结果QSM图得到一组(5个)最佳纹理特征参数,各参数独立预测PD的曲线下面积为0.697~0.823,随机森林模型的曲线下面积为0.910,交叉验证的准确度为0.888。PD组的纹理特征r4_wavelet_LLL_firstorder_Energy与简易精神状态评价量表评分呈负相关(r=0.470,P=0.011)。结论基于QSM的纹理分析对PD有较高的诊断价值,左侧壳核的纹理特征与PD患者的认知功能有一定的相关性。

关键词：帕金森病磁共振成像定量磁敏感图纹理分析随机森林模型

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超高强度钢板精准折弯成型工艺技术研究

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新技术新工艺 2024年第2期434卷 68-74页

作者：段绍锋孔进陈仕勇李笛申陆军装备部驻重庆地区军事代表局驻重庆地区第六军事代表室重庆400042

为解决特种车辆车体制造时超高强度钢板折弯成型存在的回弹、开裂、尺寸精度差以及成型不一致等问题,通过拉伸-压缩试验、缺口拉伸断裂试验等材料性能试验获取了材料力学性能数据,标定了材料本构模型参数,构建了超高强度钢板材料参数数... 详细信息

为解决特种车辆车体制造时超高强度钢板折弯成型存在的回弹、开裂、尺寸精度差以及成型不一致等问题,通过拉伸-压缩试验、缺口拉伸断裂试验等材料性能试验获取了材料力学性能数据,标定了材料本构模型参数,构建了超高强度钢板材料参数数据库和折弯成型数值模拟仿真平台,结合有限元模拟平台实现了不同凸模压下量对超高强钢V型自由折弯成形、回弹过程以及断裂的仿真预测,通过现场实物生产对比仿真验证的模拟结果可知,数值模拟与实物的吻合度达到90%以上,验证了有限元模拟结果的有效性和准确性,为企业提高生产效率提供了依据。

关键词：超高强度钢板 V型折弯回弹折弯成型数值模拟仿真平台

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Factors affecting the voxel-based analysis of diffusion tensor imaging

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Chinese Science Bulletin 2014年第31期59卷 4077-4085页

作者： Jianli Wang Binbin Nie Haitao Zhu Hua Liu Jingjuan Wang shaofeng duan Baoci Shan Key Laboratory of Nuclear Radiation and Nuclear Energy Technology Institute of High Energy PhysicsChinese Academy of Sciences Beijing Engineering Research Center of Radiographic Techniques and Equipment

Diffusion tensor imaging(DTI)provides a unique method to reveal the integrity of white matter microstructure ***-based analysis(VBA),which is a highly reproducible and user-independent technique,has been used to analyze DTI data in a number of *** anisotropy(FA),which is derived from DTI,is the most frequently used *** parameter setting during the DTI data preprocessing might affect the FA analysis ***,there is no reliable evidence on how the parameters affect the results of FA *** study sought to quantitatively investigate the factors that might affect the voxel-based analysis of FA;these include the interpolation during spatial normalization,smoothing kernel and statistical *** it is difficult to obtain the true information of the lesion in the patients,we simulated lesions on the healthy FA *** DTI data were obtained from 20 healthy *** FA maps were calculated using *** randomly divided these FA maps into two *** was used as a model patient group,and the other was used as a normal control *** lesions were added to the model patient group by decreasing the FA intensities in a specified region by 5%–50%.The model patient group and the normal control group were compared by two-sample t test statistic analysis voxelby-voxel to detect the simulated *** evaluated these factors by comparing the difference between the detected lesion through VBA and the simulated *** result showed that the space normalization of FA image should use the trilinear interpolation,and the smoothing kernel should be 2–3 times the voxel size of spatially normalized FA *** lesions with small intensity change,FWE correction must be cautiously *** study provided an important reference to the analysis of FA with VBA method.

关键词：扩散张量体素成像三线性插值可能影响统计分析结构完整性预处理过程

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Facile preparation of nano-g-C_(3)N_(4)/UiO-66-NH_(2) composite as sorbent for high-efficient extraction and preconcentration of food colorants prior to HPLC analysis

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Chinese Chemical Letters 2022年第2期33卷 903-906页

作者： Xiaowan Zhang Yixin Yang Peige Qin Lizhen Han Wenli Zhu shaofeng duan Minghua Lu Zongwei Cai Henan International Joint Laboratory of Medicinal Plants Utilization School of Chemistry and Chemical EngineeringHenan UniversityKaifeng 475004China Institute for Innovative Drug Design and Evaluation School of PharmacyHenan UniversityKaifeng 475004China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong KongChina

In this work,the nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite was prepared by one-step solvothermal *** as-prepared composite was characterized by scanning electron microscopy,Brunner-Emmet-Teller measurement,energy dispersive spectrometer,X-ray diffraction,and Fourier transform infrared *** using nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite as sorbent,a dispersive solid-phase extraction coupled with high-performance liquid chromatography was developed to sensitive analysis of food colorants including tartrazine,amaranth,carmine,sunset yellow,allura red and bright *** experiment parameters including the amount of sorbent,adsorption time,the p H of adsorption solution,desorption time,desorption solvent,the p H of desorption solution as well as the proportion between desorption solvent and buffer solvent were *** the optimized conditions,the limits of detection(S/N=3) and limits of quantitation (S/N=10) were determined in the ranges of 0.08-0.8 and 0.2-2.0 ng/m L,*** the developed sample pretreatment method,carmine and brilliant blue were determined from blueberry juice by *** contents were calculated as 1.53μg/m L and0.17μg/mL,respectively.

关键词： Nano-g-C_(3)N_(4)/Ui O-66-NH_(2)composite Metal-organic frameworks Dispersive solid-phase extraction Sample pretreatment Food colorants Food additives High-performance liquid chromatography

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An Automatic Method for Generating an Unbiased Intensity Normalizing Factor in Positron Emission Tomography Image Analysis After Stroke

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Neuroscience Bulletin 2018年第5期34卷 833-841页

作者： Binbin Nie Shengxiang Liang Xiaofeng Jiang shaofeng duan Qi Huang Tianhao Zhang Panlong Li Hua Liu Baoci Shan Division of Nuclear Technology and Applications Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049 China Beijing Engineering Research Center of Radiographic Tech- niques and Equipment Beijing 100049 China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai 200031 China University of the Chinese Academy of Sciences Beijing 100049 China School of Public Health and Family Medicine Capital Medical University Beijing 100069 China Physical Science and Technology College Zhengzhou University Zhengzhou 450052 China

Positron emission tomography （PET） imaging of functional metabolism has been widely used to investigate functional recovery and to evaluate therapeutic efficacy after stroke. The voxel intensity of a PET image is the most important indicator of cellular activity, but is affected by other factors such as the basal metabolic ratio of each subject. In order to locate dysfunctional regions accurately, intensity normalization by a scale factor is a prerequisite in the data analysis, for which the global mean value is most widely used. However, this is unsuitable for stroke studies. Alternatively, a specified scale factor calculated from a reference region is also used, comprising neither hyper- nor hypo-metabolic voxels. But there is no such recognized reference region for stroke studies. Therefore, we proposed a totally data-driven automatic method for unbiased scale factor generation. This factor was generated iteratively until the residual deviation of two adjacent scale factors was reduced by 〈 5%. Moreover, both simulated and real stroke data were used for evaluation, and these suggested that our proposed unbiased scale factor has better sensi- tivity and accuracy for stroke studies.

关键词： Unbiased scale factor Intensity normaliza-tion Stroke FDG-PET imaging Voxel-wise analysis

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Optical manipulation of the topological phase in ZrTe_(5) revealed by time-and angle-resolved photoemission

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Chinese Physics B 2024年第1期33卷 170-175页

作者：黄超之徐骋洋朱锋锋段绍峰刘见喆顾凌霄王石崇刘浩然钱冬罗卫东张文涛 Key Laboratory of Artificial Structures and Quantum Control School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China

High-resolution time-and angle-resolved photoemission measurements were conducted on the topological insulator ZrTe_(5).With strong femtosecond photoexcitation,a possible ultrafast phase transition from a weak to a strong topological insulating phase was experimentally realized by recovering the energy gap inversion in a time scale that was shorter than 0.15 *** photoinduced transient strong topological phase can last longer than 2 ps at the highest excitation fluence studied,and it cannot be attributed to the photoinduced heating of electrons or modification of the conduction band ***,the measured unoccupied electronic states are consistent with the first-principles calculation based on experimental crystal lattice constants,which favor a strong topological insulating *** findings provide new insights into the longstanding controversy about the strong and weak topological properties in ZrTe_(5),and they suggest that many-body effects including electron–electron interactions must be taken into account to understand the equilibrium weak topological insulating phase in ZrTe_(5).

关键词： time-and angle-resolved photoemission spectroscopy electronic structure topological insulator

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Combined nanosuspensions from two natural active ingredients for cancer therapy with reduced side effects

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Chinese Chemical Letters 2021年第9期32卷 2877-2881页

作者： Yonghui Qiao Zhihao Wei Tingting Qin Rufeng Song Zhiqiang Yu Qi Yuan Juan Du Qingbing Zeng Lanlan Zong shaofeng duan Xiaohui Pu Henan University of Chinese Medicine Zhengzhou 450046China Institute of Pharmacy School of PharmacyHenan UniversityKaifeng 475004China School of Pharmaceutics Sciences Southern Medical UniversityGuangzhou 510515China Department of Pharmacy The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450003China

Tumor drug resistance and systemic side effects of chemotherapeutic drugs are the main reasons for the failure of cancer *** recent years,it was found that some natural active ingredients can reverse MDR and regulate body immunity to enhance the efficacy and reduce toxicity of chemotherapeutic *** this paper,a new nanosuspensions,HCPT and QUR hybrid nanosuspensions(HQ-NPs),was prepared by the microprecipitation-high pressure homogenization method to reverse tumor drug resistance,reduce toxicity,and increase therapeutic *** in vitro investigation results showed that HQ-NPs had a unique shape(particle size was about 216.3±5.9 nm),changed crystalline,and different dissolution rates compared with HCPT-NPs and QUR-NPs,which is attributed to the strong intermolecular forces between HCPT and QUR as indicated by the results of the molecule *** was verified that the HQ-NPs could double the retention of HCPT in cells and enhance the cytotoxicity to A549/PTX cells in vitro tests compared with *** also found that HQ-NPs can significantly enhance the accumulation of HCPT in tumor sites,improve the antitumor activity of HCPT,and protect the immune organs and other normal tissues(P<0.01),compared with ***,hybrid nanosuspensions can offer promising potential as the drug delivery system for HCPT and QUR to increase the therapeutic efficacy and reduce the toxicity of HCPT.

关键词： Combination therapy Multidrug resistance Nanosuspensions Antitumor activity Immunomodulatory

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Determination of the surface states from the ultrafast electronic states in a thermoelectric material

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Chinese Physics B 2022年第2期31卷 149-153页

作者： Tongyao Wu Hongyuan Wang Yuanyuan Yang shaofeng duan Chaozhi Huang Tianwei Tang Yanfeng Guo Weidong Luo Wentao Zhang Key Laboratory of Aricial Structures and Quanum Control(Ministry of Education) Shenyang National Laboratory for Materials ScienceSchool of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China School of Physical Science and Technology Shanghai Tch UnivesityShanghai 201210 China SInstitute of Natural Sciences Shanghai Jiao Tong University.Shanghai 200240China

We reveal the electronic structure in Yb Cd_(2)Sb_(2),a thermoelectric material,by angle-resolved photoemission spectroscopy(ARPES)and time-resolved ARPES(tr ARPES).Specifically,three bulk bands at the vicinity of the Fermi level are evidenced near the Brillouin zone center,consistent with the density functional theory(DFT)*** is interesting that the spin-unpolarized bulk bands respond unexpectedly to right-and left-handed circularly polarized *** addition,a hole band of surface states,which is not sensitive to the polarization of the probe beam and is not expected from the DFT calculation,is *** find that the non-equilibrium quasiparticle recovery rate is much smaller in the surface states than that of the bulk *** results demonstrate that the surface states can be distinguished from the bulk ones from a view of time scale in the nonequilibrium physics.

关键词： electronic band structure YbCd_(2)Sb_(2) surface states time-and angle-resolved photoemission spectroscopy

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